ES2167251A1 - Nuevos disacaridos con accion antiartrosica. - Google Patents
Nuevos disacaridos con accion antiartrosica.Info
- Publication number
- ES2167251A1 ES2167251A1 ES200001741A ES200001741A ES2167251A1 ES 2167251 A1 ES2167251 A1 ES 2167251A1 ES 200001741 A ES200001741 A ES 200001741A ES 200001741 A ES200001741 A ES 200001741A ES 2167251 A1 ES2167251 A1 ES 2167251A1
- Authority
- ES
- Spain
- Prior art keywords
- hydrogen
- group
- coch3
- so3m
- so3h
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H7/00—Compounds containing non-saccharide radicals linked to saccharide radicals by a carbon-to-carbon bond
- C07H7/02—Acyclic radicals
- C07H7/033—Uronic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H11/00—Compounds containing saccharide radicals esterified by inorganic acids; Metal salts thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H3/00—Compounds containing only hydrogen atoms and saccharide radicals having only carbon, hydrogen, and oxygen atoms
- C07H3/06—Oligosaccharides, i.e. having three to five saccharide radicals attached to each other by glycosidic linkages
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biotechnology (AREA)
- Biochemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Rheumatology (AREA)
- Pain & Pain Management (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Peptides Or Proteins (AREA)
Abstract
"Nuevos disacáridos con acción antiartrósica". La presente invención se refiere a nuevos disacáridos de fórmula (I), **Figura** donde R{sup,1} se selecciona del grupo constituido por hidrógeno, (C{sub,1}-C{sub,4})-alquilo lineal o ramificado, fenilalquilo de menos de diez átomos de carbono y -COCH{sub,3}; R{sup,2} se selecciona del grupo constituido por hidrógeno, -COCH{sub,3} y SO{sub,3}M; R{sub,3) se selecciona del grupo constituido por hidrógeno, (C{sub,1}-C{sub,4}-alquilo lineal o ramificado, fenilalquilo de menos de diez átomos, -COCH{sub,3} y -COPh, siendo Ph fenilo; G se escoge entre -COOR{sup,4} y -COOM, seleccionándose R{sup,4} del grupo constituido por hidrógeno, (C{sub,1}-C{sub,2}-alquilo y arilalquilo de menos de dieciséis átomos de carbono; A se selecciona del grupo constituida por hidrógeno, -SO{sub,3}H, -SO{sub,3}M y -COCH{sub,3}; B se selecciona del grupo constituido por hidrógeno, -SO{sub,3}H, SO{sub,3}M y -COCH{sub,3}; en donde necesariamente o A o B son o bien -SO{sub,3}H, o bien -SO{sub,3}M, y siendo M es un catión orgánico o metálico. Dichos compuestos pueden ser utilizados como antiartrósicos, antiinflamatorios o para controlar la coagulación sanguínea.
Priority Applications (11)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
ES200001741A ES2167251B1 (es) | 2000-07-13 | 2000-07-13 | Nuevos disacaridos con accion antiartrosica. |
US10/332,505 US6680304B2 (en) | 2000-07-13 | 2001-07-05 | Disaccharides with anti-arthrosic properties |
DE60122156T DE60122156T2 (de) | 2000-07-13 | 2001-07-05 | Neue disaccharide mit anti-arthritischer wirkung |
EP01947467A EP1300411B1 (en) | 2000-07-13 | 2001-07-05 | Novel disaccharides with anti-arthritic action |
PCT/ES2001/000265 WO2002008239A1 (es) | 2000-07-13 | 2001-07-05 | Nuevos disacaridos con accion antiartrosica |
CA002415752A CA2415752C (en) | 2000-07-13 | 2001-07-05 | Novel disaccharides with anti-arthritic action |
DK01947467T DK1300411T3 (da) | 2000-07-13 | 2001-07-05 | Nye disaccharider med anti-arthrose egenskaber |
