ES2173846T3 - Compuestos de biciclocarbonil indol como agentes antiinflamatorios/analgesicos y como inhibidores de cox-2. - Google Patents
Compuestos de biciclocarbonil indol como agentes antiinflamatorios/analgesicos y como inhibidores de cox-2.Info
- Publication number
- ES2173846T3 ES2173846T3 ES00305372T ES00305372T ES2173846T3 ES 2173846 T3 ES2173846 T3 ES 2173846T3 ES 00305372 T ES00305372 T ES 00305372T ES 00305372 T ES00305372 T ES 00305372T ES 2173846 T3 ES2173846 T3 ES 2173846T3
- Authority
- ES
- Spain
- Prior art keywords
- halo
- alkyl
- substituted
- biciclocarbonil
- indol
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Rheumatology (AREA)
- Pain & Pain Management (AREA)
- Immunology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Indole Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
Un compuesto de la fórmula **fórmula** o las sales farmacéuticamente aceptables del mismo, en la que A es alquileno C1-6 o NR1 -; Z es C(=L)R2, o SO2R3; U es CH o N; W e Y se seleccionan independientemente entreCH2-, O, S y N-R1; m es 1, 2 ó 3; q y r son, independientemente, 0, 1 ó 2; X se selecciona independientemente a partir de halógeno, alquilo C1-4, alquilo C1-4 sustituido con halógeno, hidroxi, alcoxi C1-4, alcoxi C1-4 sustituido con halógeno, alquil C1-4-tio, nitro, amino, mono o di-(alquil C1-4)amino y ciano; n es 0, 1, 2, 3 ó 4; L es oxígeno o azufre; R1 es hidrógeno o alquilo C1-4; R2 es hidroxi, alquilo C1-6, alquilo C1-6 sustituido con halógeno, alcoxi C1-6, alcoxi C1-6 sustituido con halógeno, cicloalcoxilo C3-7, alquil-C1-4 (cicloalcoxil C3- 7), -N-R4R5, alquil C1-4 -fenil-O- o fenil-O-, estando dicho fenilo sustituido opcionalmente con 1 a 5 sustituyentes seleccionados independientemente a partir de halógeno, alquilo C1-4, hidroxi, alcoxi C1-4 y nitro; R3 es un alquilo C1-6 oun alquilo C1-6 sustituido con halógeno; y R4 y R5 se seleccionan independientemente entre hidrógeno, alquilo C1-6 y alquilo C1-6 sustituido con halógeno.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IBPCT/IB99/01243 | 1999-07-02 |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2173846T3 true ES2173846T3 (es) | 2002-11-01 |
Family
ID=11004872
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES00305372T Expired - Lifetime ES2173846T3 (es) | 1999-07-02 | 2000-06-26 | Compuestos de biciclocarbonil indol como agentes antiinflamatorios/analgesicos y como inhibidores de cox-2. |
Country Status (11)
Country | Link |
---|---|
US (1) | US6303628B1 (es) |
EP (1) | EP1065204B1 (es) |
JP (1) | JP3333179B2 (es) |
AT (1) | ATE215945T1 (es) |
BR (1) | BR0002936A (es) |
CA (1) | CA2313122C (es) |
DE (1) | DE60000120T2 (es) |
DK (1) | DK1065204T3 (es) |
ES (1) | ES2173846T3 (es) |
MX (1) | MXPA00006605A (es) |
PT (1) | PT1065204E (es) |
Families Citing this family (31)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20040072889A1 (en) * | 1997-04-21 | 2004-04-15 | Pharmacia Corporation | Method of using a COX-2 inhibitor and an alkylating-type antineoplastic agent as a combination therapy in the treatment of neoplasia |
US20030119895A1 (en) * | 1998-12-23 | 2003-06-26 | Pharmacia Corporation | Methods using a combination of a 3-heteroaryl-2-indolinone and a cyclooxygenase-2 inhibitor for the treatment of neoplasia |
US20020103141A1 (en) * | 1998-12-23 | 2002-08-01 | Mckearn John P. | Antiangiogenic combination therapy for the treatment of cancer |
