ES2541178T3 - Método de detección de cáncer colorrectal - Google Patents

Método de detección de cáncer colorrectal Download PDF

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Publication number
ES2541178T3
ES2541178T3 ES10702339.2T ES10702339T ES2541178T3 ES 2541178 T3 ES2541178 T3 ES 2541178T3 ES 10702339 T ES10702339 T ES 10702339T ES 2541178 T3 ES2541178 T3 ES 2541178T3
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colorectal cancer
predisposition
incidence
epigenetic modification
screening method
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Louwagie Joost
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Mdxhealth SA
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Mdxhealth SA
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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/57407—Specifically defined cancers
    • G01N33/57446—Specifically defined cancers of stomach or intestine
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/106—Pharmacogenomics, i.e. genetic variability in individual responses to drugs and drug metabolism
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/154—Methylation markers
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/158—Expression markers
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/795—Porphyrin- or corrin-ring-containing peptides
    • G01N2333/805—Haemoglobins; Myoglobins
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/50—Determining the risk of developing a disease
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/52—Predicting or monitoring the response to treatment, e.g. for selection of therapy based on assay results in personalised medicine; Prognosis

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Pathology (AREA)
  • Analytical Chemistry (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Hospice & Palliative Care (AREA)
  • Oncology (AREA)
  • Biotechnology (AREA)
  • Physics & Mathematics (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Biomedical Technology (AREA)
  • Medicinal Chemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biophysics (AREA)
  • Food Science & Technology (AREA)
  • Cell Biology (AREA)
  • General Physics & Mathematics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)

Abstract

Un método para detectar una predisposición a, o la incidencia de, cáncer colorrectal en una muestra fecal, que comprende: (a) detectar la presencia de sangre en la muestra fecal, en donde la detección de la presencia de sangre es indicativa de una predisposición a, o la incidencia de, cáncer colorrectal; y (b) detectar una modificación epigenética en el ADN contenido dentro de la muestra fecal, en donde la modificación epigenética es detectada en al menos un gen seleccionado entre NDRG4, PHACTR3, FOXE1, GATA4, GPNMB, TFPI2, SOX17, SYNE1, LAMA, MMP2, OSMR, SFRP2 y CDO1 y en donde la detección de la modificación epigenética en al menos uno de los genes es indicativa de una predisposición a, o la incidencia de, cáncer colorrectal y sobre la base de un resultado positivo obtenido en (a) o (b) o tanto en (a) como en (b) detectar una predisposición a, o la incidencia de, cáncer colorrectal.

Description

imagen1

Claims (1)

  1. imagen1
ES10702339.2T 2009-02-03 2010-02-03 Método de detección de cáncer colorrectal Active ES2541178T3 (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US14958109P 2009-02-03 2009-02-03
US149581P 2009-02-03
PCT/GB2010/000180 WO2010089538A2 (en) 2009-02-03 2010-02-03 Methods of detecting colorectal cancer

Publications (1)

Publication Number Publication Date
ES2541178T3 true ES2541178T3 (es) 2015-07-16

Family

ID=42078343

Family Applications (1)

Application Number Title Priority Date Filing Date
ES10702339.2T Active ES2541178T3 (es) 2009-02-03 2010-02-03 Método de detección de cáncer colorrectal

Country Status (6)

