ES2527210T3 - Células etiquetadas para su uso como un control interno funcional en ensayos de detección de células raras - Google Patents
Células etiquetadas para su uso como un control interno funcional en ensayos de detección de células raras Download PDFInfo
- Publication number
- ES2527210T3 ES2527210T3 ES10179790.0T ES10179790T ES2527210T3 ES 2527210 T3 ES2527210 T3 ES 2527210T3 ES 10179790 T ES10179790 T ES 10179790T ES 2527210 T3 ES2527210 T3 ES 2527210T3
- Authority
- ES
- Spain
- Prior art keywords
- internal control
- cell detection
- detection assays
- cells labeled
- rare cell
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 238000003556 assay Methods 0.000 title 1
- 238000001514 detection method Methods 0.000 title 1
- 239000012472 biological sample Substances 0.000 abstract 1
Classifications
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B03—SEPARATION OF SOLID MATERIALS USING LIQUIDS OR USING PNEUMATIC TABLES OR JIGS; MAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
- B03C—MAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
- B03C1/00—Magnetic separation
- B03C1/005—Pretreatment specially adapted for magnetic separation
- B03C1/01—Pretreatment specially adapted for magnetic separation by addition of magnetic adjuvants
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B82—NANOTECHNOLOGY
- B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
- B82Y25/00—Nanomagnetism, e.g. magnetoimpedance, anisotropic magnetoresistance, giant magnetoresistance or tunneling magnetoresistance
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
- G01N15/10—Investigating individual particles
- G01N15/14—Optical investigation techniques, e.g. flow cytometry
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
- G01N33/57484—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumor, cancer, neoplasia, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides, metabolites
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
- G01N33/57484—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumor, cancer, neoplasia, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides, metabolites
- G01N33/57492—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumor, cancer, neoplasia, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides, metabolites involving compounds localized on the membrane of tumor or cancer cells
-
- H—ELECTRICITY
- H01—ELECTRIC ELEMENTS
- H01F—MAGNETS; INDUCTANCES; TRANSFORMERS; SELECTION OF MATERIALS FOR THEIR MAGNETIC PROPERTIES
- H01F1/00—Magnets or magnetic bodies characterised by the magnetic materials therefor; Selection of materials for their magnetic properties
- H01F1/0036—Magnets or magnetic bodies characterised by the magnetic materials therefor; Selection of materials for their magnetic properties showing low dimensional magnetism, i.e. spin rearrangements due to a restriction of dimensions, e.g. showing giant magnetoresistivity
- H01F1/0045—Zero dimensional, e.g. nanoparticles, soft nanoparticles for medical/biological use
- H01F1/0054—Coated nanoparticles, e.g. nanoparticles coated with organic surfactant
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Urology & Nephrology (AREA)
- Molecular Biology (AREA)
- Hematology (AREA)
- Cell Biology (AREA)
- Biomedical Technology (AREA)
- General Health & Medical Sciences (AREA)
- Analytical Chemistry (AREA)
- Oncology (AREA)
- Pathology (AREA)
- General Physics & Mathematics (AREA)
- Physics & Mathematics (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Hospice & Palliative Care (AREA)
- Food Science & Technology (AREA)
- Medicinal Chemistry (AREA)
- Nanotechnology (AREA)
- Dispersion Chemistry (AREA)
- Crystallography & Structural Chemistry (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
- Sampling And Sample Adjustment (AREA)
Abstract
Un método para detectar y enumerar células raras en una población de células mezcladas, siendo la presencia de dichas células raras en dicha población indicativa de la severidad de una enfermedad, que comprende: a) Preparar una muestra inmunomagnética en la que una muestra de sangre obtenida de un sujeto de prueba se mezcla con partículas magnéticas, dicha muestra comprende una población de células mezcladas que se cree que contiene dichas células raras y dichas partículas magnéticas se acoplan a un ligando que reacciona específicamente con un determinante de las células raras para la exclusión sustancial de otros componentes de la muestra. b) Poner en contacto dicha muestra inmunomagnética con, al menos, un reactivo que marca un determinante de las células raras; y c) analizar las células raras marcadas para determinar la presencia y el número de cualquiera de las células raras en la muestra inmunomagnética, el mayor número de células raras presentes en dicha muestra, la mayor severidad de la enfermedad, donde la célula de control tiene determinantes en común con las células raras y en la que la membrana de dicha célula de control se encuentra marcada de forma detectable y los componentes celulares y restos antigénicos de la célula de control han sido estabilizados durante un período de hasta seis meses mediante la exposición a un fijador, donde, opcionalmente, dicha célula rara es una célula cancerígena y dicha enfermedad es cáncer.
