ES375447A1 - 1-phenoxy-2-hydroxy-3-alkylamino-propanes - Google Patents
1-phenoxy-2-hydroxy-3-alkylamino-propanesInfo
- Publication number
- ES375447A1 ES375447A1 ES375447A ES375447A ES375447A1 ES 375447 A1 ES375447 A1 ES 375447A1 ES 375447 A ES375447 A ES 375447A ES 375447 A ES375447 A ES 375447A ES 375447 A1 ES375447 A1 ES 375447A1
- Authority
- ES
- Spain
- Prior art keywords
- propanes
- alkylamino
- phenoxy
- hydroxy
- adrenolytics
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
- C07D309/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
- C07D309/08—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D309/10—Oxygen atoms
- C07D309/12—Oxygen atoms only hydrogen atoms and one oxygen atom directly attached to ring carbon atoms, e.g. tetrahydropyranyl ethers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Cardiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Heart & Thoracic Surgery (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
The compounds are 1-phenoxy-2-hydroxy-3-alkylamino-propanes and non-toxic acid addition salts thereof, useful as beta -adrenolytics and hypotensives in warm-blooded animals.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE1643262A DE1643262C3 (en) | 1967-12-13 | 1967-12-13 | i-Phenoxy ^ -hydroxy-S-alklyaminopropane, process for their preparation and medicaments containing these compounds |
Publications (1)
Publication Number | Publication Date |
---|---|
ES375447A1 true ES375447A1 (en) | 1972-05-01 |
Family
ID=5684274
Family Applications (11)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES361189A Expired ES361189A1 (en) | 1967-12-13 | 1968-12-07 | 1-phenoxy-2-hydroxy-3-alkylamino-propanes |
ES375453A Expired ES375453A1 (en) | 1967-12-13 | 1970-01-15 | 1-phenoxy-2-hydroxy-3-alkylamino-propanes |
ES375451A Expired ES375451A1 (en) | 1967-12-13 | 1970-01-15 | 1-phenoxy-2-hydroxy-3-alkylamino-propanes |
ES375447A Expired ES375447A1 (en) | 1967-12-13 | 1970-01-15 | 1-phenoxy-2-hydroxy-3-alkylamino-propanes |
ES375445A Expired ES375445A1 (en) | 1967-12-13 | 1970-01-15 | 1-phenoxy-2-hydroxy-3-alkylamino-propanes |
ES375449A Expired ES375449A1 (en) | 1967-12-13 | 1970-01-15 | 1-phenoxy-2-hydroxy-3-alkylamino-propanes |
ES375444A Expired ES375444A1 (en) | 1967-12-13 | 1970-01-15 | 1-phenoxy-2-hydroxy-3-alkylamino-propanes |
ES375452A Expired ES375452A1 (en) | 1967-12-13 | 1970-01-15 | 1-phenoxy-2-hydroxy-3-alkylamino-propanes |
ES375448A Expired ES375448A1 (en) | 1967-12-13 | 1970-01-15 | 1-phenoxy-2-hydroxy-3-alkylamino-propanes |
ES375446A Expired ES375446A1 (en) | 1967-12-13 | 1970-01-15 | 1-phenoxy-2-hydroxy-3-alkylamino-propanes |
ES375450A Expired ES375450A1 (en) | 1967-12-13 | 1970-01-15 | 1-phenoxy-2-hydroxy-3-alkylamino-propanes |
Family Applications Before (3)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES361189A Expired ES361189A1 (en) | 1967-12-13 | 1968-12-07 | 1-phenoxy-2-hydroxy-3-alkylamino-propanes |
ES375453A Expired ES375453A1 (en) | 1967-12-13 | 1970-01-15 | 1-phenoxy-2-hydroxy-3-alkylamino-propanes |
ES375451A Expired ES375451A1 (en) | 1967-12-13 | 1970-01-15 | 1-phenoxy-2-hydroxy-3-alkylamino-propanes |
