ES2172436A1 - Indolylpiperidine derivatives as antihistaminic and antiallergic agents - Google Patents
Indolylpiperidine derivatives as antihistaminic and antiallergic agentsInfo
- Publication number
- ES2172436A1 ES2172436A1 ES200002615A ES200002615A ES2172436A1 ES 2172436 A1 ES2172436 A1 ES 2172436A1 ES 200002615 A ES200002615 A ES 200002615A ES 200002615 A ES200002615 A ES 200002615A ES 2172436 A1 ES2172436 A1 ES 2172436A1
- Authority
- ES
- Spain
- Prior art keywords
- group
- antihistaminic
- groups
- antiallergic agents
- alkoxy
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 230000001387 anti-histamine Effects 0.000 title abstract 2
- 239000000043 antiallergic agent Substances 0.000 title abstract 2
- 239000000739 antihistaminic agent Substances 0.000 title abstract 2
- HNQZRUDJRPSFAU-UHFFFAOYSA-N 2-piperidin-1-yl-1h-indole Chemical class C1CCCCN1C1=CC2=CC=CC=C2N1 HNQZRUDJRPSFAU-UHFFFAOYSA-N 0.000 title 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 3
- 125000000217 alkyl group Chemical group 0.000 abstract 3
- 125000005843 halogen group Chemical group 0.000 abstract 3
- 125000002947 alkylene group Chemical group 0.000 abstract 2
- 125000005529 alkyleneoxy group Chemical group 0.000 abstract 2
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
- 125000002619 bicyclic group Chemical group 0.000 abstract 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 1
- 125000005842 heteroatom Chemical group 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- -1 indolyl piperidinyl Chemical class 0.000 abstract 1
- 125000000250 methylamino group Chemical group [H]N(*)C([H])([H])[H] 0.000 abstract 1
- 125000002950 monocyclic group Chemical group 0.000 abstract 1
- 125000004043 oxo group Chemical group O=* 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 125000000843 phenylene group Chemical group C1(=C(C=CC=C1)*)* 0.000 abstract 1
- 125000005551 pyridylene group Chemical group 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/02—Nasal agents, e.g. decongestants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/08—Bronchodilators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/04—Antipruritics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/14—Decongestants or antiallergics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/16—Otologicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Pulmonology (AREA)
- Ophthalmology & Optometry (AREA)
- Dermatology (AREA)
- Epidemiology (AREA)
- Immunology (AREA)
- Otolaryngology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
The invention relates to indolyl piperidinyl derivatives of formula (I) wherein: A<1> represents an alkylene, alkyleneoxy, alkylenethio, alkanoylene or hydroxyalkylene group A<2> represents an alkylene, alkyleneoxy, alkylenethio, alkanoylene or an alkyleneoxyalkylene group W<1> represents a phenylene, furanylene or pyridinylene group which is unsubstituted or substituted by one or more halogen atoms, alkoxy groups and/or alkyl groups W<2> represents a 3-10 membered monocyclic or bicyclic group containing from 1 to 3 heteroatoms said group being unsubstituted or substituted by one or more halogen atoms, alkyl groups, alkoxy groups and/or oxo groups R<1> represents a hydrogen or halogen atom or an alkyl, alkoxy or methylamino group and R<2> represents a carboxyl group and pharmaceutically acceptable salts thereof to processes for their preparation to pharmaceutical compositions containing them and to their medical use as antihistaminic and antiallergic agents.