Description
Claims (1)
-
imagen1
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US09/801,471 US20010018192A1 (en) | 1998-02-12 | 2001-03-07 | Labeled cells for use as an internal functional control in rare cell detection assays |
US801471 | 2001-03-08 |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2527210T3 true ES2527210T3 (es) | 2015-01-21 |
Family
ID=25181182
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES10179790.0T Expired - Lifetime ES2527210T3 (es) | 2001-03-07 | 2002-03-07 | Células etiquetadas para su uso como un control interno funcional en ensayos de detección de células raras |
ES02739098T Expired - Lifetime ES2357101T3 (es) | 2001-03-07 | 2002-03-07 | Celulas marcadas para su uso como control funcional interno en ensayos de detección de celulas raras. |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES02739098T Expired - Lifetime ES2357101T3 (es) | 2001-03-07 | 2002-03-07 | Celulas marcadas para su uso como control funcional interno en ensayos de detección de celulas raras. |
Country Status (11)
Country | Link |
---|---|
US (1) | US20010018192A1 (es) |
EP (2) | EP1429603B1 (es) |
JP (1) | JP2004534210A (es) |
AT (1) | ATE490466T1 (es) |
AU (1) | AU2002311773A1 (es) |
DE (1) | DE60238493D1 (es) |
DK (1) | DK2280283T3 (es) |
ES (2) | ES2527210T3 (es) |
HK (1) | HK1152378A1 (es) |
PT (1) | PT2280283E (es) |
WO (1) | WO2002077604A2 (es) |
Families Citing this family (51)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7282350B2 (en) | 1998-02-12 | 2007-10-16 | Immunivest Corporation | Labeled cell sets for use as functional controls in rare cell detection assays |
DE19983691T1 (de) * | 1998-10-29 | 2001-11-29 | Cell Works Inc | Charakterisierung mehrerer Marker von Einzelzellen |
US8980568B2 (en) | 2001-10-11 | 2015-03-17 | Aviva Biosciences Corporation | Methods and compositions for detecting non-hematopoietic cells from a blood sample |
US8986944B2 (en) | 2001-10-11 | 2015-03-24 | Aviva Biosciences Corporation | Methods and compositions for separating rare cells from fluid samples |
WO2003075007A2 (en) * | 2002-03-01 | 2003-09-12 | Cardiff & Vale National Health Service Trust | Methods for absolute cell counting |
EP2359689B1 (en) | 2002-09-27 | 2015-08-26 | The General Hospital Corporation | Microfluidic device for cell separation and use thereof |
DK1816461T3 (da) | 2002-10-16 | 2020-04-14 | Streck Laboratories Inc | Fremgangsmåde og indretning til indsamling og sikring af celler til brug for analyse |
EP1597353B1 (en) | 2003-02-27 | 2010-11-24 | Veridex, LLC | CIRCULATING TUMOR CELLS (CTC's): EARLY ASSESSMENT OF TIME TO PROGRESSION SURVIVAL AND RESPONSE TO THERAPY IN METASTATIC CANCER PATIENTS |
CA2539108A1 (en) * | 2003-09-18 | 2005-03-31 | Immunivest Corporation | Operator independent programmable sample preparation and analysis system |
WO2005030995A1 (en) * | 2003-09-23 | 2005-04-07 | University Of Missouri | Methods of synthesizing polynucleotides using thermostable enzymes |
US20050181353A1 (en) * | 2004-02-17 | 2005-08-18 | Rao Galla C. | Stabilization of cells and biological specimens for analysis |
US20070196820A1 (en) | 2005-04-05 | 2007-08-23 | Ravi Kapur | Devices and methods for enrichment and alteration of cells and other particles |
US8921102B2 (en) | 2005-07-29 | 2014-12-30 | Gpb Scientific, Llc | Devices and methods for enrichment and alteration of circulating tumor cells and other particles |
US20070128668A1 (en) * | 2005-12-01 | 2007-06-07 | Larry Burg | Quantitative use of tracer cells |
US8337755B2 (en) | 2006-03-13 | 2012-12-25 | Veridex, Llc | Operator independent programmable sample preparation and analysis system |
PT2027470E (pt) * | 2006-06-02 | 2013-01-28 | Pfizer Prod Inc | Ensaio de células tumorais circulantes |