Country Link
US (7) US20120164238A1 (es)
EP (1) EP2394170B1 (es)
CA (1) CA2751303C (es)
DK (1) DK2394170T3 (es)
ES (1) ES2541178T3 (es)
WO (1) WO2010089538A2 (es)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2010089538A2 (en) 2009-02-03 2010-08-12 Oncomethylome Sciences Sa Methods of detecting colorectal cancer
EP2553463B1 (en) 2010-03-26 2017-05-03 Hongzhi Zou Methods and materials for detecting colorectal neoplasm
WO2011135058A2 (en) * 2010-04-30 2011-11-03 Mdxhealth Sa Methods for detecting epigenetic modifications
FR2967165B1 (fr) * 2010-11-04 2014-10-10 Assist Publ Hopitaux De Paris Methode de depistage du cancer colorectal
FR2970782A1 (fr) * 2011-01-24 2012-07-27 Assist Publ Hopitaux De Paris Dispositif de diagnostic multifonctionnel
US20140031257A1 (en) * 2011-03-10 2014-01-30 Oslo Universitetssykehus Hf Methods and biomarkers for detection of gastrointestinal cancers
GB201107466D0 (en) 2011-05-05 2011-06-15 Loktionov Alexandre Device and method for non-invasive collection of colorectal mucocellular layer and disease detection
BR112014028122B1 (pt) * 2012-05-11 2022-08-23 Commonwealth Scientific And Industrial Research Organisation Método para triar o princípio ou a predisposição ao princípio de neoplasma no intestino grosso ou para monitorar neoplasma no intestino grosso em indivíduo
EP3543360B1 (en) 2013-03-14 2021-02-17 Mayo Foundation for Medical Education and Research Detecting neoplasm
EP3126529B1 (en) 2014-03-31 2020-05-27 Mayo Foundation for Medical Education and Research Detecting colorectal neoplasm
US10184154B2 (en) 2014-09-26 2019-01-22 Mayo Foundation For Medical Education And Research Detecting cholangiocarcinoma
US10030272B2 (en) 2015-02-27 2018-07-24 Mayo Foundation For Medical Education And Research Detecting gastrointestinal neoplasms
CN107532124B (zh) 2015-03-27 2022-08-09 精密科学公司 检测食管疾病
WO2017040627A1 (en) 2015-08-31 2017-03-09 Mayo Foundation For Medical Education And Research Detecting gastric neoplasm
CA3020628A1 (en) 2016-04-14 2017-10-19 Mayo Foundation For Medical Education And Research Detecting pancreatic high-grade dysplasia
US10370726B2 (en) 2016-04-14 2019-08-06 Mayo Foundation For Medical Education And Research Detecting colorectal neoplasia
GB201612815D0 (en) * 2016-07-25 2016-09-07 Belgian Volition Sa Novel combination test
WO2018160576A1 (en) 2017-02-28 2018-09-07 Mayo Foundation For Medical Education And Research Detecting prostate cancer
CN107014658B (zh) * 2017-05-27 2023-08-25 四川省肿瘤医院 提取游离细胞的方法及试剂盒
CA3084584A1 (en) 2017-11-30 2019-06-06 Mayo Foundation For Medical Education And Research Detecting breast cancer
US11795495B1 (en) * 2019-10-02 2023-10-24 FOXO Labs Inc. Machine learned epigenetic status estimator
EP4047101A4 (en) * 2019-10-16 2024-04-03 Xiamen Sciendox Biological Tech Co Ltd PRIMER SET FOR METHYLATION OF A SPECIFIC REGION OF A GENE LINKED TO HUMAN COLORECTAL CANCER, TEST, TEST KIT AND ASSOCIATED APPLICATION

