ES2177583T3 - Nuevo compuesto tetraciclico. - Google Patents

Nuevo compuesto tetraciclico.

Info

Publication number
ES2177583T3
ES2177583T3 ES94927786T ES94927786T ES2177583T3 ES 2177583 T3 ES2177583 T3 ES 2177583T3 ES 94927786 T ES94927786 T ES 94927786T ES 94927786 T ES94927786 T ES 94927786T ES 2177583 T3 ES2177583 T3 ES 2177583T3
Authority
ES
Spain
Prior art keywords
tetraciclic
compound
new
immunosuppressant
remedy
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES94927786T
Other languages
English (en)
Inventor
Fumio Suzuki
Yoshisuke Nakasato
Hiroshi Tumuki
Soichiro Sato
Tadafumi Tamura
Hiroshi Nakajima
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
KH Neochem Co Ltd
Original Assignee
Kyowa Hakko Kogyo Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kyowa Hakko Kogyo Co Ltd filed Critical Kyowa Hakko Kogyo Co Ltd
Application granted granted Critical
Publication of ES2177583T3 publication Critical patent/ES2177583T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
    • C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
    • C07D221/04—Ortho- or peri-condensed ring systems
    • C07D221/18—Ring systems of four or more rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond

Abstract

UN COMPUESTO TETRACICLICO NUEVO REPRESENTADO POR LA FORMULA GENERAL (I) O UNA SAL FARMACOLOGICAMENTE ACEPTABLE DEL MISMO. POSEE UNA ACTIVIDAD INMUNOSUPRESIVA POTENTE Y ES UTIL COMO UN INMUNOSUPRESANTE Y UN REMEDIO PARA LAS ENFERMEDADES AUTOINMUNES.
ES94927786T 1993-09-28 1994-09-28 Nuevo compuesto tetraciclico. Expired - Lifetime ES2177583T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP24136093 1993-09-28

Publications (1)

Publication Number Publication Date
ES2177583T3 true ES2177583T3 (es) 2002-12-16

Family

ID=17073136

Family Applications (1)

Application Number Title Priority Date Filing Date
ES94927786T Expired - Lifetime ES2177583T3 (es) 1993-09-28 1994-09-28 Nuevo compuesto tetraciclico.

Country Status (8)

Country Link
US (1) US5646283A (es)
EP (1) EP0721942B1 (es)
AT (1) ATE218551T1 (es)
AU (1) AU7707094A (es)
CA (1) CA2150235A1 (es)
DE (1) DE69430752T2 (es)
ES (1) ES2177583T3 (es)
WO (1) WO1995009153A1 (es)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PL332416A1 (en) * 1996-09-23 1999-09-13 Rutgers Substituted heterocyclic compounds as anticarcinogenic agents
EP1237546A2 (en) * 1999-10-01 2002-09-11 Institute of Molecular and Cell Biology Dihydroorotate dehydrogenase inhibitors for the treatment of viral-mediated diseases
US6841561B1 (en) 1999-10-01 2005-01-11 Institute Of Molecular And Cell Biology Dihydroorotate dehydrogenase inhibitors for the treatment of viral-mediated diseases
US6740650B2 (en) 1999-10-29 2004-05-25 Rutgers, The State University Of New Jersey Heterocyclic cytotoxic agents
EP1453506B1 (en) * 2001-11-14 2008-04-02 Rutgers, The State University Topoisomerase poison agents
SI1465625T1 (sl) * 2001-11-14 2010-06-30 Univ Rutgers Solubilizirani topoizomerazni strupi
MXPA04004607A (es) * 2001-11-14 2004-09-10 Univ Rutgers Agentes de venenos de topoisomerasa solubilizados.
EP1453812B1 (en) * 2001-11-14 2008-08-20 Rutgers, The State University Cytotoxic agents
US6989387B2 (en) * 2002-08-09 2006-01-24 Rutgers, The State University Of New Jersey Nitro and amino substituted topoisomerase agents
AU2003268075A1 (en) * 2002-08-09 2004-02-25 Edmond J. Lavoie Nitro and amino substituted dibenzonaphthyridines as topoisomerase agents
WO2004014862A1 (en) * 2002-08-09 2004-02-19 Rutgers, The State University Nitro and amino substituted heterocycles as topoisomerase i targeting agents
CA2510337C (en) * 2002-11-12 2013-01-08 Rutgers, The State University Of New Jersey Topoisomerase-targeting agents
EP1768662A2 (en) 2004-06-24 2007-04-04 Novartis Vaccines and Diagnostics, Inc. Small molecule immunopotentiators and assays for their detection
US9185909B2 (en) * 2007-09-17 2015-11-17 The Trustees Of Columbia University In The City Of New York Synthesis of resveratrol-based natural products
US9562051B2 (en) 2009-03-06 2017-02-07 Rutgers, The State University Of New Jersey Methylenedioxybenzo [I] phenanthridine derivatives used to treat cancer
WO2010127363A1 (en) 2009-05-01 2010-11-04 Rutgers, The State University Of New Jersey Toposiomerase inhibitors
WO2011103442A2 (en) * 2010-02-18 2011-08-25 The Trustees Of Columbia University In The City Of New York Synthesis of the potent immunosuppressant agents dalesconol a and b
AU2014352920A1 (en) 2013-11-22 2016-06-23 Genzyme Corporation Novel methods for treating neurodegenerative diseases
EP3442979A4 (en) 2016-04-04 2019-12-18 Rutgers, the State University of New Jersey topoisomerase poisons

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH0233661A (ja) * 1988-07-22 1990-02-02 Sharp Corp 住所自動入力機能付文字処理装置
US4918077A (en) * 1989-01-25 1990-04-17 E. I. Du Pont De Nemours & Co., Inc. 3-phenyl-5,6-dihydrobenz(c)acridine-7-carboxylic acids and related compounds as cancer chemotherapeutic agents
US5135934A (en) * 1990-07-06 1992-08-04 Du Pont Merck Pharmaceutical Company 3-phenyl-5,6-dihydrobenz(c) acridine-7-carboxylic acids and related compounds as immunosuppressive agents
US5223506A (en) * 1991-06-04 1993-06-29 Glaxo Inc. Cyclic antitumor compounds
DK0601191T3 (da) * 1992-04-24 1999-04-26 Kyowa Hakko Kogyo Kk Hidtil ukendt tetracyklisk forbindelse
US5428040A (en) * 1993-08-31 1995-06-27 The Du Pont Merck Pharmaceutical Company Carbocyclic fused-ring quinolinecarboxylic acids useful as immunosuppressive agents

Also Published As

Publication number Publication date
EP0721942A4 (en) 1997-03-05
CA2150235A1 (en) 1995-04-06
DE69430752T2 (de) 2002-10-17
EP0721942B1 (en) 2002-06-05
DE69430752D1 (de) 2002-07-11
EP0721942A1 (en) 1996-07-17
AU7707094A (en) 1995-04-18
US5646283A (en) 1997-07-08
ATE218551T1 (de) 2002-06-15
WO1995009153A1 (fr) 1995-04-06

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