ES2411907T8 - Uso terapéutico de anticuerpos antirreceptor TWEAK - Google Patents
Uso terapéutico de anticuerpos antirreceptor TWEAK Download PDFInfo
- Publication number
- ES2411907T8 ES2411907T8 ES08797148T ES08797148T ES2411907T8 ES 2411907 T8 ES2411907 T8 ES 2411907T8 ES 08797148 T ES08797148 T ES 08797148T ES 08797148 T ES08797148 T ES 08797148T ES 2411907 T8 ES2411907 T8 ES 2411907T8
- Authority
- ES
- Spain
- Prior art keywords
- tweak
- therapeutic use
- receptor antibodies
- antibodies
- receptor
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- 230000001225 therapeutic effect Effects 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2878—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/52—Constant or Fc region; Isotype
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
- C07K2317/732—Antibody-dependent cellular cytotoxicity [ADCC]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/75—Agonist effect on antigen
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/55—Fusion polypeptide containing a fusion with a toxin, e.g. diphteria toxin
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Immunology (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Cell Biology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US123623P | 1999-03-10 | ||
US95374507P | 2007-08-03 | 2007-08-03 | |
US953745P | 2007-08-03 | ||
US12362308P | 2008-04-09 | 2008-04-09 | |
PCT/US2008/072146 WO2009020933A2 (en) | 2007-08-03 | 2008-08-04 | Therapeutic use of anti-tweak receptor antibodies |
Publications (2)
Publication Number | Publication Date |
---|---|
ES2411907T3 ES2411907T3 (es) | 2013-07-09 |
ES2411907T8 true ES2411907T8 (es) | 2013-08-30 |
Family
ID=40193427
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES08797148T Active ES2411907T3 (es) | 2007-08-03 | 2008-08-04 | Uso terapéutico de anticuerpos antirreceptor TWEAK |
Country Status (12)
Country | Link |
---|---|
US (1) | US9056908B2 (es) |
EP (2) | EP2182982B1 (es) |
JP (1) | JP5409628B2 (es) |
KR (1) | KR20100053607A (es) |
CN (1) | CN102006886A (es) |
BR (1) | BRPI0814768A2 (es) |
CA (1) | CA2694751C (es) |
ES (1) | ES2411907T3 (es) |
IL (1) | IL203038A (es) |
MX (1) | MX2010001378A (es) |
NZ (1) | NZ582815A (es) |
WO (1) | WO2009020933A2 (es) |
Families Citing this family (34)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA2597945C (en) | 2005-02-17 | 2016-07-12 | Biogen Idec Ma Inc. | Treating neurological disorders |
WO2006138219A2 (en) | 2005-06-13 | 2006-12-28 | Biogen Idec Ma Inc. | Methods of diagnosis / prognosis of inflammatory conditions |
BRPI0912198A2 (pt) * | 2008-05-15 | 2019-09-24 | Biogen Idec Inc | anticorpos anti-fn14 e usos dos mesmos |
ES2363669B1 (es) * | 2009-06-10 | 2012-08-09 | Fundacio Privada Institut D'investigacio Biomedica De Bellvitge (Idibell) | Metodo para determinar el riesgo de desarrollar metastasis cerebral y un kit para llevar a cabo dicho procedimiento |
CN102675460B (zh) * | 2011-02-28 | 2015-08-19 | 珠海市丽珠单抗生物技术有限公司 | 抗肿瘤坏死因子α的人源化抗体 |
EP2683740B1 (en) * | 2011-03-10 | 2018-07-04 | Omeros Corporation | Generation of anti-fn14 monoclonal antibodies by ex-vivo accelerated antibody evolution |
AU2014203658B2 (en) * | 2011-08-23 | 2016-04-28 | La Trobe University | FN14 binding proteins and uses thereof |
CA2845946A1 (en) * | 2011-08-23 | 2013-02-28 | Transbio Ltd | Fn14-binding proteins and uses thereof |
