ES235737A1 - UN MÉTODO DE PREPARACIoN DE ANTIBIoTICOS DE DEMETILTITRACICLINA - Google Patents
UN MÉTODO DE PREPARACIoN DE ANTIBIoTICOS DE DEMETILTITRACICLINAInfo
- Publication number
- ES235737A1 ES235737A1 ES0235737A ES235737A ES235737A1 ES 235737 A1 ES235737 A1 ES 235737A1 ES 0235737 A ES0235737 A ES 0235737A ES 235737 A ES235737 A ES 235737A ES 235737 A1 ES235737 A1 ES 235737A1
- Authority
- ES
- Spain
- Prior art keywords
- demethyltetracycline
- epimers
- demethyltetracyclines
- preparing
- methods
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 238000000034 method Methods 0.000 title abstract 2
- RMVMLZHPWMTQGK-SOUFLCLCSA-N (4s,4as,5as,6s,12ar)-4-(dimethylamino)-1,6,10,11,12a-pentahydroxy-3,12-dioxo-4a,5,5a,6-tetrahydro-4h-tetracene-2-carboxamide Chemical compound C1([C@H]2O)=CC=CC(O)=C1C(O)=C1[C@@H]2C[C@H]2[C@H](N(C)C)C(=O)C(C(N)=O)=C(O)[C@@]2(O)C1=O RMVMLZHPWMTQGK-SOUFLCLCSA-N 0.000 abstract 4
- JCSGAUKCDAVARS-UHFFFAOYSA-N demethyltetracycline Natural products CN(C1C(=C(C(C2(C(=C3C(C4=C(C=CC=C4C(C3CC12)O)O)=O)O)O)=O)C(=O)N)O)C JCSGAUKCDAVARS-UHFFFAOYSA-N 0.000 abstract 4
- CPELXLSAUQHCOX-UHFFFAOYSA-M Bromide Chemical compound [Br-] CPELXLSAUQHCOX-UHFFFAOYSA-M 0.000 abstract 1
- VEXZGXHMUGYJMC-UHFFFAOYSA-M Chloride anion Chemical compound [Cl-] VEXZGXHMUGYJMC-UHFFFAOYSA-M 0.000 abstract 1
- 241000186984 Kitasatospora aureofaciens Species 0.000 abstract 1
- 238000010564 aerobic fermentation Methods 0.000 abstract 1
- 230000003115 biocidal effect Effects 0.000 abstract 1
- 238000000855 fermentation Methods 0.000 abstract 1
- 230000004151 fermentation Effects 0.000 abstract 1
- 235000015097 nutrients Nutrition 0.000 abstract 1
- 238000002360 preparation method Methods 0.000 abstract 1
- 229940072172 tetracycline antibiotic Drugs 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P29/00—Preparation of compounds containing a naphthacene ring system, e.g. tetracycline
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C233/00—Carboxylic acid amides
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S435/00—Chemistry: molecular biology and microbiology
- Y10S435/8215—Microorganisms
- Y10S435/822—Microorganisms using bacteria or actinomycetales
- Y10S435/886—Streptomyces
- Y10S435/889—Streptomyces aureofaciens
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Wood Science & Technology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Microbiology (AREA)
- General Chemical & Material Sciences (AREA)
- Biotechnology (AREA)
- Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
Método de preparación de antibiótico de demetiltetraciclina ( comprendiendo demetiltetraciclina) y epímeros de ellas, caracterizado por fermentar aerobiamente un medio nutricio acuoso que tiene un contenido controlado de ión cloruro y/o bromuro con una cepa de s. aureofaciens productora de demetiltetraciclina, recuperar si se desea los antibióticos de demetiltetraciclina resultantes del medio de fermentación y, si se desea, ajustar el valor del pH de una solución concentrada de los mismos para producir los epímeros de ellos.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US587518A US2878289A (en) | 1956-05-28 | 1956-05-28 | 6-demethyltetracyclines and methods for preparing the same |
Publications (1)
Publication Number | Publication Date |
---|---|
ES235737A1 true ES235737A1 (es) | 1957-12-01 |
Family
ID=24350126
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES0235737A Expired ES235737A1 (es) | 1956-05-28 | 1957-05-27 | UN MÉTODO DE PREPARACIoN DE ANTIBIoTICOS DE DEMETILTITRACICLINA |
Country Status (5)
Country | Link |
---|---|
US (1) | US2878289A (es) |
CH (1) | CH365484A (es) |
DK (1) | DK104507C (es) |
ES (1) | ES235737A1 (es) |
IS (1) | IS469B6 (es) |
Families Citing this family (32)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3105016A (en) * | 1956-04-25 | 1963-09-24 | American Cyanamid Co | Process of producing bromo-tetracycline |
US2996499A (en) * | 1958-06-20 | 1961-08-15 | American Cyanamid Co | Cosynthetic factor-1, and its production |
US3047626A (en) * | 1959-09-24 | 1962-07-31 | Pfizer & Co C | 4-desdimethylamino-6-deoxy-tetracycline derivatives |
US3023239A (en) * | 1959-12-09 | 1962-02-27 | American Cyanamid Co | Recrystallization of demethylchlortetracycline |
US3019172A (en) * | 1960-03-14 | 1962-01-30 | American Cyanamid Co | Production of 7-chloro-6-demethyltetracycline |
