ES301736A1 - Procedure for the preparation of new derivatives of tetrahidroisoquinolina. (Machine-translation by Google Translate, not legally binding) - Google Patents

Procedure for the preparation of new derivatives of tetrahidroisoquinolina. (Machine-translation by Google Translate, not legally binding)

Info

Publication number
ES301736A1
ES301736A1 ES0301736A ES301736A ES301736A1 ES 301736 A1 ES301736 A1 ES 301736A1 ES 0301736 A ES0301736 A ES 0301736A ES 301736 A ES301736 A ES 301736A ES 301736 A1 ES301736 A1 ES 301736A1
Authority
ES
Spain
Prior art keywords
formula
translation
procedure
preparation
machine
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES0301736A
Other languages
Spanish (es)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Koninklijke Pharmaceutische Fabrieken NV
Pfizer Health AB
Pharmacia LLC
Original Assignee
Koninklijke Pharmaceutische Fabrieken NV
Pharmacia AB
Pharmacia LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Koninklijke Pharmaceutische Fabrieken NV, Pharmacia AB, Pharmacia LLC filed Critical Koninklijke Pharmaceutische Fabrieken NV
Publication of ES301736A1 publication Critical patent/ES301736A1/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/02—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines
    • C07D217/10—Quaternary compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/02—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines
    • C07D217/04—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines with hydrocarbon or substituted hydrocarbon radicals attached to the ring nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/02—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines
    • C07D217/06—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines with the ring nitrogen atom acylated by carboxylic or carbonic acids, or with sulfur or nitrogen analogues thereof, e.g. carbamates

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Procedure for the preparation of new tetrahydroisoquinoline derivatives of the formulas **(See formula)** wherein A represents a lower alkylene, lower hydroxy-alkylene, or lower oxo-alkylene radical, R1 represents a lower alkyl radical, R2 represents a hydrogen atom or a lower alkyl radical, and R3 represents a halogen atom, and its non-toxic addition salts and quaternary ammonium compounds, characterized in that a compound of the formula is reacted under the Mannich reaction conditions: **(See formula)** (where R1 and R2 are as defined herein above) with formaldehyde and a ketone of the formula: **(See formula)** (where R4 represents a hydrogen atom or an alkyl group having no more than 3 carbon atoms, and R3 is as defined herein above), to form a compound of the formula: **(See formula)** (in which the various symbols are as defined herein above) and optionally reducing the carbonyl group in the product obtained to the group -CH2- or -CHOH- by known methods for such reactions. (Machine-translation by Google Translate, not legally binding)
ES0301736A 1963-07-08 1964-07-06 Procedure for the preparation of new derivatives of tetrahidroisoquinolina. (Machine-translation by Google Translate, not legally binding) Expired ES301736A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB2702263 1963-07-08

Publications (1)

Publication Number Publication Date
ES301736A1 true ES301736A1 (en) 1965-01-16

Family

ID=10252896

Family Applications (1)

Application Number Title Priority Date Filing Date
ES0301736A Expired ES301736A1 (en) 1963-07-08 1964-07-06 Procedure for the preparation of new derivatives of tetrahidroisoquinolina. (Machine-translation by Google Translate, not legally binding)

Country Status (5)

Country Link
AT (4) AT250962B (en)
BE (1) BE649952A (en)
ES (1) ES301736A1 (en)
FR (1) FR4637M (en)
NL (1) NL6407478A (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN108484574B (en) * 2018-04-12 2020-06-19 广东医科大学 Preparation and application of tetrahydroisoquinoline derivative

Also Published As

Publication number Publication date
FR4637M (en) 1966-12-05
AT250963B (en) 1966-12-12
AT250962B (en) 1966-12-12
AT250961B (en) 1966-12-12
BE649952A (en) 1965-01-04
NL6407478A (en) 1965-01-11
AT250964B (en) 1966-12-12

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