ES2579487A1 - Use of polymers based on cross-linked saccharides as bile acid sequestrants (Machine-translation by Google Translate, not legally binding) - Google Patents

Use of polymers based on cross-linked saccharides as bile acid sequestrants (Machine-translation by Google Translate, not legally binding) Download PDF

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Publication number
ES2579487A1
ES2579487A1 ES201530160A ES201530160A ES2579487A1 ES 2579487 A1 ES2579487 A1 ES 2579487A1 ES 201530160 A ES201530160 A ES 201530160A ES 201530160 A ES201530160 A ES 201530160A ES 2579487 A1 ES2579487 A1 ES 2579487A1
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ES201530160A
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Spanish (es)
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ES2579487B1 (en
Inventor
Javier LÓPEZ JARAMILLO
María Dolores Girón González
Rafael Salto González
Fernando Hernández Mateo
Francisco Santoyo González
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Universidad de Granada
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Universidad de Granada
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A61K31/716—Glucans

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Molecular Biology (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Use of polymers based on crosslinked saccharides as bile acid sequestrants. The present invention describes the use of cross-linked saccharide-based polymers as a medicament, particularly for the treatment of diseases that require sequestering sterols and/or bile acids. Such polymers are obtained from either cyclodextrins and/or polysaccharides, such as starch or dextrin, which are cross-linked with bis vinyl sulfones, producing homo- and hetero-polymeric materials. Therefore, said materials can be used in different diseases such as hyperlipidemia, diabetes, atherosclerosis, hypercholesterolemia, hypertriglyceridemia, hyperglycemia and obesity, but it is not limited thereto. (Machine-translation by Google Translate, not legally binding)

Description

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Claims (1)

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ES201530160A 2015-02-11 2015-02-11 Use of crosslinked saccharide based polymers as bile acid sequestrants Active ES2579487B1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
ES201530160A ES2579487B1 (en) 2015-02-11 2015-02-11 Use of crosslinked saccharide based polymers as bile acid sequestrants

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ES201530160A ES2579487B1 (en) 2015-02-11 2015-02-11 Use of crosslinked saccharide based polymers as bile acid sequestrants

Publications (2)

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ES2579487A1 true ES2579487A1 (en) 2016-08-11
ES2579487B1 ES2579487B1 (en) 2017-05-19

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ES201530160A Active ES2579487B1 (en) 2015-02-11 2015-02-11 Use of crosslinked saccharide based polymers as bile acid sequestrants

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ES (1) ES2579487B1 (en)

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1995012620A1 (en) * 1993-11-01 1995-05-11 Alpha-Beta Technology, Inc. Derivatized polysaccharide bile acid sequestrant for reducing cholesterol
US20070122375A1 (en) * 2005-09-12 2007-05-31 Council Of Scientific And Industrial Research Bile acid sequestrant and process for preparation thereof
WO2011012749A2 (en) * 2009-07-28 2011-02-03 Universidad De Granada Polymer matrices based on polysaccharides and cyclodextrins

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1995012620A1 (en) * 1993-11-01 1995-05-11 Alpha-Beta Technology, Inc. Derivatized polysaccharide bile acid sequestrant for reducing cholesterol
US20070122375A1 (en) * 2005-09-12 2007-05-31 Council Of Scientific And Industrial Research Bile acid sequestrant and process for preparation thereof
WO2011012749A2 (en) * 2009-07-28 2011-02-03 Universidad De Granada Polymer matrices based on polysaccharides and cyclodextrins

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
L. CHEN et al., ¿Synthesis and characterization of hyperbranched poly(sulfone-amine) modified ß-cyclodextrin¿, e-Polymers 2006, nº 45, páginas 1-8 *
M. NICHIFOR et al., ¿Bile acid sequestrants based on cationic dextran hydrogel microspheres. 2. Influence of length of alkyl substituents at the amino groups of the sorbents on the sorption of bile salts¿, Journal of Pharmaceutical Sciences, 2001, vol. 90, nº 6, páginas 681-689 *
T. DEL CASTILLO et al., ¿Monovinyl sulfone ß-cyclodextrin. A flexible drug carrier system¿, ChemMedChem, 2014, vol. 9, páginas 383-389 *

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ES2579487B1 (en) 2017-05-19

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