ES2167251A1 - Nuevos disacaridos con accion antiartrosica. - Google Patents

Nuevos disacaridos con accion antiartrosica.

Info

Publication number
ES2167251A1
ES2167251A1 ES200001741A ES200001741A ES2167251A1 ES 2167251 A1 ES2167251 A1 ES 2167251A1 ES 200001741 A ES200001741 A ES 200001741A ES 200001741 A ES200001741 A ES 200001741A ES 2167251 A1 ES2167251 A1 ES 2167251A1
Authority
ES
Spain
Prior art keywords
hydrogen
group
coch3
so3m
so3h
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
ES200001741A
Other languages
English (en)
Other versions
ES2167251B1 (es
Inventor
Pahi Francisco J Vila
Salgado Francesc Flores
Roura Ramon Ruhi
Pastor Narcis Arnau
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bioiberica SA
Original Assignee
Bioiberica SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to ES200001741A priority Critical patent/ES2167251B1/es
Application filed by Bioiberica SA filed Critical Bioiberica SA
Priority to DK01947467T priority patent/DK1300411T3/da
Priority to AT01947467T priority patent/ATE335752T1/de
Priority to DE60122156T priority patent/DE60122156T2/de
Priority to EP01947467A priority patent/EP1300411B1/en
Priority to PCT/ES2001/000265 priority patent/WO2002008239A1/es
Priority to CA002415752A priority patent/CA2415752C/en
Priority to ES01947467T priority patent/ES2267788T3/es
Priority to US10/332,505 priority patent/US6680304B2/en
Priority to PT01947467T priority patent/PT1300411E/pt
Priority to AU2001269139A priority patent/AU2001269139A1/en
Publication of ES2167251A1 publication Critical patent/ES2167251A1/es
Application granted granted Critical
Publication of ES2167251B1 publication Critical patent/ES2167251B1/es
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H7/00—Compounds containing non-saccharide radicals linked to saccharide radicals by a carbon-to-carbon bond
    • C07H7/02—Acyclic radicals
    • C07H7/033—Uronic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H11/00—Compounds containing saccharide radicals esterified by inorganic acids; Metal salts thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H3/00—Compounds containing only hydrogen atoms and saccharide radicals having only carbon, hydrogen, and oxygen atoms
    • C07H3/06—Oligosaccharides, i.e. having three to five saccharide radicals attached to each other by glycosidic linkages

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Peptides Or Proteins (AREA)

Abstract

"Nuevos disacáridos con acción antiartrósica". La presente invención se refiere a nuevos disacáridos de fórmula (I), **Figura** donde R{sup,1} se selecciona del grupo constituido por hidrógeno, (C{sub,1}-C{sub,4})-alquilo lineal o ramificado, fenilalquilo de menos de diez átomos de carbono y -COCH{sub,3}; R{sup,2} se selecciona del grupo constituido por hidrógeno, -COCH{sub,3} y SO{sub,3}M; R{sub,3) se selecciona del grupo constituido por hidrógeno, (C{sub,1}-C{sub,4}-alquilo lineal o ramificado, fenilalquilo de menos de diez átomos, -COCH{sub,3} y -COPh, siendo Ph fenilo; G se escoge entre -COOR{sup,4} y -COOM, seleccionándose R{sup,4} del grupo constituido por hidrógeno, (C{sub,1}-C{sub,2}-alquilo y arilalquilo de menos de dieciséis átomos de carbono; A se selecciona del grupo constituida por hidrógeno, -SO{sub,3}H, -SO{sub,3}M y -COCH{sub,3}; B se selecciona del grupo constituido por hidrógeno, -SO{sub,3}H, SO{sub,3}M y -COCH{sub,3}; en donde necesariamente o A o B son o bien -SO{sub,3}H, o bien -SO{sub,3}M, y siendo M es un catión orgánico o metálico. Dichos compuestos pueden ser utilizados como antiartrósicos, antiinflamatorios o para controlar la coagulación sanguínea.
ES200001741A 2000-07-13 2000-07-13 Nuevos disacaridos con accion antiartrosica. Expired - Fee Related ES2167251B1 (es)

