ES391542A1 - Isoquinobenzodiazepine derivs - cns depressants hypotensives etc - prepd from isoquinoline-carboxylic acids - Google Patents

Isoquinobenzodiazepine derivs - cns depressants hypotensives etc - prepd from isoquinoline-carboxylic acids

Info

Publication number
ES391542A1
ES391542A1 ES391542A ES391542A ES391542A1 ES 391542 A1 ES391542 A1 ES 391542A1 ES 391542 A ES391542 A ES 391542A ES 391542 A ES391542 A ES 391542A ES 391542 A1 ES391542 A1 ES 391542A1
Authority
ES
Spain
Prior art keywords
hypotensives
prepd
isoquinobenzodiazepine
derivs
isoquinoline
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES391542A
Other languages
Spanish (es)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Abbott Japan Co Ltd
Original Assignee
Hokuriku Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from JP45046907A external-priority patent/JPS5017999B1/ja
Priority claimed from JP45046906A external-priority patent/JPS5017998B1/ja
Application filed by Hokuriku Pharmaceutical Co Ltd filed Critical Hokuriku Pharmaceutical Co Ltd
Publication of ES391542A1 publication Critical patent/ES391542A1/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
    • C07D217/26—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems

Abstract

Isoquinobenzodiazepine derivs. - CNS depressants, hypotensives, etc., prepd. from isoquinoline-carboxylic acids. Cpds. of formula: (where Y is CH2, CO or SO2 R1-R4 are H, halogen, lower alkyl, alkoxy or methylenedioxy) have CNS depressant activity and affect blood pressure and are used as sedatives, analgesics, antihistamines, tranquillisers, diuretics and hypotensives, and may be prepd. by reacting the corresp. tetrahydroisoquinoline-3-carboxylic acid with the corresp. 2-(Y-X)-nitrobenzene (where Y is halogen) followed by reduction and cyclisation.
ES391542A 1970-06-02 1971-05-25 Isoquinobenzodiazepine derivs - cns depressants hypotensives etc - prepd from isoquinoline-carboxylic acids Expired ES391542A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP45046907A JPS5017999B1 (en) 1970-06-02 1970-06-02
JP45046906A JPS5017998B1 (en) 1970-06-02 1970-06-02

Publications (1)

Publication Number Publication Date
ES391542A1 true ES391542A1 (en) 1975-09-16

Family

ID=26387056

Family Applications (1)

Application Number Title Priority Date Filing Date
ES391542A Expired ES391542A1 (en) 1970-06-02 1971-05-25 Isoquinobenzodiazepine derivs - cns depressants hypotensives etc - prepd from isoquinoline-carboxylic acids

Country Status (2)

Country Link
DE (1) DE2125778A1 (en)
ES (1) ES391542A1 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BR9611479B1 (en) * 1995-11-13 2009-01-13 Unsubstituted cyclic and heterocyclic alpha-iminohydroxamic and carboxylic acids.

Also Published As

Publication number Publication date
DE2125778A1 (en) 1971-12-16

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