ES413268A1 - Un procedimiento para la preparacion de un derivado de aci-do indenilacetico. - Google Patents
Un procedimiento para la preparacion de un derivado de aci-do indenilacetico.Info
- Publication number
- ES413268A1 ES413268A1 ES413268A ES413268A ES413268A1 ES 413268 A1 ES413268 A1 ES 413268A1 ES 413268 A ES413268 A ES 413268A ES 413268 A ES413268 A ES 413268A ES 413268 A1 ES413268 A1 ES 413268A1
- Authority
- ES
- Spain
- Prior art keywords
- formula
- indenyl compounds
- see formula
- aeration
- dehydration
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 125000003454 indenyl group Chemical group C1(C=CC2=CC=CC=C12)* 0.000 title 1
- AEMRFAOFKBGASW-UHFFFAOYSA-N Glycolic acid Chemical compound OCC(O)=O AEMRFAOFKBGASW-UHFFFAOYSA-N 0.000 abstract 2
- 238000000034 method Methods 0.000 abstract 2
- PTUSXMWNCXRKAX-UHFFFAOYSA-N 2-(1h-inden-1-yl)acetic acid Chemical class C1=CC=C2C(CC(=O)O)C=CC2=C1 PTUSXMWNCXRKAX-UHFFFAOYSA-N 0.000 abstract 1
- 238000005273 aeration Methods 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 230000018044 dehydration Effects 0.000 abstract 1
- 238000006297 dehydration reaction Methods 0.000 abstract 1
- 238000002360 preparation method Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
- C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
- C07D295/182—Radicals derived from carboxylic acids
- C07D295/185—Radicals derived from carboxylic acids from aliphatic carboxylic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C205/00—Compounds containing nitro groups bound to a carbon skeleton
- C07C205/49—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by carboxyl groups
- C07C205/56—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by carboxyl groups having nitro groups bound to carbon atoms of six-membered aromatic rings and carboxyl groups bound to acyclic carbon atoms of the carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C209/00—Preparation of compounds containing amino groups bound to a carbon skeleton
- C07C209/30—Preparation of compounds containing amino groups bound to a carbon skeleton by reduction of nitrogen-to-oxygen or nitrogen-to-nitrogen bonds
- C07C209/32—Preparation of compounds containing amino groups bound to a carbon skeleton by reduction of nitrogen-to-oxygen or nitrogen-to-nitrogen bonds by reduction of nitro groups
- C07C209/36—Preparation of compounds containing amino groups bound to a carbon skeleton by reduction of nitrogen-to-oxygen or nitrogen-to-nitrogen bonds by reduction of nitro groups by reduction of nitro groups bound to carbon atoms of six-membered aromatic rings in presence of hydrogen-containing gases and a catalyst
- C07C209/365—Preparation of compounds containing amino groups bound to a carbon skeleton by reduction of nitrogen-to-oxygen or nitrogen-to-nitrogen bonds by reduction of nitro groups by reduction of nitro groups bound to carbon atoms of six-membered aromatic rings in presence of hydrogen-containing gases and a catalyst by reduction with preservation of halogen-atoms in compounds containing nitro groups and halogen atoms bound to the same carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C317/00—Sulfones; Sulfoxides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
- C07C45/45—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by condensation
- C07C45/46—Friedel-Crafts reactions
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C57/00—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms
- C07C57/52—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing halogen
- C07C57/58—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing halogen containing six-membered aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C57/00—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms
- C07C57/52—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing halogen
- C07C57/58—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing halogen containing six-membered aromatic rings
- C07C57/60—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing halogen containing six-membered aromatic rings having unsaturation outside the rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C57/00—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms
- C07C57/52—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing halogen
