ES2554245T3 - Formulaciones parasiticidas inyectables de levamisol y lactonas macrocíclicas - Google Patents
Formulaciones parasiticidas inyectables de levamisol y lactonas macrocíclicas Download PDFInfo
- Publication number
- ES2554245T3 ES2554245T3 ES11731566.3T ES11731566T ES2554245T3 ES 2554245 T3 ES2554245 T3 ES 2554245T3 ES 11731566 T ES11731566 T ES 11731566T ES 2554245 T3 ES2554245 T3 ES 2554245T3
- Authority
- ES
- Spain
- Prior art keywords
- levamisole
- macrocyclic lactones
- surfactant
- effective amount
- parasiticidal formulations
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/365—Lactones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7048—Compounds having saccharide radicals and heterocyclic rings having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin, digitoxin or digoxin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
- A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/44—Oils, fats or waxes according to two or more groups of A61K47/02-A61K47/42; Natural or modified natural oils, fats or waxes, e.g. castor oil, polyethoxylated castor oil, montan wax, lignite, shellac, rosin, beeswax or lanolin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/10—Anthelmintics
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Dermatology (AREA)
- Organic Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Biochemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Medicinal Preparation (AREA)
Abstract
Una formulación farmacéuticamente o veterinariamente aceptable adaptada para ser inyectada en un animal, formulación que comprende; a. una cantidad eficaz de un levamisol; b. una cantidad eficaz de al menos una lactona macrocíclica; c. un sistema farmacéuticamente aceptable de disolventes y tensioactivos en la que el sistema proporciona estabilidad durante el almacenamiento aceptable para tanto el levamisol como la lactona macrocíclica y en la que el sistema proporciona una viscosidad que es adecuada para inyección; en la que el sistema comprende al menos un tensioactivo, en el que el tensioactivo es CREMOPHOR EL, y un disolvente orgánico miscible en agua que es dimetilacetamida (DMA).
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US33388210P | 2010-05-12 | 2010-05-12 | |
US333882P | 2010-05-12 | ||
PCT/US2011/036321 WO2011143479A1 (en) | 2010-05-12 | 2011-05-12 | Injectable parasiticidal formulations of levamisole and macrocyclic lactones |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2554245T3 true ES2554245T3 (es) | 2015-12-17 |
Family
ID=44342950
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES11731566.3T Active ES2554245T3 (es) | 2010-05-12 | 2011-05-12 | Formulaciones parasiticidas inyectables de levamisol y lactonas macrocíclicas |
Country Status (13)
Country | Link |
---|---|
US (1) | US20110281920A1 (es) |
EP (1) | EP2568980B1 (es) |
AR (1) | AR081187A1 (es) |
AU (1) | AU2011252987B2 (es) |
DK (1) | DK2568980T3 (es) |
ES (1) | ES2554245T3 (es) |
HR (1) | HRP20160103T1 (es) |
HU (1) | HUE028600T2 (es) |
NZ (1) | NZ603699A (es) |
PL (1) | PL2568980T3 (es) |
PT (1) | PT2568980E (es) |
SI (1) | SI2568980T1 (es) |
WO (1) | WO2011143479A1 (es) |
Families Citing this family (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU2010101389C4 (en) * | 2010-12-08 | 2017-03-02 | Jurox Pty Ltd | Anthelmintic formulation |
CA2839491A1 (en) * | 2011-06-23 | 2012-12-27 | Bayer New Zealand Limited | Anti-parasitic composition comprising a macrocyclic lactone and levamisole and method of treatment of parasitic infestation |
NZ594610A (en) * | 2011-08-16 | 2013-03-28 | Virbac New Zealand Ltd | Injectable Anthelmintic Formulations cotaining levamisole and one or more macrocyclic lactones for controlling internal parasites in ruminants |