Priority Applications (17)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
ES200002615A ES2172436B1 (en) | 2000-10-31 | 2000-10-31 | INDOLILPIPERIDINE DERIVATIVES AS ANTIHISTAMINIC AND ANTIALERGIC AGENTS. |
PT01992709T PT1330453E (en) | 2000-10-31 | 2001-10-26 | INDOLILPIPERIDINE DERIVATIVES AS ANTIHISTAMINIC AND ANTIALERGIC AGENTS |
AU2002223655A AU2002223655A1 (en) | 2000-10-31 | 2001-10-26 | Indolylpiperidine derivatives as antihistaminic and antiallergic agents |
PCT/EP2001/012450 WO2002036589A1 (en) | 2000-10-31 | 2001-10-26 | Indolylpiperidine derivatives as antihistaminic and antiallergic agents |
SI200130521T SI1330453T1 (en) | 2000-10-31 | 2001-10-26 | Indolylpiperidine derivatives as antihistaminic and antiallergic agents |
AT01992709T ATE321761T1 (en) | 2000-10-31 | 2001-10-26 | INDOLYLPIPERIDINE DERIVATIVES AS ANTHISTAMINIC AND ANTIALLERGIC AGENTS |
CA002427589A CA2427589A1 (en) | 2000-10-31 | 2001-10-26 | Indolylpiperidine derivatives as antihistaminic and antiallergic agents |
ES01992709T ES2259052T3 (en) | 2000-10-31 | 2001-10-26 | INDOLIPIPERIDINE DERIVATIVES AS ANTIHISTAMINIC AND ANTIALERGIC AGENTS. |
DE60118434T DE60118434T2 (en) | 2000-10-31 | 2001-10-26 | INDOLYLPIPERIDINE DERIVATIVES AS ANTIHISTAMINIC AND ANTIALLERGIC AGENTS |
JP2002539348A JP4184785B2 (en) | 2000-10-31 | 2001-10-26 | Indolylpiperidine derivatives as antihistamines and antiallergic agents |
US10/415,693 US7189741B2 (en) | 2000-10-31 | 2001-10-26 | Indolylpiperidine derivatives as antihistaminic and antiallergic agents |
DK01992709T DK1330453T3 (en) | 2000-10-31 | 2001-10-26 | Indolylpiperidine derivatives as antihistamine and anti-allergy agents |
EP01992709A EP1330453B1 (en) | 2000-10-31 | 2001-10-26 | Indolylpiperidine derivatives as antihistaminic and antiallergic agents |
MYPI20015021A MY155914A (en) | 2000-10-31 | 2001-10-30 | Indolylpiperidine derivatives as antihistaminic and antiallergic agents |
PE2001001079A PE20020543A1 (en) | 2000-10-31 | 2001-10-30 | INDOLYLPIPERIDINE DERIVATIVES AS ANTIHISTAMINE AND ANTI-ALLERGIC AGENTS |
ARP010105068A AR031168A1 (en) | 2000-10-31 | 2001-10-30 | DERIVATIVES OF INDOLILPIPERIDINE AS ANTIHISTAMINIC AND ANTIALERGIC AGENTS |
UY27001A UY27001A1 (en) | 2000-10-31 | 2001-10-31 | DERIVATIVES OF INDOLYL PIPERIDINE AS ANTIHISTAMINE AND ANTI-ALLERGIC AGENTS |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
ES200002615A ES2172436B1 (en) | 2000-10-31 | 2000-10-31 | INDOLILPIPERIDINE DERIVATIVES AS ANTIHISTAMINIC AND ANTIALERGIC AGENTS. |
Publications (2)
Publication Number | Publication Date |
---|---|
ES2172436A1 true ES2172436A1 (en) | 2002-09-16 |
ES2172436B1 ES2172436B1 (en) | 2004-01-16 |
Family
ID=8495472
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES200002615A Expired - Fee Related ES2172436B1 (en) | 2000-10-31 | 2000-10-31 | INDOLILPIPERIDINE DERIVATIVES AS ANTIHISTAMINIC AND ANTIALERGIC AGENTS. |