WO2013166290A1 (en) | 2012-05-04 | 2013-11-07 | Abbvie Biotherapeutics Inc. | P21 biomarker assay |
WO2013177386A1 (en) * | 2012-05-24 | 2013-11-28 | Abbvie Biotherapeutics Inc. | Biomarkers for predicting response to tweak receptor (tweakr) agonist therapy |
WO2014004376A2 (en) | 2012-06-26 | 2014-01-03 | Del Mar Pharmaceuticals | Methods for treating tyrosine-kinase-inhibitor-resistant malignancies in patients with genetic polymorphisms or ahi1 dysregulations or mutations employing dianhydrogalactitol, diacetyldianhydrogalactitol, dibromodulcitol, or analogs or derivatives thereof |
NO2760138T3 (es) | 2012-10-01 | 2018-08-04 | ||
US11491154B2 (en) | 2013-04-08 | 2022-11-08 | Dennis M. Brown | Therapeutic benefit of suboptimally administered chemical compounds |
BR112015029953A2 (pt) | 2013-06-14 | 2017-09-26 | Bayer Pharma AG | anticorpos anti-tweakr e seus usos |
US9238034B2 (en) | 2013-07-09 | 2016-01-19 | The Translational Genomics Research Institute | FN14 antagonists and therapeutic uses thereof |
US9797882B2 (en) | 2013-07-09 | 2017-10-24 | The Translational Genomics Research Institute | Method of screening for a compound for inhibitory activity of FN14-tweak interaction |
KR102329024B1 (ko) | 2013-12-23 | 2021-11-19 | 바이엘 파마 악티엔게젤샤프트 | 키네신 스핀들 단백질(ksp)과의 항체 약물 접합체 (adcs) |
EP3209697A4 (en) | 2014-10-23 | 2018-05-30 | La Trobe University | Fn14-binding proteins and uses thereof |
CN107635586B (zh) * | 2014-12-15 | 2021-09-24 | 拜耳医药股份有限公司 | Ksp抑制剂与无糖基化抗-tweakr抗体的抗体-药物缀合物(adc) |
CA2990076A1 (en) | 2015-06-22 | 2016-12-29 | Bayer Pharma Aktiengesellschaft | Antibody drug conjugates (adcs) and antibody prodrug conjugates (apdcs) with enzymatically cleavable groups |
US20180318438A1 (en) | 2015-06-23 | 2018-11-08 | Bayer Pharma Aktiengesellschaft | Antibody drug conjugates of kinesin spindel protein (ksp) inhibitors with anti-tweakr-antibodies |
US11071788B2 (en) | 2015-06-23 | 2021-07-27 | Bayer Pharma Aktiengesellschaft | Antibody drug conjugates of kinesin spindel protein (KSP) inhibitors with antiB7H3-antibodies |
AU2016282724A1 (en) | 2015-06-23 | 2018-01-18 | Bayer Pharma Aktiengesellschaft | Targeted conjugates of KSP inhibitors |
WO2017060322A2 (en) | 2015-10-10 | 2017-04-13 | Bayer Pharma Aktiengesellschaft | Ptefb-inhibitor-adc |
MX2018011627A (es) | 2016-03-24 | 2019-01-10 | Bayer Pharma AG | Profarmacos de farmacos citotoxicos que tienen grupos enzimaticamente escindibles. |
EP3471776B1 (en) | 2016-06-15 | 2022-05-04 | Bayer Pharma Aktiengesellschaft | Specific antibody-drug-conjugates with ksp inhibitors and anti-cd123-antibodies |
CN110072556B (zh) | 2016-12-21 | 2023-05-02 | 拜耳制药股份公司 | 具有ksp抑制剂的特异性抗体药物缀合物(adc) |
EP3558386A1 (de) | 2016-12-21 | 2019-10-30 | Bayer Aktiengesellschaft | Prodrugs von cytotoxischen wirkstoffen mit enzymatisch spaltbaren gruppen |
AU2017380871A1 (en) | 2016-12-21 | 2019-07-11 | Bayer Aktiengesellschaft | Antibody drug conjugates (ADCs) having enzymatically cleavable groups |
US20200360531A1 (en) | 2018-01-31 | 2020-11-19 | Bayer Aktiengesellschaft | Antibody drug conjugates (adcs) with nampt inhibitors |
EP3814369A1 (en) | 2018-06-29 | 2021-05-05 | Stichting Het Nederlands Kanker Instituut- Antoni van Leeuwenhoek Ziekenhuis | Tweak-receptor agonists for use in combination with immunotherapy of a cancer |
MX2021004976A (es) * | 2018-10-31 | 2021-06-15 | Astellas Pharma Inc | Anticuerpo fn14 antihumano. |
