ES2578102T3 - Dispositivo y método para análisis de diagnóstico - Google Patents
Dispositivo y método para análisis de diagnóstico Download PDFInfo
- Publication number
- ES2578102T3 ES2578102T3 ES10732412.1T ES10732412T ES2578102T3 ES 2578102 T3 ES2578102 T3 ES 2578102T3 ES 10732412 T ES10732412 T ES 10732412T ES 2578102 T3 ES2578102 T3 ES 2578102T3
- Authority
- ES
- Spain
- Prior art keywords
- biological samples
- bacteria
- containment
- medium
- wells
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- 0 CC(*)(CCC1)C*1C1*CC1 Chemical compound CC(*)(CCC1)C*1C1*CC1 0.000 description 2
Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M1/00—Apparatus for enzymology or microbiology
- C12M1/34—Measuring or testing with condition measuring or sensing means, e.g. colony counters
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M41/00—Means for regulation, monitoring, measurement or control, e.g. flow regulation
- C12M41/12—Means for regulation, monitoring, measurement or control, e.g. flow regulation of temperature
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/02—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving viable microorganisms
- C12Q1/04—Determining presence or kind of microorganism; Use of selective media for testing antibiotics or bacteriocides; Compositions containing a chemical indicator therefor
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/02—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving viable microorganisms
- C12Q1/18—Testing for antimicrobial activity of a material
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N35/02—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations
- G01N35/028—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations having reaction cells in the form of microtitration plates
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N35/10—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
- G01N35/1081—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices characterised by the means for relatively moving the transfer device and the containers in an horizontal plane
- G01N35/109—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices characterised by the means for relatively moving the transfer device and the containers in an horizontal plane with two horizontal degrees of freedom
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Analytical Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Physics & Mathematics (AREA)
- Immunology (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- General Engineering & Computer Science (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Genetics & Genomics (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biophysics (AREA)
- Toxicology (AREA)
- Molecular Biology (AREA)
- Sustainable Development (AREA)
- Biomedical Technology (AREA)
- Thermal Sciences (AREA)
- Medicinal Chemistry (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Investigating Or Analyzing Materials By The Use Of Ultrasonic Waves (AREA)
- Testing Or Measuring Of Semiconductors Or The Like (AREA)
Abstract
Dispositivo integrado para análisis de diagnóstico usado para verificar la presencia de bacterias en al menos una muestra biológica mezclada con un medio de cultivo eugónico en forma líquida, para clasificar al menos el tipo de bacterias y para ensayar una serie de antibióticos, seleccionados de un grupo de antibióticos característico al menos para dicho tipo de bacterias identificado, identificando los que son eficaces para determinar la terapia antibiótica, caracterizado por que comprende, dentro de una estructura integrada (11): - primer medio de contención (12) provisto de elementos de contención (13) en los que se dispensan las muestras biológicas para analizar; - segundo medio de contención (14) que comprende recipientes (15) o microplacas (66) termostatizadas con pocillos (67) que contienen un medio de cultivo eugónico en forma líquida en el que se dispone una primera fracción de las muestras biológicas para analizar, y un primer recipiente (15a) y segundos recipientes (15b) o placas (66a, 66b) con un primer pocillo relativo (67a) y segundos pocillos (67b), en los que se dispone una fracción adicional de las muestras biológicas que dieron resultado positivo al análisis; - primer medio de examen (40, 49) capaz de verificar la presencia de bacterias en dichas muestras biológicas contenidas en dicho primer medio de contención (12) y dispensados en los recipientes (15) o microplacas (66) con pocillos (67) para detectar muestras biológicas positivas correspondientes y clasificar o identificar al menos el tipo de bacterias presente en dichas muestras biológicas positivas para seleccionar un grupo de antibióticos apropiados para estas; - segundo medio de examen (49, 40) capaz de verificar, en dichos primer recipiente (15a) o primer pocillo (67a) y en dichos segundos recipientes (15b) o segundos pocillos (67b), la respuesta sensible o resistente de cada muestra biológica positiva a una serie de antibióticos del grupo de antibióticos seleccionado por dicho primer medio de examen (40, 49); - tercer medio de contención (16) que comprende placas (116a, 116b) que contienen medios de cultivo sólido en los que se siembra una segunda fracción de la muestra biológica correspondiente a una muestra hallada positiva por dicho primer medio de examen (40, 49) para obtener el aislamiento y/o la identificación de dichas bacterias; - una unidad de movimiento y selección (20) controlada por una unidad de control (18) para realizar automáticamente al menos la toma de las muestras biológicas positivas y su dispensación en dicho medio de contención (14) y en dicho tercer medio de contención (16); en donde dicho primer medio de examen (40, 49) comprende un sistema de lectura provisto de medios capaces de detectar la obtención de un nivel dado de turbidez igual a 0,5 en la escala de McFarland de la suspensión bacteriana presente en dichos recipientes (15) o microplacas (66) con pocillos (67) obtenidos durante la etapa de crecimiento bacteriano exponencial.
