ES2186501A1 - Factor de crecimiento fibroblastico basico con un dominio de union especifico a colegeno. - Google Patents
Factor de crecimiento fibroblastico basico con un dominio de union especifico a colegeno.Info
- Publication number
- ES2186501A1 ES2186501A1 ES200002811A ES200002811A ES2186501A1 ES 2186501 A1 ES2186501 A1 ES 2186501A1 ES 200002811 A ES200002811 A ES 200002811A ES 200002811 A ES200002811 A ES 200002811A ES 2186501 A1 ES2186501 A1 ES 2186501A1
- Authority
- ES
- Spain
- Prior art keywords
- collagen binding
- binding domain
- growth factor
- fibroblastic growth
- factor
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 102000008186 Collagen Human genes 0.000 title abstract 3
- 108010035532 Collagen Proteins 0.000 title abstract 3
- 229920001436 collagen Polymers 0.000 title abstract 3
- 230000003328 fibroblastic effect Effects 0.000 title abstract 2
- 239000003102 growth factor Substances 0.000 title abstract 2
- 108010047303 von Willebrand Factor Proteins 0.000 abstract 2
- 102100036537 von Willebrand factor Human genes 0.000 abstract 2
- 229960001134 von willebrand factor Drugs 0.000 abstract 2
- 108020004511 Recombinant DNA Proteins 0.000 abstract 1
- 206010052428 Wound Diseases 0.000 abstract 1
- 208000027418 Wounds and injury Diseases 0.000 abstract 1
- 125000003275 alpha amino acid group Chemical group 0.000 abstract 1
- 238000013270 controlled release Methods 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 229940124597 therapeutic agent Drugs 0.000 abstract 1
- 230000017423 tissue regeneration Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/475—Growth factors; Growth regulators
- C07K14/50—Fibroblast growth factor [FGF]
- C07K14/503—Fibroblast growth factor [FGF] basic FGF [bFGF]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biochemistry (AREA)
- Genetics & Genomics (AREA)
- Gastroenterology & Hepatology (AREA)
- Molecular Biology (AREA)
- Zoology (AREA)
- Toxicology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Dermatology (AREA)
- Biophysics (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Abstract
Factor de crecimiento fibroblástico básico con un dominio de unión específico a colágeno. La presente invención describe el diseño genético y la expresión a gran escala en Escherichia coli de un factor de crecimiento fibroblástico básico, con un dominio de unión específico a colágeno, así como su purificación y renaturalización hasta alcanzar su actividad biológica. La principal característica de este factor es la incorporación de un dominio auxiliar aminoacídico modificado, de alta afinidad de unión específica al colágeno, que posibilita su almacenamiento por tiempos prolongados y le permite ser dirigido a lugares específicos donde se precise de su actuación, controlando su liberación y preservando su bioestabilidad. Estas propiedades posibilitan el uso del factor como agente terapéutico, con un papel primordial en la cicatrización de heridas y en otros procesos de reparación tisular.
