ES2150107T3 - Inmunogenos no toxicos que proceden de una proteina de regulacion retroviral, anticuerpos dirigidos contra estos inmunogenos, procedimiento para su preparacion y composiciones farmaceuticas que los contienen. - Google Patents
Inmunogenos no toxicos que proceden de una proteina de regulacion retroviral, anticuerpos dirigidos contra estos inmunogenos, procedimiento para su preparacion y composiciones farmaceuticas que los contienen.Info
- Publication number
- ES2150107T3 ES2150107T3 ES96906795T ES96906795T ES2150107T3 ES 2150107 T3 ES2150107 T3 ES 2150107T3 ES 96906795 T ES96906795 T ES 96906795T ES 96906795 T ES96906795 T ES 96906795T ES 2150107 T3 ES2150107 T3 ES 2150107T3
- Authority
- ES
- Spain
- Prior art keywords
- directed against
- antibodies directed
- immunogenes
- immunogens
- retroviral
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 102000004169 proteins and genes Human genes 0.000 title abstract 2
- 108090000623 proteins and genes Proteins 0.000 title abstract 2
- 231100000252 nontoxic Toxicity 0.000 title 1
- 230000003000 nontoxic effect Effects 0.000 title 1
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- 230000001177 retroviral effect Effects 0.000 title 1
- 102000014914 Carrier Proteins Human genes 0.000 abstract 1
- 108010078791 Carrier Proteins Proteins 0.000 abstract 1
- 150000001299 aldehydes Chemical class 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 239000007822 coupling agent Substances 0.000 abstract 1
- 102000034356 gene-regulatory proteins Human genes 0.000 abstract 1
- 108091006104 gene-regulatory proteins Proteins 0.000 abstract 1
- 230000002163 immunogen Effects 0.000 abstract 1
- 239000000126 substance Substances 0.000 abstract 1
- 230000001988 toxicity Effects 0.000 abstract 1
- 231100000419 toxicity Toxicity 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
- A61K39/21—Retroviridae, e.g. equine infectious anemia virus
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/08—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses
- C07K16/10—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses from RNA viruses
- C07K16/1036—Retroviridae, e.g. leukemia viruses
- C07K16/1045—Lentiviridae, e.g. HIV, FIV, SIV
- C07K16/1072—Regulatory proteins, e.g. tat, rev, vpt
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2740/00—Reverse transcribing RNA viruses
- C12N2740/00011—Details
- C12N2740/10011—Retroviridae
- C12N2740/16011—Human Immunodeficiency Virus, HIV
- C12N2740/16311—Human Immunodeficiency Virus, HIV concerning HIV regulatory proteins
- C12N2740/16322—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
- Y10S530/82—Proteins from microorganisms
- Y10S530/826—Viruses
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Virology (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Hematology (AREA)
- Immunology (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Gastroenterology & Hepatology (AREA)
- Public Health (AREA)
- Microbiology (AREA)
- Epidemiology (AREA)
- Pharmacology & Pharmacy (AREA)
- Mycology (AREA)
- Communicable Diseases (AREA)
- AIDS & HIV (AREA)
- Oncology (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
Abstract
COMPUESTO INMUNOGENO ADMINISTRABLE AL HOMBRE YA QUE ESTA DESPROVISTO DE TOXICIDAD, QUE SE DERIVA DE UNA PROTEINA DE REGULACION DE UN VIRUS VIH TRATAMIENTO QUIMICO MEDIANTE UN AGENTE DE ACOPLAMIENTO TAL COMO UN ALDEHIDO, O DE UNA PROTEINA PORTADORA ACTIVADA POR UN PRETRATAMIENTO MEDIANTE UN ALDEHIDO, QUE LE PERMITE SER RECONOCIDO POR ANTICUERPOS DIRIGIDOS CONTRA DICHA PROTEINA DE REGULACION, Y CONSERVAR PROPIEDADES INMUNOGENAS SUFICIENTES PARA CREAR ANTICUERPOS QUE NEUTRALIZAN O BLOQUEAN DICHA PROTEINA NATIVA, A LA VEZ QUE SE PIERDEN AL MENOS 50 % DE LAS PROPIEDADES BIOLOGICAS TOXICAS DE DICHA PROTEINA NATIVA.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR9502708A FR2731355B1 (fr) | 1995-03-08 | 1995-03-08 | Nouveaux immunogenes, nouveaux anticorps, procede de preparation et compositions pharmaceutiques les renfermant |
