ES413252A1 - Process for the production of 6-piper-azinyl-morphanthridines and related tricyclics - Google Patents
Process for the production of 6-piper-azinyl-morphanthridines and related tricyclicsInfo
- Publication number
- ES413252A1 ES413252A1 ES413252A ES413252A ES413252A1 ES 413252 A1 ES413252 A1 ES 413252A1 ES 413252 A ES413252 A ES 413252A ES 413252 A ES413252 A ES 413252A ES 413252 A1 ES413252 A1 ES 413252A1
- Authority
- ES
- Spain
- Prior art keywords
- carbon atoms
- alkyl
- formula
- hydrogen
- see formula
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/02—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms containing only hydrogen and carbon atoms in addition to the ring hetero elements
- C07D295/027—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms containing only hydrogen and carbon atoms in addition to the ring hetero elements containing only one hetero ring
- C07D295/03—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms containing only hydrogen and carbon atoms in addition to the ring hetero elements containing only one hetero ring with the ring nitrogen atoms directly attached to acyclic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
- C07D333/14—Radicals substituted by singly bound hetero atoms other than halogen
- C07D333/20—Radicals substituted by singly bound hetero atoms other than halogen by nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D333/30—Hetero atoms other than halogen
- C07D333/32—Oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
- Other In-Based Heterocyclic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
Process for the production of piperazine derivatives, of formula I, **(See formula)** wherein R1 is hydrogen, alkoxyalkyl of 2 to 6 carbon atoms in its entirety, alkyl of 1 to 4 carbon atoms, hydroxyalkyl of 1 to 4 carbon atoms, or acyloxyalkyl of 3 to 22 carbon atoms in all of the same; R4 is hydrogen, alkyl, alkoxy, or alkylthio, where the alkyl groups have 1 to 4 carbon atoms, halogen, or trifluoromethyl; and A means the structure **(See formula)** where a) when A means Z1, X is a group -CH2, -O-, -S-, (see formula), where the alkyl group has from 1 to 3 carbon atoms, R2 is hydrogen, alkyl, dialkylaminosulfonyl, alkylsulfonyl, where the alkyl groups have from 1 to 4 carbon atoms, alkoxy or alkylthio from 1 to 4 carbon, halogen, nitro, trifluoromethylsulfonyl, trifluoromethoxy, trifluoromethylthio, acetyl, cyano, or trifluoromethyl atoms, and R3 is hydrogen, halogen, or alkyl of 1 to 4 carbon atoms, or b) when A means Z2, X is a group -CH2- or -S-, characterized in that a compound of formula II is reacted, **(See formula)** where X, A and R4 have the meanings indicated above, with a metal-amine complex including titanium, zirconium, hafnium or vanadium, and a compound of formula III, **(See formula)** where R1 has the meaning indicated above. (Machine-translation by Google Translate, not legally binding)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CH489872A CH569730A5 (en) | 1972-04-04 | 1972-04-04 | |
| CH490172A CH569731A5 (en) | 1972-04-04 | 1972-04-04 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES413252A1 true ES413252A1 (en) | 1976-05-01 |
Family
ID=25696493
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES413252A Expired ES413252A1 (en) | 1972-04-04 | 1973-04-02 | Process for the production of 6-piper-azinyl-morphanthridines and related tricyclics |
Country Status (28)
| Country | Link |
|---|---|
| JP (2) | JPS4913189A (en) |
