ES2156338T3 - Derivados de criptoficina y su uso como agentes antimicrotubulos. - Google Patents

Derivados de criptoficina y su uso como agentes antimicrotubulos.

Info

Publication number
ES2156338T3
ES2156338T3 ES97301272T ES97301272T ES2156338T3 ES 2156338 T3 ES2156338 T3 ES 2156338T3 ES 97301272 T ES97301272 T ES 97301272T ES 97301272 T ES97301272 T ES 97301272T ES 2156338 T3 ES2156338 T3 ES 2156338T3
Authority
ES
Spain
Prior art keywords
ring
lower alkyl
group
alkyl group
taken together
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES97301272T
Other languages
English (en)
Inventor
Bryan Hurst Norman
Chuan Shih
Julian Stanley Kroin
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of Hawaii
Wayne State University
Eli Lilly and Co
Original Assignee
University of Hawaii
Wayne State University
Eli Lilly and Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by University of Hawaii, Wayne State University, Eli Lilly and Co filed Critical University of Hawaii
Application granted granted Critical
Publication of ES2156338T3 publication Critical patent/ES2156338T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D273/00—Heterocyclic compounds containing rings having nitrogen and oxygen atoms as the only ring hetero atoms, not provided for by groups C07D261/00 - C07D271/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D273/00—Heterocyclic compounds containing rings having nitrogen and oxygen atoms as the only ring hetero atoms, not provided for by groups C07D261/00 - C07D271/00
    • C07D273/02—Heterocyclic compounds containing rings having nitrogen and oxygen atoms as the only ring hetero atoms, not provided for by groups C07D261/00 - C07D271/00 having two nitrogen atoms and only one oxygen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Saccharide Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

LA INVENCION PROPORCIONA NUEVOS COMPUESTOS DE CRIPTOFICINA QUE PUEDEN SER UTILES PARA INTERRUMPIR EL SISTEMA DE MICROTUBULINA, COMO AGENTES ANTINEOPLASTICOS, Y PARA EL TRATAMIENTO DE CANCER. LA INVENCION PROPORCIONA ADEMAS UNA FORMULACION PARA ADMINISTRAR LOS NUEVOS COMPUESTOS DE CRIPTOFICINA. LOS COMPUESTOS SON DE LA FORMULA EN DONDE AR ES FENILO O CUALQUIER GRUPO AROMATICO O HETEROAROMATICO INSUSTITUIDO O SUSTITUIDO SIMPLE; R{SUP,1} ES HALOGENO, SH, AMINO, MONOALQUILAMINO, DIALQUILAMINO, TRIALQUILAMONIO, ALQUILTIO, DIALQUILSULFONIO, SULFATO, O FOSFATO; R{SUP,2} ES OH O SH; O R{SUP,1} Y R{SUP,2} PUEDEN SER TOMADOS JUNTOS PARA FORMAR UN ANILLO EPOXIDO, Y ANILLO DE AZIRIDINA, UN ANILLO DE EPISULFURO, UN ANILLO DE SULFATO, O ANILLO DE MONOALQUILFOSFATO; O R{SUP,1} Y R{SUP,2} PUEDEN SER TOMADOS JUNTOS PARA FORMAR UN SEGUNDO ENLACE ENTRE C{SUB,18} Y C{SUB,19}; R{SUP,3} ES UN GRUPO ALQUILO BAJO; R{SUP,4} ES H; R{SUP,5} ES H; R{SUP,4} Y R{SUP,5} PUEDEN SER TOMADOS JUNTOS PARA FORMAR UN SEGUNDO ENLACE ENTRE C{SUB,13} Y C{SUB,14}; R{SUP,6} ES UN GRUPO BENCILO, HIDROXIBENCILO, ALCOXIBENCILO, HALOHIDROXIBENCILO, DIHALOHIDROXIBENCILO, HALOALCOXIBENCILO, O DIHALOALCOXIBENCILO; R{SUP,7} ES H O UN GRUPO ALQUILO BAJO; R{SUP,8} ES H O UN GRUPO ALQUILO BAJO; O R{SUP,7} Y R{SUP,8} PUEDEN SER TOMADOS JUNTOS PARA FORMAR UN ANILLO DE CICLOPROPILO; R{SUP,9} SE SELECCIONA DEL GRUPO QUE CONSTA DE H, UN GRUPO ALQUILO BAJO, ALQUILARILO (()C{SUB,1}-C{SUB,3}()), Y ARILO; R{SUP,10} SE SELECCIONA DEL GRUPO QUE CONSTA DE H, UN GRUPO ALQUILO BAJO, ALQUILARILO (()C{SUB,1}-C{SUB,3}()), Y ARILO; R{SUP,11} ES H; ALQUILO SIMPLE; FENILO; FENILO SUSTITUIDO, BENCILO, BENCILO SUSTITUIDO; X ES O, NH O ALQUILAMINO; Y ES C, O, NH, S, SO, SO{SUB,2} O ALQUILAMINO; Y UNA SAL O SOLVATO FARMACEUTICAMENTE ACEPTABLE DE LOS MISMOS.
ES97301272T 1996-02-27 1997-02-26 Derivados de criptoficina y su uso como agentes antimicrotubulos. Expired - Lifetime ES2156338T3 (es)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US1237596P 1996-02-27 1996-02-27
US1236596P 1996-02-27 1996-02-27
US2508096P 1996-08-30 1996-08-30
US2508196P 1996-08-30 1996-08-30

