ES2166481T3 - Benzoilguanidinas sustituidas en posicion orto. - Google Patents
Benzoilguanidinas sustituidas en posicion orto.Info
- Publication number
- ES2166481T3 ES2166481T3 ES97102607T ES97102607T ES2166481T3 ES 2166481 T3 ES2166481 T3 ES 2166481T3 ES 97102607 T ES97102607 T ES 97102607T ES 97102607 T ES97102607 T ES 97102607T ES 2166481 T3 ES2166481 T3 ES 2166481T3
- Authority
- ES
- Spain
- Prior art keywords
- replaced
- indicated
- benzoilguanidinas
- ischemically
- appearance
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C279/00—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups
- C07C279/20—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups containing any of the groups, X being a hetero atom, Y being any atom, e.g. acylguanidines
- C07C279/22—Y being a hydrogen or a carbon atom, e.g. benzoylguanidines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/08—Drugs for disorders of the urinary system of the prostate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P41/00—Drugs used in surgical methods, e.g. surgery adjuvants for preventing adhesion or for vitreum substitution
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Diabetes (AREA)
- Urology & Nephrology (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Endocrinology (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Surgery (AREA)
- Neurosurgery (AREA)
- Emergency Medicine (AREA)
- Vascular Medicine (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Abstract
BENZOIL-GUANIDINAS SUSTITUIDAS EN POSICION ORTO DE FORMULA I EN LA QUE DE R(1) A R(4) TIENEN LOS SIGNIFICADOS INDICADOS EN LAS REIVINDICACIONES, SE UTILIZAN COMO MEDICAMENTOS ANTIARRITMICOS CON COMPONENTES CARDIOPROTECTORES PARA LA PREVENCION Y TRATAMIENTO DEL INFARTO, ASI COMO PARA EL TRATAMIENTO DE LA ANGINA DE PECHO. TAMBIEN INHIBEN DE MANERA PREVENTIVA LOS PROCESOS PATOFISIOLOGICOS EN LA APARICION DE LESIONES INDUCIDAS ISQUEMICAMENTE, EN PARTICULAR EN LA APARICION DE ARRITMIAS CARDIACAS INDUCIDAS ISQUEMICAMENTE.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE19608161A DE19608161A1 (de) | 1996-03-04 | 1996-03-04 | Ortho-substituierte Benzoylguanidine, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2166481T3 true ES2166481T3 (es) | 2002-04-16 |
Family
ID=7787087
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES97102607T Expired - Lifetime ES2166481T3 (es) | 1996-03-04 | 1997-02-19 | Benzoilguanidinas sustituidas en posicion orto. |
Country Status (30)
Country | Link |
---|---|
US (1) | US6262123B1 (es) |
EP (1) | EP0794172B1 (es) |
JP (1) | JP4039586B2 (es) |
KR (1) | KR970065511A (es) |
CN (1) | CN1071318C (es) |
AR (1) | AR006051A1 (es) |
AT (1) | ATE207462T1 (es) |
AU (1) | AU707619B2 (es) |
BR (1) | BR9701159A (es) |
CA (1) | CA2198980A1 (es) |
CZ (1) | CZ293144B6 (es) |
DE (2) | DE19608161A1 (es) |
DK (1) | DK0794172T3 (es) |
ES (1) | ES2166481T3 (es) |
HR (1) | HRP970125B1 (es) |
HU (1) | HUP9700542A3 (es) |
ID (1) | ID16106A (es) |
IL (1) | IL120358A (es) |
MX (1) | MX9701619A (es) |
MY (1) | MY116861A (es) |
NO (1) | NO308793B1 (es) |
NZ (1) | NZ314325A (es) |
PL (1) | PL185751B1 (es) |
PT (1) | PT794172E (es) |
RU (1) | RU2212400C2 (es) |
SI (1) | SI0794172T1 (es) |
SK (1) | SK283934B6 (es) |
TR (1) | TR199700131A2 (es) |
TW (1) | TW440558B (es) |
ZA (1) | ZA971815B (es) |
Families Citing this family (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE10001879A1 (de) * | 2000-01-19 | 2001-07-19 | Aventis Pharma Gmbh | Substituierte Benzoylguanidine, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament |
CN100371328C (zh) * | 2006-01-19 | 2008-02-27 | 中国药科大学 | 取代苯甲酰基胍衍生物、其制备方法及其医药用途 |
Family Cites Families (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
TW250477B (es) | 1992-12-15 | 1995-07-01 | Hoechst Ag | |