US20030203956A1 (en) * | 1998-12-23 | 2003-10-30 | Masterrer Jaime L. | Method of using a cyclooxygenase-2 inhibitor and one or more ornithine decarboxylase inhibitors as a combination therapy in the treatment of neoplasia |
US20030013739A1 (en) * | 1998-12-23 | 2003-01-16 | Pharmacia Corporation | Methods of using a combination of cyclooxygenase-2 selective inhibitors and thalidomide for the treatment of neoplasia |
DE10129320A1 (de) * | 2001-06-19 | 2003-04-10 | Norbert Mueller | Verwendung von COX-2 Inhibitoren zur Behandlung von Schizophrenie, wahnhaften Störungen, affektiven Störungen oder Ticstörungen |
US20060167074A1 (en) * | 2001-06-19 | 2006-07-27 | Norbert Muller | Methods and compositions for the treatment of psychiatric disorders |
SI1438289T1 (es) * | 2001-09-27 | 2005-08-31 | Hoffmann La Roche | |
US8425892B2 (en) * | 2001-10-29 | 2013-04-23 | Columbia Laboratories, Inc. | Extended, controlled-release pharmaceutical compositions using charged polymers |
US20030157061A1 (en) * | 2001-12-05 | 2003-08-21 | Pharmacia Corporation | Combinations of a cyclooxygenase-2 selective inhibitor and a TNFalpha antagonist and therapeutic uses therefor |
US20030220374A1 (en) * | 2002-01-14 | 2003-11-27 | Pharmacia Corporation | Compositions and methods of treatment involving peroxisome proliferator-activated receptor-gamma agonists and cyclooxygenase-2 selective inhibitors |
US20030212138A1 (en) * | 2002-01-14 | 2003-11-13 | Pharmacia Corporation | Combinations of peroxisome proliferator-activated receptor-alpha agonists and cyclooxygenase-2 selective inhibitors and therapeutic uses therefor |
US20040034083A1 (en) * | 2002-04-18 | 2004-02-19 | Stephenson Diane T. | Combination therapy for the treatment of Parkinson's disease with cyclooxygenase-2 (COX2) inhibitor(s) |
CA2482510A1 (en) * | 2002-04-18 | 2003-10-30 | Pharmacia Corporation | Monotherapy for the treatment of parkinson`s disease with cyclooxygenase-2 (cox 2) inhibitor(s) |
US20040147581A1 (en) * | 2002-11-18 | 2004-07-29 | Pharmacia Corporation | Method of using a Cox-2 inhibitor and a 5-HT1A receptor modulator as a combination therapy |
CA2509605C (en) | 2002-12-13 | 2010-10-05 | Warner-Lambert Company Llc | Alpha-2-delta ligand to treat lower urinary tract symptoms |
EP1572678A4 (en) * | 2002-12-19 | 2008-05-07 | Elan Pharm Inc | SUBSTITUTED N-PHENYL SULPHONAMIDES ALSBRADYKININ ANTAGONISTS |
US20040220155A1 (en) * | 2003-03-28 | 2004-11-04 | Pharmacia Corporation | Method of providing a steroid-sparing benefit with a cyclooxygenase-2 inhibitor and compositions therewith |
WO2005009342A2 (en) * | 2003-07-16 | 2005-02-03 | Pharmacia Corporation | Method for the treatment or prevention of dermatological disorders with a cyclooxygenase-2 inhibitor alone and in combination with a dermatological treatment agent and compositions therewith |
US20050119262A1 (en) * | 2003-08-21 | 2005-06-02 | Pharmacia Corporation | Method for preventing or treating an optic neuropathy with a cox-2 inhibitor and an intraocular pressure reducing agent |
WO2005023189A2 (en) * | 2003-09-03 | 2005-03-17 | Pharmacia Corporation | Method of cox-2 selective inhibitor and nitric oxide-donating agent |
EP1708718A1 (en) | 2004-01-22 | 2006-10-11 | Pfizer Limited | Triazole derivatives which inhibit vasopressin antagonistic activity |
JP2007534740A (ja) * | 2004-04-28 | 2007-11-29 | ファイザー・インク | バソプレッシンV1a受容体の阻害剤としての3−ヘテロシクリル−4−フェニル−トリアゾール誘導体 |
