ES2172436A1 - Indolylpiperidine derivatives as antihistaminic and antiallergic agents - Google Patents

Indolylpiperidine derivatives as antihistaminic and antiallergic agents

Info

Publication number
ES2172436A1
ES2172436A1 ES200002615A ES200002615A ES2172436A1 ES 2172436 A1 ES2172436 A1 ES 2172436A1 ES 200002615 A ES200002615 A ES 200002615A ES 200002615 A ES200002615 A ES 200002615A ES 2172436 A1 ES2172436 A1 ES 2172436A1
Authority
ES
Spain
Prior art keywords
group
antihistaminic
groups
antiallergic agents
alkoxy
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
ES200002615A
Other languages
Spanish (es)
Other versions
ES2172436B1 (en
Inventor
Pou Silvia Fonquerna
Santacana Lluis Pages
Duran Carles Puig
Pueyo Lidia Soca
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Almirall SA
Original Assignee
Almirall Prodesfarma SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to ES200002615A priority Critical patent/ES2172436B1/en
Application filed by Almirall Prodesfarma SA filed Critical Almirall Prodesfarma SA
Priority to DE60118434T priority patent/DE60118434T2/en
Priority to DK01992709T priority patent/DK1330453T3/en
Priority to AU2002223655A priority patent/AU2002223655A1/en
Priority to PCT/EP2001/012450 priority patent/WO2002036589A1/en
Priority to SI200130521T priority patent/SI1330453T1/en
Priority to AT01992709T priority patent/ATE321761T1/en
Priority to CA002427589A priority patent/CA2427589A1/en
Priority to ES01992709T priority patent/ES2259052T3/en
Priority to EP01992709A priority patent/EP1330453B1/en
Priority to JP2002539348A priority patent/JP4184785B2/en
Priority to US10/415,693 priority patent/US7189741B2/en
Priority to PT01992709T priority patent/PT1330453E/en
Priority to MYPI20015021A priority patent/MY155914A/en
Priority to PE2001001079A priority patent/PE20020543A1/en
Priority to ARP010105068A priority patent/AR031168A1/en
Priority to UY27001A priority patent/UY27001A1/en
Publication of ES2172436A1 publication Critical patent/ES2172436A1/en
Application granted granted Critical
Publication of ES2172436B1 publication Critical patent/ES2172436B1/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/02—Nasal agents, e.g. decongestants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/04—Antipruritics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/14—Decongestants or antiallergics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/16—Otologicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pulmonology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Dermatology (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Otolaryngology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

The invention relates to indolyl piperidinyl derivatives of formula (I) wherein: A<1> represents an alkylene, alkyleneoxy, alkylenethio, alkanoylene or hydroxyalkylene group A<2> represents an alkylene, alkyleneoxy, alkylenethio, alkanoylene or an alkyleneoxyalkylene group W<1> represents a phenylene, furanylene or pyridinylene group which is unsubstituted or substituted by one or more halogen atoms, alkoxy groups and/or alkyl groups W<2> represents a 3-10 membered monocyclic or bicyclic group containing from 1 to 3 heteroatoms said group being unsubstituted or substituted by one or more halogen atoms, alkyl groups, alkoxy groups and/or oxo groups R<1> represents a hydrogen or halogen atom or an alkyl, alkoxy or methylamino group and R<2> represents a carboxyl group and pharmaceutically acceptable salts thereof to processes for their preparation to pharmaceutical compositions containing them and to their medical use as antihistaminic and antiallergic agents.
ES200002615A 2000-10-31 2000-10-31 INDOLILPIPERIDINE DERIVATIVES AS ANTIHISTAMINIC AND ANTIALERGIC AGENTS. Expired - Fee Related ES2172436B1 (en)

Priority Applications (17)

