ES2180115T3 - Procedimiento para la preparacion de productos precursores de medicamentos para comprimidos, pellets y grageas. - Google Patents

Procedimiento para la preparacion de productos precursores de medicamentos para comprimidos, pellets y grageas.

Info

Publication number
ES2180115T3
ES2180115T3 ES98123519T ES98123519T ES2180115T3 ES 2180115 T3 ES2180115 T3 ES 2180115T3 ES 98123519 T ES98123519 T ES 98123519T ES 98123519 T ES98123519 T ES 98123519T ES 2180115 T3 ES2180115 T3 ES 2180115T3
Authority
ES
Spain
Prior art keywords
pharmaceutical
preparation
drying
pressable
flowable
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES98123519T
Other languages
English (en)
Inventor
Heinz-Walter Dr Joseph
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bionorica AG
Original Assignee
Bionorica AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bionorica AG filed Critical Bionorica AG
Application granted granted Critical
Publication of ES2180115T3 publication Critical patent/ES2180115T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F26—DRYING
    • F26B—DRYING SOLID MATERIALS OR OBJECTS BY REMOVING LIQUID THEREFROM
    • F26B5/00—Drying solid materials or objects by processes not involving the application of heat
    • F26B5/04—Drying solid materials or objects by processes not involving the application of heat by evaporation or sublimation of moisture under reduced pressure, e.g. in a vacuum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/35—Caprifoliaceae (Honeysuckle family)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/51—Gentianaceae (Gentian family)
    • A61K36/515—Gentiana
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/70—Polygonaceae (Buckwheat family), e.g. spineflower or dock
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/85—Verbenaceae (Verbena family)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/899—Poaceae or Gramineae (Grass family), e.g. bamboo, corn or sugar cane
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2/00—Processes or devices for granulating materials, e.g. fertilisers in general; Rendering particulate materials free flowing in general, e.g. making them hydrophobic
    • B01J2/10—Processes or devices for granulating materials, e.g. fertilisers in general; Rendering particulate materials free flowing in general, e.g. making them hydrophobic in stationary drums or troughs, provided with kneading or mixing appliances

Landscapes

  • Health & Medical Sciences (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Veterinary Medicine (AREA)
  • Alternative & Traditional Medicine (AREA)
  • Biotechnology (AREA)
  • Botany (AREA)
  • Medical Informatics (AREA)
  • Public Health (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Mechanical Engineering (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Preparation (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Drying Of Solid Materials (AREA)

Abstract

Procedimiento para preparar un producto precursor de medicamento fluido, listo para comprimir, en el que se humedece material de droga vegetal desecado junto con los aditivos, portadores y/o coadyuvantes deseados, en una instalación de secado al vacío, con agua o una mezcla de agua/disolvente en una cantidad del 1% hasta el 5%, presentando la instalación de secado al vacío un dispositivo agitador de varios brazos con accionamiento propio que se extiende a través de una cámara cilíndrica de mezclado y secado, y se seca la mezcla húmeda a una temperatura de la camisa exterior del aparato de 20º C hasta 50º C, a una temperatura del producto de 20º C hasta 45º C y a una presión de 20 hasta 500 mbar, para obtener el producto precursor.
ES98123519T 1998-12-15 1998-12-15 Procedimiento para la preparacion de productos precursores de medicamentos para comprimidos, pellets y grageas. Expired - Lifetime ES2180115T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP98123519A EP1010461B1 (de) 1998-12-15 1998-12-15 Verfahren zur Herstellung von Arzneimittelvorprodukte für Tabletten, Pellets und Dragees

Publications (1)

Publication Number Publication Date
ES2180115T3 true ES2180115T3 (es) 2003-02-01

Family

ID=8233117

Family Applications (1)

Application Number Title Priority Date Filing Date
ES98123519T Expired - Lifetime ES2180115T3 (es) 1998-12-15 1998-12-15 Procedimiento para la preparacion de productos precursores de medicamentos para comprimidos, pellets y grageas.

Country Status (3)

Country Link
EP (1) EP1010461B1 (es)
AT (1) ATE219963T1 (es)
ES (1) ES2180115T3 (es)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE10112167C2 (de) 2001-03-12 2003-02-13 Bionorica Ag Verfahren zur schonenden Gewinnung von Trockenextrakten

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1991006365A1 (de) * 1989-10-26 1991-05-16 Glatt Maschinen- Und Apparatebau Ag Einrichtung und verfahren zum mischen und/oder granulieren eines gutes
DE19525026A1 (de) * 1995-07-10 1997-01-16 Plantamed Arzneimittel Gmbh Verfahren zur Herstellung von pharmazeutischen Zubereitungen mit höherem Gehalt an etherischen Ölen und Phenolen
DE19547973C2 (de) * 1995-12-21 1999-08-12 Plantamed Arzneimittel Gmbh Verfahren zur schonenden Keimreduzierung von pharmazeutischen Zubereitungen

Also Published As

Publication number Publication date
EP1010461A1 (de) 2000-06-21
ATE219963T1 (de) 2002-07-15
EP1010461B1 (de) 2002-07-03

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