AU2006244393B2 (en) * | 2005-05-05 | 2012-06-21 | Cook Biotech Incorporated | Implantable materials and methods for inhibiting tissue adhesion formation |
EA017171B1 (ru) | 2006-12-22 | 2012-10-30 | Рекордати Айерленд Лимитед | КОМБИНИРОВАННАЯ ТЕРАПИЯ ЗАБОЛЕВАНИЙ НИЖНИХ МОЧЕВЫВОДЯЩИХ ПУТЕЙ С ИСПОЛЬЗОВАНИЕМ ЛИГАНДОВ αδ И НЕСТЕРОИДНЫХ ПРОТИВОВОСПАЛИТЕЛЬНЫХ ПРЕПАРАТОВ (НПВП) |
BR112014026305A2 (pt) | 2012-04-24 | 2017-06-27 | Chugai Pharmaceutical Co Ltd | derivado de quinazolidinadiona |
JP6177768B2 (ja) | 2012-04-24 | 2017-08-09 | 中外製薬株式会社 | ベンズアミド誘導体 |
CA2927830A1 (en) | 2013-10-23 | 2015-04-30 | Chugai Seiyaku Kabushiki Kaisha | Quinazolinone and isoquinolinone derivative |
JP6820854B2 (ja) * | 2015-01-18 | 2021-01-27 | エスアールアイ インターナショナルSRI International | Map4k4(hgk)インヒビター |
US9808443B1 (en) | 2016-11-28 | 2017-11-07 | King Saud University | Cyclooxygenase inhibitors |
CA3209491A1 (en) | 2021-03-15 | 2022-09-22 | Saul Yedgar | Hyaluronic acid-conjugated dipalmitoyl phosphatidyl ethanolamine in combination with non-steroidal anti-inflammatory drugs (nsaids) for treating or alleviating inflammatory disease |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5284862A (en) * | 1991-03-18 | 1994-02-08 | Warner-Lambert Company | Derivatives of 2-carboxyindoles having pharmaceutical activity |
US5436265A (en) * | 1993-11-12 | 1995-07-25 | Merck Frosst Canada, Inc. | 1-aroyl-3-indolyl alkanoic acids and derivatives thereof useful as anti-inflammatory agents |
US5510368A (en) * | 1995-05-22 | 1996-04-23 | Merck Frosst Canada, Inc. | N-benzyl-3-indoleacetic acids as antiinflammatory drugs |
IL120724A0 (en) | 1995-09-01 | 1997-08-14 | Lilly Co Eli | Indolyl neuropeptide Y receptor antagonists |
AP9801302A0 (en) * | 1997-07-23 | 2000-01-23 | Pfizer | Indole compounds as anti-inflammatory/analgesic agents.. |
AP869A (en) * | 1998-01-05 | 2000-09-04 | Pfizer | 2,3-Substituted indole compounds as anti-inflammatory and analgesic agents. |
-
1999
- 1999-07-02 MX MXPA00006605A patent/MXPA00006605A/es active IP Right Grant
-
2000
- 2000-06-26 ES ES00305372T patent/ES2173846T3/es not_active Expired - Lifetime
- 2000-06-26 EP EP00305372A patent/EP1065204B1/en not_active Expired - Lifetime
- 2000-06-26 PT PT00305372T patent/PT1065204E/pt unknown
- 2000-06-26 DK DK00305372T patent/DK1065204T3/da active
- 2000-06-26 AT AT00305372T patent/ATE215945T1/de not_active IP Right Cessation
- 2000-06-26 DE DE60000120T patent/DE60000120T2/de not_active Expired - Fee Related
- 2000-06-28 US US09/605,811 patent/US6303628B1/en not_active Expired - Fee Related
- 2000-06-29 JP JP2000195996A patent/JP3333179B2/ja not_active Expired - Fee Related
- 2000-06-29 CA CA002313122A patent/CA2313122C/en not_active Expired - Fee Related
- 2000-06-30 BR BR0002936-0A patent/BR0002936A/pt not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
CA2313122C (en) | 2004-08-24 |
EP1065204A4 (en) | 2000-11-15 |
DK1065204T3 (da) | 2002-07-22 |
JP2001031677A (ja) | 2001-02-06 |
CA2313122A1 (en) | 2001-01-02 |
EP1065204A1 (en) | 2001-01-03 |
JP3333179B2 (ja) | 2002-10-07 |
EP1065204B1 (en) | 2002-04-10 |
DE60000120D1 (de) | 2002-05-16 |
BR0002936A (pt) | 2001-04-03 |
PT1065204E (pt) | 2002-08-30 |
US6303628B1 (en) | 2001-10-16 |
ATE215945T1 (de) | 2002-04-15 |
DE60000120T2 (de) | 2002-08-14 |
MXPA00006605A (es) | 2004-12-09 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FG2A | Definitive protection |
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