ES376520A1 - Process for making desacetoxycephalosporins - Google Patents

Process for making desacetoxycephalosporins

Info

Publication number
ES376520A1
ES376520A1 ES376520A ES376520A ES376520A1 ES 376520 A1 ES376520 A1 ES 376520A1 ES 376520 A ES376520 A ES 376520A ES 376520 A ES376520 A ES 376520A ES 376520 A1 ES376520 A1 ES 376520A1
Authority
ES
Spain
Prior art keywords
ester
sulfonic acid
penicillin sulfoxide
desacetoxycephalosporins
making
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES376520A
Other languages
Spanish (es)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Eli Lilly and Co
Original Assignee
Eli Lilly and Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eli Lilly and Co filed Critical Eli Lilly and Co
Publication of ES376520A1 publication Critical patent/ES376520A1/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D499/00—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Cephalosporin Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

An improved procedure for converting a penicillin sulfoxide ester to a deacetoxycephaiosporin ester, by heating the penicillin sulfoxide ester dissolved in a solvent containing tertiary carboxamide, under acidic conditions on a temperature scale of about 80ºC, to about 150ºC, in where improvement is characterized by using in combination (1) an effective amount of a sulfonic acid, or a substance that forms a sulfonic acid in the mixture to improve the acid, while (2) elements are provided to separate or inactivate the water in the reaction mixture during the heating operation. (Machine-translation by Google Translate, not legally binding)
ES376520A 1969-02-14 1970-02-12 Process for making desacetoxycephalosporins Expired ES376520A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US79950469A 1969-02-14 1969-02-14

Publications (1)

Publication Number Publication Date
ES376520A1 true ES376520A1 (en) 1972-04-16

Family

ID=25176075

Family Applications (1)

Application Number Title Priority Date Filing Date
ES376520A Expired ES376520A1 (en) 1969-02-14 1970-02-12 Process for making desacetoxycephalosporins

Country Status (24)

Country Link
US (1) US3591585A (en)
JP (1) JPS4931998B1 (en)
AT (1) AT317419B (en)
BE (1) BE745845A (en)
BG (1) BG17978A3 (en)
BR (1) BR6915011D0 (en)
CH (1) CH555364A (en)
CS (1) CS193005B2 (en)
CY (1) CY776A (en)
DE (1) DE2006689C3 (en)
DK (1) DK143940C (en)
ES (1) ES376520A1 (en)
FR (1) FR2035416A5 (en)
GB (1) GB1296555A (en)
IE (1) IE34232B1 (en)
IL (1) IL33866A (en)
MY (1) MY7500002A (en)
NL (1) NL150456B (en)
NO (1) NO137859C (en)
PL (1) PL80825B1 (en)
RO (1) RO58031A (en)
SE (1) SE366320B (en)
YU (1) YU36184B (en)
ZA (1) ZA70407B (en)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3852281A (en) * 1970-02-18 1974-12-03 Koninklijke Gist Spiritus Process for the preparation of 7-substituted amino-desacetoxycephalosporanic acid compounds
US3714146A (en) * 1970-10-05 1973-01-30 Bristol Myers Co Novel syntheses of cephalexin and intermediates therefor
SE412238B (en) * 1971-05-24 1980-02-25 Ciba Geigy PROCEDURE FOR PREPARING 7 BETA-AMINO-CEFEM-4-CARBOXYLIC ACID COMPOUNDS BY DECARBONYLATION OF A 3-FORMYL-CEFEM-4-CARBOXYLIC ACID COMPOUND
US3862941A (en) * 1971-11-04 1975-01-28 Squibb & Sons Inc 2-(Thiocarbonylamino)acetamidocephalosporanic acid compounds
US3944545A (en) * 1972-05-10 1976-03-16 Eli Lilly And Company Process for preparing desacetoxycephalosporins
NL7411505A (en) * 1973-09-06 1975-03-10 Rhone Poulenc Sa PROCEDURE FOR THE PREPARATION AND USE OF NEW 7-TRICHLORACETAMIDO-3-DESACETOXY-CEFA-LOSPORANIC ACID PREPARATIONS.