Description
Claims (1)
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imagen1 imagen2 imagen3 imagen4
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
ITUD2009A000046A IT1397120B1 (it) | 2009-02-25 | 2009-02-25 | Dispositivo integrato per analisi diagnostiche, e relativo procedimento |
ITUD20090046 | 2009-02-25 | ||
PCT/IB2010/000364 WO2010097683A2 (en) | 2009-02-25 | 2010-02-24 | Integrated device for diagnostic analyses, and relative method |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2578102T3 true ES2578102T3 (es) | 2016-07-20 |
Family
ID=41416152
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES10732412.1T Active ES2578102T3 (es) | 2009-02-25 | 2010-02-24 | Dispositivo y método para análisis de diagnóstico |
Country Status (9)
Country | Link |
---|---|
US (1) | US8927258B2 (es) |
EP (1) | EP2401356B1 (es) |
JP (1) | JP5702738B2 (es) |
KR (2) | KR101753764B1 (es) |
CN (1) | CN102361968A (es) |
CA (1) | CA2753159C (es) |
ES (1) | ES2578102T3 (es) |
IT (1) | IT1397120B1 (es) |
WO (1) | WO2010097683A2 (es) |
Families Citing this family (29)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN202807433U (zh) * | 2012-01-20 | 2013-03-20 | 安泰凯生物技术有限公司 | 样品盛装装置 |
FR3006692B1 (fr) * | 2013-06-11 | 2016-05-06 | Biomerieux Sa | Dispositif, systeme et procede de detection permettant de detecter la presence d'un micro-organisme dans un echantillon a l'interieur d'un contenant |
WO2015009734A2 (en) * | 2013-07-15 | 2015-01-22 | President And Fellows Of Harvard College | Assays for antimicrobial activity and applications thereof |
WO2015077632A1 (en) | 2013-11-21 | 2015-05-28 | Avails Medical, Inc. | Electrical biosensor for detecting a substance in a bodily fluid, and method and system for same |
FR3015039B1 (fr) * | 2013-12-12 | 2017-02-24 | Stago Diagnostica | Procede de determination de la position d'au moins un pion de cartographie |
CN103923827B (zh) * | 2014-04-25 | 2016-01-20 | 山东省食品药品检验研究院 | 全自动定量微生物制备仪 |
US9963733B2 (en) * | 2014-06-05 | 2018-05-08 | Avails Medical, Inc. | Devices, systems and methods for detecting viable infectious agents in a fluid sample |
CN108350408B (zh) | 2015-08-25 | 2022-12-16 | 阿威尔斯医疗公司 | 用于检测流体样品中有活力的微生物的设备、***和方法 |
WO2017132095A1 (en) * | 2016-01-25 | 2017-08-03 | Avails Medical, Inc. | Devices, systems and methods for detecting viable infectious agents in a fluid sample using an electrolyte-insulator-semiconductor sensor |
US20190161785A1 (en) * | 2016-04-25 | 2019-05-30 | Aperture Bio, LLC | Systems, Devices and Methods for Sequential Analysis of Complex Matrix Samples for High Confidence Bacterial Detection and Drug Susceptibility Prediction Using a Flow Cytometer |
EP4397973A2 (en) | 2016-05-31 | 2024-07-10 | Avails Medical, Inc. | Devices, systems and methods to detect viable infectious agents in a fluid sample and susceptibility of infectious agents to anti-infectives |
JP6829950B2 (ja) * | 2016-05-31 | 2021-02-17 | シスメックス株式会社 | 分析方法、分析装置および分析システム |
IT201600069410A1 (it) * | 2016-07-04 | 2018-01-04 | Alifax Srl | Apparato integrato per analisi diagnostiche |
WO2018056584A1 (ko) | 2016-09-21 | 2018-03-29 | 삼성전자 주식회사 | 피부 상태 측정 방법 및 이를 위한 전자 장치 |
CN106497772B (zh) * | 2016-11-01 | 2019-04-16 | 山东省农业科学院畜牧兽医研究所 | 一种细菌抗药性检测***及其操作方法 |
CN106754327B (zh) * | 2017-01-18 | 2023-05-16 | 朱红 | 一种用于药敏的振荡装置及其控制方法 |
EP3612638A4 (en) * | 2017-04-19 | 2020-12-16 | Cap Diagnostics, LLC, DBA Pathnostics | COMPREHENSIVE IDENTIFICATION OF ANTIBIOTIC SENSITIVITY TEST |
US11053532B2 (en) | 2017-04-19 | 2021-07-06 | CAP Diagnostics, LLC | Methods for treating polymicrobial infections |
WO2018195513A1 (en) | 2017-04-20 | 2018-10-25 | Biomerieux, Inc. | Optical test platform |
