ES401921A1 - Procedure for the obtaining of new derivatives of the 7-amino-cephaloesporanic. (Machine-translation by Google Translate, not legally binding) - Google Patents

Abstract

Procedure for obtaining new derivatives of 7-amino-cephaloesporanic acid, of formula I **(See formula)** wherein R1 means an aminopyridine residue and R2 means an aromatic heterocyclic residue, linked through a carbon atom to the sulfur, which contains at least 2 nitrogen atoms and also a further heteroatom of the nitrogen, oxygen and sulfur group, or the esters or salts of these compounds; characterized in that a) a compound-of formula II **(See formula)** wherein Z represents the acyl radical R1'-CH2-CO-, where R1'represents an aminopyridine radical, optionally protected by a dissociable protecting group and where R2' represents a functionally modified, especially esterified, hydroxy group or an ester or a salt of these compounds, are reacted with a thiol of formula Ib **(See formula)** wherein R2 has the meaning indicated in formula I, or a metal salt thereof, or b) a compound of formula II, where Z means an esterified hydroxyacetyl group, capable of reaction and R2'means S-R2- or a salt or an ester of these compounds, are reacted with an aminopyridine, optionally protected by a dissociable protecting group, or c) a compound of formula II where Z is hydrogen and is S-R2 or a salt or ester of these compounds, they are reacted with acylating agent, bearing the acyl residue Z; and in the compounds obtained with an amino group, the protecting group is dissociated; and, if desired, an ester group, if any existing, dissociates and, if desired, the obtained compounds are transformed into their salts or from the obtained salts the internal salts are formed. (Machine-translation by Google Translate, not legally binding)