ES2694172A1 - ENCAPSULATED DEVICE SUITABLE FOR MICROFLUIDIC APPLICATIONS (Machine-translation by Google Translate, not legally binding) - Google Patents

ENCAPSULATED DEVICE SUITABLE FOR MICROFLUIDIC APPLICATIONS (Machine-translation by Google Translate, not legally binding) Download PDF

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Publication number
ES2694172A1
ES2694172A1 ES201730809A ES201730809A ES2694172A1 ES 2694172 A1 ES2694172 A1 ES 2694172A1 ES 201730809 A ES201730809 A ES 201730809A ES 201730809 A ES201730809 A ES 201730809A ES 2694172 A1 ES2694172 A1 ES 2694172A1
Authority
ES
Spain
Prior art keywords
device suitable
lid
translation
machine
legally binding
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
ES201730809A
Other languages
Spanish (es)
Inventor
José Manuel GARCÍA AZNAR
Cristina DEL AMO MATEOS
Jorge Santolaria Mazo
Alejandro BLANCO MONEO
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Universidad de Zaragoza
Original Assignee
Universidad de Zaragoza
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Universidad de Zaragoza filed Critical Universidad de Zaragoza
Priority to ES201730809A priority Critical patent/ES2694172A1/en
Publication of ES2694172A1 publication Critical patent/ES2694172A1/en
Pending legal-status Critical Current

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502715—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by interfacing components, e.g. fluidic, electrical, optical or mechanical interfaces
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L9/00—Supporting devices; Holding devices
    • B01L9/52—Supports specially adapted for flat sample carriers, e.g. for plates, slides, chips
    • B01L9/527—Supports specially adapted for flat sample carriers, e.g. for plates, slides, chips for microfluidic devices, e.g. used for lab-on-a-chip
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M23/00—Constructional details, e.g. recesses, hinges
    • C12M23/48—Holding appliances; Racks; Supports
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M33/00—Means for introduction, transport, positioning, extraction, harvesting, peeling or sampling of biological material in or from the apparatus
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/02—Adapting objects or devices to another
    • B01L2200/026—Fluid interfacing between devices or objects, e.g. connectors, inlet details
    • B01L2200/027—Fluid interfacing between devices or objects, e.g. connectors, inlet details for microfluidic devices
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/06—Fluid handling related problems
    • B01L2200/0605—Metering of fluids

Abstract

Encapsulation device suitable for microfluidic applications. The invention relates to an encapsulation device suitable for microfluidic applications, comprising at least one base element (1) and at least one cover element (2), with a main space (1') for accommodating a microfluidic chip. The lid element (2) comprises connection holes (3) to the microfluidic chip; and the base element (1) and the lid element (2) comprise corresponding mechanical joining means (4), adapted to close the main housing space (1') of the chip. Advantageously, the base element (1) comprises a metal main surface, adapted to support the lid element (2); and the lid element (2) comprises a plastic main surface formed from one or more light-curing resins, directly obtainable by 3D prototyping printing techniques, where said lid (2) is adapted to be arranged on the metal main surface of the element base (1) and closed on it by adjusting the mechanical joining means (4). (Machine-translation by Google Translate, not legally binding)

Description

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propuesto resulta especialmente adecuado para garantizar su estanqueidad, y evitar la aparición de burbujas en el citado circuito. proposed is especially suitable to ensure its tightness, and avoid the appearance of bubbles in the aforementioned circuit.

Por su parte, el acoplamiento entre los dos elementos (1, 2) principales del dispositivo se realiza, preferentemente, mediante uniones mecánicas (4) roscadas tuerca-tornillo, en una pluralidad de puntos del soporte (por ejemplo, seis puntos en las realizaciones mostradas en las Figuras 1-4), garantizando una adecuada fijación y estabilidad del dispositivo. La tapa (2) puede incluir, adicionalmente, un diseño de encaje en el interior de la base (1), presentando por ejemplo una geometría en relieve correspondiente con la del chip microfluídico a alojar, con el objetivo de evitar un mal montaje de éste en el encapsulado, mediante un diseño de tipo Poka-Yoke. For its part, the coupling between the two main elements (1, 2) of the device is preferably carried out by means of mechanical screw-threaded nut joints (4), in a plurality of points of the support (for example, six points in the embodiments). shown in Figures 1-4), guaranteeing an adequate fixation and stability of the device. The cover (2) can additionally include a design of fitting inside the base (1), presenting, for example, a geometry in relief corresponding to that of the microfluidic chip to be housed, in order to avoid a bad assembly of this one in the package, using a Poka-Yoke design.

