ES2175799T3 - Forma de dosificacion para administracion en aerosol. - Google Patents
Forma de dosificacion para administracion en aerosol.Info
- Publication number
- ES2175799T3 ES2175799T3 ES98950974T ES98950974T ES2175799T3 ES 2175799 T3 ES2175799 T3 ES 2175799T3 ES 98950974 T ES98950974 T ES 98950974T ES 98950974 T ES98950974 T ES 98950974T ES 2175799 T3 ES2175799 T3 ES 2175799T3
- Authority
- ES
- Spain
- Prior art keywords
- water
- aerosol
- administration
- dosage form
- container
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 239000000443 aerosol Substances 0.000 title abstract 2
- 239000002552 dosage form Substances 0.000 title 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 4
- 239000011159 matrix material Substances 0.000 abstract 2
- 239000008135 aqueous vehicle Substances 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 239000000463 material Substances 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/007—Pulmonary tract; Aromatherapy
- A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
- A61K9/0078—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy for inhalation via a nebulizer such as a jet nebulizer, ultrasonic nebulizer, e.g. in the form of aqueous drug solutions or dispersions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
- A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
- A61J1/14—Details; Accessories therefor
- A61J1/20—Arrangements for transferring or mixing fluids, e.g. from vial to syringe
- A61J1/2093—Containers having several compartments for products to be mixed
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M11/00—Sprayers or atomisers specially adapted for therapeutic purposes
- A61M11/02—Sprayers or atomisers specially adapted for therapeutic purposes operated by air or other gas pressure applied to the liquid or other product to be sprayed or atomised
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
- A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
- A61J1/14—Details; Accessories therefor
- A61J1/20—Arrangements for transferring or mixing fluids, e.g. from vial to syringe
- A61J1/2003—Accessories used in combination with means for transfer or mixing of fluids, e.g. for activating fluid flow, separating fluids, filtering fluid or venting
- A61J1/202—Separating means
- A61J1/2041—Separating means having removable plugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M11/00—Sprayers or atomisers specially adapted for therapeutic purposes
- A61M11/005—Sprayers or atomisers specially adapted for therapeutic purposes using ultrasonics
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicinal Chemistry (AREA)
- Pulmonology (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Dispersion Chemistry (AREA)
- Otolaryngology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Anesthesiology (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Hematology (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
