ES2469240B1 - Uso de un agente fotosensible capaz de producir especies reactivas de oxígeno en la preparación de un medicamento útil para la terapia fotodinámica de una enfermedad relacionada con células madre, uso "in vitro" y composición farmacéutica. - Google Patents

Uso de un agente fotosensible capaz de producir especies reactivas de oxígeno en la preparación de un medicamento útil para la terapia fotodinámica de una enfermedad relacionada con células madre, uso "in vitro" y composición farmacéutica. Download PDF

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Publication number
ES2469240B1
ES2469240B1 ES201231759A ES201231759A ES2469240B1 ES 2469240 B1 ES2469240 B1 ES 2469240B1 ES 201231759 A ES201231759 A ES 201231759A ES 201231759 A ES201231759 A ES 201231759A ES 2469240 B1 ES2469240 B1 ES 2469240B1
Authority
ES
Spain
Prior art keywords
preparation
oxygen species
reactive oxygen
photosensible
photodynamic therapy
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
ES201231759A
Other languages
English (en)
Other versions
ES2469240A1 (es
Inventor
Jesús ESPADA REGALADO
Elisa CARRASCO CERRO
María Inmaculada CALVO SANCHEZ
Alfonso BLAZQUEZ-CASTRO
Angeles Juarranz De La Fuente
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Consejo Superior de Investigaciones Cientificas CSIC
Original Assignee
Consejo Superior de Investigaciones Cientificas CSIC
Universidad Autonoma de Madrid
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Consejo Superior de Investigaciones Cientificas CSIC, Universidad Autonoma de Madrid filed Critical Consejo Superior de Investigaciones Cientificas CSIC
Priority to ES201231759A priority Critical patent/ES2469240B1/es
Priority to EP13855732.7A priority patent/EP2932967B1/en
Priority to US14/442,876 priority patent/US10695428B2/en
Priority to PCT/ES2013/070779 priority patent/WO2014076338A1/es
Priority to ES13855732T priority patent/ES2703332T3/es
Publication of ES2469240A1 publication Critical patent/ES2469240A1/es
Application granted granted Critical
Publication of ES2469240B1 publication Critical patent/ES2469240B1/es
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/409—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil having four such rings, e.g. porphine derivatives, bilirubin, biliverdine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K41/00—Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
    • A61K41/0057—Photodynamic therapy with a photosensitizer, i.e. agent able to produce reactive oxygen species upon exposure to light or radiation, e.g. UV or visible light; photocleavage of nucleic acids with an agent
    • A61K41/0071—PDT with porphyrins having exactly 20 ring atoms, i.e. based on the non-expanded tetrapyrrolic ring system, e.g. bacteriochlorin, chlorin-e6, or phthalocyanines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K41/00—Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
    • A61K41/0057—Photodynamic therapy with a photosensitizer, i.e. agent able to produce reactive oxygen species upon exposure to light or radiation, e.g. UV or visible light; photocleavage of nucleic acids with an agent
    • A61K41/0061—5-aminolevulinic acid-based PDT: 5-ALA-PDT involving porphyrins or precursors of protoporphyrins generated in vivo from 5-ALA
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
    • A61K8/44—Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
    • A61K8/4906—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with one nitrogen as the only hetero atom
    • A61K8/4913—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with one nitrogen as the only hetero atom having five membered rings, e.g. pyrrolidone carboxylic acid
    • A61K8/492—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with one nitrogen as the only hetero atom having five membered rings, e.g. pyrrolidone carboxylic acid having condensed rings, e.g. indol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
    • A61K8/494—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with more than one nitrogen as the only hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/10—General cosmetic use

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Birds (AREA)
  • Dermatology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)

Abstract

La presente invención es el uso de un agente fotosensible, o su precursor, capaz de producir especies reactivas de oxígeno (ROS) en la preparación de un medicamento útil para el tratamiento por terapia fotodinámica (TFD) de una enfermedad relacionada con las células madre en un sujeto, preferiblemente células madre epidérmicas.

Description

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Claims (1)

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ES201231759A 2012-11-14 2012-11-14 Uso de un agente fotosensible capaz de producir especies reactivas de oxígeno en la preparación de un medicamento útil para la terapia fotodinámica de una enfermedad relacionada con células madre, uso "in vitro" y composición farmacéutica. Expired - Fee Related ES2469240B1 (es)

Priority Applications (5)