Family Applications After (7)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES375445A Expired ES375445A1 (en) | 1967-12-13 | 1970-01-15 | 1-phenoxy-2-hydroxy-3-alkylamino-propanes |
ES375449A Expired ES375449A1 (en) | 1967-12-13 | 1970-01-15 | 1-phenoxy-2-hydroxy-3-alkylamino-propanes |
ES375444A Expired ES375444A1 (en) | 1967-12-13 | 1970-01-15 | 1-phenoxy-2-hydroxy-3-alkylamino-propanes |
ES375452A Expired ES375452A1 (en) | 1967-12-13 | 1970-01-15 | 1-phenoxy-2-hydroxy-3-alkylamino-propanes |
ES375448A Expired ES375448A1 (en) | 1967-12-13 | 1970-01-15 | 1-phenoxy-2-hydroxy-3-alkylamino-propanes |
ES375446A Expired ES375446A1 (en) | 1967-12-13 | 1970-01-15 | 1-phenoxy-2-hydroxy-3-alkylamino-propanes |
ES375450A Expired ES375450A1 (en) | 1967-12-13 | 1970-01-15 | 1-phenoxy-2-hydroxy-3-alkylamino-propanes |
Country Status (21)
Country | Link |
---|---|
US (1) | US3872147A (en) |
JP (1) | JPS5220457B1 (en) |
AT (13) | AT292670B (en) |
BE (1) | BE725490A (en) |
BG (9) | BG17298A3 (en) |
BR (1) | BR6804840D0 (en) |
CA (1) | CA954528A (en) |
CH (2) | CH532015A (en) |
DE (1) | DE1643262C3 (en) |
DK (1) | DK131029B (en) |
ES (11) | ES361189A1 (en) |
FI (1) | FI49497C (en) |
FR (2) | FR1596100A (en) |
GB (1) | GB1260866A (en) |
HU (1) | HU162734B (en) |
IE (1) | IE32758B1 (en) |
IL (1) | IL31266A (en) |
NL (3) | NL146709B (en) |
PH (1) | PH9266A (en) |
SE (1) | SE367396B (en) |
YU (12) | YU33949B (en) |
Families Citing this family (23)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3541130A (en) * | 1967-02-06 | 1970-11-17 | Boehringer Sohn Ingelheim | 1-(cyanophenoxy)-2-hydroxy-3-tert.-butylamine propanes |
US4086272A (en) * | 1970-07-18 | 1978-04-25 | Pfizer Inc. | Phenyl-alkanolamine, alkylamine and alpha-aminoalkyl ketone derivatives as heart stimulants |
US3998874A (en) * | 1971-03-23 | 1976-12-21 | Gist-Brocades N.V. | Phenylene di-ethers |
US4038414A (en) * | 1972-06-08 | 1977-07-26 | Ciba-Geigy Corporation | Amines and processes for their manufacture |
DE2309887C2 (en) * | 1973-02-28 | 1983-11-10 | C.H. Boehringer Sohn, 6507 Ingelheim | 1-aryloxy-2-hydroxy-3-alkynylaminopropane derivatives and their physiologically acceptable acid addition salts, pharmaceutical preparations and manufacturing processes for the compounds |
US4084002A (en) * | 1973-02-28 | 1978-04-11 | Boehringer Ingelheim Gmbh | Pharmaceutical compositions containing a 1-phenoxy-2-hydroxy-3-alkynylamino-propane and method of use |
US4161530A (en) * | 1975-01-06 | 1979-07-17 | Ciba-Geigy Corporation | Pharmaceutical combination preparations as hypnotics |
US4094991A (en) * | 1975-06-17 | 1978-06-13 | Nippon Shinyaku Co., Ltd. | Substituted n-(carboxymethyl)-3-aminopropan-2-ol derivatives |
US4243681A (en) * | 1977-10-11 | 1981-01-06 | Mead Johnson & Company | Alkylthiophenoxypropanolamines and pharmaceutical compositions and uses thereof |
DE2839475A1 (en) * | 1978-09-11 | 1980-03-20 | Dolorgiet Arzneimittelfabrik | ISOPROPYLAMINE COMPOUNDS, METHOD FOR THE PRODUCTION THEREOF AND MEDICINAL PRODUCTS CONTAINING THE SAME |
