ES2162165T3 - Procedimiento para la fabricacion de simvastatina o acido mevinolinico. - Google Patents
Procedimiento para la fabricacion de simvastatina o acido mevinolinico.Info
- Publication number
- ES2162165T3 ES2162165T3 ES97111277T ES97111277T ES2162165T3 ES 2162165 T3 ES2162165 T3 ES 2162165T3 ES 97111277 T ES97111277 T ES 97111277T ES 97111277 T ES97111277 T ES 97111277T ES 2162165 T3 ES2162165 T3 ES 2162165T3
- Authority
- ES
- Spain
- Prior art keywords
- formula
- treating
- iii
- simvastatin
- compound
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
- C07D309/16—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D309/28—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D309/30—Oxygen atoms, e.g. delta-lactones
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pyrane Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
UN PROCESO PARA PREPARAR SIMVASTATINA A PARTIR DE LOVASTATINA O ACIDO MEVINOLINICO EN SU FORMA DE SAL INCLUYE TRATAR CUALQUIERA DE LOS MATERIALES DE PARTIDA CON CICLOPROPILO O BUTILAMIDA, ABRIENDOSE DE ESE MODO EL ANILLO PIRANONA CUANDO EL MATERIAL DE PARTIDA ES LOVASTATINA, AÑADIR UN GRUPO METILO A LA CADENA LATERAL 2 - METILBUTIRATO, Y POSTERIORMENTE CERRAR EL ANILLO PIRANONA ABIERTO PARA PRODUCIR SIMVASTATINA. EL PROCESO SE REALIZA SIN PROTEGER Y DESPROTEGER LOS DOS GRUPOS HIDROXI DEL ANILLO PIRANONA ABIERTO. EN UNA REALIZACION PREFERIDA, SE TRATA EL MATERIAL DE PARTIDA CON CICLOPROPILAMINA, LO CUAL PRODUCE SIMVASTATINA VIA EL NUEVO INTERMEDIO CICLOPROPILAMIDA DE LOVASTATINA.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US08/816,573 US5763646A (en) | 1997-03-13 | 1997-03-13 | Process for manufacturing simvastatin from lovastatin or mevinolinic acid |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2162165T3 true ES2162165T3 (es) | 2001-12-16 |
Family
ID=25221004
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES97111277T Expired - Lifetime ES2162165T3 (es) | 1997-03-13 | 1997-07-04 | Procedimiento para la fabricacion de simvastatina o acido mevinolinico. |
Country Status (7)
Country | Link |
---|---|
US (1) | US5763646A (es) |
EP (1) | EP0864569B1 (es) |
AT (1) | ATE204271T1 (es) |
AU (1) | AU693401B1 (es) |
DE (1) | DE69706135T2 (es) |
ES (1) | ES2162165T3 (es) |
ZA (1) | ZA974023B (es) |
Families Citing this family (29)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
NO991045L (no) † | 1998-03-05 | 1999-09-06 | Synthon Bv | FremgangsmÕte ved fremstilling av simvastatin og/eller dets derivater |
EP0940395A1 (en) | 1998-03-05 | 1999-09-08 | Synthon B.V. | Process for producing simvastatin and/or its derivatives |
CA2335366A1 (en) * | 1998-06-24 | 1999-12-29 | Merck & Co., Inc. | Compositions and methods for treating elevated blood cholesterol |
EP1088333A4 (en) | 1998-06-24 | 2005-08-10 | Merck & Co Inc | METHOD AND COMPOSITIONS FOR CONNECTING OSTEOPROSIS |
US20030078211A1 (en) * | 1998-06-24 | 2003-04-24 | Merck & Co., Inc. | Compositions and methods for inhibiting bone resorption |