WO2021013693A1 (en) | 2019-07-23 | 2021-01-28 | Bayer Pharma Aktiengesellschaft | Antibody drug conjugates (adcs) with nampt inhibitors |
WO2024105206A1 (en) | 2022-11-17 | 2024-05-23 | Vincerx Pharma Gmbh | Antibody-drug-conjugates cleavable in a tumor microenvironment |
Family Cites Families (35)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DK1015477T3 (da) | 1997-05-30 | 2011-02-07 | Human Genome Sciences Inc | 32 humane sekreterede proteiner |
US7001992B2 (en) * | 1997-05-30 | 2006-02-21 | Human Genome Sciences, Inc. | Antibodies to secreted protein HEMCM42 |
AU7549498A (en) * | 1997-06-03 | 1998-12-21 | Protegene Inc. | Human proteins having transmembrane domains and dnas encoding these prot eins |
AU4409099A (en) | 1998-05-29 | 1999-12-13 | Incyte Pharmaceuticals, Inc. | Human transmembrane proteins |
IL144007A0 (en) * | 1999-01-15 | 2002-04-21 | Biogen Inc | Antagonists of tweak and of tweak receptor and their use to treat immunological disorders |
US7495086B2 (en) * | 1999-12-20 | 2009-02-24 | Immunex Corporation | TWEAK receptor |
CA2394015C (en) * | 1999-12-20 | 2013-11-05 | Immunex Corporation | Tweak receptor |
US6727225B2 (en) * | 1999-12-20 | 2004-04-27 | Immunex Corporation | TWEAK receptor |
AU4592601A (en) | 2000-03-21 | 2001-10-03 | Millennium Predictive Medicine | Novel genes, compositions, kits, and method for identification, assessment, prevention, and therapy of ovarian cancer |
US6812339B1 (en) * | 2000-09-08 | 2004-11-02 | Applera Corporation | Polymorphisms in known genes associated with human disease, methods of detection and uses thereof |
US7208151B2 (en) * | 2001-09-12 | 2007-04-24 | Biogen Idec Ma Inc. | Tweak receptor agonists as anti-angiogenic agents |
CA2422095A1 (en) | 2000-09-14 | 2002-03-21 | Biogen, Inc. | Tweak receptor agonists as anti-angiogenic agents |
WO2002053737A1 (fr) | 2000-12-28 | 2002-07-11 | Asahi Kasei Kabushiki Kaisha | Gene d'activation de nf-kb |
US7227007B2 (en) * | 2000-12-28 | 2007-06-05 | Asahi Kasei Pharma Corporation | NF-κB activating gene |
US20040214167A9 (en) * | 2000-12-28 | 2004-10-28 | Akio Matsuda | NF-kappa B activating gene |
US20040142325A1 (en) * | 2001-09-14 | 2004-07-22 | Liat Mintz | Methods and systems for annotating biomolecular sequences |
MXPA04006554A (es) | 2002-01-02 | 2005-03-31 | Genentech Inc | Composiciones y metodos para diagnostico y tratamiento de tumor. |
AU2003219167A1 (en) | 2002-03-19 | 2003-09-29 | Genset Sa | Treatment of metabolic disorders with a tnf receptor family member (fradj and/or cryptic) agonists or antagonists |
CA2500687A1 (en) | 2002-10-02 | 2004-04-15 | Genentech, Inc. | Compositions and methods for the diagnosis and treatment of tumor |
WO2004112829A2 (en) * | 2003-05-23 | 2004-12-29 | Genentech, Inc. | Compositions and methods for the diagnosis and treatment of tumors of glial origin |
ES2287773T3 (es) | 2003-07-24 | 2007-12-16 | Amgen Inc. | Composiciones y metodos relacionados con fragmentos solubles multimericos y oligomericos del receptor tweak. |
US20070298037A1 (en) * | 2003-10-16 | 2007-12-27 | Fox Brian A | ZTNFR14, A Tumor Necrosis Factor Receptor |
US7507580B2 (en) * | 2003-10-16 | 2009-03-24 | Zymogenetics, Inc. | Ztnfr14, a tumor necrosis factor receptor |
WO2005037865A2 (en) | 2003-10-16 | 2005-04-28 | Zymogenetics, Inc. | Ztnfr14, A TUMOR NECROSIS FACTOR RECEPTOR |
