ES2628210T3 - Poliuretano que tiene un revestimiento antitrombogénico - Google Patents
Poliuretano que tiene un revestimiento antitrombogénico Download PDFInfo
- Publication number
- ES2628210T3 ES2628210T3 ES14801976.3T ES14801976T ES2628210T3 ES 2628210 T3 ES2628210 T3 ES 2628210T3 ES 14801976 T ES14801976 T ES 14801976T ES 2628210 T3 ES2628210 T3 ES 2628210T3
- Authority
- ES
- Spain
- Prior art keywords
- pur
- antithrombogenic
- polyurethane
- antithrombogenic coating
- pei
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- 229920002635 polyurethane Polymers 0.000 title abstract 6
- 239000004814 polyurethane Substances 0.000 title abstract 6
- 230000002965 anti-thrombogenic effect Effects 0.000 title abstract 5
- 239000011248 coating agent Substances 0.000 title abstract 3
- 238000000576 coating method Methods 0.000 title abstract 3
- CURLTUGMZLYLDI-UHFFFAOYSA-N Carbon dioxide Chemical compound O=C=O CURLTUGMZLYLDI-UHFFFAOYSA-N 0.000 abstract 4
- 229920002873 Polyethylenimine Polymers 0.000 abstract 3
- 229910002092 carbon dioxide Inorganic materials 0.000 abstract 2
- 239000001569 carbon dioxide Substances 0.000 abstract 2
- 239000000126 substance Substances 0.000 abstract 2
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L33/00—Antithrombogenic treatment of surgical articles, e.g. sutures, catheters, prostheses, or of articles for the manipulation or conditioning of blood; Materials for such treatment
- A61L33/0005—Use of materials characterised by their function or physical properties
- A61L33/0011—Anticoagulant, e.g. heparin, platelet aggregation inhibitor, fibrinolytic agent, other than enzymes, attached to the substrate
- A61L33/0029—Anticoagulant, e.g. heparin, platelet aggregation inhibitor, fibrinolytic agent, other than enzymes, attached to the substrate using an intermediate layer of polymer
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L33/00—Antithrombogenic treatment of surgical articles, e.g. sutures, catheters, prostheses, or of articles for the manipulation or conditioning of blood; Materials for such treatment
- A61L33/0094—Physical treatment, e.g. plasma treatment
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2400/00—Materials characterised by their function or physical properties
- A61L2400/18—Modification of implant surfaces in order to improve biocompatibility, cell growth, fixation of biomolecules, e.g. plasma treatment
Landscapes
- Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Hematology (AREA)
- General Health & Medical Sciences (AREA)
- Epidemiology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Surgery (AREA)
- Physics & Mathematics (AREA)
- Plasma & Fusion (AREA)
- Chemical & Material Sciences (AREA)
- Materials Engineering (AREA)
- Materials For Medical Uses (AREA)
- Laminated Bodies (AREA)
- Thermal Transfer Or Thermal Recording In General (AREA)
Abstract
Poliuretano (PUR) que tiene un revestimiento antitrombogénico, en donde el revestimiento antitrombogénico comprende al menos una sustancia antitrombogénica covalentemente unida a una superficie del PUR mediante al menos dos enlaces, en donde un primero de dichos enlaces es un enlace amida entre la superficie del PUR y una polietilenimina (PEI) y un segundo de dichos enlaces está entre la PEI y la sustancia antitrombogénica, en donde la superficie del PUR se ha activado mediante el uso de un plasma de dióxido de carbono o un plasma modificado por adición de dióxido de carbono antes de que se forme el primero de dichos enlaces.