- C07C57/62—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing halogen containing six-membered aromatic rings and other rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
- C07C59/40—Unsaturated compounds
- C07C59/58—Unsaturated compounds containing ether groups, groups, groups, or groups
- C07C59/64—Unsaturated compounds containing ether groups, groups, groups, or groups containing six-membered aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
- C07C59/40—Unsaturated compounds
- C07C59/58—Unsaturated compounds containing ether groups, groups, groups, or groups
- C07C59/72—Unsaturated compounds containing ether groups, groups, groups, or groups containing six-membered aromatic rings and other rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
- C07C59/40—Unsaturated compounds
- C07C59/74—Unsaturated compounds containing —CHO groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
- C07C59/40—Unsaturated compounds
- C07C59/76—Unsaturated compounds containing keto groups
- C07C59/88—Unsaturated compounds containing keto groups containing halogen
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D303/00—Compounds containing three-membered rings having one oxygen atom as the only ring hetero atom
- C07D303/02—Compounds containing oxirane rings
- C07D303/38—Compounds containing oxirane rings with hydrocarbon radicals, substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
- C07D309/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
- C07D309/08—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D309/10—Oxygen atoms
- C07D309/12—Oxygen atoms only hydrogen atoms and one oxygen atom directly attached to ring carbon atoms, e.g. tetrahydropyranyl ethers
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D331/00—Heterocyclic compounds containing rings of less than five members, having one sulfur atom as the only ring hetero atom
- C07D331/02—Three-membered rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F3/00—Compounds containing elements of Groups 2 or 12 of the Periodic Table
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F3/00—Compounds containing elements of Groups 2 or 12 of the Periodic Table
- C07F3/02—Magnesium compounds
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/28—Phosphorus compounds with one or more P—C bonds
- C07F9/54—Quaternary phosphonium compounds
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/28—Phosphorus compounds with one or more P—C bonds
- C07F9/54—Quaternary phosphonium compounds
- C07F9/5407—Acyclic saturated phosphonium compounds
-
- C—CHEMISTRY; METALLURGY
- C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
- C09B—ORGANIC DYES OR CLOSELY-RELATED COMPOUNDS FOR PRODUCING DYES, e.g. PIGMENTS; MORDANTS; LAKES
- C09B23/00—Methine or polymethine dyes, e.g. cyanine dyes
- C09B23/02—Methine or polymethine dyes, e.g. cyanine dyes the polymethine chain containing an odd number of >CH- or >C[alkyl]- groups
- C09B23/04—Methine or polymethine dyes, e.g. cyanine dyes the polymethine chain containing an odd number of >CH- or >C[alkyl]- groups one >CH- group, e.g. cyanines, isocyanines, pseudocyanines
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US3389070A | 1970-05-01 | 1970-05-01 |
Publications (1)
Publication Number | Publication Date |
---|---|
ES413268A1 true ES413268A1 (es) | 1976-05-16 |
Family
ID=21873053
Family Applications (6)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES413268A Expired ES413268A1 (es) | 1970-05-01 | 1973-04-02 | Un procedimiento para la preparacion de un derivado de aci-do indenilacetico. |
ES413276A Expired ES413276A1 (es) | 1970-05-01 | 1973-04-02 | Un procedimiento para la preparacion de un derivado de aci-do indenil-acetico. |
ES413267A Expired ES413267A1 (es) | 1970-05-01 | 1973-04-02 | Un procedimiento para la preparacion de un derivado de aci-do indenilacetico. |
ES413275A Expired ES413275A1 (es) | 1970-05-01 | 1973-04-02 | Un procedimiento para la preparacion de un derivado de aci-do indenilacetico. |
ES413269A Expired ES413269A1 (es) | 1970-05-01 | 1973-04-02 | Un procedimiento para la preparacion de acidos 5 - fluor - 2 - metil - 1 - (p-metilsulfinilbenciliden) - 3 - indenil - acetico. |
ES413266A Expired ES413266A1 (es) | 1970-05-01 | 1973-04-02 | Un procedimiento para la preparacion de un derivado de aci-do indenilacetico. |
Family Applications After (5)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES413276A Expired ES413276A1 (es) | 1970-05-01 | 1973-04-02 | Un procedimiento para la preparacion de un derivado de aci-do indenil-acetico. |
