ES375923A1 - Procedure for the obtaining of triciclo-oxo-tia-zolicos derivatives. (Machine-translation by Google Translate, not legally binding)
- Google Patents
Procedure for the obtaining of triciclo-oxo-tia-zolicos derivatives. (Machine-translation by Google Translate, not legally binding)
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Sandoz AG
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Sandoz AG
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Application filed by Sandoz AGfiledCriticalSandoz AG
Publication of ES375923A1publicationCriticalpatent/ES375923A1/en
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems
(AREA)
Abstract
Procedure for obtaining tricyclo-oxa (thia) zolic derivatives of formula I, **(See formula)** where X is selected from the group consisting of an oxygen atom and a sulfur atom, it means alkyl of 1 to 4 carbon atoms, and R1 is selected from the group consisting of methyl, ethyl and β-hydroxyethyl radicals, characterized by that a compound of formula II is reacted, **(See formula)** wherein X and R1 have the meanings indicated above, and Z is selected from the group consisting of a chlorine atom and a bromine atom, with a 4-substituted piperazine compound of formula III, **(See formula)** wherein R2 has the above meaning, preferably by mixing the piperazine compound of formula III with the compound of formula II, with cooling, at a temperature of approx. -5º to + 15ºC, and then the mixture is allowed to heat to a maximum of approx. 30ºC. (Machine-translation by Google Translate, not legally binding)
ES375923A1969-01-291970-01-27Procedure for the obtaining of triciclo-oxo-tia-zolicos derivatives. (Machine-translation by Google Translate, not legally binding)
ExpiredES375923A1
(en)