US20140045885A1 (en) * | 2012-08-10 | 2014-02-13 | Siobhan P. Ellison | Decoquinate, 4-hydroxyquinolones and napthoquinones combined with levamisole, Imidazothiazole, for the prevention and treatment of sarcocystosis and equine protozoal myeloencephalitis caused by Sarcocystis and Neospora and other apicomplexan protozoans. |
RU2527329C2 (ru) * | 2012-10-25 | 2014-08-27 | Государственное научное учреждение Курский научно-исследовательский институт агропромышленного производства Россельхозакадемии | Способ получения комплексного иммунометаболического препарата с антиинфекционной активностью |
WO2014098623A1 (en) * | 2012-12-20 | 2014-06-26 | Alleva Animal Health Limited | Injectable eprinomectin formulation and anthelmintic use thereof |
PE20151726A1 (es) | 2013-04-12 | 2015-11-18 | Zoetis Services Llc | Formulaciones veterinarias estables de combinacion de lactonas macrociclicas e imidazotiazoles |
BR102013031277B1 (pt) | 2013-12-05 | 2018-10-02 | Ouro Fino Participacoes E Empreendimentos S A | processo para preparar uma suspensão anti-helmíntica e suspensão anti-helmíntica injetável |
AU2016200283B2 (en) * | 2015-02-21 | 2016-10-13 | Al Hanbali, Othman Abdul Rahim DR | LEVIA: A New Injectable Parasiticidal Veterinary Formulation of Levamisole HCI and Ivermectin Solution |
WO2018038623A1 (en) * | 2016-08-23 | 2018-03-01 | Donaghys Limited | Improvements in parasite treatments |
Family Cites Families (35)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3950360A (en) | 1972-06-08 | 1976-04-13 | Sankyo Company Limited | Antibiotic substances |
SE434277B (sv) | 1976-04-19 | 1984-07-16 | Merck & Co Inc | Sett att framstella nya antihelmintiskt verkande foreningar genom odling av streptomyces avermitilis |
US4096271A (en) * | 1977-08-03 | 1978-06-20 | American Cyanamid Company | Slow release injectable formulations of tetramisole and derivatives in benzyl benzoate |
US4199569A (en) | 1977-10-03 | 1980-04-22 | Merck & Co., Inc. | Selective hydrogenation products of C-076 compounds and derivatives thereof |
US4389397A (en) * | 1980-08-04 | 1983-06-21 | Merck & Co., Inc. | Solubilization of ivermectin in water |
US4427663A (en) | 1982-03-16 | 1984-01-24 | Merck & Co., Inc. | 4"-Keto-and 4"-amino-4"-deoxy avermectin compounds and substituted amino derivatives thereof |
EP0237482A1 (de) | 1986-03-06 | 1987-09-16 | Ciba-Geigy Ag | C(29)-Carbonyloxi-milbemycin-Derivate zur Bekämpfung von tier- und pflanzenparasitären Schädlingen |
EP0246739B1 (en) | 1986-03-25 | 1991-01-23 | Sankyo Company Limited | Macrolide compounds, their preparation and their use |
EP0252879B1 (de) | 1986-07-02 | 1992-05-06 | Ciba-Geigy Ag | Pestizide |
US4855317A (en) | 1987-03-06 | 1989-08-08 | Ciba-Geigy Corporation | Insecticides and parasiticides |
US4871719A (en) | 1987-03-24 | 1989-10-03 | Ciba-Geigy Corporation | Composition for controlling parasites in productive livestock |
US4874749A (en) | 1987-07-31 | 1989-10-17 | Merck & Co., Inc. | 4"-Deoxy-4-N-methylamino avermectin Bla/Blb |
EP0319142B1 (en) | 1987-11-03 | 1994-04-06 | Beecham Group Plc | Intermediates for the preparation of anthelmintic macrolide antibiotics |
NZ232422A (en) | 1989-02-16 | 1992-11-25 | Merck & Co Inc | 13-ketal milbemycin derivatives and parasiticides |
US5602107A (en) | 1993-05-10 | 1997-02-11 | Merck & Co., Inc. | Pour-on formulations consisting of gylcols, glycerides and avermectin compounds |
ES2359973T3 (es) | 1998-03-19 | 2011-05-30 | MERCK SHARP & DOHME CORP. | Composiciones poliméricas líquidas para la liberación controlada de sustancias bioactivas. |
US6174540B1 (en) | 1998-09-14 | 2001-01-16 | Merck & Co., Inc. | Long acting injectable formulations containing hydrogenated caster oil |
ATE313952T1 (de) * | 1999-06-04 | 2006-01-15 | Nufarm Ltd | Stabile biozidale zusammensetzung |
CR6574A (es) | 2001-02-27 | 2004-10-28 | Syngenta Participations Ag | Sales de avermectinas substituidas en la posicion 4 con propiedades plaguicidas |
EG23124A (en) | 2001-02-27 | 2004-04-28 | Syngenta Participations Ag | Avermectins substituted in the 4-position having pesticidal properties |
