ES2539812T3 - Péptidos derivados de PRAME y composiciones inmunogénicas que comprenden los mismos - Google Patents
Péptidos derivados de PRAME y composiciones inmunogénicas que comprenden los mismos Download PDFInfo
- Publication number
- ES2539812T3 ES2539812T3 ES08723922.4T ES08723922T ES2539812T3 ES 2539812 T3 ES2539812 T3 ES 2539812T3 ES 08723922 T ES08723922 T ES 08723922T ES 2539812 T3 ES2539812 T3 ES 2539812T3
- Authority
- ES
- Spain
- Prior art keywords
- prame
- same
- immunogenic compositions
- peptides derived
- acid sequence
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- 108090000765 processed proteins & peptides Proteins 0.000 title abstract 4
- 102000036673 PRAME Human genes 0.000 title abstract 3
- 108060006580 PRAME Proteins 0.000 title abstract 3
- 230000002163 immunogen Effects 0.000 title 1
- 239000000203 mixture Substances 0.000 title 1
- 102000004196 processed proteins & peptides Human genes 0.000 title 1
- 125000003275 alpha amino acid group Chemical group 0.000 abstract 2
- 150000001413 amino acids Chemical class 0.000 abstract 2
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
- C07K14/4748—Tumour specific antigens; Tumour rejection antigen precursors [TRAP], e.g. MAGE
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/0005—Vertebrate antigens
- A61K39/0011—Cancer antigens
- A61K39/001184—Cancer testis antigens, e.g. SSX, BAGE, GAGE or SAGE
- A61K39/001189—PRAME
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/46—Cellular immunotherapy
- A61K39/461—Cellular immunotherapy characterised by the cell type used
- A61K39/4611—T-cells, e.g. tumor infiltrating lymphocytes [TIL], lymphokine-activated killer cells [LAK] or regulatory T cells [Treg]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/46—Cellular immunotherapy
- A61K39/464—Cellular immunotherapy characterised by the antigen targeted or presented
- A61K39/4643—Vertebrate antigens
- A61K39/4644—Cancer antigens
- A61K39/464484—Cancer testis antigens, e.g. SSX, BAGE, GAGE or SAGE
- A61K39/464489—PRAME
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/57—Medicinal preparations containing antigens or antibodies characterised by the type of response, e.g. Th1, Th2
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/57—Medicinal preparations containing antigens or antibodies characterised by the type of response, e.g. Th1, Th2
- A61K2039/572—Medicinal preparations containing antigens or antibodies characterised by the type of response, e.g. Th1, Th2 cytotoxic response
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Immunology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Organic Chemistry (AREA)
- Mycology (AREA)
- Epidemiology (AREA)
- Microbiology (AREA)
- Oncology (AREA)
- Cell Biology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Toxicology (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Hematology (AREA)
- Engineering & Computer Science (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Péptido con una longitud de no más de 50 aminoácidos y que comprende al menos 33 aminoácidos contiguos de la secuencia de aminoácidos de la proteína de PRAME humana, donde el péptido comprende al menos un epítopo de HLA de clase II y al menos un epítopo de HLA de clase I de la secuencia de aminoácidos de la proteína de PRAME humana y donde el péptido comprende SEC ID nº 6.