SI20070A (sl) * | 1998-09-18 | 2000-04-30 | LEK, tovarna farmacevtskih in kemi�nih izdelkov, d.d. | Nove soli inhibitorjev HMG-CoA reduktaze |
DE69922348T2 (de) * | 1998-12-10 | 2005-12-01 | Kaneka Corp. | Verfahren zur herstellung eines simvastatin precursors |
CO5140104A1 (es) * | 1999-02-16 | 2002-03-22 | Novartis Ag | Derivados de mevinolina y preparacion farmaceuticas que los contienen |
WO2001034590A1 (en) * | 1999-11-11 | 2001-05-17 | Biocon India Limited | Process for manufacturing simvastatin and the novel intermediates |
US6573385B1 (en) | 1999-11-11 | 2003-06-03 | Biocon India Limited | Process for manufacturing simvastatin and novel intermediates thereof |
IN192861B (es) * | 2000-06-30 | 2004-05-22 | Ranbaxy Lab Ltd | |
US6472542B1 (en) | 2001-11-29 | 2002-10-29 | Fermic S.A. De C.V. | Method for alkylating the alpha carbon of the 2-methylbutyrate secondary chain of lovastatin |
SI21187A (sl) | 2002-03-26 | 2003-10-31 | Krka, Tovarna Zdravil D.D., Novo Mesto | Postopek za pripravo 4-oksitetrahidropiran-2-onov |
US6603022B1 (en) | 2002-05-10 | 2003-08-05 | Biocon India Limited | Process for manufacturing Simvastatin and novel intermediates thereof |
US20060019269A1 (en) * | 2002-10-17 | 2006-01-26 | Decode Genetics, Inc. | Susceptibility gene for myocardial infarction, stroke, and PAOD, methods of treatment |
US20080293750A1 (en) * | 2002-10-17 | 2008-11-27 | Anna Helgadottir | Susceptibility Gene for Myocardial Infarction, Stroke, Paod and Methods of Treatment |
WO2005042089A1 (en) * | 2003-10-31 | 2005-05-12 | Sunshine Heart Company Pty Ltd | Synchronisation control system |
WO2005066150A1 (en) * | 2004-01-02 | 2005-07-21 | Hetero Drugs Limited | A novel process for the preparation of simvastatin |
US8158362B2 (en) * | 2005-03-30 | 2012-04-17 | Decode Genetics Ehf. | Methods of diagnosing susceptibility to myocardial infarction and screening for an LTA4H haplotype |
US20100216863A1 (en) * | 2004-01-30 | 2010-08-26 | Decode Genetics Ehf. | Susceptibility Gene for Myocardial Infarction, Stroke, and PAOD; Methods of Treatment |
DE602004023004D1 (de) * | 2004-09-08 | 2009-10-15 | Jubilant Organosys Ltd | Verbessertes verfahren zur lactonisierung bei der herstellung von statinen |
CN1754870A (zh) * | 2004-09-30 | 2006-04-05 | 淮北市辉克药业有限公司 | 辛伐他汀的制备方法 |
WO2006072963A1 (en) * | 2005-01-10 | 2006-07-13 | Concord Biotech Limited | Process for preparing simvastatin from lovastatin amine salts in three steps |
WO2007020079A2 (en) * | 2005-08-17 | 2007-02-22 | Synthon B.V. | Orally disintegratable simvastatin tablets |
US20070129437A1 (en) * | 2005-12-06 | 2007-06-07 | Ferenc Korodi | Process for preparing simvastatin and intermediates thereof |
ES2343049B1 (es) | 2008-10-15 | 2011-06-10 | Neuron Biopharma, S.A. | Biosintesis de derivados de monacolina j. |
DK3190123T3 (da) | 2009-09-30 | 2019-09-30 | Codexis Inc | Forbedret lov-d acyltransferase medieret acylering |
EP2486129B1 (en) | 2009-10-08 | 2016-04-13 | The Regents of The University of California | LovD MUTANTS EXHIBITING IMPROVED PROPERTIES TOWARDS SIMVASTATIN SYNTHESIS |