Un kit farmacéutico para la administración de aerosol, que comprende: (a) una retícula de matriz abierta en estado sólido de un medicamento y un material de soporte soluble en agua o dispersable en agua aceptable farmacéuticamente contenido dentro de un primer envase substancialmente impermeable al agua; y (b) una cantidad suficiente de un vehículo acuoso para disolver en el espacio de quince segundos dicha retícula de matriz contenida dentro de un segundo envase substancialmente impermeable al agua.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US6136397P | 1997-10-08 | 1997-10-08 |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2175799T3 true ES2175799T3 (es) | 2002-11-16 |
Family
ID=22035318
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES98950974T Expired - Lifetime ES2175799T3 (es) | 1997-10-08 | 1998-10-07 | Forma de dosificacion para administracion en aerosol. |
Country Status (12)
Country | Link |
---|---|
US (1) | US6161536A (es) |
EP (1) | EP1021172B1 (es) |
JP (1) | JP2001518494A (es) |
KR (1) | KR20010024453A (es) |
AT (1) | ATE215820T1 (es) |
AU (1) | AU743174B2 (es) |
CA (1) | CA2301569A1 (es) |
DE (1) | DE69804832T2 (es) |
ES (1) | ES2175799T3 (es) |
HU (1) | HUP0003917A3 (es) |
NO (1) | NO20001747L (es) |
WO (1) | WO1999017754A1 (es) |
Families Citing this family (70)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6427682B1 (en) * | 1995-04-05 | 2002-08-06 | Aerogen, Inc. | Methods and apparatus for aerosolizing a substance |
US5758637A (en) | 1995-08-31 | 1998-06-02 | Aerogen, Inc. | Liquid dispensing apparatus and methods |
US6040344A (en) * | 1996-11-11 | 2000-03-21 | Sepracor Inc. | Formoterol process |
US6679249B2 (en) * | 1998-04-21 | 2004-01-20 | Pneumoflex Systems, L.L.C. | Apparatus for treatment of chronic obstructive pulmonary disease and associated method |
US6235177B1 (en) | 1999-09-09 | 2001-05-22 | Aerogen, Inc. | Method for the construction of an aperture plate for dispensing liquid droplets |
WO2001047491A1 (en) * | 1999-12-23 | 2001-07-05 | Coifman Robert E | Methods and formulations for the efficient delivery of water-insoluble drugs by nebulizer |
US7971588B2 (en) | 2000-05-05 | 2011-07-05 | Novartis Ag | Methods and systems for operating an aerosol generator |
US8336545B2 (en) | 2000-05-05 | 2012-12-25 | Novartis Pharma Ag | Methods and systems for operating an aerosol generator |
US7914470B2 (en) | 2001-01-12 | 2011-03-29 | Celleration, Inc. | Ultrasonic method and device for wound treatment |
US8235919B2 (en) | 2001-01-12 | 2012-08-07 | Celleration, Inc. | Ultrasonic method and device for wound treatment |
EP1353667A1 (en) * | 2001-01-25 | 2003-10-22 | Bristol-Myers Squibb Company | Parenteral formulations containing epothilone analogs |
ITMI20010428A1 (it) * | 2001-03-02 | 2002-09-02 | Chemo Breath S A | Composizioni ad uso inalatorio a base di formoterolo |
US20030055026A1 (en) | 2001-04-17 | 2003-03-20 | Dey L.P. | Formoterol/steroid bronchodilating compositions and methods of use thereof |
US6667344B2 (en) * | 2001-04-17 | 2003-12-23 | Dey, L.P. | Bronchodilating compositions and methods |
EG24184A (en) * | 2001-06-15 | 2008-10-08 | Otsuka Pharma Co Ltd | Dry powder inhalation system for transpulmonary |
US7261102B2 (en) * | 2001-09-12 | 2007-08-28 | Norton Healthcare Ltd. | Breath-enhanced ultrasonic nebulizer and dedicated unit dose ampoule |
WO2003035030A1 (en) * | 2001-10-24 | 2003-05-01 | Pari Gmbh | Kit for the preparation of a pharmaceutical composition |
CA2472644C (en) | 2002-01-07 | 2013-11-05 | Aerogen, Inc. | Devices and methods for nebulizing fluids for inhalation |