Family Cites Families (61)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4437975A (en) 1977-07-20 1984-03-20 Mobil Oil Corporation Manufacture of lube base stock oil
FI61965C (fi) 1980-01-17 1982-10-11 Suovaniemi Finnpipette Foerfarande foer detektering av hemoglobin i avfoering
EP0070366B1 (de) * 1981-07-16 1985-08-28 F. HOFFMANN-LA ROCHE & CO. Aktiengesellschaft Verfahren zum Nachweisen von okkultem Humanblut in Humanstuhlproben
US4445235A (en) * 1982-09-13 1984-05-01 Pearl Slover Stool specimen collector
AU529210B3 (en) * 1983-02-02 1983-04-14 Australian Monoclonal Development Pty. Ltd. Monoclonal antibody in occult blood diagnosis
US4859610A (en) 1985-06-05 1989-08-22 Synbiotics Corporation Immunoassay incubation device
US4889818A (en) * 1986-08-22 1989-12-26 Cetus Corporation Purified thermostable enzyme
US5198365A (en) * 1987-02-04 1993-03-30 International Immunoassay Laboratories, Inc. Fecal sample immunoassay method testing for hemoglobin
IE72468B1 (en) 1987-07-31 1997-04-09 Univ Leland Stanford Junior Selective amplification of target polynucleotide sequences
CA1322326C (en) 1987-09-16 1993-09-21 Josefina Tecson Baker Test for fecal occult blood
AU4829690A (en) 1988-12-16 1990-07-10 Siska Diagnostics, Inc. Self-sustained, sequence replication system
US5527676A (en) 1989-03-29 1996-06-18 The Johns Hopkins University Detection of loss of the wild-type P53 gene and kits therefor
US5196167A (en) 1989-04-04 1993-03-23 Helena Laboratories Corporation Fecal occult blood test product with positive and negative controls
US5137806A (en) 1989-12-11 1992-08-11 Board Of Regents, The University Of Texas System Methods and compositions for the detection of sequences in selected DNA molecules
IL116824A0 (en) 1996-01-19 1996-05-14 Huliot Plastics Ind System for the collection and transportation of a pasty material sample
US5741650A (en) 1996-01-30 1998-04-21 Exact Laboratories, Inc. Methods for detecting colon cancer from stool samples
US6017704A (en) 1996-06-03 2000-01-25 The Johns Hopkins University School Of Medicine Method of detection of methylated nucleic acid using agents which modify unmethylated cytosine and distinguishing modified methylated and non-methylated nucleic acids
US5952178A (en) 1996-08-14 1999-09-14 Exact Laboratories Methods for disease diagnosis from stool samples
JP4039590B2 (ja) * 1998-01-30 2008-01-30 栄研化学株式会社 ヘモグロビン試料の安定化
WO2000050640A1 (en) 1999-02-25 2000-08-31 Exact Laboratories, Inc. Methods for preserving dna integrity
US20060084054A1 (en) * 1999-09-27 2006-04-20 John Alsobrook Novel proteins and nucleic acids encoding same
BRPI0001536B1 (pt) * 2000-04-04 2015-09-29 Fundacao Oswaldo Cruz método para diagnosticar a infecção por parasitos do genero schistosoma e kit para uso no diagnóstico da infecção por schistosoma sp
DE10037769A1 (de) * 2000-08-03 2002-02-21 Epigenomics Gmbh Diagnose von mit CD24 assoziierten Krankheiten
WO2002018631A2 (de) * 2000-09-01 2002-03-07 Epigenomics Ag Diagnose von bestehenden erkrankungen oder der prädisposition für bestimmte erkrankungen
US6582665B2 (en) 2001-01-25 2003-06-24 Biomedical Polymers, Inc. Universal collection and transfer system
US6558907B2 (en) * 2001-05-16 2003-05-06 Corning Incorporated Methods and compositions for arraying nucleic acids onto a solid support
GB2375961B (en) * 2001-05-31 2003-04-30 Intermark Medical Innovations A device for colonic lavage
JP2004529363A (ja) * 2001-06-05 2004-09-24 ザ・チルドレンズ・ホスピタル・オブ・フィラデルフィア 膵臓に基づく脂肪吸収不良障害を診断するための方法およびキット
AU2003230616A1 (en) 2002-03-07 2003-09-22 The Johns Hopkins University Genomic screen for epigenetically silenced tumor suppressor genes
ITMI20020287U1 (it) 2002-05-31 2003-12-01 Sentinel Ch S R L Tubo di estrazione per la raccolta di campioni di feci
US6921370B2 (en) * 2002-07-25 2005-07-26 Alfa Scientific Designs, Inc. Specimen collection and storage and transport device and method
WO2004067726A2 (en) 2003-01-29 2004-08-12 Keck Graduate Institute Isothermal reactions for the amplification of oligonucleotides