EP0025331B1 (en) * | 1979-09-06 | 1983-03-02 | Beecham Group Plc | Cinnamic acid derivatives, their preparation, and pharmaceutical compositions containing them |
JPS56142262A (en) | 1980-04-08 | 1981-11-06 | Nippon Shinyaku Co Ltd | Piperazine derivative |
US4593119A (en) * | 1980-11-28 | 1986-06-03 | American Hospital Supply Corporation | Method for treatment or prophylaxis of cardiac disorders |
US4387103A (en) * | 1980-11-28 | 1983-06-07 | American Hospital Supply Corporation | Method for treatment or prophylaxis of cardiac disorders |
US4405642A (en) * | 1980-11-28 | 1983-09-20 | American Hospital Supply Corporation | Method for treatment or prophylaxis of cardiac disorders |
US4396629A (en) * | 1980-12-29 | 1983-08-02 | Sterling Drug Inc. | Compositions, processes and method |
DE3131527A1 (en) * | 1981-08-08 | 1983-02-24 | Kali-Chemie Pharma Gmbh, 3000 Hannover | 1-PHENYL-2-AMINOCARBONYLINDOL COMPOUNDS AND METHODS AND INTERMEDIATE PRODUCTS FOR THEIR PRODUCTION AND MEDICINAL PRODUCTS CONTAINING THESE COMPOUNDS |
AU575153B2 (en) * | 1984-04-09 | 1988-07-21 | Du Pont Merck Pharmaceutical Company, The | Pharmaceutical compositions and method for treatment for prophylaxis of cardiac disorders |
US4652584A (en) * | 1984-07-13 | 1987-03-24 | Mcneilab, Inc. | Acetylenic phenoxypropanol derivatives and pharmaceutical compositions for the treatment of hypertension |
US4665094A (en) * | 1985-08-29 | 1987-05-12 | Merck & Co., Inc. | Oculoselective beta-blockers for treatment of elevated intraocular pressure |
US4945182A (en) * | 1985-12-24 | 1990-07-31 | Merck & Co., Inc. | Oculoselective beta-blockers |
ATE45724T1 (en) * | 1985-12-24 | 1989-09-15 | Merck & Co Inc | OCULOSELECTIVE BETA BLOCKERS. |
US5480908A (en) * | 1993-12-13 | 1996-01-02 | American Cyanamid Company | β3 -adrenergic agents benzodioxole dicarboxylates and their use in pharmaceutical compositions |
Family Cites Families (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3459782A (en) * | 1963-08-26 | 1969-08-05 | Boehringer Sohn Ingelheim | 1-substituted phenoxy-2-hydroxy-3-isopropylamino-propanes |
-
1967
- 1967-12-13 DE DE1643262A patent/DE1643262C3/en not_active Expired
-
1968
- 1968-04-03 BG BG012150A patent/BG17298A3/en unknown
- 1968-04-30 BG BG012149A patent/BG17297A3/en unknown
- 1968-12-07 ES ES361189A patent/ES361189A1/en not_active Expired
- 1968-12-10 CH CH1843568A patent/CH532015A/en not_active IP Right Cessation
- 1968-12-10 CH CH848471A patent/CH556816A/en not_active IP Right Cessation
- 1968-12-11 NL NL686817768A patent/NL146709B/en not_active IP Right Cessation
- 1968-12-11 FI FI683535A patent/FI49497C/en active
- 1968-12-11 PH PH9832*UA patent/PH9266A/en unknown
- 1968-12-12 JP JP43091282A patent/JPS5220457B1/ja active Pending
- 1968-12-12 SE SE17070/68A patent/SE367396B/xx unknown
- 1968-12-12 YU YU2949/68A patent/YU33949B/en unknown
- 1968-12-12 DK DK608568AA patent/DK131029B/en not_active IP Right Cessation
- 1968-12-12 CA CA037,721A patent/CA954528A/en not_active Expired
- 1968-12-13 HU HUBO1162A patent/HU162734B/hu unknown
- 1968-12-13 AT AT1216668A patent/AT292670B/en not_active IP Right Cessation