US7677467B2 (en) | 2002-01-07 | 2010-03-16 | Novartis Pharma Ag | Methods and devices for aerosolizing medicament |
WO2003059424A1 (en) | 2002-01-15 | 2003-07-24 | Aerogen, Inc. | Methods and systems for operating an aerosol generator |
ES2572770T3 (es) | 2002-05-20 | 2016-06-02 | Novartis Ag | Aparato para proporcionar pulverización para tratamiento médico y métodos |
US20040045546A1 (en) | 2002-09-05 | 2004-03-11 | Peirce Management, Llc | Pharmaceutical delivery system for oral inhalation through nebulization consisting of inert substrate impregnated with substance (S) to be solubilized or suspended prior to use |
DK1572217T3 (da) | 2002-12-12 | 2008-12-15 | Nycomed Gmbh | Kombinationsmedikament af R,R-formoterol og ciclesonid |
JP2006527237A (ja) | 2003-06-13 | 2006-11-30 | アルタナ ファルマ アクチエンゲゼルシャフト | ホルモテロールと及びシクレソニドの組合せ物 |
TWI359675B (en) * | 2003-07-10 | 2012-03-11 | Dey L P | Bronchodilating β-agonist compositions |
US8616195B2 (en) | 2003-07-18 | 2013-12-31 | Novartis Ag | Nebuliser for the production of aerosolized medication |
EP1742625A1 (en) * | 2004-04-05 | 2007-01-17 | Sepracor, Inc. | (r,r)-formoterol in combination with other pharmacological agents |
US7946291B2 (en) | 2004-04-20 | 2011-05-24 | Novartis Ag | Ventilation systems and methods employing aerosol generators |
US8546423B2 (en) | 2005-05-18 | 2013-10-01 | Mpex Pharmaceuticals, Inc. | Aerosolized fluoroquinolones and uses thereof |
DK1901749T3 (en) | 2005-05-18 | 2016-10-24 | Raptor Pharmaceuticals Inc | Aerosolized fluoroquinolones AND USES THEREOF |
CA2607747C (en) | 2005-05-25 | 2015-12-01 | Aerogen, Inc. | Vibration systems and methods |
US7713218B2 (en) * | 2005-06-23 | 2010-05-11 | Celleration, Inc. | Removable applicator nozzle for ultrasound wound therapy device |
US7785277B2 (en) | 2005-06-23 | 2010-08-31 | Celleration, Inc. | Removable applicator nozzle for ultrasound wound therapy device |
US9101949B2 (en) | 2005-08-04 | 2015-08-11 | Eilaz Babaev | Ultrasonic atomization and/or seperation system |
US20080319079A1 (en) * | 2005-11-23 | 2008-12-25 | Feanny Stephen J | Method for Administering Formoterol Using a Nebulizer |
KR101405545B1 (ko) | 2005-11-28 | 2014-07-03 | 마리누스 파마슈티컬스 | ganaxolone 제형, 이의 제조방법 및 용도 |
DE102005057685A1 (de) * | 2005-12-01 | 2007-06-06 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Inhalator und Speicher für eine trockene Arzneimittelformulierung sowie diesbezügliche Verfahren und Verwendung |
US20080230053A1 (en) | 2006-09-15 | 2008-09-25 | Board Of Regents, The University Of Texas System | Pulse drug nebulization systems, formulations therefore, and methods of use |
EP2101735A2 (en) * | 2006-11-28 | 2009-09-23 | Marinus Pharmaceuticals, Inc. | Nanoparticulate formulations and methods for the making and use thereof |
US8491521B2 (en) | 2007-01-04 | 2013-07-23 | Celleration, Inc. | Removable multi-channel applicator nozzle |
US9849254B2 (en) * | 2007-05-15 | 2017-12-26 | Caddo Medical Technologies Llc | Pre-filled, small-volume nebulizer |
WO2009088553A1 (en) | 2007-10-22 | 2009-07-16 | Board Of Regents, The University Of Texas System | Dry powder drug delivery formulations, methods of use, and devices therefore |
PT2346509T (pt) | 2008-10-07 | 2020-08-05 | Horizon Orphan Llc | Inalação de levofloxacina para redução da inflamação pulmonar |
