ES2485867T3 - Compuestos opioides de carboxamido - Google Patents

Compuestos opioides de carboxamido Download PDF

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Publication number
ES2485867T3
ES2485867T3 ES05757373.5T ES05757373T ES2485867T3 ES 2485867 T3 ES2485867 T3 ES 2485867T3 ES 05757373 T ES05757373 T ES 05757373T ES 2485867 T3 ES2485867 T3 ES 2485867T3
Authority
ES
Spain
Prior art keywords
opioid
alkyl
hydrogen
carboxamide compounds
alkyldiyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
ES05757373.5T
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English (en)
Inventor
John R. Carson
Philip M. Pitis
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Janssen Pharmaceutica NV
Original Assignee
Janssen Pharmaceutica NV
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=35064532&utm_source=***_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ES2485867(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Janssen Pharmaceutica NV filed Critical Janssen Pharmaceutica NV
Application granted granted Critical
Publication of ES2485867T3 publication Critical patent/ES2485867T3/es
Active legal-status Critical Current
Anticipated expiration legal-status Critical

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C237/20—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton containing six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/28—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton
    • C07C237/30—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton having the nitrogen atom of the carboxamide group bound to hydrogen atoms or to acyclic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/28—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton
    • C07C237/38—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton having the nitrogen atom of the carboxamide group bound to a carbon atom of a ring other than a six-membered aromatic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/02—Systems containing only non-condensed rings with a three-membered ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/14—The ring being saturated

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Oncology (AREA)
  • Pain & Pain Management (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Un compuesto de la Fórmula (I)**Fórmula** donde: R1 y R2 se seleccionan independientemente del grupo consistente en hidrógeno, C1-4 alquilo y alquildiil donde R1 y R2 se toman junto con los átomos a los que están unidos para formar un anillo monocíclico; R3 y R4 se seleccionan independientemente del grupo consistente en hidrógeno, C1-4 alquilo, C3-7 cicloalquilo y alquildiil donde R3 y R4 se toman junto con los átomos a los que están unidos para formar un anillo monocíclico; Y es hidrógeno, C1-4 alquilo, C1-4 alcoxi, halógeno o trifluorometilo; y enantiómeros, diastereómeros, tautómeros, solvatos y sales de los mismos farmacéuticamente aceptables.

Description

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Claims (1)

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    imagen2
ES05757373.5T 2004-05-14 2005-05-11 Compuestos opioides de carboxamido Active ES2485867T3 (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US57129804P 2004-05-14 2004-05-14
US571298P 2004-05-14
PCT/US2005/016581 WO2005113486A1 (en) 2004-05-14 2005-05-11 Carboxamido opioid compounds

Publications (1)

Publication Number Publication Date
ES2485867T3 true ES2485867T3 (es) 2014-08-14

Family

ID=35064532

Family Applications (1)

Application Number Title Priority Date Filing Date
ES05757373.5T Active ES2485867T3 (es) 2004-05-14 2005-05-11 Compuestos opioides de carboxamido

Country Status (22)

Country Link
US (2) US7244866B2 (es)
EP (1) EP1748978B1 (es)
JP (1) JP5420170B2 (es)
KR (1) KR101204751B1 (es)
CN (1) CN1984879B (es)
AR (1) AR049276A1 (es)
AU (1) AU2005245403B2 (es)
BR (1) BRPI0511137A (es)
CA (1) CA2566601C (es)
CR (1) CR8811A (es)
EA (1) EA013261B1 (es)
EC (1) ECSP067008A (es)
ES (1) ES2485867T3 (es)
HK (1) HK1101246A1 (es)
IL (1) IL179196A (es)
MX (1) MXPA06013270A (es)
NO (1) NO20065768L (es)
NZ (1) NZ551288A (es)
TW (1) TWI418345B (es)
UA (1) UA90432C2 (es)
WO (1) WO2005113486A1 (es)
ZA (1) ZA200610446B (es)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EA013261B1 (ru) * 2004-05-14 2010-04-30 Янссен Фармацевтика, Н.В. Опиоидные соединения, замещенные карбоксамидогруппой
US20060254029A1 (en) * 2005-05-11 2006-11-16 Conrad Swenson Pocket loss prevention device
MX2009012685A (es) * 2007-05-31 2009-12-14 Sepracor Inc Cicloalquilaminas sustituidas con fenilo como inhibidores de la reabsorcion de monoamina.
EP3170395A1 (en) * 2009-03-19 2017-05-24 Alkermes Pharma Ireland Limited Morphinan derivatives with high oral bioavailability
TR201908514T4 (tr) * 2009-12-04 2019-07-22 Alkermes Pharma Ireland Ltd İlaç doz aşimi tedavi̇si̇ i̇çi̇n morfi̇nan türevleri̇
US8778960B2 (en) 2010-08-23 2014-07-15 Alkermes Pharma Ireland Limited Methods for treating antipsychotic-induced weight gain
WO2012138888A1 (en) 2011-04-05 2012-10-11 Alkermes, Inc. Process for the synthesis of quaternary amine compounds
US9211293B2 (en) 2011-12-15 2015-12-15 Alkermes Pharma Ireland Limited Opioid agonist antagonist combinations
PL3153171T3 (pl) 2011-12-15 2019-02-28 Alkermes Pharma Ireland Limited Samidorfan (alks 33) w połączeniu z buprenorfiną do leczenia zaburzeń depresyjnych
AU2014268361B2 (en) 2013-05-24 2018-09-06 Alkermes Pharma Ireland Limited Morphan and morphinan analogues, and methods of use
EP3003311A2 (en) 2013-05-24 2016-04-13 Alkermes Pharma Ireland Limited Methods for treating depressive symptoms
CN104940709A (zh) * 2015-07-22 2015-09-30 张秋英 一种镇痛麻醉喷雾剂
CN105055756A (zh) * 2015-09-18 2015-11-18 张秋英 一种***挫伤用镇痛气雾剂
KR102603671B1 (ko) 2017-01-17 2023-11-17 메비아스 디스커버리 인코포레이티드 치환된 3-디알킬아미노메틸-피페리딘-4-일-벤즈아미드 및 이를 제조 및 사용하는 방법
EP4243768A1 (en) 2020-11-12 2023-09-20 Alkermes Pharma Ireland Limited Immediate release multilayer tablet

