ES2164903T3 - Procedimiento de extraccion y de aislamiento de la 10-desacetilbaccatina iii. - Google Patents

Procedimiento de extraccion y de aislamiento de la 10-desacetilbaccatina iii.

Info

Publication number
ES2164903T3
ES2164903T3 ES96924941T ES96924941T ES2164903T3 ES 2164903 T3 ES2164903 T3 ES 2164903T3 ES 96924941 T ES96924941 T ES 96924941T ES 96924941 T ES96924941 T ES 96924941T ES 2164903 T3 ES2164903 T3 ES 2164903T3
Authority
ES
Spain
Prior art keywords
tetraol
extracting
isolation
extraction
procedure
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES96924941T
Other languages
English (en)
Inventor
Paul Negol
Marie-Jeanne Serrano
Bruno David
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pierre Fabre Medicament SA
Original Assignee
Pierre Fabre Medicament SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pierre Fabre Medicament SA filed Critical Pierre Fabre Medicament SA
Application granted granted Critical
Publication of ES2164903T3 publication Critical patent/ES2164903T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D305/00—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms
    • C07D305/14—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms condensed with carbocyclic rings or ring systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Compounds Of Unknown Constitution (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Extraction Or Liquid Replacement (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Element Separation (AREA)
  • Peptides Or Proteins (AREA)

Abstract

LA PRESENTE INVENCION CONSISTE EN UN PROCEDIMIENTO DE EXTRACCION Y AISLAMIENTO DE LA 10 - DESACETILBACATINA III (TETRAOL) A PARTIR DE HOJAS DE TEJO. COMPRENDE UNA PRIMERA FASE DE EXTRACCION DE LAS HOJAS DE TEJO MEDIANTE UN DISOLVENTE PROTEICO ADECUADO PARA OBTENER UN EXTRACTO ACUOSO, UNA SEGUNDA FASE DE EXTRACCION DEL EXTRACTO ACUOSO MEDIANTE UN DISOLVENTE ORGANICO ADECUADO, QUE PERMITE LA CRISTALIZACION SELECTIVA DEL TETRAOL, Y UNA TERCERA FASE DE AISLAMIENTO DEL TETRAOL POR CRISTALIZACION SELECTIVA A PARTIR DE LA FASE ORGANICA OBTENIDA ANTERIORMENTE. UNA ULTIMA FASE DE PURIFICACION PERMITE OBTENER UN PRODUCTO CON UN TITULO DEL ORDEN DEL 100 %.
ES96924941T 1995-07-07 1996-07-05 Procedimiento de extraccion y de aislamiento de la 10-desacetilbaccatina iii. Expired - Lifetime ES2164903T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR9508241A FR2736355B1 (fr) 1995-07-07 1995-07-07 Procede d'extraction et d'isolement de la 10-desacetylbaccatine iii

Publications (1)

Publication Number Publication Date
ES2164903T3 true ES2164903T3 (es) 2002-03-01

Family

ID=9480793

Family Applications (1)

Application Number Title Priority Date Filing Date
ES96924941T Expired - Lifetime ES2164903T3 (es) 1995-07-07 1996-07-05 Procedimiento de extraccion y de aislamiento de la 10-desacetilbaccatina iii.

Country Status (7)

Country Link
EP (1) EP0839141B1 (es)
AT (1) ATE206115T1 (es)
DE (1) DE69615562T2 (es)
ES (1) ES2164903T3 (es)
FR (1) FR2736355B1 (es)
PT (1) PT839141E (es)
WO (1) WO1997003061A1 (es)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6136989A (en) * 1998-12-30 2000-10-24 Phytogen Life Sciences, Incorporated Method for high yield and large scale extraction of paclitaxel from paclitaxel-containing material
US6759539B1 (en) * 2003-02-27 2004-07-06 Chaichem Pharmaceuticals International Process for isolation and purification of paclitaxel from natural sources
CN111505172A (zh) * 2020-06-08 2020-08-07 上海市普陀区中心医院 一种红豆杉枝叶中10-dabⅲ含量测定的方法

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2696462B1 (fr) * 1992-10-05 1994-11-25 Rhone Poulenc Rorer Sa Procédé d'obtention de la désacétyl-10 baccatine III.
FR2696463B1 (fr) * 1992-10-05 1994-11-25 Rhone Poulenc Rorer Sa Procédé d'obtention de la désacétyl-10 baccatine III.
FR2714053B1 (fr) * 1993-12-22 1996-03-08 Pf Medicament Procédé d'extraction et d'isolement de la 10-désacétylbaccatine III.

Also Published As

Publication number Publication date
FR2736355A1 (fr) 1997-01-10
DE69615562D1 (de) 2001-10-31
PT839141E (pt) 2002-03-28
FR2736355B1 (fr) 1997-11-07
EP0839141B1 (fr) 2001-09-26
EP0839141A1 (fr) 1998-05-06
ATE206115T1 (de) 2001-10-15
WO1997003061A1 (fr) 1997-01-30
DE69615562T2 (de) 2002-07-11

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