CN104744416A (zh) * | 2015-03-25 | 2015-07-01 | 河南师范大学 | 一种辛伐他汀的制备方法 |
Family Cites Families (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS5612114B2 (es) * | 1974-06-07 | 1981-03-18 | ||
US4231938A (en) * | 1979-06-15 | 1980-11-04 | Merck & Co., Inc. | Hypocholesteremic fermentation products and process of preparation |
US4444784A (en) * | 1980-08-05 | 1984-04-24 | Merck & Co., Inc. | Antihypercholesterolemic compounds |
US4293496A (en) * | 1980-02-04 | 1981-10-06 | Merck & Co., Inc. | 6(R)-[2-(8-Hydroxy-2,6-dimethylpolyhydronaphthyl-1)-ethyl]-4(R)-hydroxy-3,4,5,6-tetrahydro-2H-pyran-2-ones |
US4450171A (en) * | 1980-08-05 | 1984-05-22 | Merck & Co., Inc. | Antihypercholesterolemic compounds |
DE3480923D1 (de) * | 1983-10-11 | 1990-02-08 | Merck & Co Inc | Verfahren zur c-methylierung von 2-methylbutyraten. |
US4582915A (en) * | 1983-10-11 | 1986-04-15 | Merck & Co., Inc. | Process for C-methylation of 2-methylbutyrates |
US4584389A (en) * | 1983-10-11 | 1986-04-22 | Merck & Co., Inc. | Processes for preparing 6(R)-[2-[8(S)(2,2-dimethylbutyryloxy)-2(S),6(S)-dimethyl-1,2,3,4,4a(S),5,6,7,8,8a(S)-decahydronaphthyl-1(S)]ethyl]-4(R)-hydroxy-3,4,5,6-tetrahydro-2H-pyran-2-one |
US4611081A (en) * | 1985-07-05 | 1986-09-09 | Merck & Co., Inc. | Process for the preparation of HMG-CoA reductase inhibitors intermediates |
US4820850A (en) * | 1987-07-10 | 1989-04-11 | Merck & Co., Inc. | Process for α-C-alkylation of the 8-acyl group on mevinolin and analogs thereof |
US5177104A (en) * | 1990-04-03 | 1993-01-05 | E. R. Squibb & Sons, Inc. | 6-α-hydroxy derivatives of mevinic acids |
US5223415A (en) * | 1990-10-15 | 1993-06-29 | Merck & Co., Inc. | Biosynthetic production of 7-[1',2',6',7',8',8a'(R)-hexahydro-2'(S),6'(R)-dimethyl-8'(S)-hydroxy-1'(S)-naphthyl]-3(R),5(R)-dihydroxyheptanoic acid (triol acid) |
US5159104A (en) * | 1991-05-01 | 1992-10-27 | Merck & Co., Inc. | Process to simvastatin ester |
US5393893A (en) * | 1993-11-08 | 1995-02-28 | Apotex, Inc. | Process for producing simvastatin and analogs thereof |
-
1997
- 1997-03-13 US US08/816,573 patent/US5763646A/en not_active Expired - Lifetime
- 1997-05-09 ZA ZA9704023A patent/ZA974023B/xx unknown
- 1997-05-14 AU AU21408/97A patent/AU693401B1/en not_active Ceased
- 1997-07-04 EP EP97111277A patent/EP0864569B1/en not_active Revoked
- 1997-07-04 ES ES97111277T patent/ES2162165T3/es not_active Expired - Lifetime
- 1997-07-04 DE DE69706135T patent/DE69706135T2/de not_active Expired - Fee Related
- 1997-07-04 AT AT97111277T patent/ATE204271T1/de not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
DE69706135T2 (de) | 2002-05-02 |
EP0864569A1 (en) | 1998-09-16 |
AU693401B1 (en) | 1998-06-25 |
EP0864569B1 (en) | 2001-08-16 |
ZA974023B (en) | 1997-12-10 |
DE69706135D1 (de) | 2001-09-20 |
US5763646A (en) | 1998-06-09 |
ATE204271T1 (de) | 2001-09-15 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FG2A | Definitive protection |
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