FR9502708 | 1995-03-08 |
Publications (2)
Publication Number | Publication Date |
---|---|
ES2150107T3 true ES2150107T3 (es) | 2000-11-16 |
ES2150107T5 ES2150107T5 (es) | 2009-08-05 |
Family
ID=9476864
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES96906795T Expired - Lifetime ES2150107T5 (es) | 1995-03-08 | 1996-03-07 | Inmunogenos no toxicos que proceden de una proteina de regulacion retroviral, anticuerpos dirigidos contra estos inmunogenos, procedimiento para su preparacion y composiciones farmaceuticas que los contienen. |
Country Status (6)
Country | Link |
---|---|
KR (1) | KR100309856B1 (es) |
CN (1) | CN1226046C (es) |
ES (1) | ES2150107T5 (es) |
FR (1) | FR2731355B1 (es) |
OA (1) | OA10615A (es) |
PT (1) | PT814834E (es) |
Families Citing this family (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA2398269C (en) * | 1999-08-12 | 2013-04-09 | David I. Cohen | Non-immunosuppressant hiv tat |
US8323928B2 (en) | 1999-08-12 | 2012-12-04 | Pin Pharma, Inc. | Vaccines and immunotherapeutics derived from the human immunodeficiency virus (HIV) transactivator of transcription protein for the treatment and prevention of HIV disease |
FR2844514B1 (fr) * | 2002-09-16 | 2007-10-19 | Neovacs | Produit immunogene stable comprenant des heterocomplexes antigeniques, compositions les contenant et procede de preparation |
US9944693B2 (en) * | 2013-12-08 | 2018-04-17 | Peptcell Limited | HIV antigens and antibodies and compositions, uses and methods thereof |
Family Cites Families (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU3756789A (en) * | 1988-06-16 | 1990-01-12 | St. Louis University | Antagonists of viral transactivating proteins |
WO1991015224A1 (en) * | 1990-03-30 | 1991-10-17 | Smithkline Beecham Corporation | Inhibition of disease associated with immunodeficiency virus infection |
WO1991018454A1 (en) * | 1990-05-18 | 1991-11-28 | Centre National De La Recherche Scientifique | Compositions capable of blocking cytotoxicity of viral regulatory proteins and neurotoxic symptoms associated with retroviral infection |
EP0571549A4 (en) * | 1991-02-14 | 1995-03-15 | Jolla Cancer Res Found | INNOVATIVE INTEGRIN SPECIFICITY FOR THE HIV-TAT PROTEIN. |
WO1993022349A1 (en) * | 1992-04-24 | 1993-11-11 | The Institute For Human Genetics And Biochemistry | NATURAL HUMAN IgM ANTIBODIES |
WO1993025235A1 (en) * | 1992-06-09 | 1993-12-23 | President And Fellows Of Harvard College | Aids therapeutics based on hiv-2 vpx peptides |
WO1994015634A1 (en) * | 1992-12-30 | 1994-07-21 | Matthias Rath | Tat and rev oligopeptides in hiv treatment |
FR2700169B1 (fr) * | 1993-01-04 | 1995-03-24 | Transgene Sa | Nouveaux variants trans-dominants TAT du virus de l'immunodéficience humaine. |
AU7263994A (en) * | 1993-08-06 | 1995-02-28 | Kai Juhani Ernst Krohn | Novel mutated human and simian immunodeficiency viruses and vaccines containing said viruses |
-
1995
- 1995-03-08 FR FR9502708A patent/FR2731355B1/fr not_active Expired - Fee Related
-
1996
- 1996-03-07 ES ES96906795T patent/ES2150107T5/es not_active Expired - Lifetime
- 1996-03-07 PT PT96906795T patent/PT814834E/pt unknown
- 1996-03-07 CN CNB961931914A patent/CN1226046C/zh not_active Expired - Fee Related
- 1996-03-07 KR KR1019970706241A patent/KR100309856B1/ko not_active IP Right Cessation
-
1997
- 1997-09-08 OA OA70071A patent/OA10615A/fr unknown
Also Published As
Publication number | Publication date |
---|---|
FR2731355A1 (fr) | 1996-09-13 |
PT814834E (pt) | 2001-01-31 |
KR19980702834A (ko) | 1998-08-05 |
OA10615A (fr) | 2002-08-30 |
CN1226046C (zh) | 2005-11-09 |
KR100309856B1 (ko) | 2003-03-06 |
FR2731355B1 (fr) | 1997-05-30 |
ES2150107T5 (es) | 2009-08-05 |
CN1181020A (zh) | 1998-05-06 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FG2A | Definitive protection |
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