ES277176A1 - Procedure for preparation of 18,19-dinor 13 beta N-propil 17 alpha-etinil testosterone (Machine-translation by Google Translate, not legally binding) - Google Patents

Procedure for preparation of 18,19-dinor 13 beta N-propil 17 alpha-etinil testosterone (Machine-translation by Google Translate, not legally binding)

Info

Publication number
ES277176A1
ES277176A1 ES277176A ES277176A ES277176A1 ES 277176 A1 ES277176 A1 ES 277176A1 ES 277176 A ES277176 A ES 277176A ES 277176 A ES277176 A ES 277176A ES 277176 A1 ES277176 A1 ES 277176A1
Authority
ES
Spain
Prior art keywords
dinor
testosterone
translation
machine
legally binding
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES277176A
Other languages
Spanish (es)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sanofi Aventis France
Original Assignee
Roussel Uclaf SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from FR861446A external-priority patent/FR1376454A/en
Application filed by Roussel Uclaf SA filed Critical Roussel Uclaf SA
Publication of ES277176A1 publication Critical patent/ES277176A1/en
Expired legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
    • A61K31/568—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol substituted in positions 10 and 13 by a chain having at least one carbon atom, e.g. androstanes, e.g. testosterone
    • A61K31/569—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol substituted in positions 10 and 13 by a chain having at least one carbon atom, e.g. androstanes, e.g. testosterone substituted in position 17 alpha, e.g. ethisterone
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J21/00—Normal steroids containing carbon, hydrogen, halogen or oxygen having an oxygen-containing hetero ring spiro-condensed with the cyclopenta(a)hydrophenanthrene skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J75/00—Processes for the preparation of steroids in general

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Steroid Compounds (AREA)

Abstract

Preparation process of 18,19-dinor 13beta-n-propyl-17alpha-ethynyl-testosterone, characterized in that a cyclic ketal of 18,19-dinor-13beta-n-propyl-testosterone is formed, the ketalized product is oxidized to obtain the corresponding 17-ketone derivative, this is subjected to ethynylation, and then the ketone is released in 3. (Machine-translation by Google Translate, not legally binding)
ES277176A 1961-05-10 1962-05-09 Procedure for preparation of 18,19-dinor 13 beta N-propil 17 alpha-etinil testosterone (Machine-translation by Google Translate, not legally binding) Expired ES277176A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR861446A FR1376454A (en) 1961-05-10 1961-05-10 19-nor testosterone derivative and method of preparation
FR870347A FR1456M (en) 1961-05-10 1961-08-08 New drug in particular for the treatment of deficiencies of the corpus luteum.

Publications (1)

Publication Number Publication Date
ES277176A1 true ES277176A1 (en) 1962-08-01

Family

ID=26190476

Family Applications (1)

Application Number Title Priority Date Filing Date
ES277176A Expired ES277176A1 (en) 1961-05-10 1962-05-09 Procedure for preparation of 18,19-dinor 13 beta N-propil 17 alpha-etinil testosterone (Machine-translation by Google Translate, not legally binding)

Country Status (5)

Country Link
BE (1) BE617484A (en)
CH (1) CH411854A (en)
DE (1) DE1290139B (en)
ES (1) ES277176A1 (en)
GB (1) GB1003304A (en)

Also Published As

Publication number Publication date
BE617484A (en) 1962-11-12
GB1003304A (en) 1965-09-02
CH411854A (en) 1966-04-30
DE1290139B (en) 1969-03-06

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