Description
18
19
23
24
25
26
27
28
29
30
31
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP07104893 | 2007-03-26 | ||
EP07104893 | 2007-03-26 | ||
PCT/NL2008/050171 WO2008118017A2 (en) | 2007-03-26 | 2008-03-26 | Prame derived peptides and immunogenic compositions comprising these |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2539812T3 true ES2539812T3 (es) | 2015-07-06 |
Family
ID=38267662
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES08723922.4T Active ES2539812T3 (es) | 2007-03-26 | 2008-03-26 | Péptidos derivados de PRAME y composiciones inmunogénicas que comprenden los mismos |
Country Status (8)
Country | Link |
---|---|
US (3) | US8492514B2 (es) |
EP (3) | EP2125005B1 (es) |
JP (2) | JP5649952B2 (es) |
CN (2) | CN106220721B (es) |
AU (1) | AU2008230240B2 (es) |
CA (2) | CA2996732C (es) |
ES (1) | ES2539812T3 (es) |
WO (1) | WO2008118017A2 (es) |
Families Citing this family (29)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP3018146A1 (en) | 2009-11-18 | 2016-05-11 | MannKind Corporation | Monoclonal antibodies and diagnostic uses thereof |
NL2007536C2 (en) | 2011-10-05 | 2013-04-08 | Academisch Ziekenhuis Leiden Lumc | Adjuvant compound. |
CN104603291B (zh) | 2012-06-22 | 2018-04-06 | Htg分子诊断有限公司 | 黑素细胞病变中的分子恶性肿瘤 |
AU2014300503B2 (en) | 2013-06-28 | 2018-11-22 | Auckland Uniservices Limited | Amino acid and peptide conjugates and conjugation process |
CA2919567A1 (en) * | 2013-07-30 | 2015-02-05 | Biontech Ag | Tumor antigens for determining cancer therapy |
CA2971677A1 (en) | 2014-12-23 | 2016-06-30 | Margaret Anne Brimble | Amino acid and peptide conjugates and uses thereof |
TW201702272A (zh) * | 2015-05-22 | 2017-01-16 | 美國紀念斯隆 凱特琳癌症中心 | Prame肽專一性類t細胞受體抗體 |
EP3112375A1 (en) * | 2015-07-03 | 2017-01-04 | Ludwig-Maximilians-Universität München | Antigenic peptides for the diagnosis, therapy monitoring and/or treatment of psoriasis vulgaris |
CN106519019B (zh) * | 2015-11-06 | 2018-07-03 | 广东香雪精准医疗技术有限公司 | 识别prame抗原的tcr |
CN106831978B (zh) * | 2015-12-04 | 2020-05-26 | 中国科学院广州生物医药与健康研究院 | 识别prame抗原的t细胞受体 |
IL298653A (en) | 2015-12-11 | 2023-01-01 | Immatics Biotechnologies Gmbh | New peptides and a combination of peptides for use in immunotherapy against several types of cancer |
US11464853B2 (en) | 2016-02-26 | 2022-10-11 | Auckland Uniservices Limited | Amino acid and peptide conjugates and conjugation process |
CN106699874B (zh) * | 2016-03-29 | 2018-06-05 | 广东香雪精准医疗技术有限公司 | 识别prame抗原短肽的t细胞受体 |
CN107266552B (zh) * | 2016-03-30 | 2022-02-08 | 香雪生命科学技术(广东)有限公司 | 源自于prame的肿瘤抗原短肽 |
AU2017281389B2 (en) | 2016-06-20 | 2024-02-22 | Isa Pharmaceuticals B.V. | Formulation of a peptide vaccine |
CN108203459A (zh) * | 2016-12-19 | 2018-06-26 | 广东香雪精准医疗技术有限公司 | 源自于prame的肿瘤抗原短肽 |
CN108203460B (zh) * | 2016-12-19 | 2021-10-08 | 香雪生命科学技术(广东)有限公司 | 衍生自肿瘤抗原prame的短肽 |
CN108264550B (zh) * | 2017-01-04 | 2021-04-23 | 香雪生命科学技术(广东)有限公司 | 一种识别源自于prame抗原短肽的tcr |
PE20191248A1 (es) * | 2017-01-27 | 2019-09-18 | Immatics Biotechnologies Gmbh | Nuevos peptidos y nuevas combinaciones de peptidos para el uso en la inmunoterapia contra el cancer de ovario y otros tipos de cancer |
NL2018803B1 (en) | 2017-04-27 | 2018-11-05 | Academisch Ziekenhuis Leiden Handelend Onder De Naam Leids Univ Medisch Centrum/ H O D N Lumc | Adjuvant compounds |
CN108929378B (zh) * | 2017-05-22 | 2021-04-23 | 香雪生命科学技术(广东)有限公司 | 一种识别prame抗原的t细胞受体及编码该受体的核酸 |
GB201709866D0 (en) * | 2017-06-20 | 2017-08-02 | Immunocore Ltd | T cell receptors |
CN111511761A (zh) * | 2017-08-02 | 2020-08-07 | Idp研发制药有限公司 | 抗癌肽 |
CN109400696B (zh) * | 2017-08-17 | 2021-04-23 | 香雪生命科学技术(广东)有限公司 | 一种识别prame抗原短肽的tcr |
HUE061198T2 (hu) * | 2017-12-13 | 2023-05-28 | Inovio Pharmaceuticals Inc | A PRAME-t célzó rákvakcinák és alkalmazásaik |