Application Number Priority Date Filing Date Title
ES201231759A ES2469240B1 (es) 2012-11-14 2012-11-14 Uso de un agente fotosensible capaz de producir especies reactivas de oxígeno en la preparación de un medicamento útil para la terapia fotodinámica de una enfermedad relacionada con células madre, uso "in vitro" y composición farmacéutica.
EP13855732.7A EP2932967B1 (en) 2012-11-14 2013-11-11 Use of a photosensitive agent capable of producing reactive oxygen species in the production of a drug for the photodynamic therapy of a disease related to stem cells, in vitro use, and pharmaceutical composition
US14/442,876 US10695428B2 (en) 2012-11-14 2013-11-11 Use of a photosensitive agent capable of producing reactive oxygen species in the production of a drug for the photodynamic therapy of a disease related to stem cells, in vitro use, and pharmaceutical composition
PCT/ES2013/070779 WO2014076338A1 (es) 2012-11-14 2013-11-11 Uso de un agente fotosensible capaz de producir especies reactivas de oxígeno en la preparación de un medicamento útil para la terapia fotodinámica de una enfermedad relacionada con células madre, uso "in vitro" y composición farmacéutica
ES13855732T ES2703332T3 (es) 2012-11-14 2013-11-11 Uso de un agente fotosensible capaz de producir especies reactivas al oxígeno en la producción de un medicamento para la terapia fotodinámica de una enfermedad relacionada con células madre, uso in vitro, y composición farmacéutica

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ES201231759A ES2469240B1 (es) 2012-11-14 2012-11-14 Uso de un agente fotosensible capaz de producir especies reactivas de oxígeno en la preparación de un medicamento útil para la terapia fotodinámica de una enfermedad relacionada con células madre, uso "in vitro" y composición farmacéutica.

Publications (2)

Publication Number Publication Date
ES2469240A1 ES2469240A1 (es) 2014-06-17
ES2469240B1 true ES2469240B1 (es) 2015-04-20

Family

ID=50730628

Family Applications (2)

Application Number Title Priority Date Filing Date
ES201231759A Expired - Fee Related ES2469240B1 (es) 2012-11-14 2012-11-14 Uso de un agente fotosensible capaz de producir especies reactivas de oxígeno en la preparación de un medicamento útil para la terapia fotodinámica de una enfermedad relacionada con células madre, uso "in vitro" y composición farmacéutica.
ES13855732T Active ES2703332T3 (es) 2012-11-14 2013-11-11 Uso de un agente fotosensible capaz de producir especies reactivas al oxígeno en la producción de un medicamento para la terapia fotodinámica de una enfermedad relacionada con células madre, uso in vitro, y composición farmacéutica

Family Applications After (1)

Application Number Title Priority Date Filing Date
ES13855732T Active ES2703332T3 (es) 2012-11-14 2013-11-11 Uso de un agente fotosensible capaz de producir especies reactivas al oxígeno en la producción de un medicamento para la terapia fotodinámica de una enfermedad relacionada con células madre, uso in vitro, y composición farmacéutica

Country Status (4)

Country Link
US (1) US10695428B2 (es)
EP (1) EP2932967B1 (es)
ES (2) ES2469240B1 (es)
WO (1) WO2014076338A1 (es)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2637279C2 (ru) * 2015-12-25 2017-12-01 Сергей Петрович Кречетов Способ фотодинамической терапии
US20190099610A1 (en) * 2017-10-04 2019-04-04 Hyper Light Technologies, Llc Cancer cell treatment
CN111035612B (zh) * 2019-12-31 2020-12-18 华中科技大学 一种活性氧响应性凝胶贮库及其制备方法与应用
EP3900733A1 (en) 2020-04-24 2021-10-27 Derma Innovate S.L. Src kinase activators and eng function inhibitors as enhancers of skin homeostasis/regeneration and hair growth

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2005514346A (ja) * 2001-11-09 2005-05-19 キュー エル ティー インク． 光感作剤及び皮膚浸透エンハンサーを含有する組成物並びに光力学療法におけるそれらの使用
US7264629B2 (en) * 2001-11-09 2007-09-04 Qlt, Inc. Photodynamic therapy for the treatment of hair loss
EP1617909A1 (en) * 2003-04-23 2006-01-25 QLT Inc. Hair growth
US20070225518A1 (en) * 2006-03-22 2007-09-27 Zvi Malik 5-Aminolevulinic acid salts and their use
KR101035269B1 (ko) * 2007-04-23 2011-05-26 한국과학기술연구원 고분자 유도체-광감작제 복합체를 이용한 새로운 광역학치료제
WO2010015087A1 (en) * 2008-08-07 2010-02-11 The University Of Western Ontario Method of inducing stem cell differentiation
MX2012010007A (es) * 2010-03-01 2012-10-01 Photocure Asa Composiciones cosmeticas.
US20130243741A1 (en) * 2010-09-21 2013-09-19 Kansas State University Research Foundation Renilla/gaussia transfected cells as a light source for in-situ photodynamic therapy of cancer

Also Published As

Publication number Publication date
EP2932967A1 (en) 2015-10-21
ES2703332T3 (es) 2019-03-08
ES2469240A1 (es) 2014-06-17
US20150335746A1 (en) 2015-11-26
EP2932967A4 (en) 2016-03-30
US10695428B2 (en) 2020-06-30
WO2014076338A1 (es) 2014-05-22
EP2932967B1 (en) 2018-08-29

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