NO2344129T3 (es) | 2008-10-07 | 2018-07-21 | ||
US8534031B2 (en) * | 2008-12-30 | 2013-09-17 | Bausch & Lomb Incorporated | Packaging solutions |
SI2473170T1 (sl) | 2009-09-04 | 2019-10-30 | Horizon Orphan Llc | Uporaba aerosoliziranega levofloksacina za zdravljenje cistične fibroze |
JP5494186B2 (ja) * | 2010-04-28 | 2014-05-14 | オムロンヘルスケア株式会社 | ネブライザキットおよびネブライザ |
AU2012212269B2 (en) | 2011-01-31 | 2016-05-19 | Avalyn Pharma Inc. | Aerosol pirfenidone and pyridone analog compounds and uses thereof |
GB201111250D0 (en) * | 2011-07-01 | 2011-08-17 | Univ Central Lancashire | Method of producing a nebuliser composition |
EP2877164B1 (en) | 2012-07-24 | 2023-07-05 | Avalyn Pharma Inc. | Aerosol pirfenidone and pyridone analog compounds |
US9662345B2 (en) * | 2013-06-14 | 2017-05-30 | Professional Compounding Centers Of America | Antibiotic composition for inhalation and irrigation |
CA3172586A1 (en) | 2013-07-31 | 2015-02-05 | Avalyn Pharma Inc. | Aerosol imatininb compounds and uses thereof |
AU2014355072A1 (en) | 2013-11-26 | 2016-06-02 | Alliqua Biomedical, Inc. | Systems and methods for producing and delivering ultrasonic therapies for wound treatment and healing |
KR102518846B1 (ko) | 2016-08-11 | 2023-04-05 | 오비드 테라퓨틱스 인크. | 간질 장애의 치료를 위한 방법 및 조성물 |
JP6853275B2 (ja) * | 2016-12-05 | 2021-03-31 | 微邦科技股▲ふん▼有限公司Microbase Technology Corp. | 切替え可能な部分を有するエアゾール発生装置 |
WO2019110099A1 (en) | 2017-12-06 | 2019-06-13 | Qrumpharma Inc. | Inhalable clofazimine formulation |
US20210100963A1 (en) * | 2018-04-05 | 2021-04-08 | Royal Melbourne Institute Of Technology | Multi Surface Acoustic Nebuliser |
CA3109572A1 (en) | 2018-08-23 | 2020-02-27 | Mannkind Corporation | Compositions of clofazimine, combinations comprising them, processes for their preparation, uses and methods comprising them |
US11266662B2 (en) | 2018-12-07 | 2022-03-08 | Marinus Pharmaceuticals, Inc. | Ganaxolone for use in prophylaxis and treatment of postpartum depression |
JP2022512208A (ja) | 2018-12-13 | 2022-02-02 | マンカインド コーポレイション | ベダキリンの組成物、それらを含む組み合わせ、それらを調製するための方法、それらを含む使用及び治療方法 |
JP2023510661A (ja) | 2019-06-04 | 2023-03-15 | サーティー ホールディングス リミテッド | 窒素酸化物を生成するための方法及び組成物、並びにそれらの使用 |
BR112021023632A2 (pt) | 2019-06-04 | 2022-04-19 | Thirty Respiratory Ltd | Métodos e composições para gerar óxido nítrico e usos do mesmo para entregar óxido nítrico através do trato respiratório |
MX2022001553A (es) | 2019-08-05 | 2022-04-18 | Marinus Pharmaceuticals Inc | Ganaxolona para su uso en el tratamiento del estado epileptico. |
MX2022006014A (es) | 2019-12-06 | 2022-06-22 | Marinus Pharmaceuticals Inc | Ganaxolona para uso en el tratamiento del complejo de esclerosis tuberosa. |
GB2586301B (en) | 2020-04-07 | 2021-08-25 | Splash Tm Gmbh | Stable-Foam inhalation Device and Cartridge |
JP2023526583A (ja) | 2020-04-23 | 2023-06-22 | サーティー レスピラトリー リミテッド | 結核を治療及び抑制するための方法及び組成物 |
CN115884758A (zh) | 2020-04-23 | 2023-03-31 | 三十呼吸有限公司 | 用于治疗SARS-CoV和SARS-CoV-2的一氧化氮或释放一氧化氮的组合物 |
IL298698A (en) | 2020-06-01 | 2023-02-01 | Advent Therapeutics Inc | Pharmaceutical preparations that include insoluble active ingredients |
WO2022240897A1 (en) | 2021-05-10 | 2022-11-17 | Sepelo Therapeutics, Llc | Pharmaceutical composition comprising delafloxacin for administration into the lung |
