ES387024A1 - Procedure for the obtaining of quinazolinone derivatives. (Machine-translation by Google Translate, not legally binding) - Google Patents
Procedure for the obtaining of quinazolinone derivatives. (Machine-translation by Google Translate, not legally binding)Info
- Publication number
- ES387024A1 ES387024A1 ES387024A ES387024A ES387024A1 ES 387024 A1 ES387024 A1 ES 387024A1 ES 387024 A ES387024 A ES 387024A ES 387024 A ES387024 A ES 387024A ES 387024 A1 ES387024 A1 ES 387024A1
- Authority
- ES
- Spain
- Prior art keywords
- radical
- carbon atoms
- atom
- alkyl
- formula
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/06—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by halogen atoms or nitro radicals
- C07D295/073—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by halogen atoms or nitro radicals with the ring nitrogen atoms and the substituents separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
- C07D239/72—Quinazolines; Hydrogenated quinazolines
- C07D239/78—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 2
- C07D239/80—Oxygen atoms
- C07D239/82—Oxygen atoms with an aryl radical attached in position 4
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Plural Heterocyclic Compounds (AREA)
- Catalysts (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Quinoline Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Abstract
Procedure for obtaining quinazolinone derivatives of formula Ib, ** (See formula) ** where R 1 means an amino radical, an N-dialkylamino radical where each alkyl radical is from 1 to 4 carbon atoms, or an N-morpholino radical, R means a hydrogen, fluorine, chlorine or bromine atom, an alkyl radical from 1 to 5 carbon atoms or an alkoxy radical from 1 to 4 carbon atoms, with the proviso that R does not mean a hydrogen atom when Rº1 means a nitro radical, R'1 means an alkyl radical of 1 to 5 atoms carbon, except that it does not mean a tertiary alkyl group where the tertiary carbon atom is linked directly to the nitrogen atom of the ring, an allyl radical or a propargyl radical, and R'' means a phenyl radical or a substituted phenyl radical of formula II, ** (See formula) ** where Y means a fluorine, chlorine or bromine atom, an alkyl radical of 1 to 4 carbon atoms, an alkoxy radical of 1 to 4 carbon atoms or a trifluoromethyl group, and Y'means a hydrogen, fluorine atom, chlorine or bromine, an alkyl radical of 1 to 4 carbon atoms, or an alkoxy radical of 1 to 4 carbon atoms, characterized in that a compound of formula IIIa is cyclized, ** (See formula) ** where Rº1, R, R'1 and R'' have the meanings indicated above, with a lower alkyl carbamate (C1-C5), preferably with an excess of urethane that acts as a solvent at a temperature of at least 10º 140ºC and preferably between 160º and 180ºC in the presence of a Lewis acid. (Machine-translation by Google Translate, not legally binding)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US00775201A US3723432A (en) | 1968-11-12 | 1968-11-12 | 1-substituted-4-aryl-2(1h)-quinazolinones and their preparation |
| CH1624569A CH521972A (en) | 1968-11-12 | 1969-10-31 | Process for the preparation of 2 (1H) -quinazolinones |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES387024A1 true ES387024A1 (en) | 1973-12-01 |
Family
ID=25717572
Family Applications (11)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES387027A Expired ES387027A1 (en) | 1968-11-12 | 1971-01-05 | Procedure for the obtaining of quinazolinone derivatives. (Machine-translation by Google Translate, not legally binding) |
| ES387031A Expired ES387031A1 (en) | 1968-11-12 | 1971-01-05 | Procedure for the obtaining of quinazolinone derivatives. (Machine-translation by Google Translate, not legally binding) |
| ES387028A Expired ES387028A1 (en) | 1968-11-12 | 1971-01-05 | Procedure for the obtaining of quinazolinone derivatives. (Machine-translation by Google Translate, not legally binding) |
| ES387033A Expired ES387033A1 (en) | 1968-11-12 | 1971-01-05 | Procedure for the obtaining of quinazolinones. (Machine-translation by Google Translate, not legally binding) |
| ES387032A Expired ES387032A1 (en) | 1968-11-12 | 1971-01-05 | Procedure for the obtaining of quinazolinone derivatives. (Machine-translation by Google Translate, not legally binding) |
| ES387025A Expired ES387025A1 (en) | 1968-11-12 | 1971-01-05 | Procedure for the obtaining of quinazolinone derivatives. (Machine-translation by Google Translate, not legally binding) |
| ES387024A Expired ES387024A1 (en) | 1968-11-12 | 1971-01-05 | Procedure for the obtaining of quinazolinone derivatives. (Machine-translation by Google Translate, not legally binding) |