ES01992709T Expired - Lifetime ES2259052T3 (en) | 2000-10-31 | 2001-10-26 | INDOLIPIPERIDINE DERIVATIVES AS ANTIHISTAMINIC AND ANTIALERGIC AGENTS. |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES01992709T Expired - Lifetime ES2259052T3 (en) | 2000-10-31 | 2001-10-26 | INDOLIPIPERIDINE DERIVATIVES AS ANTIHISTAMINIC AND ANTIALERGIC AGENTS. |
Country Status (16)
Country | Link |
---|---|
US (1) | US7189741B2 (en) |
EP (1) | EP1330453B1 (en) |
JP (1) | JP4184785B2 (en) |
AR (1) | AR031168A1 (en) |
AT (1) | ATE321761T1 (en) |
AU (1) | AU2002223655A1 (en) |
CA (1) | CA2427589A1 (en) |
DE (1) | DE60118434T2 (en) |
DK (1) | DK1330453T3 (en) |
ES (2) | ES2172436B1 (en) |
MY (1) | MY155914A (en) |
PE (1) | PE20020543A1 (en) |
PT (1) | PT1330453E (en) |
SI (1) | SI1330453T1 (en) |
UY (1) | UY27001A1 (en) |
WO (1) | WO2002036589A1 (en) |
Families Citing this family (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ES2201899B1 (en) | 2002-04-01 | 2005-06-01 | Almirall Prodesfarma, S.A. | DERIVATIVES OF AZAINDOLILPIPERIDINE AS ANTIHISTAMINIC AND ANTIALERGIC AGENTS. |
ES2201907B1 (en) * | 2002-05-29 | 2005-06-01 | Almirall Prodesfarma, S.A. | NEW DERIVATIVES OF INDOLILPIPERIDINE AS POWERFUL ANTIHISTAMINIC AND ANTIALERGIC AGENTS. |
AU2003243709B2 (en) * | 2002-06-24 | 2007-01-18 | Schering Corporation | Indole derivatives useful as histamine H3 antagonists |
WO2004047769A2 (en) * | 2002-11-26 | 2004-06-10 | Isis Pharmaceuticals, Inc. | Benzimidazoles and analogs thereof as antibacterials |
JP2009515833A (en) * | 2005-10-24 | 2009-04-16 | ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ | 3-piperidin-4-yl-indole ORL-1 receptor modulator |
EP2079725B1 (en) * | 2006-10-27 | 2011-12-14 | Boehringer Ingelheim International GmbH | Piperidyl-propane-thiol ccr3 modulators |
DK2137162T3 (en) * | 2007-03-15 | 2018-11-26 | Novartis Ag | Organic compounds and their applications |
US20100041663A1 (en) | 2008-07-18 | 2010-02-18 | Novartis Ag | Organic Compounds as Smo Inhibitors |
Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0224919A2 (en) * | 1985-12-05 | 1987-06-10 | Fujisawa Pharmaceutical Co., Ltd. | New thiazole compounds, processes for the preparation thereof and pharmaceutical composition comprising the same |
WO1995001350A1 (en) * | 1993-06-29 | 1995-01-12 | Sumitomo Metal Industries, Ltd. | Tetrazole derivatives having antihistaminic and antiallergic activity |
US5650416A (en) * | 1992-02-13 | 1997-07-22 | Merrell Pharmaceuticals Inc. | Piperidinyl thiacyclic derivatives |
Family Cites Families (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DK471479A (en) | 1978-12-13 | 1980-06-14 | Pfizer | PROCEDURE FOR PREPARING IMIDAZOLD DERIVATIVES AND SALTS THEREOF |
US4843068A (en) | 1985-12-27 | 1989-06-27 | Nihon Nohyaku Co., Ltd. | Pyrazole oxime derivatives and compositions |
DK733788A (en) | 1988-01-14 | 1989-07-15 | Fujisawa Pharmaceutical Co | INDOLYL PIPERIDE INGREDIENTS AND PROCEDURES FOR PREPARING THEREOF |
IT1271417B (en) | 1993-10-15 | 1997-05-28 | Erregierre Ind Chim | COMPOUNDS WITH ANTIHISTAMIN ACTIVITY PROCEDURE FOR THEIR PREPERATION AND PHARMACEUTICAL COMPOSITIONS THAT CONTAIN THEM. |