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2071897A1 (en) * 1989-12-28 1991-06-29 Richard A. Glennon Sigma receptor ligands and the use thereof
US6071970A (en) * 1993-02-08 2000-06-06 Nps Pharmaceuticals, Inc. Compounds active at a novel site on receptor-operated calcium channels useful for treatment of neurological disorders and diseases
DE4426245A1 (de) * 1994-07-23 1996-02-22 Gruenenthal Gmbh 1-Phenyl-3-dimethylamino-propanverbindungen mit pharmakologischer Wirkung
EP1944292B9 (en) * 2000-10-31 2016-07-06 Rensselaer Polytechnic Institute 8-substituted-2,6-methano-3-benzazocines and 3-substituted morphinanes as opioid receptor binding agents
DE10059413A1 (de) * 2000-11-30 2002-06-20 Gruenenthal Gmbh Verwendung von substituierten 6-Dimethylaminomethyl-1-phenyl-cyclohexanverbindungen zur Therapie der Harninkontinenz
DE10146275A1 (de) * 2001-09-18 2003-04-24 Gruenenthal Gmbh Kombination ausgewählter Opioide mit Muscarin-Antagonisten zur Therapie der Harninkontinenz
AU2002364517A1 (en) * 2001-11-30 2003-06-17 Sepracor Inc. Tramadol analogs and uses thereof
DE10213051B4 (de) 2002-03-23 2013-03-07 Grünenthal GmbH Substituierte 4-Aminocyclohexanole
UA84277C2 (ru) * 2002-10-25 2008-10-10 Лабофарм Инк. Композиция трамадола с пролонгированным высвобождением с 24-часовым действием
ME01601B (me) 2004-03-15 2014-09-20 Janssen Pharmaceutica Nv Modulatori opioidnog receptora
EA013261B1 (ru) * 2004-05-14 2010-04-30 Янссен Фармацевтика, Н.В. Опиоидные соединения, замещенные карбоксамидогруппой

Also Published As

Publication number Publication date
CN1984879B (zh) 2011-07-27
HK1101246A1 (en) 2007-10-12
UA90432C2 (uk) 2010-04-26
MXPA06013270A (es) 2007-04-23
KR101204751B1 (ko) 2012-11-27
EP1748978B1 (en) 2014-06-04
BRPI0511137A (pt) 2007-11-27
IL179196A0 (en) 2007-03-08
KR20070015613A (ko) 2007-02-05
EA200602115A1 (ru) 2007-04-27
NO20065768L (no) 2007-02-07
JP2007537278A (ja) 2007-12-20
AU2005245403B2 (en) 2012-04-19
EA013261B1 (ru) 2010-04-30
CA2566601C (en) 2013-04-09
TWI418345B (zh) 2013-12-11
CA2566601A1 (en) 2005-12-01
AU2005245403A1 (en) 2005-12-01
TW200605871A (en) 2006-02-16
ZA200610446B (en) 2008-07-30
US7244866B2 (en) 2007-07-17
AR049276A1 (es) 2006-07-12
NZ551288A (en) 2010-10-29
US7745492B2 (en) 2010-06-29
EP1748978A1 (en) 2007-02-07
US20080280990A1 (en) 2008-11-13
US20050256203A1 (en) 2005-11-17
ECSP067008A (es) 2006-12-29
WO2005113486A1 (en) 2005-12-01
IL179196A (en) 2012-10-31
CR8811A (es) 2009-01-14
CN1984879A (zh) 2007-06-20
JP5420170B2 (ja) 2014-02-19

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