ES413267A Expired ES413267A1 (es) | 1970-05-01 | 1973-04-02 | Un procedimiento para la preparacion de un derivado de aci-do indenilacetico. |
ES413275A Expired ES413275A1 (es) | 1970-05-01 | 1973-04-02 | Un procedimiento para la preparacion de un derivado de aci-do indenilacetico. |
ES413269A Expired ES413269A1 (es) | 1970-05-01 | 1973-04-02 | Un procedimiento para la preparacion de acidos 5 - fluor - 2 - metil - 1 - (p-metilsulfinilbenciliden) - 3 - indenil - acetico. |
ES413266A Expired ES413266A1 (es) | 1970-05-01 | 1973-04-02 | Un procedimiento para la preparacion de un derivado de aci-do indenilacetico. |
Country Status (4)
Country | Link |
---|---|
US (1) | US3732292A (es) |
AT (9) | AT327879B (es) |
CS (3) | CS194170B2 (es) |
ES (6) | ES413268A1 (es) |
Families Citing this family (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3932498A (en) * | 1971-01-21 | 1976-01-13 | Merck & Co., Inc. | 3-Indenyl-γ-(ketobutyric)-acid compounds |
US3883660A (en) * | 1972-04-27 | 1975-05-13 | Merck & Co Inc | Treatment of pain, fever or inflammation with 5-fluoro-2-methyl-1-cp-methylsulfinyl-benzylidene)-3-indenylacetaldehyde |
US3860636A (en) * | 1972-12-06 | 1975-01-14 | Merck & Co Inc | Substituted indenyl phosphonic acids having anti-inflammatory activity |
US3914318A (en) * | 1973-05-24 | 1975-10-21 | Merck & Co Inc | Process for preparing 4-methylsulfinylbenzaldehyde |
US3923859A (en) * | 1973-08-31 | 1975-12-02 | Merck & Co Inc | Substituted fulvene acetic acids and derivatives |
NL170534C (nl) * | 1973-12-20 | 1982-11-16 | Merck & Co Inc | Werkwijze voor het bereiden van 5-fluor 2 methyl 1-(p-methylsulfinylbenzylideen)indeen 3-azijnzuur. |
US3944600A (en) * | 1973-12-20 | 1976-03-16 | Merck & Co., Inc. | Indenylidene-3-acetic acid process for preparing indene acetic acids |
US3870753A (en) * | 1973-12-20 | 1975-03-11 | Merck & Co Inc | Process for preparing indenyl acetic acids |
US5093356A (en) * | 1990-01-16 | 1992-03-03 | Merck Frosst Canada, Inc. | Indenyl hydroxamic acids and hydroxy ureas as inhibitors of 5-lipoxygenase |
US6214876B1 (en) * | 1994-07-21 | 2001-04-10 | Eli Lilly And Company | Indene-1-acetamide sPLA2 inhibitors |
AU9123198A (en) | 1997-08-28 | 1999-03-16 | Eli Lilly And Company | Method for treatment of non-rheumatoid athritis |
-
1970
- 1970-05-01 US US00033890A patent/US3732292A/en not_active Expired - Lifetime
- 1970-11-18 AT AT22774*7A patent/AT327879B/de active
- 1970-11-18 AT AT22574*7A patent/AT326647B/de not_active IP Right Cessation
- 1970-11-18 AT AT22774*A patent/ATA22774A/de unknown
- 1970-11-18 AT AT22874*7A patent/AT327880B/de not_active IP Right Cessation
- 1970-11-18 CS CS747129A patent/CS194170B2/cs unknown
- 1970-11-18 AT AT1039870A patent/AT321291B/de not_active IP Right Cessation
- 1970-11-18 AT AT22574*A patent/ATA22574A/de not_active IP Right Cessation
- 1970-11-18 AT AT70074*7A patent/AT327182B/de not_active IP Right Cessation
- 1970-11-18 AT AT7022874A patent/ATA22874A/de not_active IP Right Cessation
- 1970-11-18 CS CS707775A patent/CS194154B2/cs unknown
- 1970-11-18 AT AT70074*A patent/ATA70074A/de not_active IP Right Cessation
- 1970-11-18 CS CS747128A patent/CS194169B2/cs unknown
-
1973
- 1973-04-02 ES ES413268A patent/ES413268A1/es not_active Expired
- 1973-04-02 ES ES413276A patent/ES413276A1/es not_active Expired
- 1973-04-02 ES ES413267A patent/ES413267A1/es not_active Expired
- 1973-04-02 ES ES413275A patent/ES413275A1/es not_active Expired
- 1973-04-02 ES ES413269A patent/ES413269A1/es not_active Expired
- 1973-04-02 ES ES413266A patent/ES413266A1/es not_active Expired
Also Published As
Publication number | Publication date |
---|---|
ES413276A1 (es) | 1976-05-01 |
AT326647B (de) | 1975-12-29 |
ATA70074A (de) | 1975-04-15 |
AT327182B (de) | 1976-01-26 |
ATA22874A (de) | 1975-05-15 |
ES413275A1 (es) | 1976-05-01 |
CS194169B2 (en) | 1979-11-30 |
AT327880B (de) | 1976-02-25 |
ES413267A1 (es) | 1976-05-01 |
CS194154B2 (en) | 1979-11-30 |
ATA22774A (de) | 1975-05-15 |
AT327879B (de) | 1976-02-25 |
ES413266A1 (es) | 1976-06-16 |
ES413269A1 (es) | 1976-06-01 |
ATA22574A (de) | 1975-03-15 |
AT321291B (de) | 1975-03-25 |
US3732292A (en) | 1973-05-08 |
CS194170B2 (en) | 1979-11-30 |
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