WO2023285412A1 (en) | 2021-07-12 | 2023-01-19 | Isa Pharmaceuticals B.V. | Improved substance quantification in complex mixtures |
WO2024068636A1 (en) | 2022-09-27 | 2024-04-04 | Isa Pharmaceuticals B.V. | Adjuvanted immunogenic peptides for intradermal administration |
WO2024079311A1 (en) | 2022-10-13 | 2024-04-18 | Isa Pharmaceuticals B.V. | Modified long peptides suitable for use in immunisation |
WO2024149888A1 (en) | 2023-01-12 | 2024-07-18 | Isa Pharmaceuticals B.V. | Improved lipopeptide quantification |
Family Cites Families (17)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5830753A (en) | 1994-09-30 | 1998-11-03 | Ludwig Institute For Cancer Research | Isolated nucleic acid molecules coding for tumor rejection antigen precursor dage and uses thereof. |
ES2249907T3 (es) | 1998-05-23 | 2006-04-01 | Leiden University Medical Center | Anticuerpos de union cd40 y peptidos ctl para el tratamiento de tumores. |
US20030118588A1 (en) | 1999-05-22 | 2003-06-26 | Linda Diehl | Induction of anti-tumor CTL immunity through in vivo triggering of 4-1BB and/or CD40 |
EP1118860A1 (en) * | 2000-01-21 | 2001-07-25 | Rijksuniversiteit te Leiden | Methods for selecting and producing T cell peptide epitopes and vaccines incorporating said selected epitopes |
FR2804117B1 (fr) | 2000-01-21 | 2004-08-20 | Bio Merieux | Procede d'isolement de proteines et/ou d'acides nucleiques, complexes de particules et de proteines et/ou d'acides nucleiques, reactif et applications |
AU2001274923A1 (en) * | 2000-05-23 | 2001-12-03 | Lexicon Genetics Incorporated | Novel human thrombospondin-like proteins and polynucleotides encoding the same |
AUPQ776100A0 (en) * | 2000-05-26 | 2000-06-15 | Australian National University, The | Synthetic molecules and uses therefor |
US7202034B2 (en) | 2000-12-08 | 2007-04-10 | Academisch Ziekenhuis Leiden | Long peptides of 22-45 amino acid residues that induce and/or enhance antigen specific immune responses |
WO2003008537A2 (en) | 2001-04-06 | 2003-01-30 | Mannkind Corporation | Epitope sequences |
IL164281A0 (en) * | 2002-04-01 | 2005-12-18 | Euro Celtique Sa | Epitope constructs comprising antigen presenting cell targeting mechanisms |
WO2004022709A2 (en) * | 2002-09-06 | 2004-03-18 | Mannkind Corporation | Epitope sequences |
CA2522812C (en) * | 2003-04-18 | 2012-08-21 | Idm Pharma, Inc. | Hla-a2 tumor associated antigen peptides and compositions |
EP1635863B1 (en) * | 2003-06-17 | 2010-08-04 | Mannkind Corporation | Compositions to elicit, enhance and sustain immune responses against mhc class i-restricted epitopes, for prophylactic or therapeutic purposes |
US7340702B2 (en) | 2003-07-23 | 2008-03-04 | Cadence Design Systems, Inc. | Method and apparatus for induction proof |
KR20100092031A (ko) | 2004-06-17 | 2010-08-19 | 맨카인드 코포레이션 | 에피토프 유사체 |
WO2006138562A2 (en) * | 2005-06-17 | 2006-12-28 | Mannkind Corporation | Epitope analogues |
JP5416968B2 (ja) | 2005-06-17 | 2014-02-12 | マンカインド コーポレイション | 癌細胞及び腫瘍間質上に発現される優勢及び亜優勢エピトープに対する多価免疫応答を誘発するための方法及び組成物 |
-
2008
- 2008-03-26 AU AU2008230240A patent/AU2008230240B2/en not_active Ceased
- 2008-03-26 CN CN201610596359.9A patent/CN106220721B/zh not_active Expired - Fee Related
- 2008-03-26 JP JP2010500861A patent/JP5649952B2/ja active Active
- 2008-03-26 CA CA2996732A patent/CA2996732C/en active Active
- 2008-03-26 CN CN200880009876.5A patent/CN101687022B/zh not_active Expired - Fee Related
- 2008-03-26 EP EP08723922.4A patent/EP2125005B1/en active Active
- 2008-03-26 EP EP11193328.9A patent/EP2462947B1/en not_active Not-in-force
- 2008-03-26 CA CA2681132A patent/CA2681132C/en active Active