| ES387030A Expired ES387030A1 (en) | 1968-11-12 | 1971-01-05 | Procedure for the obtaining of quinazolinone derivatives. (Machine-translation by Google Translate, not legally binding) |
| ES387034A Expired ES387034A1 (en) | 1968-11-12 | 1971-01-05 | Procedure for the obtaining of quinazolinones. (Machine-translation by Google Translate, not legally binding) |
| ES387029A Expired ES387029A1 (en) | 1968-11-12 | 1971-01-05 | Procedure for the obtaining of quinazolinone derivatives. (Machine-translation by Google Translate, not legally binding) |
| ES387026A Expired ES387026A1 (en) | 1968-11-12 | 1971-01-05 | Procedure for the obtaining of quinazolinone derivatives. (Machine-translation by Google Translate, not legally binding) |
Family Applications Before (6)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES387027A Expired ES387027A1 (en) | 1968-11-12 | 1971-01-05 | Procedure for the obtaining of quinazolinone derivatives. (Machine-translation by Google Translate, not legally binding) |
| ES387031A Expired ES387031A1 (en) | 1968-11-12 | 1971-01-05 | Procedure for the obtaining of quinazolinone derivatives. (Machine-translation by Google Translate, not legally binding) |
| ES387028A Expired ES387028A1 (en) | 1968-11-12 | 1971-01-05 | Procedure for the obtaining of quinazolinone derivatives. (Machine-translation by Google Translate, not legally binding) |
| ES387033A Expired ES387033A1 (en) | 1968-11-12 | 1971-01-05 | Procedure for the obtaining of quinazolinones. (Machine-translation by Google Translate, not legally binding) |
| ES387032A Expired ES387032A1 (en) | 1968-11-12 | 1971-01-05 | Procedure for the obtaining of quinazolinone derivatives. (Machine-translation by Google Translate, not legally binding) |
| ES387025A Expired ES387025A1 (en) | 1968-11-12 | 1971-01-05 | Procedure for the obtaining of quinazolinone derivatives. (Machine-translation by Google Translate, not legally binding) |
Family Applications After (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES387030A Expired ES387030A1 (en) | 1968-11-12 | 1971-01-05 | Procedure for the obtaining of quinazolinone derivatives. (Machine-translation by Google Translate, not legally binding) |
| ES387034A Expired ES387034A1 (en) | 1968-11-12 | 1971-01-05 | Procedure for the obtaining of quinazolinones. (Machine-translation by Google Translate, not legally binding) |
| ES387029A Expired ES387029A1 (en) | 1968-11-12 | 1971-01-05 | Procedure for the obtaining of quinazolinone derivatives. (Machine-translation by Google Translate, not legally binding) |
| ES387026A Expired ES387026A1 (en) | 1968-11-12 | 1971-01-05 | Procedure for the obtaining of quinazolinone derivatives. (Machine-translation by Google Translate, not legally binding) |
Country Status (2)
| Country | Link |
|---|---|
| CH (6) | CH520686A (en) |
| ES (11) | ES387027A1 (en) |
-
1969
- 1969-10-31 CH CH187372A patent/CH520686A/en not_active IP Right Cessation
- 1969-10-31 CH CH187872A patent/CH520691A/en not_active IP Right Cessation
- 1969-10-31 CH CH187772A patent/CH520690A/en not_active IP Right Cessation
- 1969-10-31 CH CH187272A patent/CH520145A/en not_active IP Right Cessation
- 1969-10-31 CH CH187472A patent/CH520687A/en not_active IP Right Cessation
- 1969-10-31 CH CH187572A patent/CH520688A/en not_active IP Right Cessation
-
1971
- 1971-01-05 ES ES387027A patent/ES387027A1/en not_active Expired
- 1971-01-05 ES ES387031A patent/ES387031A1/en not_active Expired
- 1971-01-05 ES ES387028A patent/ES387028A1/en not_active Expired
- 1971-01-05 ES ES387033A patent/ES387033A1/en not_active Expired
- 1971-01-05 ES ES387032A patent/ES387032A1/en not_active Expired
- 1971-01-05 ES ES387025A patent/ES387025A1/en not_active Expired
- 1971-01-05 ES ES387024A patent/ES387024A1/en not_active Expired
- 1971-01-05 ES ES387030A patent/ES387030A1/en not_active Expired
- 1971-01-05 ES ES387034A patent/ES387034A1/en not_active Expired
- 1971-01-05 ES ES387029A patent/ES387029A1/en not_active Expired
- 1971-01-05 ES ES387026A patent/ES387026A1/en not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| ES387032A1 (en) | 1973-11-16 |
| ES387030A1 (en) | 1973-11-16 |
| CH520688A (en) | 1972-03-31 |
| ES387027A1 (en) | 1973-12-01 |
| CH520145A (en) | 1972-03-15 |
| ES387033A1 (en) | 1974-06-01 |
| ES387026A1 (en) | 1973-12-01 |
| ES387025A1 (en) | 1973-12-01 |
| CH520687A (en) | 1972-03-31 |
| ES387029A1 (en) | 1973-11-16 |
| CH520686A (en) | 1972-03-31 |
| ES387034A1 (en) | 1974-06-01 |
| CH520690A (en) | 1972-03-31 |
| ES387028A1 (en) | 1973-12-01 |
| ES387031A1 (en) | 1973-11-16 |
| CH520691A (en) | 1972-03-31 |
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