ES2527210T3 - Células etiquetadas para su uso como un control interno funcional en ensayos de detección de células raras - Google Patents

Células etiquetadas para su uso como un control interno funcional en ensayos de detección de células raras Download PDF

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Publication number
ES2527210T3
ES2527210T3 ES10179790.0T ES10179790T ES2527210T3 ES 2527210 T3 ES2527210 T3 ES 2527210T3 ES 10179790 T ES10179790 T ES 10179790T ES 2527210 T3 ES2527210 T3 ES 2527210T3
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internal control
cell detection
detection assays
cells labeled
rare cell
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Expired - Lifetime
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ES10179790.0T
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English (en)
Inventor
Leon W. M. M. Terstappen
Galla Chandra Rao
Herman Rutner
Paul A. Liberti
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Janssen Diagnostics LLC
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Janssen Diagnostics LLC
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    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B03—SEPARATION OF SOLID MATERIALS USING LIQUIDS OR USING PNEUMATIC TABLES OR JIGS; MAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
    • B03C—MAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
    • B03C1/00—Magnetic separation
    • B03C1/005—Pretreatment specially adapted for magnetic separation
    • B03C1/01—Pretreatment specially adapted for magnetic separation by addition of magnetic adjuvants
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y25/00—Nanomagnetism, e.g. magnetoimpedance, anisotropic magnetoresistance, giant magnetoresistance or tunneling magnetoresistance
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/10—Investigating individual particles
    • G01N15/14—Optical investigation techniques, e.g. flow cytometry
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/57484—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumor, cancer, neoplasia, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides, metabolites
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/57484—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumor, cancer, neoplasia, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides, metabolites
    • G01N33/57492—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumor, cancer, neoplasia, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides, metabolites involving compounds localized on the membrane of tumor or cancer cells
    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01F—MAGNETS; INDUCTANCES; TRANSFORMERS; SELECTION OF MATERIALS FOR THEIR MAGNETIC PROPERTIES
    • H01F1/00—Magnets or magnetic bodies characterised by the magnetic materials therefor; Selection of materials for their magnetic properties
    • H01F1/0036—Magnets or magnetic bodies characterised by the magnetic materials therefor; Selection of materials for their magnetic properties showing low dimensional magnetism, i.e. spin rearrangements due to a restriction of dimensions, e.g. showing giant magnetoresistivity
    • H01F1/0045—Zero dimensional, e.g. nanoparticles, soft nanoparticles for medical/biological use
    • H01F1/0054—Coated nanoparticles, e.g. nanoparticles coated with organic surfactant

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Urology & Nephrology (AREA)
  • Molecular Biology (AREA)
  • Hematology (AREA)
  • Cell Biology (AREA)
  • Biomedical Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Oncology (AREA)
  • Pathology (AREA)
  • General Physics & Mathematics (AREA)
  • Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Hospice & Palliative Care (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Nanotechnology (AREA)
  • Dispersion Chemistry (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
  • Sampling And Sample Adjustment (AREA)

Abstract

Un método para detectar y enumerar células raras en una población de células mezcladas, siendo la presencia de dichas células raras en dicha población indicativa de la severidad de una enfermedad, que comprende: a) Preparar una muestra inmunomagnética en la que una muestra de sangre obtenida de un sujeto de prueba se mezcla con partículas magnéticas, dicha muestra comprende una población de células mezcladas que se cree que contiene dichas células raras y dichas partículas magnéticas se acoplan a un ligando que reacciona específicamente con un determinante de las células raras para la exclusión sustancial de otros componentes de la muestra. b) Poner en contacto dicha muestra inmunomagnética con, al menos, un reactivo que marca un determinante de las células raras; y c) analizar las células raras marcadas para determinar la presencia y el número de cualquiera de las células raras en la muestra inmunomagnética, el mayor número de células raras presentes en dicha muestra, la mayor severidad de la enfermedad, donde la célula de control tiene determinantes en común con las células raras y en la que la membrana de dicha célula de control se encuentra marcada de forma detectable y los componentes celulares y restos antigénicos de la célula de control han sido estabilizados durante un período de hasta seis meses mediante la exposición a un fijador, donde, opcionalmente, dicha célula rara es una célula cancerígena y dicha enfermedad es cáncer.

Description

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Claims (1)

  1. imagen1
ES10179790.0T 2001-03-07 2002-03-07 Células etiquetadas para su uso como un control interno funcional en ensayos de detección de células raras Expired - Lifetime ES2527210T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US09/801,471 US20010018192A1 (en) 1998-02-12 2001-03-07 Labeled cells for use as an internal functional control in rare cell detection assays
US801471 2001-03-08

Publications (1)

Publication Number Publication Date
ES2527210T3 true ES2527210T3 (es) 2015-01-21

Family

ID=25181182

Family Applications (2)

Application Number Title Priority Date Filing Date
ES10179790.0T Expired - Lifetime ES2527210T3 (es) 2001-03-07 2002-03-07 Células etiquetadas para su uso como un control interno funcional en ensayos de detección de células raras
ES02739098T Expired - Lifetime ES2357101T3 (es) 2001-03-07 2002-03-07 Celulas marcadas para su uso como control funcional interno en ensayos de detección de celulas raras.

Family Applications After (1)

Application Number Title Priority Date Filing Date
ES02739098T Expired - Lifetime ES2357101T3 (es) 2001-03-07 2002-03-07 Celulas marcadas para su uso como control funcional interno en ensayos de detección de celulas raras.

Country Status (11)

Country Link
US (1) US20010018192A1 (es)
EP (2) EP1429603B1 (es)
JP (1) JP2004534210A (es)
AT (1) ATE490466T1 (es)
AU (1) AU2002311773A1 (es)
DE (1) DE60238493D1 (es)
DK (1) DK2280283T3 (es)
ES (2) ES2527210T3 (es)
HK (1) HK1152378A1 (es)
PT (1) PT2280283E (es)
WO (1) WO2002077604A2 (es)

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Also Published As

Publication number Publication date
AU2002311773A1 (en) 2002-10-08
WO2002077604A3 (en) 2004-04-01
HK1152378A1 (en) 2012-02-24
ATE490466T1 (de) 2010-12-15
EP2280283B1 (en) 2014-10-15
WO2002077604A2 (en) 2002-10-03
EP2280283A1 (en) 2011-02-02
EP1429603A4 (en) 2004-08-18
DK2280283T3 (en) 2014-11-17
EP1429603B1 (en) 2010-12-01
DE60238493D1 (de) 2011-01-13
ES2357101T3 (es) 2011-04-18
PT2280283E (pt) 2015-02-03
JP2004534210A (ja) 2004-11-11
EP1429603A2 (en) 2004-06-23
US20010018192A1 (en) 2001-08-30

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