US3070514A (en) * | 1960-05-04 | 1962-12-25 | Lepetit Spa | Process for the manufacture of 6-demethyltetracycline |
FR1430859A (es) * | 1960-05-23 | 1966-05-25 | ||
US3159537A (en) * | 1960-12-20 | 1964-12-01 | American Cyanamid Co | Potentiation of tetracycline by phosphinic acid |
US3028311A (en) * | 1960-08-05 | 1962-04-03 | Olin Mathieson | Process for preparing 6-demethyltetracyclines |
US3172822A (en) * | 1960-10-31 | 1965-03-09 | Process for preparing g-demethyl- tetracyclines | |
US3166474A (en) * | 1961-05-26 | 1965-01-19 | American Cyanamid Co | Stable aqueous propylene glycol solutions of aluminum gluconate complexes of certain tetracycline antibiotics |
US3335055A (en) * | 1961-08-30 | 1967-08-08 | American Cyanamid Co | More stable and more soluble tetracycline compositions suitable for parenteral use and method of preparing same |
US3069326A (en) * | 1961-10-31 | 1962-12-18 | American Cyanamid Co | Method of preparing 6-amino-5-hydroxy-1, 3-cyclohexadiene-1-carboxylic acid |
US3160570A (en) * | 1961-12-20 | 1964-12-08 | Merck & Co Inc | Method for producing 6-demethylchlortetracycline |
US3155586A (en) * | 1963-01-23 | 1964-11-03 | American Cyanamid Co | Stable liquid preparations of 6-demethyltetracyclines |
US3155587A (en) * | 1963-01-23 | 1964-11-03 | American Cyanamid Co | Stable liquid preparations of 7-chlorotetracycline |
FR2607M (fr) * | 1963-01-30 | 1964-06-22 | Soc Ind Fab Antibiotiques Sifa | Nouveau dérivé de la tétracycline. |
US3364260A (en) * | 1963-05-06 | 1968-01-16 | Squibb & Sons Inc | 4n-demethyl-4n-ethyl tetracyclines |
US3427166A (en) * | 1964-01-21 | 1969-02-11 | American Cyanamid Co | Stabilization of animal and poultry feeds containing a tetracycline antibiotic |
US3434844A (en) * | 1964-01-21 | 1969-03-25 | American Cyanamid Co | Stabilization of animal and poultry feeds containing a tetracycline antibiotic |
US3639214A (en) * | 1964-06-04 | 1972-02-01 | Upjohn Co | Production of 6-demethyltetracycline |
US3298927A (en) * | 1964-11-09 | 1967-01-17 | Olin Mathieson | Process for preparing 6-demethyltetracyclines using ethionine sulfoxide |
US3446841A (en) * | 1966-04-22 | 1969-05-27 | American Cyanamid Co | Isolation of 5-hydroxy-7-chlortetracycline |
US3607311A (en) * | 1968-02-16 | 1971-09-21 | Gerhard Julius Hass | Obtulinum exotoxin inhibited foods |
US3795707A (en) * | 1970-12-28 | 1974-03-05 | Rachelle Labor Italia Spa | Manufacture of alpha-6-deoxytetracyclines |
US4200630A (en) * | 1977-12-15 | 1980-04-29 | University Of Pennsylvania | Inhibition of ADH-stimulated osmotic water flow and aldosterone-stimulated sodium transport |
US5494903A (en) | 1991-10-04 | 1996-02-27 | American Cyanamid Company | 7-substituted-9-substituted amino-6-demethyl-6-deoxytetracyclines |
USRE40183E1 (en) | 1991-10-04 | 2008-03-25 | Wyeth Holdings Corporation | 7-Substituted-9-substituted amino-6-demethyl-6-deoxytetracyclines |
US6610853B1 (en) * | 1998-02-13 | 2003-08-26 | Kureha Kagaku Kogyo K.K. | N-(phenylsulfonyl)picolinamide derivatives, process for producing the same, and herbicide |
US20020077276A1 (en) * | 1999-04-27 | 2002-06-20 | Fredeking Terry M. | Compositions and methods for treating hemorrhagic virus infections and other disorders |
PT108978B (pt) | 2015-11-24 | 2020-03-09 | Hovione Farm S A | Sais de tetraciclinas |
CN111100900A (zh) * | 2019-12-19 | 2020-05-05 | 河北圣雪大成制药有限责任公司 | 一种发酵法制备去甲基四环素的方法 |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2482055A (en) * | 1948-02-11 | 1949-09-13 | American Cyanamid Co | Aureomycin and preparation of same |
BE487301A (es) * | 1948-02-11 | |||
US2734018A (en) * | 1953-09-28 | 1956-02-07 | Ircso | |
US2699054A (en) * | 1953-10-09 | 1955-01-11 | Lloyd H Conover | Tetracycline |
BE533886A (es) * | 1953-12-04 | |||
US2712517A (en) * | 1954-03-03 | 1955-07-05 | Bristol Lab Inc | Production of tetracycline and substituted tetracyclines |
-
1956
- 1956-05-23 CH CH501062A patent/CH365484A/fr unknown
- 1956-05-28 US US587518A patent/US2878289A/en not_active Expired - Lifetime
-
1957
- 1957-05-20 IS IS986A patent/IS469B6/is unknown
- 1957-05-27 ES ES0235737A patent/ES235737A1/es not_active Expired
- 1957-05-27 DK DK185757AA patent/DK104507C/da active
Also Published As
Publication number | Publication date |
---|---|
IS469B6 (is) | 1961-12-06 |
US2878289A (en) | 1959-03-17 |
CH365484A (fr) | 1962-11-15 |
DK104507C (da) | 1966-05-31 |
IS986A7 (is) | 1957-11-29 |
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