ES380950A1 - Metodo para la preparacion de un nuevo complejo de protrom-bina. - Google Patents
Metodo para la preparacion de un nuevo complejo de protrom-bina.Info
- Publication number
- ES380950A1 ES380950A1 ES380950A ES380950A ES380950A1 ES 380950 A1 ES380950 A1 ES 380950A1 ES 380950 A ES380950 A ES 380950A ES 380950 A ES380950 A ES 380950A ES 380950 A1 ES380950 A1 ES 380950A1
- Authority
- ES
- Spain
- Prior art keywords
- precipitate
- iii
- polyethylene glycol
- complex
- final
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 229920001223 polyethylene glycol Polymers 0.000 title abstract 4
- 102100027378 Prothrombin Human genes 0.000 title abstract 3
- 108010094028 Prothrombin Proteins 0.000 title abstract 3
- 229940039716 prothrombin Drugs 0.000 title abstract 3
- 239000002202 Polyethylene glycol Substances 0.000 title abstract 2
- 238000001556 precipitation Methods 0.000 title abstract 2
- 239000002244 precipitate Substances 0.000 abstract 3
- 239000006228 supernatant Substances 0.000 abstract 2
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 230000002008 hemorrhagic effect Effects 0.000 abstract 1
- 239000007924 injection Substances 0.000 abstract 1
- 238000002347 injection Methods 0.000 abstract 1
- 239000002504 physiological saline solution Substances 0.000 abstract 1
- 239000000047 product Substances 0.000 abstract 1
- 102000004169 proteins and genes Human genes 0.000 abstract 1
- 108090000623 proteins and genes Proteins 0.000 abstract 1
- 239000011780 sodium chloride Substances 0.000 abstract 1
- 239000001509 sodium citrate Substances 0.000 abstract 1
- 239000000243 solution Substances 0.000 abstract 1
- QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 abstract 1
- 235000019731 tricalcium phosphate Nutrition 0.000 abstract 1
- HRXKRNGNAMMEHJ-UHFFFAOYSA-K trisodium citrate Chemical compound [Na+].[Na+].[Na+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O HRXKRNGNAMMEHJ-UHFFFAOYSA-K 0.000 abstract 1
- 229940038773 trisodium citrate Drugs 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
- C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
- C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
- C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
- C12N9/6424—Serine endopeptidases (3.4.21)
- C12N9/6429—Thrombin (3.4.21.5)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
- C12Y304/21—Serine endopeptidases (3.4.21)
- C12Y304/21005—Thrombin (3.4.21.5)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
- Y10S530/827—Proteins from mammals or birds
- Y10S530/829—Blood
- Y10S530/83—Plasma; serum
- Y10S530/831—Cohn fractions
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Zoology (AREA)
- Genetics & Genomics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Wood Science & Technology (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US83488369A | 1969-06-19 | 1969-06-19 |
Publications (1)
Publication Number | Publication Date |
---|---|
ES380950A1 true ES380950A1 (es) | 1972-10-16 |
Family
ID=25268043
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES380950A Expired ES380950A1 (es) | 1969-06-19 | 1970-06-19 | Metodo para la preparacion de un nuevo complejo de protrom-bina. |
Country Status (13)
Country | Link |
---|---|
US (1) | US3560475A (es) |
BE (1) | BE751667A (es) |
CA (1) | CA920058A (es) |
DE (1) | DE2029455C3 (es) |
