ES2514140B1 - Uso del inhibidor de sulfatasas esteroideas STX64 para el tratamiento del envejecimiento - Google Patents

Uso del inhibidor de sulfatasas esteroideas STX64 para el tratamiento del envejecimiento Download PDF

Info

Publication number
ES2514140B1
ES2514140B1 ES201330436A ES201330436A ES2514140B1 ES 2514140 B1 ES2514140 B1 ES 2514140B1 ES 201330436 A ES201330436 A ES 201330436A ES 201330436 A ES201330436 A ES 201330436A ES 2514140 B1 ES2514140 B1 ES 2514140B1
Authority
ES
Spain
Prior art keywords
stx64
aging
treatment
steroid sulfatase
inhibitor
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
ES201330436A
Other languages
English (en)
Other versions
ES2514140A1 (es
Inventor
Manuel Jesús MUÑOZ RUIZ
María Mercedes PÉREZ JIMÉNEZ
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Universidad Pablo de Olavide
Original Assignee
Universidad Pablo de Olavide
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Universidad Pablo de Olavide filed Critical Universidad Pablo de Olavide
Priority to ES201330436A priority Critical patent/ES2514140B1/es
Priority to PCT/ES2014/070230 priority patent/WO2014154927A1/es
Priority to EP14775264.6A priority patent/EP3011950A4/en
Priority to US14/907,658 priority patent/US20160361244A1/en
Publication of ES2514140A1 publication Critical patent/ES2514140A1/es
Application granted granted Critical
Publication of ES2514140B1 publication Critical patent/ES2514140B1/es
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
    • A61K8/4973—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with oxygen as the only hetero atom
    • A61K8/498—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with oxygen as the only hetero atom having 6-membered rings or their condensed derivatives, e.g. coumarin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/365—Lactones
    • A61K31/366—Lactones having six-membered rings, e.g. delta-lactones
    • A61K31/37—Coumarins, e.g. psoralen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404—Indoles, e.g. pindolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
    • A61K31/566—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol having an oxo group in position 17, e.g. estrone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A61Q19/08—Anti-ageing preparations
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/74—Biological properties of particular ingredients
    • A61K2800/78—Enzyme modulators, e.g. Enzyme agonists
    • A61K2800/782—Enzyme inhibitors; Enzyme antagonists
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/80—Process related aspects concerning the preparation of the cosmetic composition or the storage or application thereof
    • A61K2800/91—Injection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/80—Process related aspects concerning the preparation of the cosmetic composition or the storage or application thereof
    • A61K2800/92—Oral administration

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • Birds (AREA)
  • Gerontology & Geriatric Medicine (AREA)
  • Dermatology (AREA)
  • Organic Chemistry (AREA)
  • Neurosurgery (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Hospice & Palliative Care (AREA)
  • Toxicology (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Cosmetics (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Enzymes And Modification Thereof (AREA)

Abstract

Uso del inhibidor de sulfatasas esteroideas STX64 para el tratamiento del envejecimiento.#La presente invención se refiere al uso del inhibidor de la actividad de la enzima sulfatasa esteroidea STX64 para el tratamiento del envejecimiento y, por tanto, para incrementar la longevidad de los individuos o mejorar la calidad de vida de éstos. También se refiere a una composición cosmética que comprenda dicho inhibidor con ese fin.

Description



imagen1

Claims (1)



  1. imagen1
ES201330436A 2013-03-26 2013-03-26 Uso del inhibidor de sulfatasas esteroideas STX64 para el tratamiento del envejecimiento Active ES2514140B1 (es)

Priority Applications (4)

Application Number Priority Date Filing Date Title
ES201330436A ES2514140B1 (es) 2013-03-26 2013-03-26 Uso del inhibidor de sulfatasas esteroideas STX64 para el tratamiento del envejecimiento
PCT/ES2014/070230 WO2014154927A1 (es) 2013-03-26 2014-03-26 Uso del inhibidor de sulfatasas esteroideas stx64 para el tratamiento del envejecimiento
EP14775264.6A EP3011950A4 (en) 2013-03-26 2014-03-26 Use of the inhibitor of steroid sulfatases stx64 for treating aging
US14/907,658 US20160361244A1 (en) 2013-03-26 2014-03-26 Use of the inhibitor of steroid sulfatases stx64 for treating aging

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ES201330436A ES2514140B1 (es) 2013-03-26 2013-03-26 Uso del inhibidor de sulfatasas esteroideas STX64 para el tratamiento del envejecimiento

Publications (2)

Publication Number Publication Date
ES2514140A1 ES2514140A1 (es) 2014-10-27
ES2514140B1 true ES2514140B1 (es) 2015-08-03

Family

ID=51622473

Family Applications (1)

Application Number Title Priority Date Filing Date
ES201330436A Active ES2514140B1 (es) 2013-03-26 2013-03-26 Uso del inhibidor de sulfatasas esteroideas STX64 para el tratamiento del envejecimiento

Country Status (4)