Application Number Priority Date Filing Date Title
ES200002615A ES2172436B1 (en) 2000-10-31 2000-10-31 INDOLILPIPERIDINE DERIVATIVES AS ANTIHISTAMINIC AND ANTIALERGIC AGENTS.
PT01992709T PT1330453E (en) 2000-10-31 2001-10-26 INDOLILPIPERIDINE DERIVATIVES AS ANTIHISTAMINIC AND ANTIALERGIC AGENTS
AU2002223655A AU2002223655A1 (en) 2000-10-31 2001-10-26 Indolylpiperidine derivatives as antihistaminic and antiallergic agents
PCT/EP2001/012450 WO2002036589A1 (en) 2000-10-31 2001-10-26 Indolylpiperidine derivatives as antihistaminic and antiallergic agents
SI200130521T SI1330453T1 (en) 2000-10-31 2001-10-26 Indolylpiperidine derivatives as antihistaminic and antiallergic agents
AT01992709T ATE321761T1 (en) 2000-10-31 2001-10-26 INDOLYLPIPERIDINE DERIVATIVES AS ANTHISTAMINIC AND ANTIALLERGIC AGENTS
CA002427589A CA2427589A1 (en) 2000-10-31 2001-10-26 Indolylpiperidine derivatives as antihistaminic and antiallergic agents
ES01992709T ES2259052T3 (en) 2000-10-31 2001-10-26 INDOLIPIPERIDINE DERIVATIVES AS ANTIHISTAMINIC AND ANTIALERGIC AGENTS.
DE60118434T DE60118434T2 (en) 2000-10-31 2001-10-26 INDOLYLPIPERIDINE DERIVATIVES AS ANTIHISTAMINIC AND ANTIALLERGIC AGENTS
JP2002539348A JP4184785B2 (en) 2000-10-31 2001-10-26 Indolylpiperidine derivatives as antihistamines and antiallergic agents
US10/415,693 US7189741B2 (en) 2000-10-31 2001-10-26 Indolylpiperidine derivatives as antihistaminic and antiallergic agents
DK01992709T DK1330453T3 (en) 2000-10-31 2001-10-26 Indolylpiperidine derivatives as antihistamine and anti-allergy agents
EP01992709A EP1330453B1 (en) 2000-10-31 2001-10-26 Indolylpiperidine derivatives as antihistaminic and antiallergic agents
MYPI20015021A MY155914A (en) 2000-10-31 2001-10-30 Indolylpiperidine derivatives as antihistaminic and antiallergic agents
PE2001001079A PE20020543A1 (en) 2000-10-31 2001-10-30 INDOLYLPIPERIDINE DERIVATIVES AS ANTIHISTAMINE AND ANTI-ALLERGIC AGENTS
ARP010105068A AR031168A1 (en) 2000-10-31 2001-10-30 DERIVATIVES OF INDOLILPIPERIDINE AS ANTIHISTAMINIC AND ANTIALERGIC AGENTS
UY27001A UY27001A1 (en) 2000-10-31 2001-10-31 DERIVATIVES OF INDOLYL PIPERIDINE AS ANTIHISTAMINE AND ANTI-ALLERGIC AGENTS

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ES200002615A ES2172436B1 (en) 2000-10-31 2000-10-31 INDOLILPIPERIDINE DERIVATIVES AS ANTIHISTAMINIC AND ANTIALERGIC AGENTS.

Publications (2)

Publication Number Publication Date
ES2172436A1 true ES2172436A1 (en) 2002-09-16
ES2172436B1 ES2172436B1 (en) 2004-01-16

Family

ID=8495472

Family Applications (2)

Application Number Title Priority Date Filing Date
ES200002615A Expired - Fee Related ES2172436B1 (en) 2000-10-31 2000-10-31 INDOLILPIPERIDINE DERIVATIVES AS ANTIHISTAMINIC AND ANTIALERGIC AGENTS.
ES01992709T Expired - Lifetime ES2259052T3 (en) 2000-10-31 2001-10-26 INDOLIPIPERIDINE DERIVATIVES AS ANTIHISTAMINIC AND ANTIALERGIC AGENTS.

Family Applications After (1)

Application Number Title Priority Date Filing Date
ES01992709T Expired - Lifetime ES2259052T3 (en) 2000-10-31 2001-10-26 INDOLIPIPERIDINE DERIVATIVES AS ANTIHISTAMINIC AND ANTIALERGIC AGENTS.

Country Status (16)

Country Link
US (1) US7189741B2 (en)
EP (1) EP1330453B1 (en)
JP (1) JP4184785B2 (en)
AR (1) AR031168A1 (en)
AT (1) ATE321761T1 (en)
AU (1) AU2002223655A1 (en)
CA (1) CA2427589A1 (en)
DE (1) DE60118434T2 (en)
DK (1) DK1330453T3 (en)
ES (2) ES2172436B1 (en)
MY (1) MY155914A (en)
PE (1) PE20020543A1 (en)
PT (1) PT1330453E (en)
SI (1) SI1330453T1 (en)
UY (1) UY27001A1 (en)
WO (1) WO2002036589A1 (en)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2201899B1 (en) 2002-04-01 2005-06-01 Almirall Prodesfarma, S.A. DERIVATIVES OF AZAINDOLILPIPERIDINE AS ANTIHISTAMINIC AND ANTIALERGIC AGENTS.
ES2201907B1 (en) * 2002-05-29 2005-06-01 Almirall Prodesfarma, S.A. NEW DERIVATIVES OF INDOLILPIPERIDINE AS POWERFUL ANTIHISTAMINIC AND ANTIALERGIC AGENTS.
AU2003243709B2 (en) * 2002-06-24 2007-01-18 Schering Corporation Indole derivatives useful as histamine H3 antagonists
WO2004047769A2 (en) * 2002-11-26 2004-06-10 Isis Pharmaceuticals, Inc. Benzimidazoles and analogs thereof as antibacterials
JP2009515833A (en) * 2005-10-24 2009-04-16 ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ 3-piperidin-4-yl-indole ORL-1 receptor modulator
EP2079725B1 (en) * 2006-10-27 2011-12-14 Boehringer Ingelheim International GmbH Piperidyl-propane-thiol ccr3 modulators
DK2137162T3 (en) * 2007-03-15 2018-11-26 Novartis Ag Organic compounds and their applications
US20100041663A1 (en) 2008-07-18 2010-02-18 Novartis Ag Organic Compounds as Smo Inhibitors