DK (1) | DK127676B (es) |
ES (1) | ES380950A1 (es) |
FR (1) | FR2052987B1 (es) |
GB (1) | GB1253339A (es) |
IL (1) | IL34599A (es) |
IT (1) | IT1043810B (es) |
NL (1) | NL170150C (es) |
SE (1) | SE397474B (es) |
ZA (1) | ZA703574B (es) |
Families Citing this family (33)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3803115A (en) * | 1972-05-17 | 1974-04-09 | Baxter Laboratories Inc | Stabilization of ahf using heparin |
US3956259A (en) * | 1973-01-30 | 1976-05-11 | Baxter Laboratories, Inc. | Fractionation of blood using block copolymer of ethylene oxide and polyoxypropylene polymer to recover fraction suitable for organ perfusate |
US4073886A (en) * | 1973-01-30 | 1978-02-14 | Baxter Travenol Laboratories, Inc. | Blood fractionation process using block copolymers of ethylene oxide and polyoxypropylene |
US4025500A (en) * | 1974-06-06 | 1977-05-24 | Baxter Laboratories, Inc. | Preparation of albumin by fractionation of blood plasma or serum |
US4001401A (en) * | 1975-02-02 | 1977-01-04 | Alza Corporation | Blood substitute and blood plasma expander comprising polyhemoglobin |
US4046877A (en) * | 1975-07-18 | 1977-09-06 | Syntex (U.S.A.) Inc. | Method of increasing immunologic competence |
DE2902158A1 (de) * | 1979-01-20 | 1980-07-31 | Biotest Serum Institut Gmbh | Verfahren zur herstellung von fibrinogen, einem die gerinnungsfaktoren ii, vii, ix und x enthaltenden prothrombinkomplex, antithrombin iii und einer loesung von lagerstabilen serumproteinen |
FR2472390A1 (fr) * | 1979-05-04 | 1981-07-03 | Merieux Inst | Procede de preparation de concentres de complexe prothrombinique hautement purifies, et concentres obtenus |
US4286056A (en) * | 1980-01-28 | 1981-08-25 | Baxter Travenol Laboratories, Inc. | Method for making therapeutic enzyme compositions |
WO1981002105A1 (en) * | 1980-01-28 | 1981-08-06 | Baxter Travenol Lab | Therapeutic compositions & methods for manufacture and use |
US4287180A (en) * | 1980-01-28 | 1981-09-01 | Baxter Travenol Laboratories, Inc. | Method for treating blood clotting factor inhibitors |
US4404132A (en) * | 1980-05-27 | 1983-09-13 | Cutter Laboratories, Inc. | Blood coagulation promoting product |
US4361510A (en) * | 1980-05-27 | 1982-11-30 | Cutter Laboratories, Inc. | Blood coagulation promoting product |
US4391746A (en) * | 1980-05-27 | 1983-07-05 | Cutter Laboratories, Inc. | Blood-coagulation-promoting products and methods of preparing them |
US4364861A (en) * | 1980-05-27 | 1982-12-21 | Cutter Laboratories, Inc. | Blood-coagulation-promoting products and methods of preparing them |
US4382083A (en) * | 1981-06-25 | 1983-05-03 | Baxter Travenol Laboratories, Inc. | Therapeutic method for treating blood-clotting defects with factor VIIa |
US4479938A (en) * | 1981-06-25 | 1984-10-30 | Baxter Travenol Laboratories, Inc. | Therapeutic composition containing factor VIIa |
US5055557A (en) * | 1983-03-04 | 1991-10-08 | Scripps Clinic & Research Foundation | Ultrapurification of factor IX and other vitamin K-dependent proteins |
US5614500A (en) * | 1983-03-04 | 1997-03-25 | The Scripps Research Institute | Compositions containing highly purified factor IX proteins prepared by immunoaffinity chromatography |
US4786726A (en) * | 1986-01-06 | 1988-11-22 | Blood Systems, Inc. | Factor IX therapeutic blood product, means and methods of preparing same |