- 1968-12-13 BR BR204840/68A patent/BR6804840D0/en unknown
- 1968-12-13 IE IE1519/68A patent/IE32758B1/en unknown
- 1968-12-13 AT AT879570A patent/AT292674B/en active
- 1968-12-13 AT AT879770A patent/AT292676B/en active
- 1968-12-13 AT AT879970A patent/AT298459B/en not_active IP Right Cessation
- 1968-12-13 AT AT879870A patent/AT292677B/en active
- 1968-12-13 BG BG12146A patent/BG19135A3/xx unknown
- 1968-12-13 AT AT880270A patent/AT292680B/en active
- 1968-12-13 AT AT879470A patent/AT294799B/en not_active IP Right Cessation
- 1968-12-13 AT AT879370A patent/AT292673B/en active
- 1968-12-13 FR FR1596100D patent/FR1596100A/fr not_active Expired
- 1968-12-13 IL IL31266A patent/IL31266A/en unknown
- 1968-12-13 AT AT880170A patent/AT292679B/en active
- 1968-12-13 AT AT880070A patent/AT292678B/en not_active IP Right Cessation
- 1968-12-13 BE BE725490D patent/BE725490A/xx not_active IP Right Cessation
- 1968-12-13 AT AT879670A patent/AT292675B/en not_active IP Right Cessation
- 1968-12-13 BG BG011231A patent/BG16329A3/en unknown
- 1968-12-13 GB GB59518/68A patent/GB1260866A/en not_active Expired
- 1968-12-13 AT AT595771A patent/AT298463B/en not_active IP Right Cessation
-
1969
- 1969-03-13 FR FR183279A patent/FR8328M/fr not_active Expired
- 1969-04-30 BG BG012143A patent/BG16330A3/en unknown
- 1969-04-30 BG BG012147A patent/BG16331A3/en unknown
- 1969-04-30 BG BG012148A patent/BG16332A3/en unknown
- 1969-04-30 BG BG012144A patent/BG16444A3/en unknown
- 1969-04-30 BG BG012145A patent/BG16445A3/en unknown
-
1970
- 1970-01-15 ES ES375453A patent/ES375453A1/en not_active Expired
- 1970-01-15 ES ES375451A patent/ES375451A1/en not_active Expired
- 1970-01-15 ES ES375447A patent/ES375447A1/en not_active Expired
- 1970-01-15 ES ES375445A patent/ES375445A1/en not_active Expired
- 1970-01-15 ES ES375449A patent/ES375449A1/en not_active Expired
- 1970-01-15 ES ES375444A patent/ES375444A1/en not_active Expired
- 1970-01-15 ES ES375452A patent/ES375452A1/en not_active Expired
- 1970-01-15 ES ES375448A patent/ES375448A1/en not_active Expired
- 1970-01-15 ES ES375446A patent/ES375446A1/en not_active Expired
- 1970-01-15 ES ES375450A patent/ES375450A1/en not_active Expired
- 1970-12-13 AT AT08803/70A patent/AT292681B/en active
-
1971
- 1971-12-02 US US204316A patent/US3872147A/en not_active Expired - Lifetime
-
1974
- 1974-09-03 YU YU2384/74A patent/YU33948B/en unknown
- 1974-09-03 YU YU2375/74A patent/YU33946B/en unknown
- 1974-09-03 YU YU2381/74A patent/YU33774B/en unknown
- 1974-09-03 YU YU2377/74A patent/YU33947B/en unknown
- 1974-09-03 YU YU2376/74A patent/YU33773B/en unknown
- 1974-09-03 YU YU2380/74A patent/YU33854B/en unknown
- 1974-09-03 YU YU2378/74A patent/YU33852B/en unknown
- 1974-09-03 YU YU2379/74A patent/YU33853B/en unknown
- 1974-09-03 YU YU2383/74A patent/YU33856B/en unknown
- 1974-09-03 YU YU2382/74A patent/YU33855B/en unknown
- 1974-09-03 YU YU2374/74A patent/YU33851B/en unknown
-
1975
- 1975-02-14 NL NL7501792A patent/NL7501792A/en unknown
- 1975-02-14 NL NL757501794A patent/NL151354B/en not_active IP Right Cessation
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