| AR (1) | AR195913A1 (en) |
| AT (1) | AT340428B (en) |
| BE (1) | BE797671A (en) |
| BG (1) | BG21221A3 (en) |
| CA (1) | CA1029372A (en) |
| CH (2) | CH569731A5 (en) |
| CS (1) | CS178125B2 (en) |
| CY (1) | CY990A (en) |
| DD (1) | DD105614A5 (en) |
| DK (1) | DK150850C (en) |
| ES (1) | ES413252A1 (en) |
| FI (1) | FI61029C (en) |
| FR (1) | FR2179071B1 (en) |
| GB (1) | GB1418363A (en) |
| HK (1) | HK11079A (en) |
| HU (1) | HU166524B (en) |
| IL (1) | IL41936A (en) |
| LU (1) | LU67351A1 (en) |
| MY (1) | MY7900116A (en) |
| NL (1) | NL175621C (en) |
| NO (1) | NO138210C (en) |
| PH (1) | PH11180A (en) |
| PL (1) | PL89178B1 (en) |
| RO (1) | RO72458A (en) |
| SE (1) | SE399890B (en) |
| SU (1) | SU457220A3 (en) |
| YU (1) | YU39906B (en) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NL7403657A (en) * | 1973-03-23 | 1974-09-25 | ||
| JPS51135089A (en) * | 1975-05-19 | 1976-11-22 | Hitachi Zosen Corp | Under-water operation assistant ship |
| IT1207417B (en) * | 1982-03-15 | 1989-05-17 | Menarini Sas | AZEPINA-6-ONE WITH ACTIVITIES TRICYCLIC COMPOUNDS DERIVED FROM PHARMACOLOGICAL, AND PROCEDURES OF 5,6-DIHYDRO-11H-DIBENZO (B, E) RELATED MANUFACTURE |
| GB8607684D0 (en) * | 1986-03-27 | 1986-04-30 | Ici America Inc | Thiazepine compounds |
| EP2088147A1 (en) | 2003-12-22 | 2009-08-12 | Arcadia Pharmaceuticals Inc. | Dibenzo-condensed azepine, diazepine, oxazepine and thiazepine derivatives as muscarinic agonists and methods of treatment of neuropsychiatric disorders |
| ME01516B (en) | 2008-06-20 | 2014-04-20 | Astrazeneca Ab | Dibenzothiazepine derivative and use thereof |
-
1972
- 1972-04-04 CH CH490172A patent/CH569731A5/xx not_active IP Right Cessation
- 1972-04-04 CH CH489872A patent/CH569730A5/xx not_active IP Right Cessation
-
1973
- 1973-01-29 JP JP48011246A patent/JPS4913189A/ja active Pending
- 1973-03-26 DK DK165273A patent/DK150850C/en not_active IP Right Cessation
- 1973-03-27 FI FI943/73A patent/FI61029C/en active
- 1973-03-27 NO NO1257/73A patent/NO138210C/en unknown
- 1973-03-28 SE SE7304365A patent/SE399890B/en unknown
- 1973-03-29 SU SU1900401A patent/SU457220A3/en active
- 1973-03-30 PH PH14474A patent/PH11180A/en unknown
- 1973-03-30 NL NLAANVRAGE7304441,A patent/NL175621C/en active Search and Examination
- 1973-04-02 BE BE129561A patent/BE797671A/en not_active IP Right Cessation
- 1973-04-02 CY CY990A patent/CY990A/en unknown
- 1973-04-02 BG BG023138A patent/BG21221A3/en unknown
- 1973-04-02 PL PL1973161672A patent/PL89178B1/pl unknown
- 1973-04-02 CS CS2346A patent/CS178125B2/cs unknown
- 1973-04-02 RO RO7374359A patent/RO72458A/en unknown
- 1973-04-02 GB GB1566773A patent/GB1418363A/en not_active Expired
- 1973-04-02 CA CA167,668A patent/CA1029372A/en not_active Expired
- 1973-04-02 ES ES413252A patent/ES413252A1/en not_active Expired
- 1973-04-02 YU YU881/73A patent/YU39906B/en unknown
- 1973-04-03 AR AR247360A patent/AR195913A1/en active
- 1973-04-03 LU LU67351A patent/LU67351A1/xx unknown
- 1973-04-03 HU HUWA277A patent/HU166524B/hu unknown
- 1973-04-03 DD DD169911A patent/DD105614A5/xx unknown
- 1973-04-03 JP JP48037479A patent/JPS5142118B2/ja not_active Expired
- 1973-04-03 IL IL41936A patent/IL41936A/en unknown
- 1973-04-03 AT AT291173A patent/AT340428B/en not_active IP Right Cessation
- 1973-04-04 FR FR7312056A patent/FR2179071B1/fr not_active Expired
-
1979
- 1979-03-08 HK HK110/79A patent/HK11079A/en unknown
- 1979-12-30 MY MY116/79A patent/MY7900116A/en unknown
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