AR036486A1 (es) | 2001-08-28 | 2004-09-15 | Syngenta Participations Ag | Derivados 4"-desoxi-4"-(s)-amino avermectina, composicion plaguicida, procedimiento para la preparacion de esa composicion, metodo para controlar plagas, y uso de estos derivados para preparar una composicion |
AR037938A1 (es) | 2001-12-21 | 2004-12-22 | Syngenta Participations Ag | Derivados de avermectina b1 que tienen un substituyente de aminosulfoniloxilo en la posicion 4'' |
NZ520295A (en) * | 2002-07-19 | 2005-04-29 | Ashmont Holdings Ltd | Anthelmintic formulations comprising levamisole and either an avermectin or milbemycin |
AU2002952597A0 (en) * | 2002-11-11 | 2002-11-28 | Schering-Plough Pty. Limited | Topical parasiticide formulations and methods of treatment |
GB0302310D0 (en) | 2003-01-31 | 2003-03-05 | Syngenta Participations Ag | Avermectin- and avermectin monosaccharide derivatives substituted in the 4"- or 4' - positionhaving pesticidal properties |
GB0302308D0 (en) | 2003-01-31 | 2003-03-05 | Syngenta Participations Ag | Avermectin and avermectin monosaccharide derivatives substituted in the 4"- or 4'-position having pesticidal properties |
AU2003900505A0 (en) * | 2003-02-05 | 2003-02-20 | Jurox Pty Ltd | Anthelmintic composition |
GB0313937D0 (en) | 2003-06-16 | 2003-07-23 | Syngenta Participations Ag | Avermectin B1 monosaccharide derivatives having an aminosulfonyloxy substituentin the 4'-position |
GB0320176D0 (en) | 2003-08-28 | 2003-10-01 | Syngenta Participations Ag | Avermectins and avermectin monosaccharides substitued in the 4'-and 4"-positionhaving pesticidal properties |
US8697031B2 (en) * | 2004-06-04 | 2014-04-15 | Case Western Reserve University | Dual function polymer micelles |
US7312248B2 (en) * | 2004-09-23 | 2007-12-25 | Schering-Plough Animal Health Corporation | Control of parasites in animals by the use of novel trifluoromethanesulfonanilide oxime ether derivatives |
BRPI0506279B1 (pt) | 2005-12-16 | 2018-01-09 | Npa - Núcleo De Pesquisas Aplicadas Ltda | Composição sinergística de antihelmínticos e endectocidas |
US8399442B2 (en) * | 2005-12-30 | 2013-03-19 | Astex Therapeutics Limited | Pharmaceutical compounds |
CA2734459A1 (en) | 2008-08-18 | 2010-02-25 | Intervet International B.V. | Anthelmintic compositions |
US8313752B2 (en) * | 2009-04-14 | 2012-11-20 | Merial Limited | Macrocyclic lactone combination compositions, vaccines and methods for producing same |
-
2011
- 2011-05-12 AU AU2011252987A patent/AU2011252987B2/en active Active
- 2011-05-12 DK DK11731566.3T patent/DK2568980T3/en active
- 2011-05-12 US US13/106,677 patent/US20110281920A1/en not_active Abandoned
- 2011-05-12 NZ NZ603699A patent/NZ603699A/xx unknown
- 2011-05-12 HU HUE11731566A patent/HUE028600T2/en unknown
- 2011-05-12 EP EP11731566.3A patent/EP2568980B1/en active Active
- 2011-05-12 ES ES11731566.3T patent/ES2554245T3/es active Active
- 2011-05-12 WO PCT/US2011/036321 patent/WO2011143479A1/en active Application Filing
- 2011-05-12 AR ARP110101654A patent/AR081187A1/es unknown
- 2011-05-12 SI SI201130720T patent/SI2568980T1/sl unknown
- 2011-05-12 PT PT117315663T patent/PT2568980E/pt unknown
- 2011-05-12 PL PL11731566T patent/PL2568980T3/pl unknown
-
2016
- 2016-01-29 HR HRP20160103TT patent/HRP20160103T1/hr unknown
Also Published As
Publication number | Publication date |
---|---|
PT2568980E (pt) | 2016-03-15 |
SI2568980T1 (sl) | 2016-02-29 |
AU2011252987B2 (en) | 2013-05-02 |
PL2568980T3 (pl) | 2016-05-31 |
EP2568980A1 (en) | 2013-03-20 |
NZ603699A (en) | 2013-08-30 |
WO2011143479A1 (en) | 2011-11-17 |
HUE028600T2 (en) | 2016-12-28 |
HRP20160103T1 (hr) | 2016-02-26 |
US20110281920A1 (en) | 2011-11-17 |
EP2568980B1 (en) | 2015-11-11 |
AR081187A1 (es) | 2012-07-04 |
AU2011252987A1 (en) | 2012-12-13 |
DK2568980T3 (en) | 2015-11-30 |
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