WO2019005296A1 (en) | 2017-06-27 | 2019-01-03 | Avails Medical, Inc. | APPARATUS, SYSTEMS AND METHODS FOR DETERMINING THE SENSITIVITY OF MICROORGANISMS TO ANTI-INFECTIOUS |
CN107723228A (zh) * | 2017-09-20 | 2018-02-23 | 凤阳高科动物保健品厂 | 一种兽用抗生素药敏快速测试盒 |
CN111182971B (zh) | 2017-10-03 | 2022-08-30 | 阿威尔斯医疗公司 | 用于基于氧化还原反应测定微生物的浓度和微生物对抗感染剂的敏感性的装置、***和方法 |
KR102054862B1 (ko) * | 2018-11-02 | 2019-12-11 | 이성윤 | 스태커를 이용한 마이크로플레이트용 면역학 검사장치 |
KR102159084B1 (ko) | 2019-01-28 | 2020-09-23 | 한국기계연구원 | 항균특성 평가 장치 및 이를 이용한 항균특성 평가방법 |
KR102116819B1 (ko) * | 2019-03-08 | 2020-06-01 | 건양대학교산학협력단 | 약물 내성 확인용 소변 검출키트 |
KR102547548B1 (ko) * | 2020-11-03 | 2023-06-26 | 문병로 | 집합적 진단 제어 방법 및 그 시스템 |
CN113403192B (zh) * | 2021-06-16 | 2024-02-27 | 广东阳光生物科技有限公司 | 微生物检测装置、微生物检测***以及微生物检测方法 |
CN221123306U (zh) * | 2022-07-19 | 2024-06-11 | 贝克顿·迪金森公司 | 用于滚筒位置检测的*** |
KR20240027359A (ko) | 2022-08-23 | 2024-03-04 | 한국기계연구원 | 채취 및 진단 일체형 통합 고속진단장치 및 이를 이용한 통합 고속진단방법 |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5012119A (en) | 1989-05-19 | 1991-04-30 | Xinix, Inc. | Method and apparatus for monitoring particles using back-scattered light without interference by bubbles |
US5863754A (en) * | 1995-05-12 | 1999-01-26 | Pasteur Sanofi Diagnostics | Process for bacteria identification and for determination of the sensitivity of bacteria to antibiotics and apparatus and measuring supports for carrying out this process |
WO1998041610A2 (en) * | 1997-03-17 | 1998-09-24 | Canadian Space Agency | Method and apparatus for automatically inoculating culture media with bacterial specimens from clinical specimen containers |
FR2853326B1 (fr) * | 2003-04-07 | 2005-05-06 | Biomerieux Sa | Procede de detection et/ou d'identification de bacteries presentes dans un echantillon |
ES2340776T3 (es) * | 2004-01-22 | 2010-06-09 | Medvet Science Pty. Ltd. | Dispositivo de distribucion microbiana en lineas. |
EP1779094B1 (en) * | 2004-08-19 | 2018-10-03 | Becton, Dickinson and Company | Apparatus for performing optical measurements on blood culture bottles |
ITUD20040170A1 (it) * | 2004-08-25 | 2004-11-25 | Alifax Technology Srl | Dispositivo integrato per analisi diagnostiche, e relativo procedimento |
-
2009
- 2009-02-25 IT ITUD2009A000046A patent/IT1397120B1/it active
-
2010
- 2010-02-24 CA CA2753159A patent/CA2753159C/en not_active Expired - Fee Related
- 2010-02-24 JP JP2011551541A patent/JP5702738B2/ja not_active Expired - Fee Related
- 2010-02-24 US US13/203,187 patent/US8927258B2/en active Active
- 2010-02-24 KR KR1020117022342A patent/KR101753764B1/ko active IP Right Grant
- 2010-02-24 CN CN2010800131474A patent/CN102361968A/zh active Pending
- 2010-02-24 EP EP10732412.1A patent/EP2401356B1/en active Active
- 2010-02-24 KR KR1020177017688A patent/KR101914599B1/ko active IP Right Grant
- 2010-02-24 ES ES10732412.1T patent/ES2578102T3/es active Active
- 2010-02-24 WO PCT/IB2010/000364 patent/WO2010097683A2/en active Application Filing
Also Published As
Publication number | Publication date |
---|---|
KR101753764B1 (ko) | 2017-07-06 |
CA2753159C (en) | 2020-03-24 |
JP5702738B2 (ja) | 2015-04-15 |
WO2010097683A2 (en) | 2010-09-02 |
KR101914599B1 (ko) | 2018-11-02 |
EP2401356B1 (en) | 2016-04-20 |
CN102361968A (zh) | 2012-02-22 |
CA2753159A1 (en) | 2010-09-02 |
JP2012518427A (ja) | 2012-08-16 |
ITUD20090046A1 (it) | 2010-08-26 |
US8927258B2 (en) | 2015-01-06 |
WO2010097683A3 (en) | 2010-11-04 |
EP2401356A2 (en) | 2012-01-04 |
IT1397120B1 (it) | 2012-12-28 |
KR20110131228A (ko) | 2011-12-06 |
US20110306032A1 (en) | 2011-12-15 |
KR20170080707A (ko) | 2017-07-10 |
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