ES260703A1 - Procedure for the manufacture of tetrahidroisoquinoline derivatives (Machine-translation by Google Translate, not legally binding)
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Procedure for the manufacture of tetrahidroisoquinoline derivatives (Machine-translation by Google Translate, not legally binding)
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F Hoffmann La Roche AG
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F Hoffmann La Roche AG
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C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
C07D217/12—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring
C07D217/18—Aralkyl radicals
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Chemical & Material Sciences
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Organic Chemistry
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Pharmaceuticals Containing Other Organic And Inorganic Compounds
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Other In-Based Heterocyclic Compounds
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Abstract
Procedure for the manufacture of derivatives of tetrahydroisoquinoline, of the general formula in which R1 represents halogen, R2 represents hydrogen or alkyl and does not represent an integer from 1 to 3, and addition salts of said derivatives which process comprises condensing homoveratrylamine with a nuclear halogenated beta-phenyl propionic acid that can carry an alkyl group in the alpha position, cyclizing the resulting acid amide converting it into the corresponding 1- phenethyl-3,4-dihydroisoquinoline derivative, reducing the latter, the methylar in the nitrogen atom is the resulting substituted tetrahydro isoquinoline and, if desired, converting the thus-substituted substituted 1-phenethyl-2-methyl-1,2,3,4-tetrahydroisoquinoline into an acid addition salt. (Machine-translation by Google Translate, not legally binding)
ES0260703A1959-12-091960-08-30Procedure for the manufacture of tetrahidroisoquinoline derivatives (Machine-translation by Google Translate, not legally binding)
ExpiredES260703A1
(en)
A procedure for preparing the amides of the eugenic acid or 2-hydroxy-3-metoxy-5-alil-benzoic acid, of its esteres and its eteres. (Machine-translation by Google Translate, not legally binding)