ES391971A1 - Production of penicillamine and its homologues - Google Patents
Production of penicillamine and its homologuesInfo
- Publication number
- ES391971A1 ES391971A1 ES71391971A ES391971A ES391971A1 ES 391971 A1 ES391971 A1 ES 391971A1 ES 71391971 A ES71391971 A ES 71391971A ES 391971 A ES391971 A ES 391971A ES 391971 A1 ES391971 A1 ES 391971A1
- Authority
- ES
- Spain
- Prior art keywords
- thiazolidin
- salts
- penicillamine
- carbonitriles
- transformed
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/08—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D277/10—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/04—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
- C07D277/06—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Thiazole And Isothizaole Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
Procedure for the preparation of penicillamine and its homologs by reaction of branched aldehydes in the carbon atom in the alpha position with sulfur and ammonia to form thiazolines- Δ 3, transformation of thiazolines- Δ 3 by anhydrous hydrogen cyanide into thiazolidin- 4-carbonitriles, hydrolysis of nitriles to form thiazolidin-4-carboxylic acid salts and ammonium salts, treatment of the mixture and separation of ammonium salts, and hydrolytic degradation of thiazolidin-4-carboxylic acids, characterized in that, under action of mineral acids, the thiazolidin-4-carbonitriles are first transformed at low temperature into the thiazolidin-4-carboxamide salts, and later they are transformed at high temperature into the thiazolidin-4-carboxylic acid salts. (Machine-translation by Google Translate, not legally binding)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE2032952A DE2032952C3 (en) | 1970-07-03 | 1970-07-03 | Process for the preparation of D, L-penicillamine |
DE19712123232 DE2123232C3 (en) | 1971-05-11 | 1971-05-11 | Process for the preparation of DJ ^ penicillamine |
Publications (1)
Publication Number | Publication Date |
---|---|
ES391971A1 true ES391971A1 (en) | 1974-05-01 |
Family
ID=25759383
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES71391971A Expired ES391971A1 (en) | 1970-07-03 | 1971-06-05 | Production of penicillamine and its homologues |
Country Status (16)
Country | Link |
---|---|
JP (1) | JPS544936B1 (en) |
AT (2) | AT322523B (en) |
BE (1) | BE769390A (en) |
CA (1) | CA949977A (en) |
CH (1) | CH575388A5 (en) |
DK (1) | DK145180C (en) |
ES (1) | ES391971A1 (en) |
FR (1) | FR2100257A5 (en) |
GB (1) | GB1346198A (en) |
IE (1) | IE35409B1 (en) |
IL (1) | IL37171A (en) |
IT (1) | IT1035036B (en) |
NL (1) | NL171891C (en) |
RO (1) | RO59924A (en) |
SE (1) | SE395001B (en) |
SU (1) | SU508207A3 (en) |
Family Cites Families (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CH540234A (en) * | 1968-09-06 | 1973-08-15 | Degussa | Process for the manufacture of penicillamine |
-
1971
- 1971-06-05 ES ES71391971A patent/ES391971A1/en not_active Expired
- 1971-06-14 DK DK288571A patent/DK145180C/en active
- 1971-06-21 NL NLAANVRAGE7108503,A patent/NL171891C/en not_active IP Right Cessation
- 1971-06-24 GB GB2963571A patent/GB1346198A/en not_active Expired
- 1971-06-25 RO RO67459A patent/RO59924A/ro unknown
- 1971-06-28 IL IL37171A patent/IL37171A/en unknown
- 1971-06-29 IE IE829/71A patent/IE35409B1/en unknown
- 1971-07-01 BE BE769390A patent/BE769390A/en not_active IP Right Cessation
- 1971-07-02 CH CH979471A patent/CH575388A5/xx not_active IP Right Cessation
- 1971-07-02 SU SU1677804A patent/SU508207A3/en active
- 1971-07-02 SE SE7108614A patent/SE395001B/en unknown
- 1971-07-02 AT AT819973*1A patent/AT322523B/en not_active IP Right Cessation
- 1971-07-02 AT AT576871A patent/AT313864B/en not_active IP Right Cessation
- 1971-07-02 IT IT51366/71A patent/IT1035036B/en active
- 1971-07-03 JP JP4917971A patent/JPS544936B1/ja active Pending
- 1971-07-05 CA CA117,354A patent/CA949977A/en not_active Expired
- 1971-07-05 FR FR7124505A patent/FR2100257A5/fr not_active Expired
Also Published As
Publication number | Publication date |
---|---|
IT1035036B (en) | 1979-10-20 |
RO59924A (en) | 1976-07-15 |
IE35409B1 (en) | 1976-02-04 |
CH575388A5 (en) | 1976-05-14 |
IL37171A0 (en) | 1971-08-25 |
FR2100257A5 (en) | 1972-03-17 |
DK145180B (en) | 1982-09-27 |
SU508207A3 (en) | 1976-03-25 |
GB1346198A (en) | 1974-02-06 |
IL37171A (en) | 1974-10-22 |
NL171891C (en) | 1983-06-01 |
CA949977A (en) | 1974-06-25 |
BE769390A (en) | 1972-01-03 |
JPS544936B1 (en) | 1979-03-12 |
AT322523B (en) | 1975-05-26 |
SE395001B (en) | 1977-07-25 |
NL7108503A (en) | 1972-01-05 |
AT313864B (en) | 1974-03-11 |
IE35409L (en) | 1972-01-03 |
DK145180C (en) | 1983-02-28 |
NL171891B (en) | 1983-01-03 |
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