ES2571991T3 - Procedures for treating and / or reversing diseases and / or neurodegenerative disorders - Google Patents

Procedures for treating and / or reversing diseases and / or neurodegenerative disorders

Info

Publication number
ES2571991T3
ES2571991T3 ES11746068T ES11746068T ES2571991T3 ES 2571991 T3 ES2571991 T3 ES 2571991T3 ES 11746068 T ES11746068 T ES 11746068T ES 11746068 T ES11746068 T ES 11746068T ES 2571991 T3 ES2571991 T3 ES 2571991T3
Authority
ES
Spain
Prior art keywords
neural stem
procedures
treating
neurodegenerative disorders
brain
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
ES11746068T
Other languages
Spanish (es)
Inventor
Woei-Cherng Shyu
Shinn-Zong Lin
Hsiao-Jung Wang
Karl K Johe
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
NEURALSTEM Inc
Original Assignee
NEURALSTEM Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by NEURALSTEM Inc filed Critical NEURALSTEM Inc
Application granted granted Critical
Publication of ES2571991T3 publication Critical patent/ES2571991T3/en
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/30—Nerves; Brain; Eyes; Corneal cells; Cerebrospinal fluid; Neuronal stem cells; Neuronal precursor cells; Glial cells; Oligodendrocytes; Schwann cells; Astroglia; Astrocytes; Choroid plexus; Spinal cord tissue
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0618—Cells of the nervous system
    • C12N5/0623—Stem cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/18—Growth factors; Growth regulators
    • A61K38/1808—Epidermal growth factor [EGF] urogastrone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/18—Growth factors; Growth regulators
    • A61K38/1825—Fibroblast growth factor [FGF]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/18—Growth factors; Growth regulators
    • A61K38/1841—Transforming growth factor [TGF]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biotechnology (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Developmental Biology & Embryology (AREA)
  • Cell Biology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • General Engineering & Computer Science (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Urology & Nephrology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Virology (AREA)
  • Psychiatry (AREA)
  • Dermatology (AREA)
  • Vascular Medicine (AREA)
  • Hospice & Palliative Care (AREA)

Abstract

Una cantidad terapéuticamente eficaz de una población expandida de células madre neurales a partir de al menos una célula madre neural obtenida a partir del tejido de la médula espinal de un ser humano, para su uso en el tratamiento de una enfermedad o un trastorno asociado a la pérdida de células neuronales en cerebro, en la que la población de células madre neurales es para la administración a al menos un área del cerebro de un sujeto; y en la que la población de células madre neurales es para la administración a, cerca de o alrededor de, el área o las áreas, el cerebro del sujeto afectadas por la pérdida de células neuronales.A therapeutically effective amount of an expanded population of neural stem cells from at least one neural stem cell obtained from the spinal cord tissue of a human being, for use in the treatment of a disease or disorder associated with the loss of neuronal cells in the brain, in which the population of neural stem cells is for administration to at least one area of the brain of a subject; and in which the population of neural stem cells is for administration to, near or around, the area or areas, the subject's brain affected by the loss of neuronal cells.

ES11746068T 2010-07-28 2011-07-28 Procedures for treating and / or reversing diseases and / or neurodegenerative disorders Active ES2571991T3 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US36840910P 2010-07-28 2010-07-28
PCT/US2011/045732 WO2012016049A1 (en) 2010-07-28 2011-07-28 Methods for treating and/or reversing neurodegenerative diseases and/or disorders

Publications (1)

Publication Number Publication Date
ES2571991T3 true ES2571991T3 (en) 2016-05-27

Family

ID=44630526

Family Applications (1)

Application Number Title Priority Date Filing Date
ES11746068T Active ES2571991T3 (en) 2010-07-28 2011-07-28 Procedures for treating and / or reversing diseases and / or neurodegenerative disorders

Country Status (16)

Country Link
US (1) US9540611B2 (en)
EP (1) EP2598154B1 (en)
JP (2) JP6077996B2 (en)
KR (1) KR101765980B1 (en)
CN (1) CN103237553A (en)
AU (1) AU2011282642B2 (en)
CA (1) CA2806904C (en)
ES (1) ES2571991T3 (en)
IL (1) IL224416A (en)
MX (1) MX341316B (en)
MY (1) MY168084A (en)
NZ (2) NZ607195A (en)
RU (1) RU2013108868A (en)
SG (1) SG187226A1 (en)
WO (1) WO2012016049A1 (en)
ZA (1) ZA201300954B (en)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
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WO2006055685A2 (en) * 2004-11-17 2006-05-26 Neuralstem, Inc. Transplantation of human neural cells for treatment of neurodegenerative conditions
US9789073B2 (en) 2013-03-14 2017-10-17 Pathak Holdings, Llc Compositions, methods and devices for local drug delivery
WO2014160387A2 (en) * 2013-03-14 2014-10-02 Pathak Holdings, Llc Compositions, methods and devices for local drug delivery
US9072678B2 (en) 2013-03-14 2015-07-07 Pathak Holdings Llc Methods for local drug delivery by microinjection
US10624865B2 (en) 2013-03-14 2020-04-21 Pathak Holdings Llc Methods, compositions, and devices for drug/live cell microarrays
WO2015006474A1 (en) * 2013-07-09 2015-01-15 Neuralstem, Inc. Methods of treating a subject with a cognitive dysfunction using spinal cord-derived neural stem cells
AU2015279552B2 (en) 2014-06-27 2021-01-21 Angiocrine Bioscience, Inc. Neural cells expressing adenovirus E4ORF1, and methods of making and using the same
WO2017031092A1 (en) * 2015-08-15 2017-02-23 Asterias Biotherapeutics, Inc. Stem cell-derived oligodendrocyte progenitor cells for the treatment of white matter stroke
CN106619722A (en) * 2016-12-05 2017-05-10 上海安集协康生物技术股份有限公司 Neural stem cell injection for treating brain damage disease
CN115089613A (en) * 2022-07-25 2022-09-23 朗姿赛尔生物科技（广州）有限公司 Application of neural stem cell transplantation in neurodegenerative diseases

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Also Published As

Publication number Publication date
MX2013001124A (en) 2013-08-01
JP6077996B2 (en) 2017-02-08
EP2598154A1 (en) 2013-06-05
AU2011282642A1 (en) 2013-03-07
US20120177612A1 (en) 2012-07-12
IL224416A (en) 2017-06-29
AU2011282642B2 (en) 2015-06-11
RU2013108868A (en) 2014-09-10
MY168084A (en) 2018-10-11
JP2015214589A (en) 2015-12-03
MX341316B (en) 2016-08-15
WO2012016049A1 (en) 2012-02-02
EP2598154B1 (en) 2016-03-23
CA2806904C (en) 2018-11-27
ZA201300954B (en) 2014-04-30
KR20140048064A (en) 2014-04-23
US9540611B2 (en) 2017-01-10
NZ623207A (en) 2014-12-24
KR101765980B1 (en) 2017-08-07
SG187226A1 (en) 2013-03-28
CA2806904A1 (en) 2012-02-02
CN103237553A (en) 2013-08-07
NZ607195A (en) 2014-08-29
JP2013532690A (en) 2013-08-19

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