ES363453A1 - Procedure for producing a benzazocine derivative. (Machine-translation by Google Translate, not legally binding) - Google Patents
Procedure for producing a benzazocine derivative. (Machine-translation by Google Translate, not legally binding)Info
- Publication number
- ES363453A1 ES363453A1 ES363453A ES363453A ES363453A1 ES 363453 A1 ES363453 A1 ES 363453A1 ES 363453 A ES363453 A ES 363453A ES 363453 A ES363453 A ES 363453A ES 363453 A1 ES363453 A1 ES 363453A1
- Authority
- ES
- Spain
- Prior art keywords
- group
- carbon atoms
- derivative
- formula
- alcohol
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Landscapes
- Plural Heterocyclic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
Procedure to produce a benzazocin derivative of formula: **(See formula)** (where R1 represents methoxy, hydroxy, or acyloxy, including the case where two groups together form an alcoholelenedioxy group; m is an integer from 1 to 3; R2 represents an alcohol group having at most 4 carbon atoms; and R4 represents a alcohol group having a maximum of 6 carbon atoms, an aralcohyl group having up to 10 carbon atoms, an alkoxylaminocarbonylalkyl or mono- or dialkoxylaminoalcohyl group in which the alcoholic group has a maximum of 3 carbon atoms, an acyl group having a maximum of 4 carbon atoms, a tetrahydrofurfuryl group or a hydrogen atom), which comprises reacting a phenylalkyl amine derivative of the formula: **(See formula)** (where R1, R4 and m have the same meanings defined above, and X'represents a radical (see formula) where R2 has the same meaning as before, or represents a functional group derived from a carboxylic group), with a Grignard reagent of formula R2MgX (where R2 has the same meaning defined above, and X represents a halogen), whereby the corresponding phenylalkyl amino alcohol derivative is produced, and subjecting the thus produced phenylalcoxylamino alcohol to a ring closure reaction, and optionally subjecting the thus produced benzazocine derivative to one or more of the following procedures: (1) reducing the group when the group is reducible; (2) when the group (s) (R1) m are alkoxy or acyloxy, convert them to hydroxyl groups; (3) when the group (s) (R1) m are hydroxyl group (s), convert them to alkoxy or acyloxy group (s). (Machine-translation by Google Translate, not legally binding)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP807868 | 1968-02-09 | ||
JP1308768 | 1968-02-29 | ||
JP3512068 | 1968-05-24 |
Publications (1)
Publication Number | Publication Date |
---|---|
ES363453A1 true ES363453A1 (en) | 1970-12-16 |
Family
ID=27277865
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES363453A Expired ES363453A1 (en) | 1968-02-09 | 1969-02-08 | Procedure for producing a benzazocine derivative. (Machine-translation by Google Translate, not legally binding) |
Country Status (3)
Country | Link |
---|---|
DK (1) | DK125797B (en) |
ES (1) | ES363453A1 (en) |
NO (1) | NO129253B (en) |
-
1969
- 1969-02-07 DK DK66169A patent/DK125797B/en unknown
- 1969-02-08 NO NO49869A patent/NO129253B/no unknown
- 1969-02-08 ES ES363453A patent/ES363453A1/en not_active Expired
Also Published As
Publication number | Publication date |
---|---|
NO129253B (en) | 1974-03-18 |
DK125797B (en) | 1973-05-07 |
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