- 2008-03-26 WO PCT/NL2008/050171 patent/WO2008118017A2/en active Application Filing
- 2008-03-26 EP EP19162264.6A patent/EP3533461A3/en not_active Withdrawn
- 2008-03-26 ES ES08723922.4T patent/ES2539812T3/es active Active
-
2009
- 2009-09-24 US US12/586,625 patent/US8492514B2/en active Active
-
2013
- 2013-07-18 US US13/945,335 patent/US9441025B2/en active Active
-
2014
- 2014-08-01 JP JP2014158054A patent/JP5985551B2/ja not_active Expired - Fee Related
-
2016
- 2016-08-04 US US15/228,234 patent/US10450356B2/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
CA2681132A1 (en) | 2008-10-02 |
JP2010522748A (ja) | 2010-07-08 |
CN101687022A8 (zh) | 2016-08-24 |
US20160333065A1 (en) | 2016-11-17 |
JP2014240407A (ja) | 2014-12-25 |
CN106220721B (zh) | 2020-04-07 |
CA2996732C (en) | 2020-10-27 |
US20100120683A1 (en) | 2010-05-13 |
US8492514B2 (en) | 2013-07-23 |
JP5985551B2 (ja) | 2016-09-06 |
CN106220721A (zh) | 2016-12-14 |
WO2008118017A2 (en) | 2008-10-02 |
US20140348862A1 (en) | 2014-11-27 |
CA2996732A1 (en) | 2008-10-02 |
EP2462947B1 (en) | 2019-03-13 |
EP3533461A3 (en) | 2019-12-18 |
US10450356B2 (en) | 2019-10-22 |
EP2125005B1 (en) | 2015-04-08 |
CN101687022A (zh) | 2010-03-31 |
AU2008230240B2 (en) | 2012-09-13 |
CA2681132C (en) | 2018-05-01 |
EP2125005A2 (en) | 2009-12-02 |
CN101687022B (zh) | 2016-09-07 |
WO2008118017A3 (en) | 2008-12-31 |
JP5649952B2 (ja) | 2015-01-07 |
EP2462947A1 (en) | 2012-06-13 |
EP3533461A2 (en) | 2019-09-04 |
US9441025B2 (en) | 2016-09-13 |
AU2008230240A1 (en) | 2008-10-02 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
ES2539812T3 (es) | Péptidos derivados de PRAME y composiciones inmunogénicas que comprenden los mismos | |
ES2486675T3 (es) | Análogo de péptido de oxintomodulina | |
ES2531142T3 (es) | Péptidos WT1 de unión a HLA de clase II, y composiciones y métodos que los comprenden | |
ES2616658T3 (es) | Péptidos que mimetizan el factor de crecimiento y sus usos | |
AR076349A1 (es) | Peptido auxiliar del antigeno del cancer | |
EA200870237A1 (ru) | Последовательности пептидов и композиции | |
RS53872B1 (en) | NEW AND POWERFUL CLASS II MHC PEPTIDES DERIVATED FROM SURVIVINE AND UNAURANTS | |
ES2545457T3 (es) | Vacunas de péptidos para cánceres que expresan los polipéptidos DEPDC1 | |
ES2616258T3 (es) | Péptidos, conjugados y métodos para aumentar la inmunogenicidad de una vacuna | |
AR082235A2 (es) | Composicion de hepcidina, metodos para identificar compuestos que se unen a esta y peptidos analogos | |
ES2530777T3 (es) | Vacunas peptídicas para cánceres que expresan antígenos asociados a tumores | |
ES2668967T3 (es) | Inmunógenos de Escherichia coli con solubilidad mejorada | |
PE20100253A1 (es) | Mutantes de fgf21 | |
ES2528133T3 (es) | Péptidos y composiciones para prevención de la adhesión celular, y métodos para utilizar los mismos | |
NZ593833A (en) | Extended recombinant polypeptides and compositions comprising same | |
ES2691070T3 (es) | Péptidos antiinflamatorios y composición que comprende los mismos | |
ES2534752T3 (es) | Nuevo péptido antigénico contra el cáncer y utilización del mismo | |
CR9452A (es) | Agentes terapeuticos a base de peptidos de toxinas | |
RS54133B1 (en) | ANTI-IL-6 ANTIBODIES, PREPARATIONS, PREPARATION AND USE PROCEDURES | |
ES2507094T3 (es) | Proteína específica del timo | |
ES2160485B1 (es) | Peptidos inhibidores de la exocitosis neuronal, composiciones cosmeticas y farmaceuticas que los contienen. | |
AR067980A1 (es) | Peptidos de cdh3 y agentes que los comprenden | |
BR112018000660A2 (pt) | peptídeos anti-inflamatórios e seu uso | |
ES2531115T3 (es) | Combinaciones de clados de RrgB neumocócicos | |
ES2530457T3 (es) | Secuencias peptídicas, su forma ramificada y uso de estas para aplicaciones antimicrobianas |