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0224919A2 (en) * 1985-12-05 1987-06-10 Fujisawa Pharmaceutical Co., Ltd. New thiazole compounds, processes for the preparation thereof and pharmaceutical composition comprising the same
WO1995001350A1 (en) * 1993-06-29 1995-01-12 Sumitomo Metal Industries, Ltd. Tetrazole derivatives having antihistaminic and antiallergic activity
US5650416A (en) * 1992-02-13 1997-07-22 Merrell Pharmaceuticals Inc. Piperidinyl thiacyclic derivatives

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK471479A (en) 1978-12-13 1980-06-14 Pfizer PROCEDURE FOR PREPARING IMIDAZOLD DERIVATIVES AND SALTS THEREOF
US4843068A (en) 1985-12-27 1989-06-27 Nihon Nohyaku Co., Ltd. Pyrazole oxime derivatives and compositions
DK733788A (en) 1988-01-14 1989-07-15 Fujisawa Pharmaceutical Co INDOLYL PIPERIDE INGREDIENTS AND PROCEDURES FOR PREPARING THEREOF
IT1271417B (en) 1993-10-15 1997-05-28 Erregierre Ind Chim COMPOUNDS WITH ANTIHISTAMIN ACTIVITY PROCEDURE FOR THEIR PREPERATION AND PHARMACEUTICAL COMPOSITIONS THAT CONTAIN THEM.
DE19500689A1 (en) 1995-01-12 1996-07-18 Merck Patent Gmbh Indole piperidine derivatives
DE19707628A1 (en) 1997-02-26 1998-08-27 Merck Patent Gmbh Oxazolidinones
AR013669A1 (en) 1997-10-07 2001-01-10 Smithkline Beecham Corp COMPOUNDS AND METHODS
ES2165274B1 (en) * 1999-06-04 2003-04-01 Almirall Prodesfarma Sa NEW DERIVATIVES OF INDOLILPIPERIDINE AS ANTIHISTAMINIC AND ANTIALERGIC AGENTS.
AR028685A1 (en) 2000-06-14 2003-05-21 Lundbeck & Co As H INDOL DERIVATIVES

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0224919A2 (en) * 1985-12-05 1987-06-10 Fujisawa Pharmaceutical Co., Ltd. New thiazole compounds, processes for the preparation thereof and pharmaceutical composition comprising the same
US5650416A (en) * 1992-02-13 1997-07-22 Merrell Pharmaceuticals Inc. Piperidinyl thiacyclic derivatives
WO1995001350A1 (en) * 1993-06-29 1995-01-12 Sumitomo Metal Industries, Ltd. Tetrazole derivatives having antihistaminic and antiallergic activity

Also Published As

Publication number Publication date
UY27001A1 (en) 2001-12-28
EP1330453A1 (en) 2003-07-30
AU2002223655A1 (en) 2002-05-15
EP1330453B1 (en) 2006-03-29
DE60118434D1 (en) 2006-05-18
ES2172436B1 (en) 2004-01-16
US7189741B2 (en) 2007-03-13
DE60118434T2 (en) 2006-12-14
JP4184785B2 (en) 2008-11-19
ES2259052T3 (en) 2006-09-16
DK1330453T3 (en) 2006-08-07
PT1330453E (en) 2006-07-31
WO2002036589A1 (en) 2002-05-10
US20040116471A1 (en) 2004-06-17
AR031168A1 (en) 2003-09-10
MY155914A (en) 2015-12-15
CA2427589A1 (en) 2002-05-10
JP2004513127A (en) 2004-04-30
PE20020543A1 (en) 2002-07-17
ATE321761T1 (en) 2006-04-15
SI1330453T1 (en) 2006-08-31

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