WO2008008515A2 (en) | 2006-07-14 | 2008-01-17 | Aviva Biosciences Corporation | Methods and compositions for detecting rare cells from a biological sample |
US8110101B2 (en) | 2007-08-30 | 2012-02-07 | Veridex, Llc | Method and apparatus for imaging target components in a biological sample using permanent magnets |
US7828968B2 (en) | 2007-08-30 | 2010-11-09 | Veridex, Llc | Method and apparatus for imaging target components in a biological sample using permanent magnets |
BRPI0819854B1 (pt) * | 2007-11-27 | 2019-06-04 | Veridex, Llc | Método para isolar, enriquecer e analisar células de melanoma circulantes em uma amostra de sangue |
WO2010068812A1 (en) | 2008-12-10 | 2010-06-17 | Abqmr, Inc. | Nuclear magnetic resonance apparatus, methods and associated technology |
US11634747B2 (en) * | 2009-01-21 | 2023-04-25 | Streck Llc | Preservation of fetal nucleic acids in maternal plasma |
US8304187B2 (en) | 2009-02-18 | 2012-11-06 | Streck, Inc. | Preservation of cell-free RNA in blood samples |
EP2499259B1 (en) * | 2009-11-09 | 2016-04-06 | Streck Inc. | Stabilization of rna in and extracting from intact cells within a blood sample |
US9476812B2 (en) | 2010-04-21 | 2016-10-25 | Dna Electronics, Inc. | Methods for isolating a target analyte from a heterogeneous sample |
US20110262989A1 (en) | 2010-04-21 | 2011-10-27 | Nanomr, Inc. | Isolating a target analyte from a body fluid |
US9428547B2 (en) | 2010-04-21 | 2016-08-30 | Dna Electronics, Inc. | Compositions for isolating a target analyte from a heterogeneous sample |
US8841104B2 (en) | 2010-04-21 | 2014-09-23 | Nanomr, Inc. | Methods for isolating a target analyte from a heterogeneous sample |
EP2657346B1 (en) | 2010-12-24 | 2017-08-23 | ARKRAY, Inc. | Method for detecting cancer cell |
US9956281B2 (en) | 2011-05-04 | 2018-05-01 | Streck, Inc. | Inactivated virus compositions and methods of preparing such compositions |
US9535065B2 (en) * | 2011-09-06 | 2017-01-03 | Becton, Dickinson And Company | Methods and compositions for cytometric detection of rare target cells in a sample |
US20150056649A1 (en) * | 2012-01-13 | 2015-02-26 | Konica Minolta, Inc. | Method for quantifying cell of interest in blood, and method for evaluating system for quantifying said cell |
EP2903603A4 (en) * | 2012-09-27 | 2016-08-10 | Cynvenio Biosystems Inc | STIMULUS-SENSITIVE MICROPARTICLES AND METHOD OF USE |
EP2917362A4 (en) * | 2012-11-07 | 2016-07-13 | Sandstone Diagnostics Inc | METHODS AND DEVICES FOR SAMPLE PROCESSING AND CELL NUMBERING |
US9551704B2 (en) | 2012-12-19 | 2017-01-24 | Dna Electronics, Inc. | Target detection |
US9804069B2 (en) | 2012-12-19 | 2017-10-31 | Dnae Group Holdings Limited | Methods for degrading nucleic acid |
US9599610B2 (en) | 2012-12-19 | 2017-03-21 | Dnae Group Holdings Limited | Target capture system |
US9995742B2 (en) | 2012-12-19 | 2018-06-12 | Dnae Group Holdings Limited | Sample entry |
US10000557B2 (en) | 2012-12-19 | 2018-06-19 | Dnae Group Holdings Limited | Methods for raising antibodies |
US9434940B2 (en) | 2012-12-19 | 2016-09-06 | Dna Electronics, Inc. | Methods for universal target capture |
WO2014124179A1 (en) | 2013-02-07 | 2014-08-14 | Sandstone Diagnostics, Inc. | Automated sample processing, fluid distribution, and sedimentation assay |
US20150233932A1 (en) * | 2013-02-19 | 2015-08-20 | Ching-Ping Tseng | Methods, Systems, and Compositions for Enrichment of Rare Cells |
CA2917912C (en) | 2013-07-24 | 2019-09-17 | Streck, Inc. | Compositions and methods for stabilizing circulating tumor cells |
US20160178614A1 (en) * | 2013-08-02 | 2016-06-23 | Siemens Healthcare Diagnostics Inc. | Cell-based control and method |
JP6331524B2 (ja) * | 2014-03-14 | 2018-05-30 | 日立化成株式会社 | 標準細胞液 |
CN104568923A (zh) * | 2014-12-01 | 2015-04-29 | 浙江省肿瘤医院 | 电化学发光检测外周血循环肿瘤细胞抗原的方法及试剂盒 |
US11168351B2 (en) | 2015-03-05 | 2021-11-09 | Streck, Inc. | Stabilization of nucleic acids in urine |
