ES269147A1 - Serine derivative - Google Patents

Serine derivative

Info

Publication number
ES269147A1
ES269147A1 ES0269147A ES269147A ES269147A1 ES 269147 A1 ES269147 A1 ES 269147A1 ES 0269147 A ES0269147 A ES 0269147A ES 269147 A ES269147 A ES 269147A ES 269147 A1 ES269147 A1 ES 269147A1
Authority
ES
Spain
Prior art keywords
dichloroacetyl
methyl
compounds
inert solvent
serine
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES0269147A
Other languages
Spanish (es)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck Frosst Canada and Co
Original Assignee
Charles E Frosst and Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Charles E Frosst and Co filed Critical Charles E Frosst and Co
Publication of ES269147A1 publication Critical patent/ES269147A1/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C229/34—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton containing six-membered aromatic rings
    • C07C229/36—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton containing six-membered aromatic rings with at least one amino group and one carboxyl group bound to the same carbon atom of the carbon skeleton

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

The invention comprises O-dichloroacetyl-DL-serine derivatives of the general formula <FORM:0911489/IV (b)/1> (wherein R represents hydrogen, methyl or ethyl) and non-toxic addition salts thereof. These compounds may be prepared by reacting serine or its methyl or ethyl ester with glacial dichloroacetic acid and hydrogen chloride gas or dichloroacetic anhydride in the presence of an inert solvent, or by treating the corresponding N-dichloroacetyl compounds with a strong inorganic acid in the presence of an inert solvent. The products have anti-tumour activity, and may be administered with the usual excipients.
ES0269147A 1960-08-08 1961-07-04 Serine derivative Expired ES269147A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB27407/60A GB911489A (en) 1960-08-08 1960-08-08 Serine derivative

Publications (1)

Publication Number Publication Date
ES269147A1 true ES269147A1 (en) 1961-11-16

Family

ID=10259072

Family Applications (1)

Application Number Title Priority Date Filing Date
ES0269147A Expired ES269147A1 (en) 1960-08-08 1961-07-04 Serine derivative

Country Status (5)

Country Link
BE (1) BE605281A (en)
CH (1) CH395130A (en)
ES (1) ES269147A1 (en)
FR (1) FR1395M (en)
GB (1) GB911489A (en)

Also Published As

Publication number Publication date
FR1395M (en) 1962-07-09
GB911489A (en) 1962-11-28
CH395130A (en) 1965-07-15
BE605281A (en) 1961-12-22

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