Publications (1)

Publication Number Publication Date
ES2156338T3 true ES2156338T3 (es) 2001-06-16

Family

ID=27486177

Family Applications (1)

Application Number Title Priority Date Filing Date
ES97301272T Expired - Lifetime ES2156338T3 (es) 1996-02-27 1997-02-26 Derivados de criptoficina y su uso como agentes antimicrotubulos.

Country Status (7)

Country Link
EP (1) EP0792875B1 (es)
AT (1) ATE201018T1 (es)
AU (1) AU2058197A (es)
DE (1) DE69704731D1 (es)
DK (1) DK0792875T3 (es)
ES (1) ES2156338T3 (es)
WO (1) WO1997031632A1 (es)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
YU10899A (sh) * 1996-08-30 2002-03-18 Eli Lilli And Company Farmaceutska jedinjenja
JP2001502297A (ja) * 1996-08-30 2001-02-20 イーライ・リリー・アンド・カンパニー 医薬用化合物
CA2263764A1 (en) * 1996-09-06 1998-03-12 Michael John Martinelli Process and novel intermediates
HUP0000212A3 (en) * 1996-09-06 2001-12-28 Wayne State University Detroit Process to prepare cryptophycin derivatives and intermediates thereof
WO1998038158A1 (en) * 1997-02-26 1998-09-03 Eli Lilly And Company Process for preparing pharmaceutical compounds
CA2347246A1 (en) * 1998-10-16 2000-04-27 James Abraham Aikins Stereoselective process for producing cryptophycins
EP1229934B1 (en) 1999-10-01 2014-03-05 Immunogen, Inc. Compositions and methods for treating cancer using immunoconjugates and chemotherapeutic agents
JP2004505112A (ja) * 2000-08-02 2004-02-19 スリル　バイオメディカル　コーポレイション 癌治療のための環状ポリアミン化合物
US20050096324A1 (en) * 2003-11-05 2005-05-05 Zhi-Fu Tao Macrocyclic kinase inhibitors
US7163939B2 (en) 2003-11-05 2007-01-16 Abbott Laboratories Macrocyclic kinase inhibitors

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5026703A (en) * 1990-06-11 1991-06-25 Merck & Co., Inc. Peptide oxytocin antagonists
CA2179490A1 (en) * 1993-12-21 1995-06-29 Trimurtulu Golakoti New cryptophycins

Also Published As

Publication number Publication date
EP0792875B1 (en) 2001-05-09
EP0792875A1 (en) 1997-09-03
WO1997031632A1 (en) 1997-09-04
ATE201018T1 (de) 2001-05-15
DK0792875T3 (da) 2001-05-28
DE69704731D1 (de) 2001-06-13
AU2058197A (en) 1997-09-16

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