AT01947467T ATE335752T1 (de) | 2000-07-13 | 2001-07-05 | Neue disaccharide mit anti-arthritischer wirkung |
PT01947467T PT1300411E (pt) | 2000-07-13 | 2001-07-05 | Novos dissacaráridos |
AU2001269139A AU2001269139A1 (en) | 2000-07-13 | 2001-07-05 | Novel disaccharides with anti-arthritic action |
ES01947467T ES2267788T3 (es) | 2000-07-13 | 2001-07-05 | Nuevos disacaridos con accion antiartrosica. |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
ES200001741A ES2167251B1 (es) | 2000-07-13 | 2000-07-13 | Nuevos disacaridos con accion antiartrosica. |
Publications (2)
Publication Number | Publication Date |
---|---|
ES2167251A1 true ES2167251A1 (es) | 2002-05-01 |
ES2167251B1 ES2167251B1 (es) | 2003-09-16 |
Family
ID=8494247
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES200001741A Expired - Fee Related ES2167251B1 (es) | 2000-07-13 | 2000-07-13 | Nuevos disacaridos con accion antiartrosica. |
ES01947467T Expired - Lifetime ES2267788T3 (es) | 2000-07-13 | 2001-07-05 | Nuevos disacaridos con accion antiartrosica. |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES01947467T Expired - Lifetime ES2267788T3 (es) | 2000-07-13 | 2001-07-05 | Nuevos disacaridos con accion antiartrosica. |
Country Status (10)
Country | Link |
---|---|
US (1) | US6680304B2 (es) |
EP (1) | EP1300411B1 (es) |
AT (1) | ATE335752T1 (es) |
AU (1) | AU2001269139A1 (es) |
CA (1) | CA2415752C (es) |
DE (1) | DE60122156T2 (es) |
DK (1) | DK1300411T3 (es) |
ES (2) | ES2167251B1 (es) |
PT (1) | PT1300411E (es) |
WO (1) | WO2002008239A1 (es) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ES2684097A1 (es) * | 2017-03-29 | 2018-10-01 | Bioiberica, S.A.U. | Disacáridos sulfatados para el tratamiento del dolor neuropático |
Families Citing this family (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2007525486A (ja) * | 2003-11-24 | 2007-09-06 | オプティマー・ファーマスーティカルズ・インコーポレイテッド | 化合物の投与による哺乳動物の症状の処置及び化合物の使用方法 |
EP1761550A2 (en) * | 2004-05-26 | 2007-03-14 | California Institute of Technology | Small molecule stimulators of neuronal growth |
ES2327480B1 (es) * | 2007-06-15 | 2010-08-10 | Bioiberica, S.A. | "disacaridos para el tratamiento de tendones, ligamentos y huesos". |
US8912149B1 (en) | 2007-11-28 | 2014-12-16 | California Institute Of Technology | Glycosaminoglycan mimetics |
ES2364683B1 (es) * | 2009-12-29 | 2012-08-08 | Bioibérica S.A. | Disacáridos sulfatados para el tratamiento de enfermedades neurodegenerativas y/o neurovasculares. |
JP2014500863A (ja) * | 2010-10-29 | 2014-01-16 | オプコ ヘルス インコーポレイテッド | エラスターゼ関連障害を治療するための高硫酸化二糖 |
US10227370B2 (en) | 2013-08-02 | 2019-03-12 | California Institute Of Technology | Heparan sulfate/heparin mimetics with anti-chemokine and anti-inflammatory activity |
US9770461B2 (en) | 2013-08-02 | 2017-09-26 | California Institute Of Technology | Tailored glycopolymers as anticoagulant heparin mimetics |
Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0211610A2 (en) * | 1985-08-01 | 1987-02-25 | Unilever Plc | Oligosaccharides as a hair growth promotor |
WO1993009766A1 (en) * | 1991-11-15 | 1993-05-27 | Arthro Research And Development Corporation | Method for treatment of acute and chronic painful arthropathic conditions in human and other mammals |
EP0704216A1 (en) * | 1994-09-28 | 1996-04-03 | Ibsa - Institut Biochimique S.A. | Gel-like pharmaceutical compositions containing chondroitin sulfate salts suitable for oral administration |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2789587B1 (fr) | 1999-02-11 | 2003-01-24 | Inst Nat Sante Rech Med | Moyens pour la regulation de la differenciation hematopoietique |