EP1566636A1 (en) | 2004-02-23 | 2005-08-24 | AXARON Bioscience AG | Use of Tweak modulators and inhibitors for the treatment of neurological conditions |
JP4829780B2 (ja) * | 2004-03-26 | 2011-12-07 | 武田薬品工業株式会社 | 呼吸器疾患の予防・治療剤 |
EP1853312B1 (en) * | 2005-03-07 | 2014-12-10 | Genentech, Inc. | Methods and compositions for modulating tweak and fn14 activity |
ES2432564T3 (es) * | 2005-05-10 | 2013-12-04 | Biogen Idec Ma Inc. | Tratamiento y evaluación de trastornos inflamatorios |
WO2006125632A2 (en) | 2005-05-24 | 2006-11-30 | Rechtsanwalt Dr. Martin Prager Als Insolvenzverwalter Über Das Vermögen Der Xantos Biomedicine Ag, Pluta Rechtsanwalts Gmbh | Agonistic antibodies that bind to the tweak receptor fn14 and thereby modulate adiposity-associated phenotypes as well as their use in therapy |
WO2006130429A2 (en) | 2005-05-27 | 2006-12-07 | Biogen Idec Ma Inc. | Treatment of cancer |
WO2006138219A2 (en) | 2005-06-13 | 2006-12-28 | Biogen Idec Ma Inc. | Methods of diagnosis / prognosis of inflammatory conditions |
EP1876448A1 (en) | 2005-09-30 | 2008-01-09 | DIGILAB BioVisioN GmbH | Method and analytical reagents for identifying therapeutics using biomarkers responsive to thiazolidinediones. |
WO2008140565A2 (en) | 2006-11-08 | 2008-11-20 | Zymogenetics, Inc. | Use of tumor necrosis factor receptor 14 antagonists for treating psoriasis |
EP2240601B1 (en) | 2007-12-27 | 2016-10-12 | Compugen Ltd. | Biomarkers for the prediction of renal injury |
EP2080812A1 (en) | 2008-01-18 | 2009-07-22 | Transmedi SA | Compositions and methods of detecting post-stop peptides |
-
2008
- 2008-08-04 ES ES08797148T patent/ES2411907T3/es active Active
- 2008-08-04 CN CN2008801015223A patent/CN102006886A/zh active Pending
- 2008-08-04 US US12/185,689 patent/US9056908B2/en not_active Expired - Fee Related
- 2008-08-04 CA CA2694751A patent/CA2694751C/en not_active Expired - Fee Related
- 2008-08-04 NZ NZ582815A patent/NZ582815A/en not_active IP Right Cessation
- 2008-08-04 JP JP2010519276A patent/JP5409628B2/ja not_active Expired - Fee Related
- 2008-08-04 EP EP08797148A patent/EP2182982B1/en not_active Not-in-force
- 2008-08-04 BR BRPI0814768-0A2A patent/BRPI0814768A2/pt not_active IP Right Cessation
- 2008-08-04 EP EP12175773A patent/EP2545938A1/en not_active Withdrawn
- 2008-08-04 MX MX2010001378A patent/MX2010001378A/es active IP Right Grant
- 2008-08-04 WO PCT/US2008/072146 patent/WO2009020933A2/en active Application Filing
- 2008-08-04 KR KR1020107004817A patent/KR20100053607A/ko not_active Application Discontinuation
-
2009
- 2009-12-29 IL IL203038A patent/IL203038A/en not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
KR20100053607A (ko) | 2010-05-20 |
WO2009020933A2 (en) | 2009-02-12 |
WO2009020933A9 (en) | 2009-07-09 |
AU2008284025A2 (en) | 2010-04-01 |
MX2010001378A (es) | 2010-06-02 |
BRPI0814768A2 (pt) | 2015-03-03 |
EP2182982A2 (en) | 2010-05-12 |
EP2182982B1 (en) | 2013-03-27 |
EP2545938A1 (en) | 2013-01-16 |
ES2411907T3 (es) | 2013-07-09 |
JP5409628B2 (ja) | 2014-02-05 |
NZ582815A (en) | 2012-07-27 |
CA2694751C (en) | 2015-07-14 |
IL203038A (en) | 2014-03-31 |
AU2008284025A1 (en) | 2009-02-12 |
WO2009020933A3 (en) | 2009-03-26 |
CA2694751A1 (en) | 2009-02-12 |
US9056908B2 (en) | 2015-06-16 |
JP2010535713A (ja) | 2010-11-25 |
CN102006886A (zh) | 2011-04-06 |
US20090074762A1 (en) | 2009-03-19 |
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