ES2570153T3 - Anticuerpos anti-C5aR con propiedades mejoradas - Google Patents

Anticuerpos anti-C5aR con propiedades mejoradas

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Publication number
ES2570153T3
ES2570153T3 ES12155157T ES12155157T ES2570153T3 ES 2570153 T3 ES2570153 T3 ES 2570153T3 ES 12155157 T ES12155157 T ES 12155157T ES 12155157 T ES12155157 T ES 12155157T ES 2570153 T3 ES2570153 T3 ES 2570153T3
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chain variable
variable region
seq
improved properties
c5ar
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Charles Reay Mackay
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Novo Nordisk AS
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Novo Nordisk AS
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2896—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against molecules with a "CD"-designation, not provided for elsewhere
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
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    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A61P21/04—Drugs for disorders of the muscular or neuromuscular system for myasthenia gravis
    • A—HUMAN NECESSITIES
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    • A—HUMAN NECESSITIES
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    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/10—Cells modified by introduction of foreign genetic material
    • C12N5/12—Fused cells, e.g. hybridomas
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
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    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
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    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
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    • C07—ORGANIC CHEMISTRY
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    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

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Abstract

Un anticuerpo que comprende: una región variable de la cadena pesada tal y como se muestra en SEQ ID NO: [7H3 Vh] y (ii) una región variable de la cadena ligera tal y como se muestra en SEQ ID NO: 6 [7H3 Vl]; o (ii) una región variable de la cadena pesada que comprende las secuencias de bucle de CDR1, CDR2 y CDR3 de una región variable de la cadena pesada tal y como se muestra en SEQ ID NO: 5 [7H3 Vh], de acuerdo con la numeración de Kabat, y una región variable de la cadena ligera que comprende las secuencias de bucle de CDR1, CDR2 y CDR3 de una región variable de la cadena ligera tal y como se muestra en SEQ ID NO: 6 [7H3 Vl], de acuerdo con la numeración de Kabat, en donde el anticuerpo se une a C5aR humano y reduce o inhibe la unión de C5a a C5aR.
ES12155157T 2006-08-22 2007-08-22 Anticuerpos anti-C5aR con propiedades mejoradas Active ES2570153T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US83963406P 2006-08-22 2006-08-22

Publications (1)

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ES2570153T3 true ES2570153T3 (es) 2016-05-17

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ID=39106388

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Application Number Title Priority Date Filing Date
ES12155157T Active ES2570153T3 (es) 2006-08-22 2007-08-22 Anticuerpos anti-C5aR con propiedades mejoradas

Country Status (15)

Country Link
US (1) US8337852B2 (es)
EP (2) EP2455404B1 (es)
JP (1) JP5162587B2 (es)
KR (1) KR20090053899A (es)
CN (2) CN101506237B (es)
AU (1) AU2007288118A1 (es)
BR (1) BRPI0715703A2 (es)
CA (1) CA2660156A1 (es)
ES (1) ES2570153T3 (es)
IL (1) IL196960A0 (es)
MX (1) MX2009001914A (es)
NO (1) NO20091181L (es)
RU (1) RU2009110154A (es)
WO (1) WO2008022390A1 (es)
ZA (1) ZA200900954B (es)

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AU2009217224B2 (en) * 2008-02-20 2014-09-11 G2 Inflammation Pty Ltd Humanized anti-C5aR antibodies
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US11130801B2 (en) * 2011-01-13 2021-09-28 Case Western Reserve University Method for inhibiting platelet derived growth factor signaling with C3aR or C5aR antibodies
EP2718322B1 (en) * 2011-06-06 2018-08-08 Novo Nordisk A/S Therapeutic antibodies
KR102006997B1 (ko) * 2012-07-03 2019-08-02 한국생명공학연구원 ＩｇＧ Ｆｃ 위치선택적 결합 펩티드 및 이를 포함하는 하이브리드 분자
CN106957366B (zh) * 2016-01-12 2022-02-01 上海昀怡健康科技发展有限公司 一种C5aR抗体及其制备方法和应用
JP6923212B2 (ja) * 2016-02-17 2021-08-18 国立大学法人 東京医科歯科大学 動脈硬化性疾患の発症の予測因子および検査方法
CN106614260B (zh) * 2016-09-06 2019-11-08 广东省人民医院 一种C5aR基因敲除小鼠cGVHD模型的建立方法
TW202348249A (zh) * 2017-04-03 2023-12-16 德商因夫萊亞斯有限公司 使用c5a活性抑制劑於發炎性疾病之治療
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TW202140553A (zh) * 2020-01-13 2021-11-01 美商威特拉公司 C5ar1抗體分子及其用途
KR20230142831A (ko) 2021-01-13 2023-10-11 비스테라, 인크. 인간화된 보체 5a 수용체 1 항체 및 이의 사용 방법

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CN104059149A (zh) 2014-09-24
AU2007288118A1 (en) 2008-02-28
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