ES287587A1 - A procedure for the synthetic manufacture of 2odeoxi-5-fluoro-pure citidine or its anode alpha pure (Machine-translation by Google Translate, not legally binding) - Google Patents

A procedure for the synthetic manufacture of 2odeoxi-5-fluoro-pure citidine or its anode alpha pure (Machine-translation by Google Translate, not legally binding)

Info

Publication number
ES287587A1
ES287587A1 ES287587A ES287587A ES287587A1 ES 287587 A1 ES287587 A1 ES 287587A1 ES 287587 A ES287587 A ES 287587A ES 287587 A ES287587 A ES 287587A ES 287587 A1 ES287587 A1 ES 287587A1
Authority
ES
Spain
Prior art keywords
pure
fluoro
anomer
translation
alpha
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES287587A
Other languages
Spanish (es)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
F Hoffmann La Roche AG
Original Assignee
F Hoffmann La Roche AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by F Hoffmann La Roche AG filed Critical F Hoffmann La Roche AG
Publication of ES287587A1 publication Critical patent/ES287587A1/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/47—One nitrogen atom and one oxygen or sulfur atom, e.g. cytosine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

A process for the synthetic manufacture of pure 2'-deoxy-5-fluoro-cytisine or its pure alpha anomer, respectively, characterized in that it comprises reacting 5-fluoro-cytosine with an acylating agent, reacting the -N-mono-acyl-5-fluoro-cytosine produced with a mercury salt to form the monomercurial salt of said 4-N-mono-acyl-5-fluoro-cytosine, reacting said monomercurial salt with a halide of 3, 5-diaroyl-2-deoxy-D-ribofuranosyl to produce a mixture containing the alpha anomer and the beta anomer of 4-N-mono-acyl-1- (3 ', 5'-di-O-aroyl-2 '-deoxy-D-ribofuranosyl) -5-fluoro-cytosine, separating said beta anomer from said alpha anomer and hydrolyzing said beta anomer and/or said alpha anomer separately by treating them with an alkali. (Machine-translation by Google Translate, not legally binding)
ES287587A 1962-05-01 1963-04-30 A procedure for the synthetic manufacture of 2odeoxi-5-fluoro-pure citidine or its anode alpha pure (Machine-translation by Google Translate, not legally binding) Expired ES287587A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US19143862A 1962-05-01 1962-05-01

Publications (1)

Publication Number Publication Date
ES287587A1 true ES287587A1 (en) 1963-11-01

Family

ID=22705512

Family Applications (1)

Application Number Title Priority Date Filing Date
ES287587A Expired ES287587A1 (en) 1962-05-01 1963-04-30 A procedure for the synthetic manufacture of 2odeoxi-5-fluoro-pure citidine or its anode alpha pure (Machine-translation by Google Translate, not legally binding)

Country Status (6)

Country Link
BR (1) BR6348745D0 (en)
CH (1) CH421973A (en)
DK (1) DK115916B (en)
ES (1) ES287587A1 (en)
FR (1) FR1514917A (en)
GB (3) GB989456A (en)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
UA106889C2 (en) * 2009-08-07 2014-10-27 ДАУ АГРОСАЙЄНСІЗ ЕлЕлСі N1-ACYL-5-FLORPYRIMIDINONE DERIVATIVES
WO2014105844A1 (en) 2012-12-28 2014-07-03 Dow Agrosciences Llc N-(substituted)-5-fluoro-4-imino-3-methyl-2-oxo-3,4-dihydropyrimidine-1 (2h)-carboxylate derivatives
UA117123C2 (en) 2012-12-28 2018-06-25 Адама Махтешім Лтд. 1-(substituted-benzoyl)-5-fluoro-4-imino-3-methyl-3,4-dihydropyrimidin-2(1h)-one derivatives
KR20150100869A (en) 2012-12-28 2015-09-02 다우 아그로사이언시즈 엘엘씨 N-(substituted)-5-fluoro-4-imino-3-methyl-2-oxo-3,4-dihydropyrimidine-1 (2h)-carboxamides derivatives
WO2014105845A1 (en) 2012-12-31 2014-07-03 Dow Agrosciences Llc 3-alkyl-5-fluoro-4-substituted-imino-3,4-dihydropyrimidin-2(1h)-one derivatives as fungicides

Also Published As

Publication number Publication date
CH421973A (en) 1966-10-15
GB989456A (en) 1965-04-22
GB1002278A (en) 1965-08-25
GB989455A (en) 1965-04-22
BR6348745D0 (en) 1973-07-03
FR1514917A (en) 1968-03-01
DK115916B (en) 1969-11-24

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