Priority Applications (11)

Application Number Priority Date Filing Date Title
ES200001741A ES2167251B1 (es) 2000-07-13 2000-07-13 Nuevos disacaridos con accion antiartrosica.
US10/332,505 US6680304B2 (en) 2000-07-13 2001-07-05 Disaccharides with anti-arthrosic properties
DE60122156T DE60122156T2 (de) 2000-07-13 2001-07-05 Neue disaccharide mit anti-arthritischer wirkung
EP01947467A EP1300411B1 (en) 2000-07-13 2001-07-05 Novel disaccharides with anti-arthritic action
PCT/ES2001/000265 WO2002008239A1 (es) 2000-07-13 2001-07-05 Nuevos disacaridos con accion antiartrosica
CA002415752A CA2415752C (en) 2000-07-13 2001-07-05 Novel disaccharides with anti-arthritic action
DK01947467T DK1300411T3 (da) 2000-07-13 2001-07-05 Nye disaccharider med anti-arthrose egenskaber
AT01947467T ATE335752T1 (de) 2000-07-13 2001-07-05 Neue disaccharide mit anti-arthritischer wirkung
PT01947467T PT1300411E (pt) 2000-07-13 2001-07-05 Novos dissacaráridos
AU2001269139A AU2001269139A1 (en) 2000-07-13 2001-07-05 Novel disaccharides with anti-arthritic action
ES01947467T ES2267788T3 (es) 2000-07-13 2001-07-05 Nuevos disacaridos con accion antiartrosica.

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ES200001741A ES2167251B1 (es) 2000-07-13 2000-07-13 Nuevos disacaridos con accion antiartrosica.

Publications (2)

Publication Number Publication Date
ES2167251A1 true ES2167251A1 (es) 2002-05-01
ES2167251B1 ES2167251B1 (es) 2003-09-16

Family

ID=8494247

Family Applications (2)

Application Number Title Priority Date Filing Date
ES200001741A Expired - Fee Related ES2167251B1 (es) 2000-07-13 2000-07-13 Nuevos disacaridos con accion antiartrosica.
ES01947467T Expired - Lifetime ES2267788T3 (es) 2000-07-13 2001-07-05 Nuevos disacaridos con accion antiartrosica.

Family Applications After (1)

Application Number Title Priority Date Filing Date
ES01947467T Expired - Lifetime ES2267788T3 (es) 2000-07-13 2001-07-05 Nuevos disacaridos con accion antiartrosica.

Country Status (10)

Country Link
US (1) US6680304B2 (es)
EP (1) EP1300411B1 (es)
AT (1) ATE335752T1 (es)
AU (1) AU2001269139A1 (es)
CA (1) CA2415752C (es)
DE (1) DE60122156T2 (es)
DK (1) DK1300411T3 (es)
ES (2) ES2167251B1 (es)
PT (1) PT1300411E (es)
WO (1) WO2002008239A1 (es)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2684097A1 (es) * 2017-03-29 2018-10-01 Bioiberica, S.A.U. Disacáridos sulfatados para el tratamiento del dolor neuropático

