ES2491340A1 - New composition of chitosan conjugates or derivatives with thiolactones (Machine-translation by Google Translate, not legally binding) - Google Patents

New composition of chitosan conjugates or derivatives with thiolactones (Machine-translation by Google Translate, not legally binding) Download PDF

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Publication number
ES2491340A1
ES2491340A1 ES201300228A ES201300228A ES2491340A1 ES 2491340 A1 ES2491340 A1 ES 2491340A1 ES 201300228 A ES201300228 A ES 201300228A ES 201300228 A ES201300228 A ES 201300228A ES 2491340 A1 ES2491340 A1 ES 2491340A1
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ES
Spain
Prior art keywords
thiolactones
translation
derivatives
machine
legally binding
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
ES201300228A
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Spanish (es)
Other versions
ES2491340B1 (en
Inventor
María Violante DE PAZ BÁÑEZ
María Rosa JIMÉNEZ-CASTELLANOS BALLESTEROS
María Jesús LUCERO MUÑOZ
Marta CASAS DELGADO
Cristina FERRIS VILLANUEVA
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Universidad de Sevilla
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Universidad de Sevilla
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Publication date
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Priority to ES201300228A priority Critical patent/ES2491340B1/en
Publication of ES2491340A1 publication Critical patent/ES2491340A1/en
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Publication of ES2491340B1 publication Critical patent/ES2491340B1/en
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Classifications

    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/0006—Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar, e.g. colominic acid
    • C08B37/0024—Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar, e.g. colominic acid beta-D-Glucans; (beta-1,3)-D-Glucans, e.g. paramylon, coriolan, sclerotan, pachyman, callose, scleroglucan, schizophyllan, laminaran, lentinan or curdlan; (beta-1,6)-D-Glucans, e.g. pustulan; (beta-1,4)-D-Glucans; (beta-1,3)(beta-1,4)-D-Glucans, e.g. lichenan; Derivatives thereof
    • C08B37/0027—2-Acetamido-2-deoxy-beta-glucans; Derivatives thereof
    • C08B37/003—Chitin, i.e. 2-acetamido-2-deoxy-(beta-1,4)-D-glucan or N-acetyl-beta-1,4-D-glucosamine; Chitosan, i.e. deacetylated product of chitin or (beta-1,4)-D-glucosamine; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A61K31/716—Glucans
    • A61K31/722—Chitin, chitosan
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
    • A61K8/73—Polysaccharides
    • A61K8/736—Chitin; Chitosan; Derivatives thereof

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Molecular Biology (AREA)
  • Epidemiology (AREA)
  • Biochemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Birds (AREA)
  • Materials Engineering (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Polymers & Plastics (AREA)
  • Organic Chemistry (AREA)
  • Cosmetics (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Medicinal Preparation (AREA)

Abstract

The present invention relates to conjugates of chitosan (or its derivatives) with thiolactones (synthesis and chemical structures), in the cosmetic, biomedical-pharmaceutical compositions containing said conjugates, and to their applications, which have the following properties: non-toxic, biodegradable, with excellent properties of mucoadhesion, cohesion and enzymatic inhibition, with improved properties of permeability, cellular uptake and great stability as cannula coating agents and other medical devices and as drug transporting systems, that is, with long residence times of the active ingredients encompassed, which guarantees excellent control in the release of the drugs included in the formulation and also capable of gelling in the presence of oxygen. (Machine-translation by Google Translate, not legally binding)

Description

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Claims (1)

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ES201300228A 2013-03-05 2013-03-05 New composition of chitosan conjugates or derivatives with thiolactones Active ES2491340B1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
ES201300228A ES2491340B1 (en) 2013-03-05 2013-03-05 New composition of chitosan conjugates or derivatives with thiolactones

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ES201300228A ES2491340B1 (en) 2013-03-05 2013-03-05 New composition of chitosan conjugates or derivatives with thiolactones

Publications (2)

Publication Number Publication Date
ES2491340A1 true ES2491340A1 (en) 2014-09-05
ES2491340B1 ES2491340B1 (en) 2015-03-31

Family

ID=51452824

Family Applications (1)

Application Number Title Priority Date Filing Date
ES201300228A Active ES2491340B1 (en) 2013-03-05 2013-03-05 New composition of chitosan conjugates or derivatives with thiolactones

Country Status (1)

Country Link
ES (1) ES2491340B1 (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN110217084A (en) * 2019-06-28 2019-09-10 佛山科学技术学院 A kind of automobile protective fence

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10618986B2 (en) 2016-10-19 2020-04-14 Alcon Inc. Hydrophilic copolymer with pendant thiol groups

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20040236095A1 (en) * 2001-08-31 2004-11-25 Martin Prinz Chitosan-thio-amidine conjugates and their cosmetic as well as pharmeceutic use

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20040236095A1 (en) * 2001-08-31 2004-11-25 Martin Prinz Chitosan-thio-amidine conjugates and their cosmetic as well as pharmeceutic use

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
K Juntapram et al, Carbohydrate Polymers marzo 2012, vol 87, nº 4, págs 2399-2408. "Synthesis and characterization of chitosan-homocysteine thiolactone as a mucoadhesive polymer", todo el documento *
T Schmitz et al, International Journal of Pharmaceutics 2008, vol 347, nº 1, págs 79-85. "Synthesis and characterization of a chitosan-N-acetyl cysteine conjugate" *

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN110217084A (en) * 2019-06-28 2019-09-10 佛山科学技术学院 A kind of automobile protective fence
CN110217084B (en) * 2019-06-28 2024-03-26 佛山科学技术学院 Automobile protection fence

Also Published As

Publication number Publication date
ES2491340B1 (en) 2015-03-31

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