ES2180433A1 - Use of haematopoietic stem cells in the generation of neural stem cells - Google Patents

Use of haematopoietic stem cells in the generation of neural stem cells

Info

Publication number
ES2180433A1
ES2180433A1 ES200101223A ES200101223A ES2180433A1 ES 2180433 A1 ES2180433 A1 ES 2180433A1 ES 200101223 A ES200101223 A ES 200101223A ES 200101223 A ES200101223 A ES 200101223A ES 2180433 A1 ES2180433 A1 ES 2180433A1
Authority
ES
Spain
Prior art keywords
stem cells
haematopoietic
generation
cells
haematopoietic stem
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
ES200101223A
Other languages
Spanish (es)
Other versions
ES2180433B1 (en
Inventor
Martinez Pedro Alarcon
Jimenez Sonia Bonilla
Gonzalez Augusto Gerardo Silva
Perez Salvador Martinez
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Universidad Miguel Hernandez de Elche UMH
Original Assignee
Universidad Miguel Hernandez de Elche UMH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Universidad Miguel Hernandez de Elche UMH filed Critical Universidad Miguel Hernandez de Elche UMH
Priority to ES200101223A priority Critical patent/ES2180433B1/en
Priority to PCT/ES2002/000253 priority patent/WO2002096439A1/en
Priority to IL15435602A priority patent/IL154356A0/en
Publication of ES2180433A1 publication Critical patent/ES2180433A1/en
Application granted granted Critical
Publication of ES2180433B1 publication Critical patent/ES2180433B1/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0618—Cells of the nervous system
    • C12N5/0623—Stem cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2506/00—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells
    • C12N2506/11—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from blood or immune system cells

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Biotechnology (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • Neurology (AREA)
  • Microbiology (AREA)
  • Cell Biology (AREA)
  • Neurosurgery (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Developmental Biology & Embryology (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

The invention relates to the production of neural stem cells consisting in cultivating haematopoietic stem cells in conditions that promote the growth and differentiation of said haematopoietic stem cells into neural stem cells which can be used to regenerate populations of cells lost in the nervous system. The invention also relates to the use of haematopoietic stem cells in the production of a pharmaceutical composition that is used to treat neurodegenerative diseases and/or pathological conditions involving degenerated neuronal cells, both in localised and multifocal processes.
ES200101223A 2001-05-28 2001-05-28 EMPLOYMENT OF HEMATOPOYETIC MOTHER CELLS IN THE GENERATION OF NEURAL MOTHER CELLS. Expired - Fee Related ES2180433B1 (en)

Priority Applications (3)

Application Number Priority Date Filing Date Title
ES200101223A ES2180433B1 (en) 2001-05-28 2001-05-28 EMPLOYMENT OF HEMATOPOYETIC MOTHER CELLS IN THE GENERATION OF NEURAL MOTHER CELLS.
PCT/ES2002/000253 WO2002096439A1 (en) 2001-05-28 2002-05-27 Use of haematopoietic stem cells in the generation of neural stem cells
IL15435602A IL154356A0 (en) 2001-05-28 2002-05-27 The use of haematopoietic stem cells in the generation of neural stem cells

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ES200101223A ES2180433B1 (en) 2001-05-28 2001-05-28 EMPLOYMENT OF HEMATOPOYETIC MOTHER CELLS IN THE GENERATION OF NEURAL MOTHER CELLS.

Publications (2)

Publication Number Publication Date
ES2180433A1 true ES2180433A1 (en) 2003-02-01
ES2180433B1 ES2180433B1 (en) 2004-05-16

Family

ID=8497869

Family Applications (1)

Application Number Title Priority Date Filing Date
ES200101223A Expired - Fee Related ES2180433B1 (en) 2001-05-28 2001-05-28 EMPLOYMENT OF HEMATOPOYETIC MOTHER CELLS IN THE GENERATION OF NEURAL MOTHER CELLS.

Country Status (3)

Country Link
ES (1) ES2180433B1 (en)
IL (1) IL154356A0 (en)
WO (1) WO2002096439A1 (en)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030194454A1 (en) 1998-07-28 2003-10-16 Bessette Steven M. Pesticidal compositions containing rosemary oil and wintergreen oil
WO2018071898A1 (en) * 2016-10-14 2018-04-19 Children's Medical Center Corporation Compositions and methods for treating diseases and disorders of the central nervous system
WO2018136434A1 (en) 2017-01-17 2018-07-26 Children's Medical Center Corporation Compositions and methods for diagnosing and treating peroxisomal diseases
CA3050691A1 (en) 2017-01-17 2018-07-26 Dana-Farber Cancer Institute, Inc. Compositions and methods for treating lysosomal storage diseases and disorders
CN107320495A (en) * 2017-06-19 2017-11-07 北正赛欧（北京）生物科技有限公司 Composition and its application for promoting cellular damage reparation

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999056759A1 (en) * 1998-05-07 1999-11-11 University Of South Florida Bone marrow cells as a source of neurons for brain and spinal cord repair
WO2000069448A1 (en) * 1999-05-14 2000-11-23 Henry Ford Health System Bone marrow transplantation for treatment of stroke
WO2001021766A2 (en) * 1999-09-23 2001-03-29 Cell Science Therapeutics Methods and devices for obtaining non-hematopoietic lineage cells from hematopoietic progenitor cells

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999056759A1 (en) * 1998-05-07 1999-11-11 University Of South Florida Bone marrow cells as a source of neurons for brain and spinal cord repair
WO2000069448A1 (en) * 1999-05-14 2000-11-23 Henry Ford Health System Bone marrow transplantation for treatment of stroke
WO2001021766A2 (en) * 1999-09-23 2001-03-29 Cell Science Therapeutics Methods and devices for obtaining non-hematopoietic lineage cells from hematopoietic progenitor cells

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
MEZEY EVA et al. Bone marrow: A possible alternative source of cells in the adult nervous system. (2000) European Journal of Pharmacology, Vol. 405, pßginas 297-302. *
REYES MORAYMA et al. Turning marrow into brain: Generation of glial and neuronal cells from adult bone marrow. (1999) Blood, Vol. 94, 10, Suppl. 1 Part 1, pßgina 377a. *
WOODBURY, DALE et al. Adult rat and human bone marrow stromal cells differentiate into neurons. (2000) Journal of Neuroscience Research, 61 (4), pßginas 364-370. *

Also Published As

Publication number Publication date
WO2002096439A1 (en) 2002-12-05
IL154356A0 (en) 2003-09-17
ES2180433B1 (en) 2004-05-16

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