Priority Applications (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
ES200002811A ES2186501B1 (es) | 2000-11-23 | 2000-11-23 | Factor de crecimiento fibroblastico basico con un dominio de union especifico a colegeno. |
EP01997505A EP1357130A1 (en) | 2000-11-23 | 2001-11-23 | Basic fibroblastic growth factor with a specific collagen binding domain |
PCT/ES2001/000449 WO2002042331A1 (es) | 2000-11-23 | 2001-11-23 | Factor de crecimiento fibroblastico basico con un dominio de union especifico a colageno |
AU2002220756A AU2002220756A1 (en) | 2000-11-23 | 2001-11-23 | Basic fibroblastic growth factor with a specific collagen binding domain |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
ES200002811A ES2186501B1 (es) | 2000-11-23 | 2000-11-23 | Factor de crecimiento fibroblastico basico con un dominio de union especifico a colegeno. |
Publications (2)
Publication Number | Publication Date |
---|---|
ES2186501A1 true ES2186501A1 (es) | 2003-05-01 |
ES2186501B1 ES2186501B1 (es) | 2006-05-16 |
Family
ID=8495741
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES200002811A Expired - Fee Related ES2186501B1 (es) | 2000-11-23 | 2000-11-23 | Factor de crecimiento fibroblastico basico con un dominio de union especifico a colegeno. |
Country Status (4)
Country | Link |
---|---|
EP (1) | EP1357130A1 (es) |
AU (1) | AU2002220756A1 (es) |
ES (1) | ES2186501B1 (es) |
WO (1) | WO2002042331A1 (es) |
Families Citing this family (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2007073661A1 (fr) * | 2005-12-26 | 2007-07-05 | Yantai Zhenghai Bio-Technology Co., Ltd. | Matieres de squelette de collagene activees et leurs facteurs speciaux de restauration active fusionnee |
ES2342707B1 (es) * | 2008-12-31 | 2011-06-10 | Universidad De Malaga | Proteina morfogenetica de hueso-2 (bmp-2) con un dominio de union especifico a colageno tipo i, procedimiento de obtencion y aplicaciones. |
ES2417705B1 (es) * | 2012-01-04 | 2014-05-27 | Centro De Investigación Biomédica En Red En Bioingeniería, Biomateriales Y Nanomedicina (Ciber-Bbn) | Péptido biomimético rgd con dominio de afinidad por el colágeno tipo i y sus usos como factor osteogénico. |
Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1998044938A1 (en) * | 1997-04-10 | 1998-10-15 | University Of Southern California | Modified proteins which bind extracellular matrix components |
WO2000006195A1 (en) * | 1998-07-31 | 2000-02-10 | University Of Southern California | Targeting pharmaceutical agents to injured tissues |
WO2000049159A1 (en) * | 1999-02-19 | 2000-08-24 | Terumo Kabushiki Kaisha | Collagen-binding physiologically active polypeptide |
-
2000
- 2000-11-23 ES ES200002811A patent/ES2186501B1/es not_active Expired - Fee Related
-
2001
- 2001-11-23 WO PCT/ES2001/000449 patent/WO2002042331A1/es not_active Application Discontinuation
- 2001-11-23 AU AU2002220756A patent/AU2002220756A1/en not_active Abandoned
- 2001-11-23 EP EP01997505A patent/EP1357130A1/en not_active Withdrawn
Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1998044938A1 (en) * | 1997-04-10 | 1998-10-15 | University Of Southern California | Modified proteins which bind extracellular matrix components |
WO2000006195A1 (en) * | 1998-07-31 | 2000-02-10 | University Of Southern California | Targeting pharmaceutical agents to injured tissues |
WO2000049159A1 (en) * | 1999-02-19 | 2000-08-24 | Terumo Kabushiki Kaisha | Collagen-binding physiologically active polypeptide |
Non-Patent Citations (2)
Title |
---|
ANDRADES, J.A. et al. "A recombinant human TGF-Beta1 fusion protein with collagen-binding domain promotes migration, growth and differentiation of bone marrow mesenchymal cells". EXPERIMENTAL CELL RESEARCH, Vol. 250, 1999, pßginas 485-498. Todo el documento, especialmente pßgina 487, figura 1. * |
NISHI, N. et al. "Collagen-binding growth factors: Production and characterization of functional fusion proteins having a collagen-binding domain". PROC. NATL. ACAD. SCI. USA, Vol. 95, junio 1998, pßginas 7018-7023, todo el documento. * |
Also Published As
Publication number | Publication date |
---|---|
ES2186501B1 (es) | 2006-05-16 |
WO2002042331A1 (es) | 2002-05-30 |
AU2002220756A1 (en) | 2002-06-03 |
EP1357130A1 (en) | 2003-10-29 |
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Legal Events
Date | Code | Title | Description |
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EC2A | Search report published |
Date of ref document: 20030501 Kind code of ref document: A1 |
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FG2A | Definitive protection |
Ref document number: 2186501B1 Country of ref document: ES |
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FD2A | Announcement of lapse in spain |
Effective date: 20210302 |