ES2196197T3 - Derivados de benzamida con propiedades inhibidoras de trombina. - Google Patents
Derivados de benzamida con propiedades inhibidoras de trombina.Info
- Publication number
- ES2196197T3 ES2196197T3 ES96944604T ES96944604T ES2196197T3 ES 2196197 T3 ES2196197 T3 ES 2196197T3 ES 96944604 T ES96944604 T ES 96944604T ES 96944604 T ES96944604 T ES 96944604T ES 2196197 T3 ES2196197 T3 ES 2196197T3
- Authority
- ES
- Spain
- Prior art keywords
- alkyl
- halogen
- alkoxy
- optionally substituted
- chain
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/72—Nitrogen atoms
- C07D213/74—Amino or imino radicals substituted by hydrocarbon or substituted hydrocarbon radicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4409—Non condensed pyridines; Hydrogenated derivatives thereof only substituted in position 4, e.g. isoniazid, iproniazid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pyridine Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
Un compuesto representado por la fórmula (I)**fórmula** donde R1 y R2 representan independientemente un grupo o R1 y R2 forman juntos un grupo heterocicloalquilo o heterocicloalquenilo C3-7, que puede estar opcionalmente sustituido con alquilo C1-6, alcoxi C1-4, halógeno, ácido carboxílico o un grupo éster de ácido carboxílico C1-4; R3 representa hidrógeno, alquilo C1-3, halógeno, o alcoxi C1-2; R4, R5 y R6 representan independientemente hidrógeno, o halógeno; R7 representa hidrógeno o alquilo C1-6; R8 representa hidrógeno, cicloalquilo C3-7, cicloalquenilo C3-7, heterocicloalquilo C3-7, heterocicloalquenilo C3-7, fenilo, naftilo, un anillo heterocíclico aromático de 5 ó 6 miembros que contiene uno o más heteroátomos seleccionados de átomos de nitrógeno, azufre y oxígeno, o un sistema bicíclico de anillos condensados que contiene uno o más átomos de nitrógeno, azufre y oxígeno, grupos que opcionalmente están sustituidos con uno o más grupos seleccionados de halógeno, hidroxi, CN, alquilo C1-6, alcoxi C1-6, aciloxi C1-6, NR9R10, NHCOR11, NHSO2R12, COR13, CO2R14, CONR15R16, y SO2NHR17.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GBGB9525620.2A GB9525620D0 (en) | 1995-12-15 | 1995-12-15 | Chemical compounds |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2196197T3 true ES2196197T3 (es) | 2003-12-16 |
Family
ID=10785445
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES96944604T Expired - Lifetime ES2196197T3 (es) | 1995-12-15 | 1996-12-13 | Derivados de benzamida con propiedades inhibidoras de trombina. |
Country Status (8)
Country | Link |
---|---|
US (1) | US6326386B1 (es) |
EP (1) | EP1021411B1 (es) |
AT (1) | ATE233733T1 (es) |
AU (1) | AU1303097A (es) |
DE (1) | DE69626554T2 (es) |
ES (1) | ES2196197T3 (es) |
GB (1) | GB9525620D0 (es) |
WO (1) | WO1997022589A1 (es) |
Families Citing this family (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB9821483D0 (en) | 1998-10-03 | 1998-11-25 | Glaxo Group Ltd | Chemical compounds |
TW499412B (en) | 1996-11-26 | 2002-08-21 | Dimensional Pharm Inc | Aminoguanidines and alkoxyguanidines as protease inhibitors |
US6344486B1 (en) | 1998-04-03 | 2002-02-05 | 3-Dimensional Pharmaceuticals, Inc. | Benzamide and sulfonamide substituted aminoguanidines and alkoxyguanidines as protease inhibitors |
AR023819A1 (es) * | 1999-05-03 | 2002-09-04 | Astrazeneca Ab | FORMULACIoN FARMACEUTICA, KIT DE PARTES Y UTILIZACION DE DICHA FORMULACION |
WO2001017947A1 (fr) * | 1999-09-06 | 2001-03-15 | Takeda Chemical Industries, Ltd. | Procedes de preparation de composes 2,3-dihydroazepine |
KR20030022353A (ko) | 2000-08-04 | 2003-03-15 | 3-디멘져널 파마슈티칼즈 인코오포레이티드 | 사이클릭 옥시구아니딘 프로테아제 저해제 |
GB0117144D0 (en) * | 2001-07-13 | 2001-09-05 | Glaxo Group Ltd | Process |
JP2006526017A (ja) * | 2003-05-14 | 2006-11-16 | サイトキネティクス・インコーポレーテッド | 化合物、組成物および方法 |
US8697387B2 (en) * | 2006-06-02 | 2014-04-15 | DiscoverRx Corporation | Methods for identifying agents and their use for the prevention of restenosis |
AU2012252165A1 (en) | 2011-05-09 | 2013-03-21 | Cambridge Enterprise Limited | Methods of modulating micrornas in the treatment of pulmonary arterial hypertension |
JP6738326B2 (ja) * | 2014-06-06 | 2020-08-12 | ザ スクリプス リサーチ インスティテュート | フッ化硫黄(vi)化合物およびそれの製造方法 |
TWI808055B (zh) | 2016-05-11 | 2023-07-11 | 美商滬亞生物國際有限公司 | Hdac 抑制劑與 pd-1 抑制劑之組合治療 |
TWI794171B (zh) | 2016-05-11 | 2023-03-01 | 美商滬亞生物國際有限公司 | Hdac抑制劑與pd-l1抑制劑之組合治療 |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
TW257757B (es) * | 1993-03-03 | 1995-09-21 | Boehringer Mannheim Gmbh | |
WO1994022834A1 (en) * | 1993-03-29 | 1994-10-13 | Zeneca Limited | Heterocyclic derivatives as platelet aggregation inhibitors |
-
1995
- 1995-12-15 GB GBGB9525620.2A patent/GB9525620D0/en active Pending
-
1996
- 1996-12-13 AT AT96944604T patent/ATE233733T1/de not_active IP Right Cessation
- 1996-12-13 AU AU13030/97A patent/AU1303097A/en not_active Abandoned
- 1996-12-13 DE DE69626554T patent/DE69626554T2/de not_active Expired - Fee Related
- 1996-12-13 ES ES96944604T patent/ES2196197T3/es not_active Expired - Lifetime
- 1996-12-13 WO PCT/EP1996/005743 patent/WO1997022589A1/en active IP Right Grant
- 1996-12-13 EP EP96944604A patent/EP1021411B1/en not_active Expired - Lifetime
-
2000
- 2000-10-04 US US09/678,610 patent/US6326386B1/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
US6326386B1 (en) | 2001-12-04 |
WO1997022589A1 (en) | 1997-06-26 |
GB9525620D0 (en) | 1996-02-14 |
DE69626554T2 (de) | 2004-02-12 |
EP1021411B1 (en) | 2003-03-05 |
EP1021411A1 (en) | 2000-07-26 |
ATE233733T1 (de) | 2003-03-15 |
DE69626554D1 (de) | 2003-04-10 |
AU1303097A (en) | 1997-07-14 |
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