Como se ha mencionado, según la descripción proporcionada la invención está orientada para facilitar al usuario el análisis 4D de los efectos del flujo de fluido aplicado a cultivos celulares en 3D, aunque también se puede utilizar sin limitación para el estudio de cultivos bidimensionales. Para facilitar la monitorización del chip a través del dispositivo, la tapa (2) comprende, preferentemente, al menos una ventana (5) de inspección óptica que comunica con el chip microfluídico, y que está dispuesta para facilitar el acceso por parte del sistema de microscopía utilizado para registrar la actividad en el chip durante los ensayos. As mentioned, according to the description provided the invention is oriented to facilitate the user 4D analysis of the effects of fluid flow applied to 3D cell cultures, although it can also be used without limitation for the study of two-dimensional cultures. To facilitate the monitoring of the chip through the device, the lid (2) preferably comprises at least one optical inspection window (5) communicating with the microfluidic chip, and which is arranged to facilitate access by the system of microscopy used to record the activity on the chip during the tests.

A modo de resumen, se describen de nuevo las ventajas principales de la invención: By way of summary, the main advantages of the invention are described again:

-Combinación de un material metálico en la base y un material plástico en la tapa, para adaptarse a las pequeñas deformaciones que pudiera sufrir el material de la impresora 3D, compensándose gracias a las diferencias de coeficientes de elasticidad de ambos materiales. -Combination of a metallic material in the base and a plastic material in the lid, to adapt to the small deformations that could suffer the material of the 3D printer, compensating thanks to the differences of coefficients of elasticity of both materials.

-Acoplamiento sencillo basado preferentemente en uniones atornilladas, que permite regular en altura y ajustar la tapa (2) a las dimensiones del chip que se aloja en su interior. Simple coupling, preferably based on bolted joints, which allows to adjust in height and adjust the cover (2) to the dimensions of the chip that is housed inside.

-Capacidad de realizar una multiplicidad de ensayos simultáneos, mediante el uso de una pluralidad de alojamientos de chips en la base (1). -Ability to perform a multiplicity of simultaneous tests, by using a plurality of chip housings in the base (1).

-Versatilidad para adaptar el dispositivo a todo tipo de chips, así como a diferentes tamaños de los mismos por la simplicidad del proceso de fabricación de -Versatility to adapt the device to all types of chips, as well as to different sizes of them due to the simplicity of the manufacturing process.

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Claims (1)

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ES201730809A 2017-06-16 2017-06-16 ENCAPSULATED DEVICE SUITABLE FOR MICROFLUIDIC APPLICATIONS (Machine-translation by Google Translate, not legally binding) Pending ES2694172A1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
ES201730809A ES2694172A1 (en) 2017-06-16 2017-06-16 ENCAPSULATED DEVICE SUITABLE FOR MICROFLUIDIC APPLICATIONS (Machine-translation by Google Translate, not legally binding)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ES201730809A ES2694172A1 (en) 2017-06-16 2017-06-16 ENCAPSULATED DEVICE SUITABLE FOR MICROFLUIDIC APPLICATIONS (Machine-translation by Google Translate, not legally binding)

Publications (1)

Publication Number Publication Date
ES2694172A1 true ES2694172A1 (en) 2018-12-18

Family

ID=64651062

Family Applications (1)

Application Number Title Priority Date Filing Date
ES201730809A Pending ES2694172A1 (en) 2017-06-16 2017-06-16 ENCAPSULATED DEVICE SUITABLE FOR MICROFLUIDIC APPLICATIONS (Machine-translation by Google Translate, not legally binding)

Country Status (1)

Country Link
ES (1) ES2694172A1 (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN109759157A (en) * 2019-03-20 2019-05-17 河北工业大学 A kind of micro-fluidic chip for microbubble separation

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20050136685A1 (en) * 2003-12-19 2005-06-23 Kei Takenaka Chips, and apparatus and method for reaction analysis
US20070128715A1 (en) * 2005-07-08 2007-06-07 Jelena Vukasinovic Centimeter-scale, integrated diagnostics incubator for biological culturing
US20100151571A1 (en) * 2006-07-07 2010-06-17 Georgia Tech Research Corporation Centimeter-scale, integrated diagnostics incubator for biological culturing
ES2459269A1 (en) * 2012-10-04 2014-05-08 Universidad De Zaragoza Device and method for encapsulating microfluidic systems

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20050136685A1 (en) * 2003-12-19 2005-06-23 Kei Takenaka Chips, and apparatus and method for reaction analysis
US20070128715A1 (en) * 2005-07-08 2007-06-07 Jelena Vukasinovic Centimeter-scale, integrated diagnostics incubator for biological culturing
US20100151571A1 (en) * 2006-07-07 2010-06-17 Georgia Tech Research Corporation Centimeter-scale, integrated diagnostics incubator for biological culturing
ES2459269A1 (en) * 2012-10-04 2014-05-08 Universidad De Zaragoza Device and method for encapsulating microfluidic systems

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN109759157A (en) * 2019-03-20 2019-05-17 河北工业大学 A kind of micro-fluidic chip for microbubble separation

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