JP6582486B2 (ja) * | 2015-03-27 | 2019-10-02 | コニカミノルタ株式会社 | 血液中の稀少細胞検出方法 |
US20170145475A1 (en) | 2015-11-20 | 2017-05-25 | Streck, Inc. | Single spin process for blood plasma separation and plasma composition including preservative |
WO2018022991A1 (en) | 2016-07-29 | 2018-02-01 | Streck, Inc. | Suspension composition for hematology analysis control |
JP6485576B2 (ja) * | 2018-04-19 | 2019-03-20 | 日立化成株式会社 | 標準細胞液 |
Family Cites Families (24)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5188935A (en) * | 1984-05-31 | 1993-02-23 | Coulter Electronics, Inc. | Reagent system and method for identification, enumeration and examination of classes and subclasses of blood leukocytes |
US5597531A (en) * | 1985-10-04 | 1997-01-28 | Immunivest Corporation | Resuspendable coated magnetic particles and stable magnetic particle suspensions |
US4795698A (en) * | 1985-10-04 | 1989-01-03 | Immunicon Corporation | Magnetic-polymer particles |
US5187099A (en) * | 1986-10-29 | 1993-02-16 | Coulter Corporation | Control slide for immunoassay kit using a low-temperature melting paraffin |
JP2619911B2 (ja) | 1988-04-08 | 1997-06-11 | 東亜医用電子株式会社 | 網状赤血球測定装置用標準血液 |
US5059518A (en) * | 1988-10-20 | 1991-10-22 | Coulter Corporation | Stabilized lyophilized mammalian cells and method of making same |
US5698271A (en) * | 1989-08-22 | 1997-12-16 | Immunivest Corporation | Methods for the manufacture of magnetically responsive particles |
US5610022A (en) * | 1989-09-26 | 1997-03-11 | City Of Hope | Internal control for immunocytochemistry assay |
IE76319B1 (en) | 1990-07-23 | 1997-10-22 | Becton Dickinson Co | Preservation of cells as controls or standards in cellular analysis |
US5478722A (en) * | 1991-02-17 | 1995-12-26 | The Curators Of The University Of Missouri | Preserved cell preparations for flow cytometry and immunology |
US5270208A (en) * | 1991-05-09 | 1993-12-14 | Streck Laboratories, Inc. | White blood cell hematology control |
AU669692B2 (en) * | 1992-02-24 | 1996-06-20 | Coulter International Corporation | Suspension media for hematological composition and method for its use |
WO1993018397A1 (en) * | 1992-03-02 | 1993-09-16 | Streck Laboratories, Inc. | Reference control for use with manual and flow cytometric reticulocyte counting devices |
US5763204A (en) * | 1992-09-14 | 1998-06-09 | Coulter Corporation | Preparation of preserved, non-infectious control cell for use in the identification of a disease through blood testing |
US5342754A (en) * | 1992-09-14 | 1994-08-30 | Coulter Corporation | Preserved, non-infectious control cell for use in the identification of a disease through blood testing |
JPH08510051A (ja) | 1993-01-08 | 1996-10-22 | クールター コーポレイション | 保存対照細胞を蛍光および光散乱測定の校正において用いる方法 |
DE69428552T2 (de) * | 1993-01-26 | 2002-04-11 | Becton Dickinson And Co., Franklin Lakes | Verfahren zum Nachweis von seltenen Ereignissen |
US5629933A (en) * | 1995-06-07 | 1997-05-13 | International Business Machines Corporation | Method and system for enhanced communication in a multisession packet based communication system |
JP3875754B2 (ja) * | 1995-11-17 | 2007-01-31 | シスメックス株式会社 | フローサイトメータ用標準液 |
WO1997046882A1 (en) * | 1996-06-07 | 1997-12-11 | Immunivest Corporation | Magnetic separation employing external and internal gradients |
US5968831A (en) * | 1996-10-29 | 1999-10-19 | Coulter International Corp. | Cell control used to confirm enzymatic activity |
WO2000002049A1 (fr) * | 1998-07-01 | 2000-01-13 | Nitto Denko Corporation | Test immunologique et kit de test immunologique |
DE50015293D1 (de) | 1999-04-13 | 2008-09-11 | Wilex Ag | Diagnostischer und therapeutischer Einsatz von Antikörpern gegen den Urokinase-Rezeptor |
GB0022017D0 (en) * | 2000-09-08 | 2000-10-25 | Univ Dundee | Cell assays |
-
2001
- 2001-03-07 US US09/801,471 patent/US20010018192A1/en not_active Abandoned