WO2023028364A1 (en) | 2021-08-27 | 2023-03-02 | Sepelo Therapeutics, Llc | Targeted compositions and uses therof |
Family Cites Families (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3898338A (en) * | 1971-10-07 | 1975-08-05 | Mead Johnson & Co | 1,4-Bis-acylpiperazine mucolytic process |
IE45770B1 (en) * | 1976-10-06 | 1982-11-17 | Wyeth John & Brother Ltd | Pharmaceutical dosage forms |
GB1548022A (en) * | 1976-10-06 | 1979-07-04 | Wyeth John & Brother Ltd | Pharmaceutial dosage forms |
US4089432A (en) * | 1977-05-06 | 1978-05-16 | The Upjohn Company | Vial and closure |
US4194640A (en) * | 1977-05-06 | 1980-03-25 | The Upjohn Company | Vial and closure |
US4274543A (en) * | 1978-01-23 | 1981-06-23 | The Upjohn Company | Vial and closure structure |
US4267925A (en) * | 1979-10-01 | 1981-05-19 | The Upjohn Company | Closure for large-volume vial |
US4258845A (en) * | 1979-11-20 | 1981-03-31 | The Upjohn Company | Activator closure for two-compartment vial |
US4331233A (en) * | 1980-05-30 | 1982-05-25 | The Upjohn Company | Activation closure for vial |
HU219349B (en) * | 1991-12-24 | 2001-03-28 | Yamanouchi Pharma Co Ltd | Intrabuccally disintegrating preparation and production thereof |
US5215079A (en) * | 1992-05-19 | 1993-06-01 | Armstrong Pharmaceuticals, Inc. | Single dose metered dose inhaler for delivery of vaccines and other drugs |
US5586550A (en) * | 1995-08-31 | 1996-12-24 | Fluid Propulsion Technologies, Inc. | Apparatus and methods for the delivery of therapeutic liquids to the respiratory system |
WO1997035882A1 (en) * | 1996-03-27 | 1997-10-02 | Ortho Pharmaceutical Corporation | Lyophilized pulmonary surfactant peptide compositions |
-
1998
- 1998-10-07 CA CA 2301569 patent/CA2301569A1/en not_active Abandoned
- 1998-10-07 AT AT98950974T patent/ATE215820T1/de not_active IP Right Cessation
- 1998-10-07 JP JP2000514626A patent/JP2001518494A/ja active Pending
- 1998-10-07 EP EP98950974A patent/EP1021172B1/en not_active Expired - Lifetime
- 1998-10-07 KR KR1020007003759A patent/KR20010024453A/ko not_active Application Discontinuation
- 1998-10-07 AU AU96879/98A patent/AU743174B2/en not_active Ceased
- 1998-10-07 WO PCT/US1998/021115 patent/WO1999017754A1/en not_active Application Discontinuation
- 1998-10-07 DE DE1998604832 patent/DE69804832T2/de not_active Expired - Fee Related
- 1998-10-07 US US09/168,216 patent/US6161536A/en not_active Expired - Fee Related
- 1998-10-07 HU HU0003917A patent/HUP0003917A3/hu unknown
- 1998-10-07 ES ES98950974T patent/ES2175799T3/es not_active Expired - Lifetime
-
2000
- 2000-04-05 NO NO20001747A patent/NO20001747L/no not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
DE69804832D1 (de) | 2002-05-16 |
NO20001747D0 (no) | 2000-04-05 |
WO1999017754A1 (en) | 1999-04-15 |
JP2001518494A (ja) | 2001-10-16 |
HUP0003917A3 (en) | 2001-04-28 |
EP1021172B1 (en) | 2002-04-10 |
AU9687998A (en) | 1999-04-27 |
EP1021172A1 (en) | 2000-07-26 |
US6161536A (en) | 2000-12-19 |
KR20010024453A (ko) | 2001-03-26 |
HUP0003917A2 (en) | 2001-03-28 |
CA2301569A1 (en) | 1999-04-15 |
NO20001747L (no) | 2000-04-05 |
DE69804832T2 (de) | 2002-11-07 |
ATE215820T1 (de) | 2002-04-15 |
AU743174B2 (en) | 2002-01-17 |
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