DE19500689A1 (en) | 1995-01-12 | 1996-07-18 | Merck Patent Gmbh | Indole piperidine derivatives |
DE19707628A1 (en) | 1997-02-26 | 1998-08-27 | Merck Patent Gmbh | Oxazolidinones |
AR013669A1 (en) | 1997-10-07 | 2001-01-10 | Smithkline Beecham Corp | COMPOUNDS AND METHODS |
ES2165274B1 (en) * | 1999-06-04 | 2003-04-01 | Almirall Prodesfarma Sa | NEW DERIVATIVES OF INDOLILPIPERIDINE AS ANTIHISTAMINIC AND ANTIALERGIC AGENTS. |
AR028685A1 (en) | 2000-06-14 | 2003-05-21 | Lundbeck & Co As H | INDOL DERIVATIVES |
-
2000
- 2000-10-31 ES ES200002615A patent/ES2172436B1/en not_active Expired - Fee Related
-
2001
- 2001-10-26 JP JP2002539348A patent/JP4184785B2/en not_active Expired - Fee Related
- 2001-10-26 WO PCT/EP2001/012450 patent/WO2002036589A1/en active IP Right Grant
- 2001-10-26 ES ES01992709T patent/ES2259052T3/en not_active Expired - Lifetime
- 2001-10-26 EP EP01992709A patent/EP1330453B1/en not_active Expired - Lifetime
- 2001-10-26 AT AT01992709T patent/ATE321761T1/en not_active IP Right Cessation
- 2001-10-26 US US10/415,693 patent/US7189741B2/en not_active Expired - Fee Related
- 2001-10-26 AU AU2002223655A patent/AU2002223655A1/en not_active Abandoned
- 2001-10-26 DK DK01992709T patent/DK1330453T3/en active
- 2001-10-26 SI SI200130521T patent/SI1330453T1/en unknown
- 2001-10-26 DE DE60118434T patent/DE60118434T2/en not_active Expired - Lifetime
- 2001-10-26 PT PT01992709T patent/PT1330453E/en unknown
- 2001-10-26 CA CA002427589A patent/CA2427589A1/en not_active Abandoned
- 2001-10-30 MY MYPI20015021A patent/MY155914A/en unknown
- 2001-10-30 PE PE2001001079A patent/PE20020543A1/en not_active Application Discontinuation
- 2001-10-30 AR ARP010105068A patent/AR031168A1/en not_active Application Discontinuation
- 2001-10-31 UY UY27001A patent/UY27001A1/en unknown
Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0224919A2 (en) * | 1985-12-05 | 1987-06-10 | Fujisawa Pharmaceutical Co., Ltd. | New thiazole compounds, processes for the preparation thereof and pharmaceutical composition comprising the same |
US5650416A (en) * | 1992-02-13 | 1997-07-22 | Merrell Pharmaceuticals Inc. | Piperidinyl thiacyclic derivatives |
WO1995001350A1 (en) * | 1993-06-29 | 1995-01-12 | Sumitomo Metal Industries, Ltd. | Tetrazole derivatives having antihistaminic and antiallergic activity |
Also Published As
Publication number | Publication date |
---|---|
UY27001A1 (en) | 2001-12-28 |
EP1330453A1 (en) | 2003-07-30 |
AU2002223655A1 (en) | 2002-05-15 |
EP1330453B1 (en) | 2006-03-29 |
DE60118434D1 (en) | 2006-05-18 |
ES2172436B1 (en) | 2004-01-16 |
US7189741B2 (en) | 2007-03-13 |
DE60118434T2 (en) | 2006-12-14 |
JP4184785B2 (en) | 2008-11-19 |
ES2259052T3 (en) | 2006-09-16 |
DK1330453T3 (en) | 2006-08-07 |
PT1330453E (en) | 2006-07-31 |
WO2002036589A1 (en) | 2002-05-10 |
US20040116471A1 (en) | 2004-06-17 |
AR031168A1 (en) | 2003-09-10 |
MY155914A (en) | 2015-12-15 |
CA2427589A1 (en) | 2002-05-10 |
JP2004513127A (en) | 2004-04-30 |
PE20020543A1 (en) | 2002-07-17 |
