ES406929A1 - Analgesic derivatives of the series of sulphur-containing arylamines - Google Patents

Analgesic derivatives of the series of sulphur-containing arylamines

Info

Publication number
ES406929A1
ES406929A1 ES406929A ES406929A ES406929A1 ES 406929 A1 ES406929 A1 ES 406929A1 ES 406929 A ES406929 A ES 406929A ES 406929 A ES406929 A ES 406929A ES 406929 A1 ES406929 A1 ES 406929A1
Authority
ES
Spain
Prior art keywords
formula
nr1r2
group
aryl
amine
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES406929A
Other languages
Spanish (es)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Individual
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of ES406929A1 publication Critical patent/ES406929A1/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
    • C07D295/084—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C07D295/088—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C317/00—Sulfones; Sulfoxides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pain & Pain Management (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biomedical Technology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Hydrogenated Pyridines (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Procedure for obtaining amine aryl-mercaptans S-oxide compounds, useful as analgesic substances, which respond to the general formula: Ar - SOx - A - NR1R2 (I) where x is an integer having a value from 1 to 2; A is a C2-C4 alkylene group; NR1R2 represents a secondary, tertiary and N-heterocyclic amino group with 5 to 7 vertices that can comprise a second heteroatom chosen from among the sulfur, oxygen and nitrogen atoms, and that can comprise at least one substituent chosen mainly from among the alkyl groups in C1-C5 hydroxyalkyl containing from 1 to 5 carbon atoms and phenyl; Ar represents an aryl group, an aryl group mainly substituted by at least one halogen atom, and a 2-benzimidazolyl group, and their addition salts with acids, characterized in that it comprises reacting, in arbitrary sequence, a) in acid acetic, at a temperature greater than or equal to 20ºC, hydrogen peroxide on a chlorinated derivative of an arylthioalkyl of formula: Ar - S - A - Cl (II) wherein Ar and A are defined as above, and b) condensing an amine of formula: HNR1R2 (III) wherein NR1R2 is defined as above, and c) transforming, if appropriate, the compound of formula I, thus obtained, into an acid addition salt. (Machine-translation by Google Translate, not legally binding)
ES406929A 1971-09-22 1972-09-22 Analgesic derivatives of the series of sulphur-containing arylamines Expired ES406929A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB4424171A GB1371650A (en) 1971-09-22 1971-09-22 Analgesic derivatives of the series of sulphur-containing arylamines

Publications (1)

Publication Number Publication Date
ES406929A1 true ES406929A1 (en) 1976-02-01

Family

ID=10432415

Family Applications (2)

Application Number Title Priority Date Filing Date
ES406929A Expired ES406929A1 (en) 1971-09-22 1972-09-22 Analgesic derivatives of the series of sulphur-containing arylamines
ES436363A Expired ES436363A1 (en) 1971-09-22 1975-04-07 Analgesic derivatives of the series of sulphur-containing arylamines

Family Applications After (1)

Application Number Title Priority Date Filing Date
ES436363A Expired ES436363A1 (en) 1971-09-22 1975-04-07 Analgesic derivatives of the series of sulphur-containing arylamines

Country Status (13)

Country Link
JP (1) JPS5755718B2 (en)
AR (2) AR202378A1 (en)
AU (1) AU472048B2 (en)
BE (1) BE788805A (en)
CA (1) CA996129A (en)
CH (2) CH566308A5 (en)
DE (1) DE2246429C3 (en)
ES (2) ES406929A1 (en)
FR (1) FR2154528B1 (en)
GB (1) GB1371650A (en)
IL (1) IL40393A0 (en)
IN (1) IN137842B (en)
NL (1) NL7212829A (en)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2285859A1 (en) * 1974-09-30 1976-04-23 Lafon Labor PHENYLSULFINYL-AMIDINES AND DERIVATIVES
US4155907A (en) * 1976-08-16 1979-05-22 The Dow Chemical Company Method for inhibiting ADP-induced platelet aggregation using phenylthioalkylamines
FR2432316A1 (en) * 1978-08-02 1980-02-29 Choay Sa NOVEL MEDICINAL PRODUCTS CONTAINING, AS ACTIVE SUBSTANCE, BENZENESULFONE-LIKE COMPOUNDS, NOVEL SUCH COMPOUNDS AND PROCESS FOR THEIR PREPARATION
JPS5739044Y2 (en) * 1978-08-21 1982-08-27
FR2447909A1 (en) * 1979-01-31 1980-08-29 Choay Sa Alkyl phenyl sulphone(s) - used as antilipaemic agents, act on the central nervous system, and affect mitosis
JPS5964720U (en) * 1982-10-22 1984-04-28 日本軽金属株式会社 liquid container
CA1341314C (en) * 1984-07-06 2001-11-06 David Cox Derivatives of benzimidazole, benzothiazole and benzoxazole
AR243167A1 (en) 1985-08-24 1993-07-30 Hoechst Ag Substituted toluidines, process for their preparation, pharmaceutical compositions containing them and their use as gastric secretion inhibitors
JP2933739B2 (en) * 1990-04-09 1999-08-16 明治製菓株式会社 Thiazole or imidazole derivatives and anti-ulcer agents

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DD70880A (en) *
FR2100668A1 (en) * 1971-05-19 1972-03-24 Sumitomo Chemical Co Pharmacol-active heterocyclic cpds
JPS4946312A (en) * 1972-09-05 1974-05-02

Also Published As

Publication number Publication date
AR198415A1 (en) 1974-06-21
JPS4836147A (en) 1973-05-28
FR2154528B1 (en) 1975-10-17
GB1371650A (en) 1974-10-23
DE2246429A1 (en) 1973-03-29
ES436363A1 (en) 1977-01-01
IN137842B (en) 1975-09-27
NL7212829A (en) 1973-03-26
CA996129A (en) 1976-08-31
DE2246429C3 (en) 1982-05-19
AU472048B2 (en) 1976-05-13
DE2246429B2 (en) 1981-07-02
CH566308A5 (en) 1975-09-15
AR202378A1 (en) 1975-06-06
FR2154528A1 (en) 1973-05-11
CH565757A5 (en) 1975-08-29
AU4698472A (en) 1974-03-28
JPS5755718B2 (en) 1982-11-25
IL40393A0 (en) 1972-11-28
BE788805A (en) 1973-01-02

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