ES302593A1 - Procedure for obtaining derivatives of dibenzocicloheptenes. (Machine-translation by Google Translate, not legally binding)
- Google Patents
Procedure for obtaining derivatives of dibenzocicloheptenes. (Machine-translation by Google Translate, not legally binding)
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Merck and Co Inc
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Merck and Co Inc
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Priority claimed from US296463Aexternal-prioritypatent/US3390179A/en
Application filed by Merck and Co IncfiledCriticalMerck and Co Inc
Publication of ES302593A1publicationCriticalpatent/ES302593A1/en
Organic Low-Molecular-Weight Compounds And Preparation Thereof
(AREA)
Pyridine Compounds
(AREA)
Abstract
Process for obtaining dibenzocycloheptene derivatives, and especially for preparing compounds of the formula ** (See formula) ** where R and R 'are selected from the group consisting of simple levyalkyl radicals or linked by an atom selected from carbon, nitrogen and oxygen, to form a heterocyclic ring selected from the group consisting of 1-piperidyl, 1-pyrrolidyl, 4-morpholinyl and -levialkyl-4-piperazinyl; and X, X 'are selected from the group consisting of hydrogen, levyalkyl, levyalkenyl, halogen, trifluoromethyl, hydroxyl, levialkoxyl, mercapto, levialkylmercapto, levyalkylsulfonyl, sulfamoyl, levyalkylsulphamoyl and dilevyalkylsulphamoyl; which comprises: 1, treating a compound of formula ** (See formula) ** where X, X 'are as defined, and R ", R'" are selected from hydrogen, alkyl, aryl and aralkyl, with a Grignard reagent of formula (see formula), where H denotes halogen, and R, R 'are as defined; 2, hydrolyze the Grignard derivative obtained in the 1st phase, to form the corresponding 5-hydroxy-5- (3-tertiary-aminopropyl) -derivative; 3º, dehydrate the derivative obtained in the 2nd phase, to form the corresponding 5- (3-tertiaryminopropylidene) derivative; and 4th, hydrolyze the derivative obtained in the 3rd phase. (Machine-translation by Google Translate, not legally binding)
ES0302593A1963-07-221964-07-22Procedure for obtaining derivatives of dibenzocicloheptenes. (Machine-translation by Google Translate, not legally binding)
ExpiredES302593A1
(en)
Procedure for the preparation of compounds of 2- (2º-hydroxy-3º-propenyl-phenyl) -benzotriazol (Machine-translation by Google Translate, not legally binding)
Procedure for preparing N-alcohilamino-alcohilic derivatives of espirotetralinosuccinimidas and their salts. (Machine-translation by Google Translate, not legally binding)