ATE321761T1 (en) | 2006-04-15 |
SI1330453T1 (en) | 2006-08-31 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
EA200200938A1 (en) | PHARMACEUTICAL COMPOSITIONS CONTAINING DERIVATIVES OF AZETIDINE, NEW DERIVATIVES OF AZETIDINE AND THEIR RECEIVING | |
DK0889877T3 (en) | Meta-substituted phenylene derivatives and their use as alpha-beta3 integrin antagonists or inhibitors | |
DK0889876T3 (en) | Meta-substituted phenylene sulfonamide derivatives | |
BR0111263A (en) | 2-Aminocarbonyl-9h-purine derivatives | |
TR200101155T2 (en) | 4-Aroil Piperidine CCR-3 Receptor Antagonists III | |
PL315636A1 (en) | Cosmetic or pharmaceutic compositions containing magnipherine or its derivatives | |
AR020032A1 (en) | DERIVATIVES OF 1,3-METHYL Erythromycin. | |
DK0928788T3 (en) | Imidazolidin-4-one derivatives useful as anticancer agents | |
EA200600811A1 (en) | NEW TETRAHYDROSPIRO {PIPERIDIN-2,7'-PYRROLO [3,2-b] PYRIDINE} DERIVATIVES AND NEW INDOLA DERIVATIVES, APPLICATION FOR THE TREATMENT OF DISORDERS RELATED TO 5-HT-RECEPTOR | |
WO2002051819A3 (en) | Heterocyclic compounds having antibacterial activity, process for their preparation and pharmaceutical compositions containing them | |
ES2165274A1 (en) | Indolylpiperidine derivatives as antihistaminic and antiallergic agents | |
AU4205000A (en) | Xanthine derivatives and analogs as cell signaling inhibitors | |
YU53100A (en) | 2-arylethyl-(piperidin-4-ylmethyl)amine derivatives as muscarinic receptor antagonists | |
MXPA03000161A (en) | Novel compounds having antiinflammatory activity: process for their preparation and pharmaceutical compositions containing them. | |
EA200300071A1 (en) | THERAPEUTIC PREPARATION FOR THE TREATMENT OF FEAR NEUROSIS (ALARM) OR DEPRESSIONS AND DERIVATIVES OF PIPERAZINE | |
PT992509E (en) | NEW MACROLIDED DERIVATIVES | |
ES2172436A1 (en) | Indolylpiperidine derivatives as antihistaminic and antiallergic agents | |
EA200301203A1 (en) | NEW COMPOUNDS AND COMPOSITIONS AS KATEPSIN INHIBITORS | |
EA200100916A1 (en) | MEDICINE CONTAINING DERIVATIVE OF SULPOPIRANOSYLACYLGLYCERINE | |
HUP0400545A2 (en) | 1,4-disubstituted piperazine derivatives useful as uro-selectives alpha1-adrenoceptor blockers, and pharmaceutical compositions containing them | |
NO983444D0 (en) | Benzo (c) quinolizine derivatives, their preparation and use as 5 <alfa> reductase inhibitors | |
ES2172376A1 (en) | Novel isoquinoline derivatives, preparation method and pharmaceutical compositions containing them | |
HU0004701D0 (en) | ||
DE60130628D1 (en) | AMINOPHENOXYACETAMIDE DERIVATIVES AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEREOF | |
GR900300046T1 (en) | Oxabicycloheptane derivatives, pharmaceutical composition and use |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
EC2A | Search report published |
Date of ref document: 20020916 Kind code of ref document: A1 Effective date: 20020916 |
|
FG2A | Definitive protection |
Ref document number: 2172436B1 Country of ref document: ES |
|
FD1A | Patent lapsed |
Effective date: 20100315 |