ZA877535B (en) * | 1986-10-09 | 1988-04-11 | F. Hoffmann-La Roche & Co. Aktiengesellschaft | Factor ix-peptides |
USH1509H (en) * | 1989-06-09 | 1995-12-05 | Eran; Harutyun | Heparin enhanced process for separating antihemophilic factor (Factor VIII) and fibronectin from cryoprecipitate |
US5659017A (en) * | 1995-11-07 | 1997-08-19 | Alpha Therapeutic Corporation | Anion exchange process for the purification of Factor VIII |
USRE38431E1 (en) * | 1995-12-01 | 2004-02-17 | The American National Red Cross | Methods of production and use of liquid formulations of plasma proteins |
US6320029B1 (en) | 1996-11-29 | 2001-11-20 | The American National Red Cross | Methods of production and use of liquid formulations of plasma proteins |
US5925738A (en) * | 1995-12-01 | 1999-07-20 | The American National Red Cross | Methods of production and use of liquid formulations of plasma proteins |
JP3944267B2 (ja) * | 1996-08-09 | 2007-07-11 | 財団法人化学及血清療法研究所 | プロトロンビンの活性化方法および該方法に基づくトロンビンの製造方法 |
US5770705A (en) * | 1996-11-01 | 1998-06-23 | Shanbrom Technologies Llc | Method for recovering proteins from plasma using insoluble, water-absorbing material |
US7297716B2 (en) * | 2000-10-23 | 2007-11-20 | Shanbrom Technologies, Llc | Enhanced production of blood components, blood cells and plasma without freezing |
US7411006B2 (en) * | 2000-10-23 | 2008-08-12 | Shanbrom Technologies, Llc | Enhanced production of blood clotting factors and fibrin fabric |
US8389687B2 (en) * | 2000-10-23 | 2013-03-05 | Shanbrom Technologies, Llc | Polyvinylpyrrolidone cryoprecipitate extraction of clotting factors |
WO2005094873A1 (en) | 2004-03-19 | 2005-10-13 | Baxter International Inc. | Factor ixa for the treatment of bleeding disorders |
WO2022064478A1 (en) | 2020-09-23 | 2022-03-31 | Omrix Biopharmaceuticals Ltd. | Hemostatic formulations and uses thereof |
-
1969
- 1969-06-19 US US834883A patent/US3560475A/en not_active Expired - Lifetime
- 1969-12-29 CA CA070973A patent/CA920058A/en not_active Expired
-
1970
- 1970-05-26 ZA ZA703574A patent/ZA703574B/xx unknown
- 1970-05-26 IL IL34599A patent/IL34599A/en unknown
- 1970-05-28 GB GB25674/70A patent/GB1253339A/en not_active Expired
- 1970-06-09 BE BE751667D patent/BE751667A/xx not_active IP Right Cessation
- 1970-06-15 DE DE2029455A patent/DE2029455C3/de not_active Expired
- 1970-06-17 SE SE7008429A patent/SE397474B/xx unknown
- 1970-06-18 IT IT26213/70A patent/IT1043810B/it active
- 1970-06-18 NL NLAANVRAGE7008957,A patent/NL170150C/xx not_active IP Right Cessation
- 1970-06-18 FR FR7022476A patent/FR2052987B1/fr not_active Expired
- 1970-06-19 DK DK317070AA patent/DK127676B/da unknown
- 1970-06-19 ES ES380950A patent/ES380950A1/es not_active Expired
Also Published As
Publication number | Publication date |
---|---|
BE751667A (fr) | 1970-11-16 |
IT1043810B (it) | 1980-02-29 |
NL170150C (nl) | 1982-10-01 |
NL170150B (nl) | 1982-05-03 |
FR2052987B1 (es) | 1974-05-24 |
SE397474B (sv) | 1977-11-07 |
DK127676B (da) | 1973-12-17 |
IL34599A0 (en) | 1970-07-19 |
CA920058A (en) | 1973-01-30 |
NL7008957A (es) | 1970-12-22 |
US3560475A (en) | 1971-02-02 |
GB1253339A (en) | 1971-11-10 |
DE2029455A1 (de) | 1971-02-25 |
DE2029455C3 (de) | 1979-04-19 |
IL34599A (en) | 1973-07-30 |
DE2029455B2 (de) | 1978-08-24 |
ZA703574B (en) | 1971-01-27 |
FR2052987A1 (es) | 1971-04-16 |
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