-
2002
- 2002-03-07 ES ES10179790.0T patent/ES2527210T3/es not_active Expired - Lifetime
- 2002-03-07 AT AT02739098T patent/ATE490466T1/de active
- 2002-03-07 DE DE60238493T patent/DE60238493D1/de not_active Expired - Lifetime
- 2002-03-07 JP JP2002575608A patent/JP2004534210A/ja active Pending
- 2002-03-07 DK DK10179790.0T patent/DK2280283T3/en active
- 2002-03-07 EP EP02739098A patent/EP1429603B1/en not_active Expired - Lifetime
- 2002-03-07 EP EP10179790.0A patent/EP2280283B1/en not_active Expired - Lifetime
- 2002-03-07 AU AU2002311773A patent/AU2002311773A1/en not_active Abandoned
- 2002-03-07 PT PT101797900T patent/PT2280283E/pt unknown
- 2002-03-07 WO PCT/US2002/006967 patent/WO2002077604A2/en active Search and Examination
- 2002-03-07 ES ES02739098T patent/ES2357101T3/es not_active Expired - Lifetime
-
2011
- 2011-06-21 HK HK11106359.9A patent/HK1152378A1/xx not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
AU2002311773A1 (en) | 2002-10-08 |
WO2002077604A3 (en) | 2004-04-01 |
HK1152378A1 (en) | 2012-02-24 |
ATE490466T1 (de) | 2010-12-15 |
EP2280283B1 (en) | 2014-10-15 |
WO2002077604A2 (en) | 2002-10-03 |
EP2280283A1 (en) | 2011-02-02 |
EP1429603A4 (en) | 2004-08-18 |
DK2280283T3 (en) | 2014-11-17 |
EP1429603B1 (en) | 2010-12-01 |
DE60238493D1 (de) | 2011-01-13 |
ES2357101T3 (es) | 2011-04-18 |
PT2280283E (pt) | 2015-02-03 |
JP2004534210A (ja) | 2004-11-11 |
EP1429603A2 (en) | 2004-06-23 |
US20010018192A1 (en) | 2001-08-30 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
ES2527210T3 (es) | Células etiquetadas para su uso como un control interno funcional en ensayos de detección de células raras | |
AU1461702A (en) | Microvolume immunoabsorbant assays with amplified electrochemical detection | |
MXPA02005796A (es) | Tira de prueba electroquimica para usarse en la determinacion de analitos. | |
ITTO20010411A0 (it) | Metodo e dispositivo per l'esecuzione di test e saggi ad alta processivita' ed alto valore biologico su cellule e/o composti. | |
AU2002230650A1 (en) | Method for diagnosing pathology in biological samples | |
ATE403150T1 (de) | Biochemisches und immunochemisches testgerät | |
ES2157669T3 (es) | Un dispositivo para realizar un ensayo, uso de una membrana en la fabricacion de dicho dispositivo, kit que comprende dicho dispositivo, y metodo para la deteccion de un analito usando dicho dispositivo. | |
WO2007086900A3 (en) | Stilbazium research assays | |
NO20032961D0 (no) | Flytende brenselblandinger for elektrokjemiske brenselceller | |
DK1432786T3 (da) | Hurtig detektion af replikerede celler | |
EP0880699A4 (en) | DISPLACEMENT TEST ON A POROUS MEMBRANE | |
BRPI0002963B8 (pt) | processo e dispositivo medidor eletroquímico para medir uma concentração de analito em uma amostra. | |
AU2001237981A1 (en) | Immunochromatographic methods for detecting an analyte in a sample which employ semiconductor nanocrystals as detectable labels | |
DE60113619D1 (de) | Wärmekontrollsystem für eine elektrochemische Zelle | |
HK1073887A1 (en) | A sensor for electro-chemical analysis of a sample and the method for maunfacturing the same | |
WO2000062064A3 (en) | Quality control for cytochemical assays | |
WO2004049909A3 (en) | Device for sample collection and storage | |
AU2002364120A1 (en) | Sensor for the use in testing biological chemical or environmental samples | |
WO2003093796A3 (en) | Sample preparation method and device | |
PT918991E (pt) | Metodo de ensaio | |
NL1021971A1 (nl) | Brandstofcelinrichting. | |
ATE405837T1 (de) | Festphase immunochromatographische testverfahren | |
AR022861A1 (es) | Un dispositivo de analisis que incluye discos con almohadilla de inoculacion y metodos de uso | |
CA2407760A1 (en) | Methods for diagnosis of low grade astrocytoma | |
AU2001277625A1 (en) | Electrochemical strip test for small volumes |