JP2007524369A (ja) * 2003-03-17 2007-08-30 ザ ジョンズ ホプキンス ユニバーシティー 膵癌における異常メチル化遺伝子
ATE451617T1 (de) 2003-03-19 2009-12-15 Hamamatsu Found Sci & Tech Pro Verfahren zur erkennung eines kolonkrebsmarkers
CN1764832A (zh) 2003-03-25 2006-04-26 爱科来株式会社 传感器储存容器
US20040194206A1 (en) 2003-04-01 2004-10-07 Kieturakis Maciej J. Screening methods and kits for gastrointestinal diseases
GB0318702D0 (en) 2003-08-08 2003-09-10 Neill Ian O Method and apparatus for removing cellular material from faecal stools and container for collecting faecal stools
CA2535910C (en) 2003-08-14 2016-04-26 Case Western Reserve University Methods and compositions for detecting colon cancers
US20050075543A1 (en) * 2003-10-03 2005-04-07 Calabrese Charles A. Method of anonymous medical testing and providing the patient with the test results
US7371527B1 (en) * 2003-10-21 2008-05-13 Johns Hopkins University School Of Medicine Hypermethylation of GATA-4 and GATA-5 transcription factor genes in cancer
US7381547B2 (en) 2004-04-28 2008-06-03 Tzam Diagnostics, Llc Methods and compositions to detect bacteria using multiplex PCR
US20080124714A1 (en) * 2004-05-14 2008-05-29 Exact Sciences Corporation Method for Stabilizing Biological Samples for Nucleic Acid Analysis
GB0415277D0 (en) * 2004-07-07 2004-08-11 Colonix Ltd Apparatus and method for sampling mucosal surfaces
US7563598B2 (en) 2004-07-30 2009-07-21 Ambergen, Inc. Detection of truncation mutations by mass spectrometry
US7195878B2 (en) 2004-09-30 2007-03-27 Cryo-Genomics Device and method for fecal testing
US7780915B2 (en) * 2005-02-16 2010-08-24 Epitope Diagnostcs, Inc. Fecal sample test device and methods of use
US20060210448A1 (en) * 2005-03-10 2006-09-21 Naishu Wang Fecal specimen collection, preserving and transport device and method
US7569183B2 (en) * 2005-03-28 2009-08-04 Alfresa Pharma Corporation Fecal assay method and analyzer
CA2604852A1 (en) 2005-04-15 2006-10-26 Oncomethylome Sciences, S.A. Methylation markers for diagnosis and treatment of cancers
US7779489B2 (en) * 2005-07-19 2010-08-24 Finell Rebecca M Potty bench with storage
US7288413B2 (en) 2005-08-12 2007-10-30 Beckman Coulter, Inc. Combined chemical and immunochemical fecal occult blood test
US7794656B2 (en) * 2006-01-23 2010-09-14 Quidel Corporation Device for handling and analysis of a biological sample
US20080085867A1 (en) 2006-07-14 2008-04-10 The Johns Hopkins University Early detection and prognosis of colon cancers
GB0700374D0 (en) * 2007-01-09 2007-02-14 Oncomethylome Sciences S A NDRG family methylation markers
US20080221056A1 (en) * 2007-02-12 2008-09-11 Johns Hopkins University Early Detection and Prognosis of Colon Cancers
EP2471957A1 (en) * 2007-02-21 2012-07-04 Oslo Universitetssykehus HF New markers for cancer
US20080227208A1 (en) * 2007-03-16 2008-09-18 Hsiao-Ching Yee Devices and Methods for Detection of Occult Blood
FR2919065B1 (fr) 2007-07-19 2009-10-02 Biomerieux Sa Procede de dosage de l'apolipoproteine ai pour le diagnostic in vitro du cancer colorectal
FR2919063B1 (fr) 2007-07-19 2009-10-02 Biomerieux Sa Procede de dosage du leucocyte elastase inhibitor pour le diagnostic in vitro du cancer colorectal.
US8673555B2 (en) 2008-02-15 2014-03-18 Mayo Foundation For Medical Education And Research Detecting neoplasm
WO2010089538A2 (en) * 2009-02-03 2010-08-12 Oncomethylome Sciences Sa Methods of detecting colorectal cancer

Also Published As

Publication number Publication date
US11634781B2 (en) 2023-04-25
WO2010089538A9 (en) 2011-05-26
WO2010089538A3 (en) 2010-11-25
CA2751303A1 (en) 2010-08-12
US20230313317A1 (en) 2023-10-05
US20120164238A1 (en) 2012-06-28
EP2394170A2 (en) 2011-12-14
US11970746B2 (en) 2024-04-30
US11987848B2 (en) 2024-05-21
CA2751303C (en) 2020-09-01
US20230048152A1 (en) 2023-02-16
US20230272488A1 (en) 2023-08-31
US20170298448A1 (en) 2017-10-19
EP2394170B1 (en) 2015-04-01
DK2394170T3 (en) 2015-07-13
US11845991B2 (en) 2023-12-19
US20160194723A1 (en) 2016-07-07
WO2010089538A2 (en) 2010-08-12
US20190276900A1 (en) 2019-09-12

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