ES314999A1 - A procedure for elaborating substituteed propane derivatives. (Machine-translation by Google Translate, not legally binding)
- Google Patents
A procedure for elaborating substituteed propane derivatives. (Machine-translation by Google Translate, not legally binding)
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F Hoffmann La Roche AG
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F Hoffmann La Roche AG
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Organic Low-Molecular-Weight Compounds And Preparation Thereof
(AREA)
Pyridine Compounds
(AREA)
Abstract
A process for preparing substituted propane derivatives, essentially compounds of the general formula I ** (See formula) ** where R represents hydrogen, alkyl with 1 to 12 carbon atoms, cycloalkyl with 3 to 8 carbon atoms, aralkyl, aryl or a five or six membered heterocyclic radical, while rings A or B, or both, may be saturated, in which case the relevant nitrogen atom can carry an alkyl group or the said five or six member heterocyclic radical is saturated, and its salts, characterized in that it consists of treating an alcohol of the general formula II ** (See formula) ** wherein A and B have the meaning set forth above and R1 has the same meaning as defined for R above and, in the case where A and B are unsaturated, additionally represents an alkanilic group with 2 to 12 carbon atoms or a alkinyl group with 2 to 12 carbon atoms, or a salt thereof, with a dehydrating agent and in hydrogenating a product thus obtained, of the general formula III ** (See formula) ** where R1, A and B have the same meaning as before, or a salt thereof, in the presence of a noble metal catalyst; in hydrogenating, if desired, an aromatic product obtained and in N-alkylating, if desired, at any stage of the process a product obtained and/or transforming it into a salt. (Machine-translation by Google Translate, not legally binding)
ES0314999A1964-07-071965-07-06A procedure for elaborating substituteed propane derivatives. (Machine-translation by Google Translate, not legally binding)
ExpiredES314999A1
(en)