Description
Claims (1)
-
imagen1
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP13192956 | 2013-11-14 | ||
EP13192956 | 2013-11-14 | ||
PCT/EP2014/074380 WO2015071313A1 (en) | 2013-11-14 | 2014-11-12 | Polyurethane having an antithrombogenic coating |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2628210T3 true ES2628210T3 (es) | 2017-08-02 |
Family
ID=49582641
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES14801976.3T Active ES2628210T3 (es) | 2013-11-14 | 2014-11-12 | Poliuretano que tiene un revestimiento antitrombogénico |
Country Status (5)
Country | Link |
---|---|
US (1) | US9867912B2 (es) |
EP (1) | EP3068454B1 (es) |
CN (1) | CN105899244B (es) |
ES (1) | ES2628210T3 (es) |
WO (1) | WO2015071313A1 (es) |
Families Citing this family (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2019042261A1 (zh) * | 2017-08-28 | 2019-03-07 | 武汉杨森生物技术有限公司 | 复合肝素抗凝涂层液、涂层用微球及制备方法与应用 |
CN110028692B (zh) * | 2019-03-14 | 2020-11-03 | 江苏赛腾医疗科技有限公司 | 一种基于离子键-共价键协同表面肝素化抗凝血医用装置的制备方法 |
CN113795282A (zh) * | 2019-03-19 | 2021-12-14 | 杰美特涂层科技(厦门)有限公司 | 包含共价键合肝素涂层的医疗装置 |
CN113350580A (zh) * | 2021-06-11 | 2021-09-07 | 海思盖德(苏州)生物医学科技有限公司 | 一种应用于医疗器械中的肝素涂层制备方法 |
CN114306758A (zh) * | 2021-12-28 | 2022-04-12 | 上海宏创医疗科技有限公司 | 一种长效抗凝血涂层、制备方法及其应用 |
Family Cites Families (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4521564A (en) | 1984-02-10 | 1985-06-04 | Warner-Lambert Company | Covalent bonded antithrombogenic polyurethane material |
CN85108692A (zh) * | 1985-12-21 | 1987-06-24 | 南京大学 | 聚乙二醇醚在聚氨酯表面的接枝共聚方法 |
US5132108A (en) * | 1990-11-08 | 1992-07-21 | Cordis Corporation | Radiofrequency plasma treated polymeric surfaces having immobilized anti-thrombogenic agents |
US5405919A (en) * | 1992-08-24 | 1995-04-11 | The United States Of America As Represented By The Secretary Of Health And Human Services | Polymer-bound nitric oxide/nucleophile adduct compositions, pharmaceutical compositions and methods of treating biological disorders |
CN1057540C (zh) * | 1995-09-26 | 2000-10-18 | 财团法人工业技术研究院 | 含酰胺键的聚氨酯制品 |
US6491965B1 (en) | 1995-11-30 | 2002-12-10 | Hamilton Civic Hospitals Research Development, Inc. | Medical device comprising glycosaminoglycan-antithrombin III/heparin cofactor II conjugates |
US6033582A (en) * | 1996-01-22 | 2000-03-07 | Etex Corporation | Surface modification of medical implants |
DE19902948A1 (de) * | 1999-01-26 | 2000-07-27 | Creavis Tech & Innovation Gmbh | Verfahren zur Modifizierung von Polymersubstraten durch Oberflächenfixierung eigenschaftsbestimmende Makromoleküle |
US7456025B2 (en) * | 2001-08-28 | 2008-11-25 | Porex Corporation | Sintered polymer membrane for analyte detection device |
US8679520B2 (en) | 2001-10-15 | 2014-03-25 | Hemoteq Ag | Coating of stents for preventing restenosis |
US8383156B2 (en) * | 2007-04-30 | 2013-02-26 | Cordis Corporation | Coating for a medical device having an anti-thrombotic conjugate |
KR101132732B1 (ko) * | 2008-11-26 | 2012-04-06 | 한국과학기술연구원 | 인 시튜 조직재생용 지능형 다공성 생분해 고분자 지지체 및 이의 제조방법 |
KR20130086518A (ko) | 2010-05-27 | 2013-08-02 | 헤모텍 아게 | 밀집한 메시의 고분자 섬유로 이루어진 피복으로 관내 인공 삽입물의 피복 |
-
2014
- 2014-11-12 ES ES14801976.3T patent/ES2628210T3/es active Active
- 2014-11-12 EP EP14801976.3A patent/EP3068454B1/en active Active
- 2014-11-12 US US15/036,806 patent/US9867912B2/en active Active
- 2014-11-12 CN CN201480062544.9A patent/CN105899244B/zh active Active
- 2014-11-12 WO PCT/EP2014/074380 patent/WO2015071313A1/en active Application Filing
Also Published As
Publication number | Publication date |
---|---|
WO2015071313A1 (en) | 2015-05-21 |
CN105899244B (zh) | 2019-02-19 |
US9867912B2 (en) | 2018-01-16 |
US20160279304A1 (en) | 2016-09-29 |
EP3068454A1 (en) | 2016-09-21 |
CN105899244A (zh) | 2016-08-24 |
EP3068454B1 (en) | 2017-04-19 |
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