FR2792319B1 (fr) | 1999-04-14 | 2001-07-06 | Pf Medicament | Procede de preparation de monosulfate de 4 ou 6 disaccharides, leur utilisation en cosmetique et en tant que medicament notamment pour le traitement des maladies du collagene |
-
2000
- 2000-07-13 ES ES200001741A patent/ES2167251B1/es not_active Expired - Fee Related
-
2001
- 2001-07-05 US US10/332,505 patent/US6680304B2/en not_active Expired - Lifetime
- 2001-07-05 AT AT01947467T patent/ATE335752T1/de not_active IP Right Cessation
- 2001-07-05 CA CA002415752A patent/CA2415752C/en not_active Expired - Fee Related
- 2001-07-05 DE DE60122156T patent/DE60122156T2/de not_active Expired - Lifetime
- 2001-07-05 DK DK01947467T patent/DK1300411T3/da active
- 2001-07-05 PT PT01947467T patent/PT1300411E/pt unknown
- 2001-07-05 AU AU2001269139A patent/AU2001269139A1/en not_active Abandoned
- 2001-07-05 EP EP01947467A patent/EP1300411B1/en not_active Expired - Lifetime
- 2001-07-05 WO PCT/ES2001/000265 patent/WO2002008239A1/es active IP Right Grant
- 2001-07-05 ES ES01947467T patent/ES2267788T3/es not_active Expired - Lifetime
Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0211610A2 (en) * | 1985-08-01 | 1987-02-25 | Unilever Plc | Oligosaccharides as a hair growth promotor |
WO1993009766A1 (en) * | 1991-11-15 | 1993-05-27 | Arthro Research And Development Corporation | Method for treatment of acute and chronic painful arthropathic conditions in human and other mammals |
EP0704216A1 (en) * | 1994-09-28 | 1996-04-03 | Ibsa - Institut Biochimique S.A. | Gel-like pharmaceutical compositions containing chondroitin sulfate salts suitable for oral administration |
Non-Patent Citations (4)
Title |
---|
GECIOVA, R. y col. Physico-chemical properties of hyaluronan and its hydrophobic derivatives: a calorimetric and viscometric study a). Macromol. Chem. Phys., 1995, Vol. 196, paginas 2891-2903. * |
JACQUINET, J.C. Syntheses of the methyl glycosides of the repeating units of chondroitin 4- and 6-sulfate. Carbohydrate Research, 1990, Vol. 199, no 2, paginas 153-181. Pagina 157, compuestos 33,34. * |
JACQUINET, J.C. y col. Multigram syntheses of the disaccharide repeating units of chondroitin 4- and 6-sulfates. Carbohydrate Research, 1998, Vol. 314 (3-4), paginas 283-288. * |
TAKANASH y col. The synthesis of hyalobiuronic acid and chondrosine. J. Amer. Chem. Soc., 1962, Vol. 84, pagina 3029. * |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ES2684097A1 (es) * | 2017-03-29 | 2018-10-01 | Bioiberica, S.A.U. | Disacáridos sulfatados para el tratamiento del dolor neuropático |
Also Published As
Publication number | Publication date |
---|---|
WO2002008239A1 (es) | 2002-01-31 |
ES2167251B1 (es) | 2003-09-16 |
EP1300411B1 (en) | 2006-08-09 |
DE60122156T2 (de) | 2007-08-23 |
CA2415752A1 (en) | 2003-01-10 |
US20030181400A1 (en) | 2003-09-25 |
PT1300411E (pt) | 2006-12-29 |
CA2415752C (en) | 2009-09-15 |
DK1300411T3 (da) | 2006-12-04 |
DE60122156D1 (de) | 2006-09-21 |
US6680304B2 (en) | 2004-01-20 |
ATE335752T1 (de) | 2006-09-15 |
EP1300411A1 (en) | 2003-04-09 |
AU2001269139A1 (en) | 2002-02-05 |
ES2267788T3 (es) | 2007-03-16 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FG2A | Definitive protection |
Ref document number: 2167251B1 Country of ref document: ES |
|
FD1A | Patent lapsed |
Effective date: 20100315 |