Country Link
US (1) US20160361244A1 (es)
EP (1) EP3011950A4 (es)
ES (1) ES2514140B1 (es)
WO (1) WO2014154927A1 (es)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP4098264A1 (en) * 2017-06-01 2022-12-07 Nexyon Biotech Co., Ltd. Pharmaceutical composition for prevention or treatment of bone-related disease
US20210251953A1 (en) * 2018-06-19 2021-08-19 Universidad Pablo De Olavide Compositions for treating and/or preventing protein-aggregation diseases
KR102162633B1 (ko) 2019-03-13 2020-10-07 연세대학교 산학협력단 비만 또는 지질 관련 대사성 질환의 예방 또는 치료용 조성물
EP3988095A1 (en) * 2020-10-26 2022-04-27 Universidad Pablo de Olavide Sulfated c19 steroid hormones to extend lifespan and protect against aging-associated proteotoxicity

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1995026717A1 (en) 1994-04-05 1995-10-12 Celltech Therapeutics Limited Use of estrone derivatives as steroid sulphatase inhibitors
US5556847A (en) * 1994-10-27 1996-09-17 Duquesne University Of The Holy Ghost Methods of effecting memory enhancement mediated by steroid sulfatase inhibitors
JP4320089B2 (ja) 1999-07-06 2009-08-26 あすか製薬株式会社 フェニルスルファメート誘導体
GB0020498D0 (en) * 2000-08-18 2000-10-11 Sterix Ltd Compound
JPWO2004035089A1 (ja) 2002-10-09 2006-02-09 協和醗酵工業株式会社 ホルモン依存性癌の治療剤
US8030298B2 (en) * 2005-05-26 2011-10-04 Abbott Products Gmbh 17β-HSD1 and STS inhibitors
GB0511190D0 (en) * 2005-06-01 2005-07-06 Sterix Ltd Use
GB0624105D0 (en) * 2006-12-01 2007-01-10 Sterix Ltd Use
CA2684604A1 (en) * 2007-05-15 2008-11-27 Puretech Ventures Methods and compositions for treating skin conditions
AU2010236016A1 (en) * 2010-02-01 2011-08-18 Peter Maccallum Cancer Institute Method of treatment of EGFR inhibitor toxicity

Also Published As

Publication number Publication date
WO2014154927A1 (es) 2014-10-02
ES2514140A1 (es) 2014-10-27
US20160361244A1 (en) 2016-12-15
EP3011950A4 (en) 2017-03-15
EP3011950A1 (en) 2016-04-27

Similar Documents

Publication Publication Date Title
DOP2019000180A (es) INHIBIDORES DE TGFß1 ISOFORMA-ESPECÍFICOS CONTEXTO-PERMISIVOS Y USO DE LOS MISMOS
CL2016002027A1 (es) Ciclopropilamina como inhibidor de la lsd1
CL2017002066A1 (es) Proteasas de cisteína
SV2017005461A (es) Benzamidas sustituidas con 1,3-tiazol-2-ilo
DOP2015000234A (es) COMPOSICIONES DE ARNi CONTRA EL COMPONENTE C5 DEL COMPLEMENTO Y METODOS PARA SU USO.
DOP2016000109A (es) Formas sólidas de ácido {[5-(3-clorofenil) -3-hidroxipiridin-2-carbonil] amino} acético, composiciones, y usos de las mismas.
CL2016001547A1 (es) Composiciones para el cuidado oral
CL2015002472A1 (es) Como inhibidores de mutant idh-yl-oxazolidin-2-onas 3-pirimidin-4.
ECSP15026557A (es) Compuestos y sus métodos de empleo
CL2015002501A1 (es) Compuestos y usos de estos para la modulación de la hemoglobina
AR090465A1 (es) Formas solidas de un profarmaco de nucleotidos de tiofosforamidato
UY34988A (es) Anticuerpos humanos para gfr alfa 3 y métodos para su uso
UY35276A (es) Nuevos compuestos que inhiben la actividad de Lp-PLA2
CL2019002733A1 (es) Formulaciones de clorhidrato del ácido 1-amino-1-ciclopropanocarboxílico.
ES2514140B1 (es) Uso del inhibidor de sulfatasas esteroideas STX64 para el tratamiento del envejecimiento
CL2016001546A1 (es) Composición para el cuidado oral que comprende serina y al menos una sal de zinc.
CO2018012180A2 (es) Métodos de tratamiento para enfermedades colestásicas y fibróticas
DOP2018000066A (es) Compuestos útiles para inhibir ror-gamma-t
CL2017000845A1 (es) Inhibidores de gingipaina de lisina
CL2016002151A1 (es) Derivados de piridazina para uso en la prevención o el tratamiento de un trastorno atáxico
BR112017009000A2 (pt) apilimod para uso no tratamento de melanoma
PE20150167A1 (es) (r)-nifuratel, su uso para el tratamiento de las infecciones y sintesis de (r) y (s)-nifuratel
CL2015000537A1 (es) Siarn y su uso en los métodos y composiciones para el tratamiento y/o prevención de enfermedades de los ojos.
CL2017000563A1 (es) Uso de elsiglutida para tratar mucositis gastrointestinal que incluye diarrea inducida por quimioterapia.
CL2015002191A1 (es) Composición antifúngica tópica para el tratamiento de onicomicosis.

Legal Events

Date Code Title Description
FG2A Definitive protection

Ref document number: 2514140

Country of ref document: ES

Kind code of ref document: B1

Effective date: 20150803