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2007525486A (ja) * 2003-11-24 2007-09-06 オプティマー・ファーマスーティカルズ・インコーポレイテッド 化合物の投与による哺乳動物の症状の処置及び化合物の使用方法
EP1761550A2 (en) * 2004-05-26 2007-03-14 California Institute of Technology Small molecule stimulators of neuronal growth
ES2327480B1 (es) * 2007-06-15 2010-08-10 Bioiberica, S.A. "disacaridos para el tratamiento de tendones, ligamentos y huesos".
US8912149B1 (en) 2007-11-28 2014-12-16 California Institute Of Technology Glycosaminoglycan mimetics
ES2364683B1 (es) * 2009-12-29 2012-08-08 Bioibérica S.A. Disacáridos sulfatados para el tratamiento de enfermedades neurodegenerativas y/o neurovasculares.
JP2014500863A (ja) * 2010-10-29 2014-01-16 オプコ ヘルス インコーポレイテッド エラスターゼ関連障害を治療するための高硫酸化二糖
US10227370B2 (en) 2013-08-02 2019-03-12 California Institute Of Technology Heparan sulfate/heparin mimetics with anti-chemokine and anti-inflammatory activity
US9770461B2 (en) 2013-08-02 2017-09-26 California Institute Of Technology Tailored glycopolymers as anticoagulant heparin mimetics

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0211610A2 (en) * 1985-08-01 1987-02-25 Unilever Plc Oligosaccharides as a hair growth promotor
WO1993009766A1 (en) * 1991-11-15 1993-05-27 Arthro Research And Development Corporation Method for treatment of acute and chronic painful arthropathic conditions in human and other mammals
EP0704216A1 (en) * 1994-09-28 1996-04-03 Ibsa - Institut Biochimique S.A. Gel-like pharmaceutical compositions containing chondroitin sulfate salts suitable for oral administration

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2789587B1 (fr) 1999-02-11 2003-01-24 Inst Nat Sante Rech Med Moyens pour la regulation de la differenciation hematopoietique
FR2792319B1 (fr) 1999-04-14 2001-07-06 Pf Medicament Procede de preparation de monosulfate de 4 ou 6 disaccharides, leur utilisation en cosmetique et en tant que medicament notamment pour le traitement des maladies du collagene

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0211610A2 (en) * 1985-08-01 1987-02-25 Unilever Plc Oligosaccharides as a hair growth promotor
WO1993009766A1 (en) * 1991-11-15 1993-05-27 Arthro Research And Development Corporation Method for treatment of acute and chronic painful arthropathic conditions in human and other mammals
EP0704216A1 (en) * 1994-09-28 1996-04-03 Ibsa - Institut Biochimique S.A. Gel-like pharmaceutical compositions containing chondroitin sulfate salts suitable for oral administration

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
GECIOVA, R. y col. Physico-chemical properties of hyaluronan and its hydrophobic derivatives: a calorimetric and viscometric study a). Macromol. Chem. Phys., 1995, Vol. 196, paginas 2891-2903. *
JACQUINET, J.C. Syntheses of the methyl glycosides of the repeating units of chondroitin 4- and 6-sulfate. Carbohydrate Research, 1990, Vol. 199, no 2, paginas 153-181. Pagina 157, compuestos 33,34. *
JACQUINET, J.C. y col. Multigram syntheses of the disaccharide repeating units of chondroitin 4- and 6-sulfates. Carbohydrate Research, 1998, Vol. 314 (3-4), paginas 283-288. *
TAKANASH y col. The synthesis of hyalobiuronic acid and chondrosine. J. Amer. Chem. Soc., 1962, Vol. 84, pagina 3029. *

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2684097A1 (es) * 2017-03-29 2018-10-01 Bioiberica, S.A.U. Disacáridos sulfatados para el tratamiento del dolor neuropático

Also Published As

Publication number Publication date
WO2002008239A1 (es) 2002-01-31
ES2167251B1 (es) 2003-09-16
EP1300411B1 (en) 2006-08-09
DE60122156T2 (de) 2007-08-23
CA2415752A1 (en) 2003-01-10
US20030181400A1 (en) 2003-09-25
PT1300411E (pt) 2006-12-29
CA2415752C (en) 2009-09-15
DK1300411T3 (da) 2006-12-04
DE60122156D1 (de) 2006-09-21
US6680304B2 (en) 2004-01-20
ATE335752T1 (de) 2006-09-15
EP1300411A1 (en) 2003-04-09
AU2001269139A1 (en) 2002-02-05
ES2267788T3 (es) 2007-03-16

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