ES2540467T3 - Estructura cristalina de glutaminil ciclasa - Google Patents

Estructura cristalina de glutaminil ciclasa Download PDF

Info

Publication number
ES2540467T3
ES2540467T3 ES11745800.0T ES11745800T ES2540467T3 ES 2540467 T3 ES2540467 T3 ES 2540467T3 ES 11745800 T ES11745800 T ES 11745800T ES 2540467 T3 ES2540467 T3 ES 2540467T3
Authority
ES
Spain
Prior art keywords
glutaminyl cyclase
crystalline structure
cyclase
glutaminyl
crystal
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
ES11745800.0T
Other languages
English (en)
Inventor
Stephan Schilling
Jens-Ulrich Rahfeld
Birgit Koch
Michael Wermann
Christoph Parthier
David Ruiz-Carillo
Milton Stubbs
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Vivoryon Therapeutics AG
Original Assignee
Probiodrug AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Probiodrug AG filed Critical Probiodrug AG
Application granted granted Critical
Publication of ES2540467T3 publication Critical patent/ES2540467T3/es
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/1025—Acyltransferases (2.3)
    • C12N9/104—Aminoacyltransferases (2.3.2)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y203/00—Acyltransferases (2.3)
    • C12Y203/02—Aminoacyltransferases (2.3.2)
    • C12Y203/02005—Glutaminyl-peptide cyclotransferase (2.3.2.5)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2299/00—Coordinates from 3D structures of peptides, e.g. proteins or enzymes
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16C—COMPUTATIONAL CHEMISTRY; CHEMOINFORMATICS; COMPUTATIONAL MATERIALS SCIENCE
    • G16C20/00—Chemoinformatics, i.e. ICT specially adapted for the handling of physicochemical or structural data of chemical particles, elements, compounds or mixtures
    • G16C20/50—Molecular design, e.g. of drugs

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

Un cristal que comprende glutaminil ciclasa humana que tiene un grupo espacial caracterizado de C121 y dimensiones de celda unidad de +/- 5% de a >= 82,6 Å, b >= 63,9 Å, c >= 77,5 Å, α >= 90,0º, β >= 105,7º y γ >= 90,0º.

Description

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Claims (1)

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ES11745800.0T 2010-08-19 2011-08-19 Estructura cristalina de glutaminil ciclasa Active ES2540467T3 (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US37510310P 2010-08-19 2010-08-19
US375103P 2010-08-19
PCT/EP2011/064289 WO2012022804A1 (en) 2010-08-19 2011-08-19 Crystal structure of glutaminyl cyclase

Publications (1)

Publication Number Publication Date
ES2540467T3 true ES2540467T3 (es) 2015-07-09

Family

ID=44630510

Family Applications (1)

Application Number Title Priority Date Filing Date
ES11745800.0T Active ES2540467T3 (es) 2010-08-19 2011-08-19 Estructura cristalina de glutaminil ciclasa

Country Status (6)

Country Link
US (2) US8409837B2 (es)
EP (1) EP2606129B1 (es)
JP (1) JP5952816B2 (es)
DK (1) DK2606129T3 (es)
ES (1) ES2540467T3 (es)
WO (1) WO2012022804A1 (es)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2014015157A2 (en) 2012-07-19 2014-01-23 Philadelphia Health & Education Corporation Novel sigma receptor ligands and methods of modulating cellular protein homeostasis using same
WO2019089902A1 (en) 2017-11-01 2019-05-09 Drexel University Compounds, compositions, and methods for treating diseases

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2003528319A (ja) * 2000-03-21 2003-09-24 コンセンサス ファーマシューティカルズ， インコーポレイテッド Ｃｃケモカインレセプター５に対する結合化合物およびそれらを同定するための方法
IL156618A0 (en) * 2000-12-28 2004-01-04 Altus Biologics Inc Crystals of whole antibodies and fragments thereof, methods for the preparation thereof and diagnostic kits utilizing the same
EP1620082B9 (en) 2003-05-05 2010-08-25 Probiodrug AG Medical use of inhibitors of glutaminyl and glutamate cyclases for treating alzheimer's disease and down syndrome
ZA200508439B (en) 2003-05-05 2007-03-28 Probiodrug Ag Medical use of inhibitors of glutaminyl and glutamate cyclases
JP5707014B2 (ja) 2003-10-15 2015-04-22 プロビオドルグ エージー グルタミニル、及びグルタミン酸シクラーゼのエフェクターの使用
EP1713780B1 (en) 2004-02-05 2012-01-18 Probiodrug AG Novel inhibitors of glutaminyl cyclase
US7572614B2 (en) * 2006-02-24 2009-08-11 Academia Sinica Crystal structure of soluble glutaminyl cyclase
EA016584B1 (ru) 2006-09-21 2012-06-29 Пробиодруг Аг Новые гены, родственные гену глутаминилциклазы
DK2086960T3 (da) 2006-11-09 2014-06-10 Probiodrug Ag Nye inhibitorer af glutaminylcyclase.
WO2008055945A1 (en) 2006-11-09 2008-05-15 Probiodrug Ag 3-hydr0xy-1,5-dihydr0-pyrr0l-2-one derivatives as inhibitors of glutaminyl cyclase for the treatment of ulcer, cancer and other diseases
JP5456479B2 (ja) 2006-11-09 2014-03-26 プロビオドルグ エージー グルタミニルシクラーゼの新規阻害剤
US9126987B2 (en) 2006-11-30 2015-09-08 Probiodrug Ag Inhibitors of glutaminyl cyclase
SI2121944T1 (sl) 2007-01-19 2011-12-30 Probiodrug Ag In vivo presejalni modeli za zdravljenje Alzheimerjeve bolezni in drugih motenj, povezanih s QPCT
WO2009020654A1 (en) * 2007-08-08 2009-02-12 Abbott Laboratories Compositions and methods for crystallizing antibodies
US20090202557A1 (en) * 2008-01-30 2009-08-13 Argiriadi Maria A Compositions and methods for crystallizing antibody fragments
EP2274327B1 (en) * 2008-04-27 2019-03-27 H. Lundbeck A/S Crystal structure of human sortilin and uses thereof for identifying ligands to sortilin
WO2010026209A1 (en) 2008-09-04 2010-03-11 Probiodrug Ag Use of isoQC inhibitors

Also Published As

Publication number Publication date
US8409837B2 (en) 2013-04-02
JP2013541325A (ja) 2013-11-14
US8859250B2 (en) 2014-10-14
EP2606129B1 (en) 2015-03-25
US20130217090A1 (en) 2013-08-22
EP2606129A1 (en) 2013-06-26
JP5952816B2 (ja) 2016-07-13
WO2012022804A1 (en) 2012-02-23
US20120045815A1 (en) 2012-02-23
DK2606129T3 (en) 2015-06-29

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