Also Published As

Publication number Publication date
DE2006689B2 (en) 1974-08-01
ZA70407B (en) 1971-08-25
CS193005B2 (en) 1979-09-17
NO137859C (en) 1978-05-10
BG17978A3 (en) 1974-03-05
NL150456B (en) 1976-08-16
BR6915011D0 (en) 1973-05-24
BE745845A (en) 1970-08-12
US3591585A (en) 1971-07-06
AT317419B (en) 1974-08-26
IL33866A (en) 1973-06-29
CH555364A (en) 1974-10-31
IE34232B1 (en) 1975-03-19
YU36184B (en) 1982-02-25
DK143940B (en) 1981-11-02
DE2006689C3 (en) 1975-04-03
MY7500002A (en) 1975-12-31
PL80825B1 (en) 1975-08-30
GB1296555A (en) 1972-11-15
FR2035416A5 (en) 1970-12-18
YU33170A (en) 1981-06-30
JPS4931998B1 (en) 1974-08-27
DK143940C (en) 1982-04-19
RO58031A (en) 1975-03-15
SE366320B (en) 1974-04-22
CY776A (en) 1975-03-01
NL7002042A (en) 1970-08-18
IE34232L (en) 1970-08-14
DE2006689A1 (en) 1970-08-27
NO137859B (en) 1978-01-30
IL33866A0 (en) 1970-04-20

Similar Documents

Publication Publication Date Title
ES376520A1 (en) Process for making desacetoxycephalosporins
ES323192A1 (en) Procedure for the obtaining of a new derivative of ester of phosphoric acid. (Machine-translation by Google Translate, not legally binding)
ES281438A1 (en) Procedure for obtaining benzoic acid (Machine-translation by Google Translate, not legally binding)
ES309765A1 (en) A procedure for preparing a nitrite ester of an alcohol. (Machine-translation by Google Translate, not legally binding)
ES289427A1 (en) Procedure for the preparation of colorants (Machine-translation by Google Translate, not legally binding)
ES285162A1 (en) Procedure for the obtaining of arilol-alcanos (Machine-translation by Google Translate, not legally binding)
ES413273A1 (en) A procedure for the preparation of 5-fluor-2-methyl-1- (p-metilsulfinilbenciliden) -3-indenil-acetic acid. (Machine-translation by Google Translate, not legally binding)
GB1091365A (en) Process for producing 5-guanylic acid
ES280713A1 (en) Procedure for the preparation of alcanforated derivatives of 2-aminotiazoline (Machine-translation by Google Translate, not legally binding)
ES410166A1 (en) A procedure for preparing 2- (6-metoxy-2-nafthy) propionic acid. (Machine-translation by Google Translate, not legally binding)
ES382195A1 (en) A procedure for preparing the acid 2 - (6-metoxy-2-nafthy) -propionic. (Machine-translation by Google Translate, not legally binding)
ES329705A1 (en) Procedure for the obtaining of dialylamide from the 3-chloropiridazon- (6) -1-acetic acid. (Machine-translation by Google Translate, not legally binding)
ES395538A1 (en) Procedure for the preparation of the new d-alfametimino-bencilpenicilanico acid. (Machine-translation by Google Translate, not legally binding)
ES457687A1 (en) New procedure for obtaining 2-methyl-5-metoxin-p-chlorobenzoyl-indol-3-acetic acid. (Machine-translation by Google Translate, not legally binding)
ES426123A2 (en) 2-propyl-5-thiazole carboxylates
ES323543A3 (en) Procedure for the preparation of derivatives of 2-estiriloxazol. (Machine-translation by Google Translate, not legally binding)
ES483181A1 (en) Improved procedure for the preparation of 4-hydroxyphenylaceic acid. (Machine-translation by Google Translate, not legally binding)
ES311312A1 (en) Procedure for preparation of cycloexan-carboxylic acid. (Machine-translation by Google Translate, not legally binding)
ES370966A1 (en) Procedure for the obtaining of salts of bismuto basicas of polyuronic acids. (Machine-translation by Google Translate, not legally binding)
ES269737A1 (en) Method for the removal of deposited crude maleic acid
ES294862A1 (en) Procedure for preparing l-ornitine l-aspartate (Machine-translation by Google Translate, not legally binding)
ES309936A1 (en) Procedure for the obtaining of a derivative of fluorcyclohexene. (Machine-translation by Google Translate, not legally binding)
ES236986A1 (en) Procedure for the obtaining of the tannin content of the manter coil for conversion in discolored curtient extracts (Machine-translation by Google Translate, not legally binding)
ES150971U (en) A fixed hand for cabinets. (Machine-translation by Google Translate, not legally binding)
ES287343A1 (en) Procedure for the obtaining of heterocyclic esters of the acid tionotiolfosfºr- (con) -ico (Machine-translation by Google Translate, not legally binding)