DE59403818D1 (de) | 1993-02-20 | 1997-10-02 | Hoechst Ag | Substituierte Benzoylguanidine, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament, als Inhibitoren des zellulären Na+/H+-Austauschs oder als Diagnostikum sowie sie enthaltendes Medikament |
DE4318756A1 (de) | 1993-06-05 | 1994-12-08 | Hoechst Ag | Substituierte Benzoylguanidine, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament |
DE4328869A1 (de) * | 1993-08-27 | 1995-03-02 | Hoechst Ag | Ortho-substituierte Benzoylguanidine, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament |
DE4404183A1 (de) * | 1994-02-10 | 1995-08-17 | Merck Patent Gmbh | 4-Amino-1-piperidylbenzoylguanidine |
DE4417004A1 (de) | 1994-05-13 | 1995-11-16 | Hoechst Ag | Perfluoralkyl-substituierte Benzoylguanidine, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament |
DE4421495A1 (de) * | 1994-06-20 | 1995-12-21 | Merck Patent Gmbh | Heterocyclyloxy-benzoylguanidine |
DE4430213A1 (de) * | 1994-08-28 | 1996-02-29 | Merck Patent Gmbh | Arylbenzoylguanidine |
DE4430861A1 (de) * | 1994-08-31 | 1996-03-07 | Merck Patent Gmbh | Heterocyclyl-benzoylguanidine |
DE19517848A1 (de) * | 1995-05-16 | 1996-11-21 | Merck Patent Gmbh | Fluorhaltige Benzoylguanidine |
DE19531138A1 (de) * | 1995-08-24 | 1997-02-27 | Merck Patent Gmbh | Alkenyl-benzoylguanidin-Derivate |
DE19624178A1 (de) * | 1996-06-18 | 1998-01-08 | Hoechst Ag | Ortho-substituierte Benzoylguanidine, Verfahren zu ihrer Herstellung ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament |
-
1996
- 1996-03-04 DE DE19608161A patent/DE19608161A1/de not_active Withdrawn
-
1997
- 1997-02-11 PL PL97318415A patent/PL185751B1/pl not_active IP Right Cessation
- 1997-02-19 EP EP97102607A patent/EP0794172B1/de not_active Expired - Lifetime
- 1997-02-19 AT AT97102607T patent/ATE207462T1/de not_active IP Right Cessation
- 1997-02-19 PT PT97102607T patent/PT794172E/pt unknown
- 1997-02-19 SI SI9730252T patent/SI0794172T1/xx unknown
- 1997-02-19 DK DK97102607T patent/DK0794172T3/da active
- 1997-02-19 ES ES97102607T patent/ES2166481T3/es not_active Expired - Lifetime
- 1997-02-19 DE DE59705019T patent/DE59705019D1/de not_active Expired - Lifetime
- 1997-02-27 TW TW086102369A patent/TW440558B/zh not_active IP Right Cessation
- 1997-02-28 AU AU14997/97A patent/AU707619B2/en not_active Ceased
- 1997-02-28 NZ NZ314325A patent/NZ314325A/en unknown
- 1997-02-28 CN CN97102833A patent/CN1071318C/zh not_active Expired - Fee Related
- 1997-02-28 AR ARP970100820A patent/AR006051A1/es unknown
- 1997-02-28 SK SK276-97A patent/SK283934B6/sk unknown
- 1997-03-03 MX MX9701619A patent/MX9701619A/es not_active IP Right Cessation
- 1997-03-03 KR KR1019970006865A patent/KR970065511A/ko not_active Application Discontinuation
- 1997-03-03 CZ CZ1997654A patent/CZ293144B6/cs not_active IP Right Cessation
- 1997-03-03 MY MYPI97000835A patent/MY116861A/en unknown
- 1997-03-03 NO NO970963A patent/NO308793B1/no unknown
- 1997-03-03 ZA ZA9701815A patent/ZA971815B/xx unknown
- 1997-03-03 ID IDP970641A patent/ID16106A/id unknown
- 1997-03-03 IL IL12035897A patent/IL120358A/en not_active IP Right Cessation
- 1997-03-03 RU RU97103361/04A patent/RU2212400C2/ru not_active IP Right Cessation
- 1997-03-03 BR BR9701159A patent/BR9701159A/pt not_active Application Discontinuation
- 1997-03-03 HR HR970125A patent/HRP970125B1/xx not_active IP Right Cessation
- 1997-03-03 CA CA002198980A patent/CA2198980A1/en not_active Abandoned
- 1997-03-03 TR TR97/00131A patent/TR199700131A2/xx unknown
- 1997-03-03 JP JP04747997A patent/JP4039586B2/ja not_active Expired - Fee Related
- 1997-03-04 HU HU9700542A patent/HUP9700542A3/hu unknown
-
1999
- 1999-09-17 US US09/398,196 patent/US6262123B1/en not_active Expired - Fee Related
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FG2A | Definitive protection |
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